{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:37:24Z","timestamp":1773283044142,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","ijaaonline.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.ijantimicag.2018.05.006","type":"journal-article","created":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T12:55:41Z","timestamp":1526648141000},"page":"886-892","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Extended spectrum beta-lactamase-producing Enterobacteriaceae infections in hematopoietic stem cell transplant recipients: Epidemiology and molecular characterization"],"prefix":"10.1016","volume":"52","author":[{"given":"Molka","family":"Kharrat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosra","family":"Chebbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7946-5924","authenticated-orcid":false,"given":"Farah","family":"Ben Tanfous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amel","family":"Lakhal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saloua","family":"Ladeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek Ben","family":"Othmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wafa","family":"Achour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ijantimicag.2018.05.006_bib0001","doi-asserted-by":"crossref","DOI":"10.4084\/mjhid.2015.045","article-title":"Bacterial infections in hematopoietic stem cell transplant recipients","volume":"7","author":"Balletto","year":"2015","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"10.1016\/j.ijantimicag.2018.05.006_bib0003","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jgar.2017.12.014","article-title":"Molecular characterization and epidemiology of extended spectrum beta-lactamase producing Klebsiella pneumoniae isolates from immunocompromised patients in Tunisia","volume":"13","author":"Tanfous","year":"2018","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.ijantimicag.2018.05.006_bib0004","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s00277-017-3098-3","article-title":"Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)","volume":"96","author":"Heinz","year":"2017","journal-title":"Ann Hematol"},{"issue":"1","key":"10.1016\/j.ijantimicag.2018.05.006_bib0005","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-013268","volume":"7","author":"Gudiol","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.ijantimicag.2018.05.006_bib0006","series-title":"REMIC\u202f: R\u00e9f\u00e9rentiel en microbiologie m\u00e9dicale","year":"2015"},{"issue":"12","key":"10.1016\/j.ijantimicag.2018.05.006_bib0008","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.1128\/JCM.42.12.5767-5773.2004","article-title":"Emergence of extended-spectrum-\u03b2-lactamase (CTX-M-9)-producing multiresistant strains of Salmonella enterica serotype virchow in poultry and humans in France","volume":"42","author":"Weill F\u00e7","year":"2004","journal-title":"J Clin Microbiol"},{"issue":"8","key":"10.1016\/j.ijantimicag.2018.05.006_bib0009","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1128\/JCM.39.8.2864-2872.2001","article-title":"Characterization of clinical isolates of Klebsiella pneumoniae from 19 laboratories using the National Committee for Clinical Laboratory Standards Extended-Spectrum \u03b2-Lactamase Detection Methods","volume":"39","author":"Steward","year":"2001","journal-title":"J Clin Microbiol"},{"issue":"1","key":"10.1016\/j.ijantimicag.2018.05.006_bib0010","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/jac\/dki412","article-title":"Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum (beta)-lactamases","volume":"57","author":"Woodford","year":"2006","journal-title":"J Antimicrob Chemother"},{"issue":"2","key":"10.1016\/j.ijantimicag.2018.05.006_bib0011","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/jac\/dkl481","article-title":"Multiplex PCR for rapid detection of genes encoding acquired metallo-beta-lactamases","volume":"59","author":"Ellington","year":"2007","journal-title":"J Antimicrob Chemother"},{"issue":"11","key":"10.1016\/j.ijantimicag.2018.05.006_bib0012","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.1128\/AAC.00585-11","article-title":"Genetic features of blaNDM-1-positive Enterobacteriaceae","volume":"55","author":"Poirel","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"10.1016\/j.ijantimicag.2018.05.006_bib0013","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1128\/AAC.48.1.15-22.2004","article-title":"Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae","volume":"48","author":"Poirel","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"issue":"8","key":"10.1016\/j.ijantimicag.2018.05.006_bib0014","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.fm.2010.05.020","article-title":"Strain typing of acetic acid bacteria responsible for vinegar production by the submerged elaboration method","volume":"27","author":"Fernandez-Perez","year":"2010","journal-title":"Food Microbiol"},{"issue":"8","key":"10.1016\/j.ijantimicag.2018.05.006_bib0015","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.ijantimicag.2018.05.006_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/599376","article-title":"Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America","volume":"49","author":"Mermel","year":"2009","journal-title":"Clin Infect Dis"},{"issue":"10","key":"10.1016\/j.ijantimicag.2018.05.006_bib0017","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.3855\/jidc.6805","article-title":"Emergence of multidrug resistant isolates and mortality predictors in patients with solid tumors or hematological malignancies","volume":"9","author":"Bastug","year":"2015","journal-title":"J Infect Dev Ctries"},{"issue":"11","key":"10.1016\/j.ijantimicag.2018.05.006_bib0018","first-page":"720","article-title":"Risk factors for adverse outcomes and multidrug-resistant Gram-negative bacteraemia in haematology patients with febrile neutropenia in a Singaporean university hospital","volume":"53","author":"Poon","year":"2012","journal-title":"Singapore Med J"},{"issue":"12","key":"10.1016\/j.ijantimicag.2018.05.006_bib0019","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1093\/jac\/dku305","article-title":"A multicentre cohort study on colonization and infection with ESBL-producing Enterobacteriaceae in high-risk patients with haematological malignancies","volume":"69","author":"Vehreschild","year":"2014","journal-title":"J Antimicrob Chemother"},{"issue":"12","key":"10.1016\/j.ijantimicag.2018.05.006_bib0020","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/sj.bmt.1705677","article-title":"Epidemiology of bacteremia and factors associated with multi-drug-resistant gram-negative bacteremia in hematopoietic stem cell transplant recipients","volume":"39","author":"Oliveira","year":"2007","journal-title":"Bone Marrow Transplant"},{"issue":"1","key":"10.1016\/j.ijantimicag.2018.05.006_bib0021","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bbmt.2008.10.024","article-title":"Blood stream infections in allogeneic hematopoietic stem cell transplant recipients: reemergence of Gram-negative rods and increasing antibiotic resistance","volume":"15","author":"Mikulska","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"issue":"1","key":"10.1016\/j.ijantimicag.2018.05.006_bib0022","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00520-015-2772-z","article-title":"Fecal ESBL Escherichia coli carriage as a risk factor for bacteremia in patients with hematological malignancies","volume":"24","author":"Cornejo-Juarez","year":"2016","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.ijantimicag.2018.05.006_bib0023","article-title":"The changing epidemiology of blood stream infections and resistance in haematopoietic stem cell transplantation recipients","volume":"33","author":"Yemisen","year":"2015","journal-title":"Turk J Haematol"},{"issue":"1","key":"10.1016\/j.ijantimicag.2018.05.006_bib0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/1040841X.2013.875515","article-title":"Colonization and infection with extended spectrum beta-lactamase producing Enterobacteriaceae in high-risk patients - Review of the literature from a clinical perspective","volume":"42","author":"Biehl","year":"2016","journal-title":"Crit Rev Microbiol"},{"issue":"1","key":"10.1016\/j.ijantimicag.2018.05.006_bib0025","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00277-011-1247-7","article-title":"Risk factors for infection and treatment outcome of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae bacteremia in patients with hematologic malignancy","volume":"91","author":"Kang","year":"2012","journal-title":"Ann Hematol"},{"issue":"4","key":"10.1016\/j.ijantimicag.2018.05.006_bib0026","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00277-012-1631-y","article-title":"Escherichia coli and Klebsiella pneumoniae bacteremia in patients with neutropenic fever: factors associated with extended-spectrum beta-lactamase production and its impact on outcome","volume":"92","author":"Kim","year":"2012","journal-title":"Ann Hematol"},{"key":"10.1016\/j.ijantimicag.2018.05.006_bib0027","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00164-17","article-title":"Efficacy of beta-lactam\/beta-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum beta-lactamase-producing Enterobacteriaceae in hematological patients with neutropenia","author":"Gudiol","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2018.05.006_bib0028","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3389\/fmicb.2012.00110","article-title":"CTX-M Enzymes: Origin and Diffusion","volume":"3","author":"Canton","year":"2012","journal-title":"Front Microbiol"},{"issue":"7","key":"10.1016\/j.ijantimicag.2018.05.006_bib0029","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1007\/s10096-017-2932-9","article-title":"Clinical and microbiological determinants of severe and fatal outcomes in patients infected with Enterobacteriaceae producing extended-spectrum beta-lactamase","volume":"36","author":"Surgers","year":"2017","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.ijantimicag.2018.05.006_bib0030","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/1471-2180-13-147","article-title":"Molecular epidemiology of extended-spectrum beta-lactamase-producing Escherichia coli in Tunisia and characterization of their virulence factors and plasmid addiction systems","volume":"13","author":"Mnif","year":"2013","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.ijantimicag.2018.05.006_bib0031","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2334-11-12","article-title":"Clinical profiles of patients colonized or infected with extended-spectrum beta-lactamase producing Enterobacteriaceae isolates: a 20 month retrospective study at a Belgian University Hospital","volume":"11","author":"Schoevaerdts","year":"2011","journal-title":"BMC Infect Dis"},{"issue":"9","key":"10.1016\/j.ijantimicag.2018.05.006_bib0032","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.medmal.2014.03.010","article-title":"Epidemiology of Enterobacteriaceae producing CTX-M type extended spectrum beta-lactamase (ESBL)","volume":"44","author":"Lahlaoui","year":"2014","journal-title":"Med Mal Infect"},{"issue":"1","key":"10.1016\/j.ijantimicag.2018.05.006_bib0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1179\/1973947815Y.0000000063","article-title":"Current methods for the identification of carbapenemases","volume":"28","author":"Bialvaei","year":"2016","journal-title":"J Chemother"},{"issue":"Pt 12","key":"10.1016\/j.ijantimicag.2018.05.006_bib0034","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1099\/jmm.0.045229-0","article-title":"Emergence of carbapenem-resistant OXA-48 carbapenemase-producing Enterobacteriaceae in Tunisia","volume":"61","author":"Saidani","year":"2012","journal-title":"J Med Microbiol"},{"issue":"1","key":"10.1016\/j.ijantimicag.2018.05.006_bib0035","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3109\/1040841X.2016.1160867","article-title":"Prevalence and emergence of carbapenemases-producing Gram-negative bacteria in Mediterranean basin","volume":"43","author":"Mathlouthi","year":"2017","journal-title":"Crit Rev Microbiol"},{"issue":"3","key":"10.1016\/j.ijantimicag.2018.05.006_bib0036","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1089\/mdr.2016.0090","article-title":"First Description of KPC-2-Producing Escherichia coli and ST15 OXA-48-Positive Klebsiella pneumoniae in Tunisia","volume":"23","author":"Ben Tanfous","year":"2017","journal-title":"Microb Drug Resist"},{"issue":"9","key":"10.1016\/j.ijantimicag.2018.05.006_bib0037","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1093\/cid\/ciu052","article-title":"The global challenge of carbapenem-resistant Enterobacteriaceae in transplant recipients and patients with hematologic malignancies","volume":"58","author":"Satlin","year":"2014","journal-title":"Clin Infect Dis"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857918301377?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857918301377?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T07:58:19Z","timestamp":1544515099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857918301377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S0924857918301377"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2018.05.006","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extended spectrum beta-lactamase-producing Enterobacteriaceae infections in hematopoietic stem cell transplant recipients: Epidemiology and molecular characterization","name":"articletitle","label":"Article Title"},{"value":"International Journal of Antimicrobial Agents","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2018.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.","name":"copyright","label":"Copyright"}]}}