{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:10:42Z","timestamp":1773911442596,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH 201211047RSC"],"award-info":[{"award-number":["NTUH 201211047RSC"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014476","name":"Pfizer Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014476","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.ijantimicag.2023.106930","type":"journal-article","created":{"date-parts":[[2023,7,23]],"date-time":"2023-07-23T17:27:12Z","timestamp":1690133232000},"page":"106930","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Geographical patterns of in vitro susceptibilities to tigecycline and colistin among worldwide isolates of Acinetobacter baumannii, Escherichia coli and Klebsiella pneumoniae: Data from the Antimicrobial Testing Leadership and Surveillance (ATLAS) programme, 2016\u20132021"],"prefix":"10.1016","volume":"62","author":[{"given":"Jiun-Ling","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Cheng","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Chien","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Ren","family":"Hsueh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2023.106930_bib0001","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1086\/429323","article-title":"Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections","volume":"40","author":"Falagas","year":"2005","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/femsre\/fuab049","article-title":"Global colistin use: a review of the emergence of resistant Enterobacterales and the impact on their genetic basis","volume":"46","author":"Binsker","year":"2022","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0003","doi-asserted-by":"crossref","first-page":"106713","DOI":"10.1016\/j.ijantimicag.2023.106713","article-title":"Colistin: from the shadows to a One Health approach for addressing antimicrobial resistance","volume":"61","author":"Rhouma","year":"2023","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0004","article-title":"Executive summary of the consensus document of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) on the diagnosis and antimicrobial treatment of infections due to carbapenem-resistant Gram-negative bacteria","author":"Pintado","year":"2022","journal-title":"Enferm Infecc Microbiol Clin (Engl Ed)"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmii.2023.01.017","article-title":"Guidelines for the diagnosis, treatment, prevention and control of infections caused by carbapenem-resistant Gram-negative bacilli","author":"Zeng","year":"2023","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0006","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jmii.2022.02.001","article-title":"Recommendations and guidelines for the treatment of infections due to multidrug resistant organisms","volume":"55","author":"Sy","year":"2022","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmii.2021.09.002","article-title":"Antimicrobial treatment of monomicrobial phenotypic carbapenem-resistant Klebsiella pneumoniae bacteremia: Two are better than one","volume":"55","author":"Tsai","year":"2022","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0008","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1093\/jac\/dkab079","article-title":"Prevalence of RND efflux pump regulator variants associated with tigecycline resistance in carbapenem-resistant Acinetobacter baumannii from a worldwide survey","volume":"76","author":"Luca\u00dfen","year":"2021","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0009","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/s41564-019-0496-4","article-title":"Plasmid-encoded tet(X) genes that confer high-level tigecycline resistance in Escherichia coli","volume":"4","author":"Sun","year":"2019","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0010","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.1038\/s41467-020-18475-9","article-title":"Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X)","volume":"11","author":"Zhang","year":"2020","journal-title":"Nature Communications"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0011","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ijantimicag.2016.04.017","article-title":"Tsakris A Current perspectives on tigecycline resistance in Enterobacteriaceae: susceptibility testing issues and mechanisms of resistance","volume":"48","author":"Pournaras","year":"2016","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0012","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.jmii.2021.07.007","article-title":"Distribution of \u03b2-lactamases and emergence of carbapenemases co-occurring Enterobacterales isolates with high-level antibiotic resistance identified from patients with intra-abdominal infection in the Asia-Pacific region, 2015\u20132018","volume":"55","author":"Chen","year":"2022","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0013","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jgar.2022.08.002","article-title":"Global update on the in vitro activity of tigecycline and comparators against isolates of Acinetobacter baumannii and rates of resistant phenotypes (2016\u20132018)","volume":"31","author":"Seifert","year":"2022","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0014","unstructured":"Performance standards for antimicrobial susceptibility testing. 31st ed. Pennsylvania: CLSI;2021. CLSI supplement M100."},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0015","series-title":"Antibacterial Susceptibility Test Interpretive Criteria","year":"2022"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0016","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/jac\/dkn165","article-title":"Tigecycline for the treatment of multidrug-resistant (including carbapenem-resistant) Acinetobacter infections: a review of the scientific evidence","volume":"62","author":"Karageorgopoulos","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0017","doi-asserted-by":"crossref","first-page":"110145","DOI":"10.1016\/j.ijfoodmicro.2023.110145","article-title":"First detection of tet(X4)-positive Enterobacterales in retail vegetables and clonal spread of Escherichia coli ST195 producing tet(X4) in animals, foods, and humans across China and Thailand","volume":"391\u2013393","author":"Yue","year":"2023","journal-title":"Int J Food Microbiol"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0018","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02084-20","article-title":"Coproduction of tet(X7) conferring high-level tigecycline resistance, fosfomycin fosA4, and colistin mcr-1.1 in Escherichia coli strains from chickens in Egypt","volume":"65","author":"Soliman","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0019","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00732-22","article-title":"Emergence and characterization of tigecycline resistance gene tet(X4) in ST609 Escherichia coli isolates from wastewater in Turkey","volume":"10","author":"K\u00fcrekci","year":"2022","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0020","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jgar.2021.07.019","article-title":"First report of mobile tigecycline resistance gene tet(X4)-harbouring multidrug-resistant Escherichia coli from wastewater in Norway","volume":"27","author":"Marathe","year":"2021","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0021","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgph.0001305","article-title":"Global trends in antimicrobial use in food-producing animals: 2020 to 2030","volume":"3","author":"Mulchandani","year":"2023","journal-title":"PLOS Glob Public Health"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0022","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/jac\/dkt443","article-title":"Correlation between veterinary antimicrobial use and antimicrobial resistance in food-producing animals: a report on seven countries","volume":"69","author":"Chantziaras","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0023","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jmii.2015.04.004","article-title":"Distribution of different efflux pump genes in clinical isolates of multidrug-resistant Acinetobacter baumannii and their correlation with antimicrobial resistance","volume":"50","author":"Lin","year":"2017","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0024","first-page":"1","article-title":"In vitro activity of tigecycline against Acinetobacter baumannii: global epidemiology and resistance mechanisms","volume":"897","author":"Pournaras","year":"2016","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0025","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1128\/AAC.01727-13","article-title":"Molecular epidemiology and mechanisms of tigecycline resistance in clinical isolates of Acinetobacter baumannii from a Chinese university hospital","volume":"58","author":"Deng","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0026","doi-asserted-by":"crossref","first-page":"584789","DOI":"10.3389\/fmicb.2020.584789","article-title":"AdeABC Efflux Pump Controlled by AdeRS Two component system conferring resistance to tigecycline, omadacycline and eravacycline in clinical carbapenem resistant Acinetobacter nosocomialis","volume":"11","author":"Lee","year":"2020","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0027","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13073-020-00807-5","article-title":"Genetic diversity and characteristics of high-level tigecycline resistance tet(X) in Acinetobacter species","volume":"12","author":"Chen","year":"2020","journal-title":"Genome Med"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0028","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10096-021-04290-7","article-title":"Impact of a 4-year antimicrobial stewardship program implemented in a Greek tertiary hospital","volume":"41","author":"Chrysou","year":"2022","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0029","doi-asserted-by":"crossref","first-page":"S135","DOI":"10.1093\/cid\/ciy641","article-title":"Antimicrobial stewardship in China: systems, actions and future strategies","volume":"67","author":"Xiao","year":"2018","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0030","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.jmii.2015.10.014","article-title":"Emergence of tigecycline- and carbapenem-nonsusceptible Klebsiella pneumoniae ST11 clone in patients without exposure to tigecycline","volume":"49","author":"Sheng","year":"2016","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0031","doi-asserted-by":"crossref","first-page":"644949","DOI":"10.3389\/fmicb.2021.644949","article-title":"The plasmid-borne tet(A) gene is an important factor causing tigecycline resistance in ST11 carbapenem-resistant Klebsiella pneumoniae under selective pressure","volume":"12","author":"Xu","year":"2021","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0032","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1093\/jac\/dkaa015","article-title":"Tigecycline efflux in Acinetobacter baumannii is mediated by tetA in synergy with RND-type efflux transporters","volume":"75","author":"Foong","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0033","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jgar.2022.01.007","article-title":"Evolution of tet(A) variant mediating tigecycline resistance in KPC-2-producing Klebsiella pneumoniae during tigecycline treatment","volume":"28","author":"Liao","year":"2022","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0034","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jmii.2021.07.015","article-title":"Multicenter surveillance of antimicrobial susceptibilities and resistance mechanisms among Enterobacterales species and non-fermenting Gram-negative bacteria from different infection sources in Taiwan from 2016 to 2018","volume":"55","author":"Jean","year":"2022","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0035","article-title":"Prevention EcfD, Control Authority EFS, ECDC\/EFSA\/EMA second joint report on the integrated analysis of the consumption of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from humans and food-producing animals","volume":"15","author":"Agency","year":"2017","journal-title":"EFSA J"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0036","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3389\/fmicb.2020.00668","article-title":"Abundance of colistin-resistant, OXA-23- and ArmA-producing Acinetobacter baumannii belonging to international clone 2 in Greece","volume":"11","author":"Palmieri","year":"2020","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0037","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jmii.2021.02.001","article-title":"Activities of imipenem-relebactam combination against carbapenem-nonsusceptible Enterobacteriaceae in Taiwan","volume":"55","author":"Yang","year":"2022","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.ijantimicag.2023.106930_bib0038","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.jmii.2021.08.012","volume":"55","author":"Liu","year":"2022","journal-title":"J Microbiol Immunol Infect"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857923002091?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857923002091?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T17:48:49Z","timestamp":1760377729000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857923002091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S0924857923002091"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2023.106930","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Geographical patterns of in vitro susceptibilities to tigecycline and colistin among worldwide isolates of Acinetobacter baumannii, Escherichia coli and Klebsiella pneumoniae: Data from the Antimicrobial Testing Leadership and Surveillance (ATLAS) programme, 2016\u20132021","name":"articletitle","label":"Article Title"},{"value":"International Journal of Antimicrobial Agents","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2023.106930","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106930"}}