{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:16:29Z","timestamp":1793837789417,"version":"4.6.1"},"reference-count":60,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","ijaaonline.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.ijantimicag.2017.12.020","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T18:14:10Z","timestamp":1514398450000},"page":"535-547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Intravenous colistin combination antimicrobial treatment vs. monotherapy: a systematic review and meta-analysis"],"prefix":"10.1016","volume":"51","author":[{"given":"Konstantinos Z.","family":"Vardakas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas D.","family":"Mavroudis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Georgiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew E.","family":"Falagas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0010","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S1473-3099(06)70580-1","article-title":"Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections","volume":"6","author":"Li","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0015","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1086\/429323","article-title":"Colistin: the revival of polymyxins for the management of multidrug-resistant Gram-negative bacterial infections","volume":"40","author":"Falagas","year":"2005","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0020","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1517\/14740338.2015.1088520","article-title":"The safety of polymyxin antibiotics","volume":"14","author":"Kelesidis","year":"2015","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0025","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1473-3099(14)70850-3","article-title":"Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus","volume":"15","author":"Nation","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijantimicag.2013.06.013","article-title":"Multicomponent antibiotic substances produced by fermentation: implications for regulatory authorities, critically ill patients and generics","volume":"43","author":"Brink","year":"2014","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0035","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1128\/AAC.47.5.1766-1770.2003","article-title":"Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration","volume":"47","author":"Li","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0040","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1128\/AAC.06426-11","article-title":"Application of a loading dose of colistin methanesulfonate in critically ill patients: population pharmacokinetics, protein binding, and prediction of bacterial kill","volume":"56","author":"Mohamed","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0045","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1093\/jac\/dkv086","article-title":"Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study","volume":"70","author":"Tumbarello","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0050","doi-asserted-by":"crossref","first-page":"E23","DOI":"10.1111\/1469-0691.12070","article-title":"High rate of colistin resistance among patients with carbapenem-resistant Klebsiella pneumoniae infection accounts for an excess of mortality","volume":"19","author":"Capone","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0055","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/cid\/cis588","article-title":"Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy","volume":"55","author":"Tumbarello","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0060","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1017\/S095026881200194X","article-title":"Colistin vs. the combination of colistin and rifampicin for the treatment of carbapenem-resistant Acinetobacter baumannii ventilator-associated pneumonia","volume":"141","author":"Aydemir","year":"2013","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0065","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/cid\/cit253","article-title":"Colistin and rifampicin compared with colistin alone for the treatment of serious infections due to extensively drug-resistant Acinetobacter baumannii: a multicenter, randomized clinical trial","volume":"57","author":"Durante-Mangoni","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0070","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1128\/AAC.02435-13","article-title":"Preliminary study of colistin versus colistin plus fosfomycin for treatment of carbapenem-resistant Acinetobacter baumannii infections","volume":"58","author":"Sirijatuphat","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0075","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1046\/j.1445-2197.2003.02748.x","article-title":"Methodological index for non-randomized studies (minors): development and validation of a new instrument","volume":"73","author":"Slim","year":"2003","journal-title":"ANZ J Surg"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0080","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0085","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1471-2334-14-102","article-title":"Effectiveness of tigecycline-based versus colistin-based therapy for treatment of pneumonia caused by multidrug-resistant Acinetobacter baumannii in a critical setting: a matched cohort analysis","volume":"14","author":"Chuang","year":"2014","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0090","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1128\/AAC.00782-08","article-title":"Prospective observational study of the impact of VIM-1 metallo-beta-lactamase on the outcome of patients with Klebsiella pneumoniae bloodstream infections","volume":"53","author":"Daikos","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0095","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1128\/AAC.02166-13","article-title":"Carbapenemase-producing Klebsiella pneumoniae bloodstream infections: lowering mortality by antibiotic combination schemes and the role of carbapenems","volume":"58","author":"Daikos","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0100","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ijantimicag.2009.10.005","article-title":"Colistin therapy for microbiologically documented multidrug-resistant Gram-negative bacterial infections: a retrospective cohort study of 258 patients","volume":"35","author":"Falagas","year":"2010","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0105","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ijantimicag.2008.05.016","article-title":"Pandrug-resistant Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii infections: characteristics and outcome in a series of 28 patients","volume":"32","author":"Falagas","year":"2008","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0110","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000356004","article-title":"Clinical efficacy and safety of the combination of colistin plus vancomycin for the treatment of severe infections caused by carbapenem-resistant Acinetobacter baumannii","volume":"59","author":"Garnacho-Montero","year":"2013","journal-title":"Chemotherapy"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0115","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.medcli.2011.06.024","article-title":"Multidrug and carbapenem-resistant Acinetobacter baumannii infections: factors associated with mortality","volume":"138","author":"Hernandez-Torres","year":"2011","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0120","doi-asserted-by":"crossref","first-page":"O117","DOI":"10.1111\/1469-0691.12341","article-title":"Infections caused by carbapenem-resistant Klebsiella pneumoniae among patients in intensive care units in Greece: a multi-centre study on clinical outcome and therapeutic options","volume":"20","author":"Kontopidou","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0125","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.ajic.2011.12.014","article-title":"Retrospective evaluation of colistin versus tigecycline for the treatment of Acinetobacter baumannii and\/or carbapenem-resistant Enterobacteriaceae infections","volume":"40","author":"Ku","year":"2012","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0130","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3346\/jkms.2011.26.3.325","article-title":"The outcomes of using colistin for treating multidrug resistant Acinetobacter species bloodstream infections","volume":"26","author":"Lim","year":"2011","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0135","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1093\/jac\/dku233","article-title":"Monotherapy versus combination therapy for sepsis due to multidrug-resistant Acinetobacter baumannii: analysis of a multicentre prospective cohort","volume":"69","author":"Lopez-Cortes","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0140","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1086\/657135","article-title":"Bloodstream infections caused by metallo-beta-lactamase\/Klebsiella pneumoniae carbapenemase-producing K. pneumoniae among intensive care unit patients in Greece: risk factors for infection and impact of type of resistance on outcomes","volume":"31","author":"Mouloudi","year":"2010","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0145","doi-asserted-by":"crossref","first-page":"E72","DOI":"10.1111\/1469-0691.12091","article-title":"Bacteraemia due to OXA-48-carbapenemase-producing Enterobacteriaceae: a major clinical challenge","volume":"19","author":"Navarro-San Francisco","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0150","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/resp.12698","article-title":"Nosocomial Acinetobacter pneumonia: treatment and prognostic factors in 356 cases","volume":"21","author":"Ozvatan","year":"2015","journal-title":"Respirology"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0155","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3109\/00365548.2014.923106","article-title":"Risk factors for infection and predictors of mortality among patients with KPC-producing Klebsiella pneumoniae bloodstream infections in the intensive care unit","volume":"46","author":"Papadimitriou-Olivgeris","year":"2014","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0160","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1007\/s10096-016-2681-1","article-title":"Colistin combination therapy improves microbiologic cure in critically ill patients with multi-drug resistant Gram-negative pneumonia","volume":"35","author":"Parchem","year":"2016","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0165","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1128\/AAC.00871-13","article-title":"Clinical experience of colistin\u2013glycopeptide combination in critically ill patients infected with Gram-negative bacteria","volume":"58","author":"Petrosillo","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0170","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jinf.2008.01.003","article-title":"Intravenous colistin sulphomethate sodium for therapy of infections due to multidrug-resistant Gram-negative bacteria","volume":"56","author":"Pintado","year":"2008","journal-title":"J Infect"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0175","doi-asserted-by":"crossref","first-page":"750","DOI":"10.4103\/0972-5229.144021","article-title":"Carbapenem resistant Gram-negative bacteremia in an Indian intensive care unit: a review of the clinical profile and treatment outcome of 50 patients","volume":"18","author":"Porwal","year":"2014","journal-title":"Indian J Crit Care Med"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0180","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s15010-014-0635-z","article-title":"Characteristics, risk factors and outcomes of adult cancer patients with extensively drug-resistant Pseudomonas aeruginosa infections","volume":"42","author":"Samonis","year":"2014","journal-title":"Infection"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0185","doi-asserted-by":"crossref","first-page":"448","DOI":"10.4103\/0255-0857.103767","article-title":"Colistin against colistin-only-susceptible Acinetobacter baumannii-related infections: monotherapy or combination therapy?","volume":"30","author":"Simsek","year":"2012","journal-title":"Indian J Med Microbiol"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0190","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1086\/528719","article-title":"Clinical experience of serious infections caused by Enterobacteriaceae producing VIM-1 metallo-beta-lactamase in a Greek university hospital","volume":"46","author":"Souli","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0195","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.jinf.2014.11.003","article-title":"Characteristics, risk factors and outcomes of carbapenem-resistant Klebsiella pneumoniae infections in the intensive care unit","volume":"70","author":"Vardakas","year":"2014","journal-title":"J Infect"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0200","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3855\/jidc.6195","article-title":"Colistin alone or combined with sulbactam or carbapenem against A. baumannii in ventilator-associated pneumonia","volume":"9","author":"Yilmaz","year":"2015","journal-title":"J Infect Dev Ctries"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0205","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1111\/j.1469-0691.2011.03514.x","article-title":"Predictors of mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment","volume":"17","author":"Zarkotou","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0210","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s10096-014-2070-6","article-title":"Comparison of colistin\u2013carbapenem, colistin\u2013sulbactam, and colistin plus other antibacterial agents for the treatment of extremely drug-resistant Acinetobacter baumannii bloodstream infections","volume":"33","author":"Batirel","year":"2014","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0215","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4046\/trd.2009.67.3.212","article-title":"The comparative efficacy of colistin monotherapy and combination therapy based on in vitro antimicrobial synergy in ventilator-associated pneumonia caused by multi-drug resistant Acinetobacter baumannii","volume":"67","author":"Jang","year":"2009","journal-title":"Tuberc Respir Dis"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0220","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jinf.2012.10.028","article-title":"Predictors of mortality in patients with infections due to multi-drug resistant Gram negative bacteria: the study, the patient, the bug or the drug?","volume":"66","author":"Vardakas","year":"2013","journal-title":"J Infect"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0225","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S1473-3099(05)70164-X","article-title":"Role of glycopeptides as part of initial empirical treatment of febrile neutropenic patients: a meta-analysis of randomised controlled trials","volume":"5","author":"Vardakas","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0230","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1503\/cmaj.080358","article-title":"Respiratory fluoroquinolones for the treatment of community-acquired pneumonia: a meta-analysis of randomized controlled trials","volume":"179","author":"Vardakas","year":"2008","journal-title":"CMAJ"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0235","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ijantimicag.2012.12.006","article-title":"Beta-lactam plus aminoglycoside or fluoroquinolone combination versus beta-lactam monotherapy for Pseudomonas aeruginosa infections: a meta-analysis","volume":"41","author":"Vardakas","year":"2013","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0240","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.cmi.2016.12.002","article-title":"Fluoroquinolones or macrolides in combination with beta-lactams in adult patients hospitalized with community acquired pneumonia: a systematic review and meta-analysis","volume":"23","author":"Vardakas","year":"2017","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0245","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s10096-011-1360-5","article-title":"Synergy of fosfomycin with carbapenems, colistin, netilmicin, and tigecycline against multidrug-resistant Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa clinical isolates","volume":"31","author":"Samonis","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0250","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/jac\/dki204","article-title":"In vitro selection of resistance in Pseudomonas aeruginosa and Acinetobacter spp. by levofloxacin and ciprofloxacin alone and in combination with beta-lactams and amikacin","volume":"56","author":"Drago","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0255","doi-asserted-by":"crossref","first-page":"6837","DOI":"10.1128\/AAC.01344-16","article-title":"Genomic characterization of colistin heteroresistance in Klebsiella pneumoniae during a nosocomial outbreak","volume":"60","author":"Halaby","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0260","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1128\/AAC.00103-06","article-title":"Heteroresistance to colistin in multidrug-resistant Acinetobacter baumannii","volume":"50","author":"Li","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0265","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.3389\/fmicb.2016.01304","article-title":"Tigecycline\u2013amikacin combination effectively suppresses the selection of resistance in clinical isolates of KPC-producing Klebsiella pneumoniae","volume":"7","author":"Ni","year":"2016","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0270","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.diagmicrobio.2016.07.017","article-title":"In vitro antimicrobial synergy of colistin with rifampicin and carbapenems against colistin-resistant Acinetobacter baumannii clinical isolates","volume":"86","author":"Hong","year":"2016","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0275","doi-asserted-by":"crossref","first-page":"6892","DOI":"10.1128\/AAC.00981-16","article-title":"Correlation of checkerboard synergy testing with time-kill analysis and clinical outcomes of extensively drug-resistant Acinetobacter baumannii respiratory infections","volume":"60","author":"Bremmer","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0280","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3343\/alm.2016.36.2.124","article-title":"In vitro interactions of antibiotic combinations of colistin, tigecycline, and doripenem against extensively drug-resistant and multidrug-resistant Acinetobacter baumannii","volume":"36","author":"Park","year":"2016","journal-title":"Ann Lab Med"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0285","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1097\/CCM.0000000000000933","article-title":"Excess mortality associated with colistin\u2013tigecycline compared with colistin\u2013carbapenem combination therapy for extensively drug-resistant Acinetobacter baumannii bacteremia: a multicenter prospective observational study","volume":"43","author":"Cheng","year":"2015","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0290","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.ijantimicag.2016.08.009","article-title":"Colistin loading dose: evaluation of the published pharmacokinetic and clinical data","volume":"48","author":"Vardakas","year":"2016","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0295","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1093\/cid\/ciw684","article-title":"The effectiveness and safety of high-dose colistin: prospective cohort study","volume":"63","author":"Benattar","year":"2016","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0300","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1093\/jac\/dku168","article-title":"Combination therapy for carbapenem-resistant Gram-negative bacteria","volume":"69","author":"Paul","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2017.12.020_bib0305","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/jac\/dkw377","article-title":"Polymyxin monotherapy or in combination against carbapenem-resistant bacteria: systematic review and meta-analysis","volume":"72","author":"Zusman","year":"2017","journal-title":"J Antimicrob Chemother"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857917304545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857917304545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T12:33:38Z","timestamp":1542371618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857917304545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0924857917304545"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2017.12.020","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intravenous colistin combination antimicrobial treatment vs. monotherapy: a systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"International Journal of Antimicrobial Agents","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2017.12.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.","name":"copyright","label":"Copyright"}]}}