{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:37:46Z","timestamp":1793122666175,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31170967"],"award-info":[{"award-number":["31170967"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["LJQ2013103"],"award-info":[{"award-number":["LJQ2013103"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013806","name":"Shenyang Pharmaceutical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.ijbiomac.2014.11.013","type":"journal-article","created":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T02:32:38Z","timestamp":1416969158000},"page":"49-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Surface functional modification of self-assembled insulin nanospheres for improving intestinal absorption"],"prefix":"10.1016","volume":"74","author":[{"given":"Kai","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiming","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0005","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1517\/17425247.2012.737779","volume":"9","author":"Soares","year":"2012","journal-title":"Expert Opin. Drug. Deliv."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0010","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nbt0298-153","volume":"16","author":"Putney","year":"1998","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0015","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1463-1326.2009.01150.x","volume":"12","author":"Iyer","year":"2010","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0020","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.drudis.2006.08.005","volume":"11","author":"Morishita","year":"2006","journal-title":"Drug. Discov. Today."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0025","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/(SICI)1098-1128(200003)20:2<169::AID-MED4>3.0.CO;2-0","volume":"20","author":"Leone-Bay","year":"2000","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0030","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ejpb.2010.07.002","volume":"76","author":"Sharma","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0035","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ijbiomac.2012.05.005","volume":"51","author":"Zhao","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0040","first-page":"640","volume":"72C","author":"Mukhopadhyay","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0045","first-page":"3333","volume":"7","author":"Zhang","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0050","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/nbt874","volume":"21","author":"Zhang","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0055","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0928-0987(97)10007-0","volume":"6","author":"McClean","year":"1998","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0060","doi-asserted-by":"crossref","first-page":"8723","DOI":"10.1016\/j.biomaterials.2012.08.037","volume":"33","author":"Shi","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0065","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijbiomac.2011.10.003","volume":"50","author":"Kim","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0070","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0168-3659(03)00194-9","volume":"90","author":"Sinha","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0080","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1529\/biophysj.105.062802","volume":"89","author":"Bromberg","year":"2005","journal-title":"Biophys. J."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0085","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jconrel.2006.05.013","volume":"114","author":"Cui","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0090","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/1520-6017(200101)90:1<29::AID-JPS4>3.0.CO;2-4","volume":"90","author":"Nielsen","year":"2001","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0095","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ijbiomac.2013.08.037","volume":"62","author":"Ahmad","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0100","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.1021\/bi00719a015","volume":"13","author":"Goldman","year":"1974","journal-title":"Biochemistry"},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0105","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1021\/bi00781a015","volume":"10","author":"Ettinger","year":"1971","journal-title":"Biochemistry"},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0115","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1096\/fasebj.6.8.1592207","volume":"6","author":"Seckler","year":"1992","journal-title":"FASEB J."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0120","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nmeth.f.203","volume":"5","author":"Chayen","year":"2008","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0125","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/S0006-3495(98)74036-6","volume":"75","author":"Yip","year":"1998","journal-title":"Biophys. J."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0130","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0168-3659(02)00488-1","volume":"88","author":"Castellanos","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0135","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00253-003-1312-9","volume":"62","author":"Yoshida","year":"2003","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0140","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1194\/jlr.M600168-JLR200","volume":"47","author":"Tsujita","year":"2006","journal-title":"J. Lipid. Res."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0145","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0273-2300(03)00029-1","volume":"37","author":"Hiraki","year":"2003","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0150","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1517\/17425247.2012.652614","volume":"9","author":"Lima","year":"2012","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0155","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0939-6411(03)00161-9","volume":"57","author":"Berger","year":"2004","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0160","doi-asserted-by":"crossref","first-page":"492","DOI":"10.2337\/diab.21.2.S492","volume":"21","author":"Blundell","year":"1972","journal-title":"Diabetes"},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0165","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF01059088","volume":"17","author":"Mosekilde","year":"1989","journal-title":"J. Pharmacokinet. Biopharm."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0170","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.addr.2011.12.014","volume":"64","author":"Khafagy","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0175","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.addr.2004.10.010","volume":"57","author":"Zorko","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0180","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1021\/bi0612824","volume":"46","author":"Nakase","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0185","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1074\/jbc.M110017200","volume":"277","author":"Suzuki","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0190","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/jcp.1041640311","volume":"164","author":"Ma","year":"1995","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ijbiomac.2014.11.013_bib0195","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1136\/gut.52.3.439","volume":"52","author":"Berkes","year":"2003","journal-title":"Gut"}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813014007612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813014007612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:29:57Z","timestamp":1793122197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813014007612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":37,"alternative-id":["S0141813014007612"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2014.11.013","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Surface functional modification of self-assembled insulin nanospheres for improving intestinal absorption","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2014.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}