{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T06:58:52Z","timestamp":1793689132456,"version":"4.5.1"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.ijbiomac.2014.05.033","type":"journal-article","created":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T16:31:27Z","timestamp":1400603487000},"page":"124-136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["Bioadhesive tablets containing cyclodextrin complex of itraconazole for the treatment of vaginal candidiasis"],"prefix":"10.1016","volume":"69","author":[{"given":"Erdal","family":"Cevher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe","family":"A\u00e7ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genada","family":"Sinani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buket","family":"Aksu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mire","family":"Zloh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00fctfiye","family":"M\u00fclaz\u0131mo\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0005","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1099\/jmm.0.46548-0","volume":"55","author":"Enoch","year":"2006","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0010","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1517\/14656566.3.8.1059","volume":"3","author":"Sobel","year":"2002","journal-title":"Expert Opin. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0015","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2165\/00003495-200161001-00003","volume":"61","author":"De Beule","year":"2001","journal-title":"Drugs"},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0020","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1517\/14656566.1.2.287","volume":"1","author":"Pi\u00e9rard","year":"2000","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0025","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1439-0507.1989.tb02296.x","volume":"32","author":"Heykants","year":"1989","journal-title":"Mycoses"},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0030","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0378-5173(99)00191-X","volume":"187","author":"Jung","year":"1999","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0035","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nrd1576","volume":"3","author":"Davis","year":"2004","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0040","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1023\/A:1016212804288","volume":"12","author":"Amidon","year":"1995","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0045","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1056\/NEJM199401273300407","volume":"330","author":"Como","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0050","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.ijpharm.2012.07.054","volume":"436","author":"Park","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0055","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/jac\/48.suppl_1.5","volume":"48","author":"Andrews","year":"2001","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0060","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jpba.2007.06.011","volume":"45","author":"Hassan","year":"2007","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0065","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ejps.2006.11.015","volume":"30","author":"Janssens","year":"2007","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0070","first-page":"213","volume":"1","author":"Liu","year":"2006","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0075","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ejpb.2007.11.006","volume":"69","author":"Mellaerts","year":"2008","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0080","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1002\/jps.22524","volume":"100","author":"Sathigari","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0085","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1021\/js950534b","volume":"85","author":"Loftsson","year":"1996","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0090","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1021\/cr970022c","volume":"98","author":"Szejtli","year":"1998","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0095","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0032-9592(03)00258-9","volume":"39","author":"Del Valle","year":"2004","journal-title":"Process. Biochem."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0100","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1021\/ja00005a019","volume":"113","author":"Munoz de la Pena","year":"1991","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v14.i1.10","volume":"14","author":"Thompson","year":"1997","journal-title":"Crit. Rev. Ther. Drug. Carrier. Syst."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0110","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1021\/js960075u","volume":"85","author":"Rajewski","year":"1996","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0115","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.supflu.2007.09.006","volume":"44","author":"Lee","year":"2006","journal-title":"J. Supercrit. Fluid"},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0120","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1002\/jps.20878","volume":"96","author":"Buchanan","year":"2007","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0125","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0168-3659(02)00086-X","volume":"82","author":"Chang","year":"2002","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0130","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.colsurfb.2012.10.038","volume":"103","author":"Mirza","year":"2013","journal-title":"Colloids Surf. B. Biointerfaces"},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0135","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.addr.2005.07.004","volume":"57","author":"Valenta","year":"2005","journal-title":"Adv. Drug. Del. Rev."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0140","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1208\/s12249-009-9288-0","volume":"10","author":"Dobaria","year":"2009","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0145","first-page":"117","volume":"4","author":"Higuchi","year":"1965","journal-title":"Adv. Anal. Chem. Instrum."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0150","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/0378-4347(87)80249-9","volume":"413","author":"Woestenborgh","year":"1987","journal-title":"J. Chromatogr. Biomed. Appl."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0155","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1063\/1.438208","volume":"71","author":"Jeener","year":"1979","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0160","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/jcc.540110405","volume":"11","author":"Mohamadi","year":"1990","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0165","series-title":"Reviews in Computational Chemistry","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/9780470125830.ch1","article-title":"Continuum solution model: classical and quantum mechanical implementations","author":"Cramer","year":"1995"},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0170","doi-asserted-by":"crossref","first-page":"6127","DOI":"10.1021\/ja00172a038","volume":"112","author":"Still","year":"1990","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0175","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/jcc.540150811","volume":"15","author":"Shenkin","year":"1994","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0180","series-title":"Reference method for broth dilution antifungal susceptibility testing of yeasts. Approved Standard. Document M27-A","author":"National Committee for Clinical Laboratory Standards","year":"1997"},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0185","unstructured":"European Pharmacopoeia, 7th ed., 2013."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0190","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/jps.2600721021","volume":"72","author":"Korsmeyer","year":"1983","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0195","first-page":"110","volume":"60","author":"Peppas","year":"1985","journal-title":"Pharm. Acta. Helv."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0200","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0168-3659(87)90035-6","volume":"5","author":"Ritger","year":"1987","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0205","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2165\/00003495-199651040-00006","volume":"51","author":"Haria","year":"1996","journal-title":"Drugs"},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0210","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1002\/jps.10126","volume":"91","author":"Peeters","year":"2002","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0215","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1021\/js9801889","volume":"87","author":"Li","year":"1998","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-4644(1996)25+<1::AID-JCB1>3.0.CO;2-4","volume":"265","author":"Kelloff","year":"1996","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0225","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0928-0987(93)90023-4","volume":"1","author":"Loftsson","year":"1993","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0230","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0378-5173(92)90281-6","volume":"80","author":"Pitha","year":"1992","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0235","first-page":"105","volume":"39","author":"Reer","year":"1993","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0240","doi-asserted-by":"crossref","first-page":"6701","DOI":"10.1021\/j100170a059","volume":"95","author":"Zung","year":"1991","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0245","series-title":"Solubilization in Aqueous Media","author":"Yalkowsky","year":"1999"},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0250","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1021\/js990159d","volume":"88","author":"Li","year":"1999","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0255","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijpharm.2003.10.012","volume":"270","author":"Jambhekar","year":"2004","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0260","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/jps.2600591112","volume":"59","author":"Higuchi","year":"1970","journal-title":"J. Pharm Sci."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0265","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0378-5173(98)00163-X","volume":"171","author":"Ahmed","year":"1998","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0270","doi-asserted-by":"crossref","first-page":"4319","DOI":"10.1002\/jps.21312","volume":"97","author":"Cevher","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0275","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/jps.20535","volume":"95","author":"Al-Marzouqi","year":"2006","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0280","doi-asserted-by":"crossref","first-page":"E329","DOI":"10.1208\/pt060243","volume":"6","author":"Challa","year":"2005","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0285","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000430581","volume":"11","author":"Korteweg","year":"1963","journal-title":"Antibiot. Chemother."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0290","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1263\/jbb.102.369","volume":"102","author":"Hamada","year":"2006","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0295","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1341-321X(06)70894-7","volume":"12","author":"Tansho","year":"2006","journal-title":"J. Infect. Chemother."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0300","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0378-5173(98)00004-0","volume":"165","author":"Savolainen","year":"1998","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0305","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1021\/jf070197f","volume":"55","author":"Zhu","year":"2007","journal-title":"J. Agric. Food. Chem."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0310","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0378-5173(97)00297-4","volume":"160","author":"Tur","year":"1998","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0315","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.3109\/03639049509069258","volume":"21","author":"Fabregas","year":"1995","journal-title":"Drug. Dev. Ind. Pharm."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0320","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ejps.2003.10.029","volume":"21","author":"Jug","year":"2004","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0325","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0014-827X(03)00044-2","volume":"58","author":"Baloglu","year":"2003","journal-title":"Farmaco"},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0330","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/00218468108071184","volume":"12","author":"Huntsberger","year":"1989","journal-title":"J. Adhesion"},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0335","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1081\/DDC-200037245","volume":"30","author":"Nafee","year":"2004","journal-title":"Drug. Dev. Ind. Pharm."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0340","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0168-3659(85)90050-1","volume":"2","author":"Peppas","year":"1985","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0345","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.2042-7158.1991.tb03514.x","volume":"43","author":"Bottenberg","year":"1991","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0350","series-title":"Noveon Pharmaceutical Bulletin 16: Bioadhesion","year":"2014"},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0355","first-page":"337","volume":"56","author":"Sharma","year":"2006","journal-title":"Acta Pharm."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0360","first-page":"285","volume":"48","author":"Mortazavi","year":"1994","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0365","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0378-5173(89)90229-9","volume":"52","author":"Ranga Rao","year":"1989","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0370","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1080\/03639040600599822","volume":"32","author":"Khamanga","year":"2006","journal-title":"Drug. Dev. Ind. Pharm."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0375","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/jps.2600820715","volume":"82","author":"Fassihi","year":"1993","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2014.05.033_bib0380","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1080\/10837450600939784","volume":"11","author":"Baloglu","year":"2006","journal-title":"Pharm. Dev. Technol."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813014003298?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813014003298?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T22:27:53Z","timestamp":1538605673000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813014003298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":76,"alternative-id":["S0141813014003298"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2014.05.033","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bioadhesive tablets containing cyclodextrin complex of itraconazole for the treatment of vaginal candidiasis","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2014.05.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}