{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:09:17Z","timestamp":1793660957426,"version":"4.5.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.ijantimicag.2019.10.010","type":"journal-article","created":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T23:26:52Z","timestamp":1576452412000},"page":"105829","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["In vitro activity of the novel fluorocycline TP-6076 against carbapenem-resistant Acinetobacter baumannii"],"prefix":"10.1016","volume":"55","author":[{"given":"Harald","family":"Seifert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danuta","family":"Stefanik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Olesky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8677-9454","authenticated-orcid":false,"given":"Paul G.","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2019.10.010_bib0001","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1128\/CMR.00058-07","article-title":"Acinetobacter baumannii: emergence of a successful pathogen","volume":"21","author":"Peleg","year":"2008","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ijantimicag.2019.10.010_bib0002","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/j.1469-0691.2006.01456.x","article-title":"Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology","volume":"12","author":"Poirel","year":"2006","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ijantimicag.2019.10.010_bib0003","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/jac\/dkp428","article-title":"Global spread of carbapenem-resistant Acinetobacter baumannii","volume":"65","author":"Higgins","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2019.10.010_bib0004","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1093\/jac\/dkm058","article-title":"AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus\u2013Acinetobacter baumannii complex","volume":"59","author":"Ruzin","year":"2007","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2019.10.010_bib0005","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1093\/jac\/dkx322","article-title":"MagicBullet Working Group WP4. High incidence of pandrug-resistant Acinetobacter baumannii isolates collected from patients with ventilator-associated pneumonia in Greece, Italy and Spain as part of the MagicBullet clinical trial","volume":"72","author":"Nowak","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2019.10.010_bib0006","series-title":"ASM Microbe 2017; 1\u20135 June 2017","article-title":"TP-6076, a fully synthetic tetracycline antibacterial agent, is highly potent against a broad range of pathogens, including carbapenem-resistant Enterobacteriaceae","author":"Sun","year":"2017"},{"key":"10.1016\/j.ijantimicag.2019.10.010_bib0007","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ijantimicag.2018.03.009","article-title":"Activity of TP-6076 against carbapenem-resistant Acinetobacter baumannii isolates collected from inpatients in Greek hospitals","volume":"52","author":"Falagas","year":"2018","journal-title":"Int J Antimicrob Agents"},{"issue":"Suppl 1","key":"10.1016\/j.ijantimicag.2019.10.010_bib0008","doi-asserted-by":"crossref","first-page":"S420","DOI":"10.1093\/ofid\/ofy210.1202","article-title":"Safety, tolerability and pharmacokinetics of multiple doses of TP-6076, a novel, fully synthetic tetracycline, in a phase 1 study","volume":"5","author":"Tsai","year":"2018","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.ijantimicag.2019.10.010_bib0009","series-title":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically","year":"2018"},{"key":"10.1016\/j.ijantimicag.2019.10.010_bib0010","series-title":"Performance standards for antimicrobial susceptibility testing","year":"2018"},{"key":"10.1016\/j.ijantimicag.2019.10.010_bib0011","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ijantimicag.2006.01.004","article-title":"Multiplex PCR for genes encoding prevalent OXA carbapenemases in Acinetobacter spp","volume":"27","author":"Woodford","year":"2006","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2019.10.010_bib0012","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S1473-3099(17)30753-3","article-title":"WHO Pathogens Priority List Working Group. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis","volume":"18","author":"Tacconelli","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijantimicag.2019.10.010_bib0013","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153014","article-title":"Head-to-head comparison of two multi-locus sequence typing (MLST) schemes for characterization of Acinetobacter baumannii outbreak and sporadic isolates","volume":"11","author":"Tomaschek","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ijantimicag.2019.10.010_bib0014","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/cid\/civ225","article-title":"Fatal outbreak of an emerging clone of extensively drug-resistant Acinetobacter baumannii with enhanced virulence","volume":"61","author":"Jones","year":"2015","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2019.10.010_bib0015","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1007\/s00134-015-4079-4","article-title":"European Society of Intensive Care Medicine. Task force on management and prevention of Acinetobacter baumannii infections in the ICU","volume":"41","author":"Garnacho-Montero","year":"2015","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ijantimicag.2019.10.010_bib0016","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.1128\/AAC.00436-16","article-title":"In vitro activity of eravacycline against carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii","volume":"60","author":"Livermore","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2019.10.010_bib0017","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ijantimicag.2017.06.022","article-title":"In-vitro activity of the novel fluorocycline eravacycline against carbapenem non-susceptible Acinetobacter baumannii","volume":"51","author":"Seifert","year":"2018","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2019.10.010_bib0018","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1093\/cid\/ciy1029","article-title":"IGNITE4: results of a phase 3, randomized, multicenter, prospective trial of eravacycline vs meropenem in the treatment of complicated intraabdominal infections","volume":"69","author":"Solomkin","year":"2019","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2019.10.010_bib0019","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1093\/jac\/dky083","article-title":"Diversity of mutations in regulatory genes of resistance\u2013nodulation\u2013cell division efflux pumps in association with tigecycline resistance in Acinetobacter baumannii","volume":"73","author":"Gerson","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2019.10.010_bib0020","series-title":"Abstracts of the 29th European Congress of Clinical Microbiology and Infections Diseases (ECCMID); 12\u201316 April 2019","article-title":"In vivo efficacy of TP-6076 in murine thigh and lung infection models challenged with Acinetobacter baumannii","author":"Olesky","year":"2019"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857919302900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857919302900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T17:35:47Z","timestamp":1760376947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857919302900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S0924857919302900"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2019.10.010","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro activity of the novel fluorocycline TP-6076 against carbapenem-resistant Acinetobacter baumannii","name":"articletitle","label":"Article Title"},{"value":"International Journal of Antimicrobial Agents","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2019.10.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105829"}}