{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:45:50Z","timestamp":1788871550039,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Anna Centenary Research Fellowship, Anna University","award":["CR\/ACRF\/Jan.2012\/50"],"award-info":[{"award-number":["CR\/ACRF\/Jan.2012\/50"]}]},{"name":"Centre for Biotechnology (CBT)"},{"name":"Centre for Nanoscience and Technology (CNST)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.ijbiomac.2014.11.014","type":"journal-article","created":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T16:35:19Z","timestamp":1417019719000},"page":"131-137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Immunopotentiating nano-chitosan as potent vaccine carter for efficacious prophylaxis of filarial antigens"],"prefix":"10.1016","volume":"73","author":[{"given":"Balasubramaniyan","family":"Malathi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santhanam","family":"Mona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devasena","family":"Thiyagarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perumal","family":"Kaliraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0005","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1046\/j.1365-3156.2000.00620.x","volume":"5","author":"Ottesen.","year":"2000","journal-title":"Trop. Med. Int. Health"},{"issue":"5","key":"10.1016\/j.ijbiomac.2014.11.014_bib0010","doi-asserted-by":"crossref","first-page":"560","DOI":"10.4269\/ajtmh.2002.66.560","volume":"66","author":"Supali.","year":"2002","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0015","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0140-6736(10)60586-7","volume":"376","author":"Taylor.","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0020","doi-asserted-by":"crossref","first-page":"5454","DOI":"10.1128\/IAI.68.9.5454-5458.2000","volume":"68","author":"Allen","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0025","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.actatropica.2008.04.018","volume":"107","author":"Anand","year":"2008","journal-title":"Acta Trop."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0030","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s00436-007-0571-2","volume":"101","author":"Anand.","year":"2007","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0035","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-3024.2005.00792.x","volume":"27","author":"Hoerauf.","year":"2005","journal-title":"Parasite Immunol."},{"issue":"7","key":"10.1016\/j.ijbiomac.2014.11.014_bib0040","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1128\/IAI.71.7.4119-4126.2003","volume":"71","author":"Kunchithapautham.","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0045","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.1016\/j.vaccine.2010.05.012","volume":"28","author":"Madhumathi.","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0050","doi-asserted-by":"crossref","first-page":"4174","DOI":"10.1128\/IAI.68.7.4174-4179.2000","volume":"68","author":"Gregory.","year":"2000","journal-title":"Infect. Immun."},{"issue":"4","key":"10.1016\/j.ijbiomac.2014.11.014_bib0055","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1128\/IAI.74.4.2366-2372.2006","volume":"74","author":"Porthouse.","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0060","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0166-6851(02)00219-0","volume":"125","author":"Gomez-Escobar.","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0065","doi-asserted-by":"crossref","first-page":"4707","DOI":"10.1128\/IAI.72.8.4707-4715.2004","volume":"72","author":"Gnanasekar.","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0070","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.drudis.2009.02.009","volume":"14","author":"O\u2019Hagan.","year":"2009","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0075","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0169-409X(02)00228-4","volume":"55","author":"Panyam.","year":"2003","journal-title":"Adv. Drug Delivery Rev."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0080","series-title":"Natural Chelating Polymers; Alginic Acid, Chitin and Chitosan","first-page":"83","author":"Muzzarelli","year":"1973"},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0085","series-title":"Chitin, Chitosan and Related Enzymes","first-page":"XVII","year":"1984"},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0090","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1023\/A:1018901302450","volume":"11","author":"Illum.","year":"1994","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0095","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0378-5173(92)90353-4","volume":"78","author":"Lehr.","year":"1992","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0100","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0378-5173(98)00367-6","volume":"178","author":"Soane.","year":"1999","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0105","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0378-5173(01)00602-0","volume":"217","author":"Soane.","year":"2001","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0110","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0378-5173(99)00126-X","volume":"185","author":"Thanou","year":"1999","journal-title":"Int. J. Pharm."},{"issue":"17\u201318","key":"10.1016\/j.ijbiomac.2014.11.014_bib0115","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/S0264-410X(96)00151-X","volume":"14","author":"Williamson","year":"1996","journal-title":"Vaccine"},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0120","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s10295-010-0753-2","volume":"37","author":"Bhuvanesh.","year":"2010","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0125","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/(SICI)1097-4628(19970103)63:1<125::AID-APP13>3.0.CO;2-4","volume":"63","author":"Calvo.","year":"1997","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0130","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","volume":"76","author":"Towbin.","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0135","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1016\/j.vaccine.2006.01.011","volume":"24","author":"Jaganathan.","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0140","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1365-2249.1991.tb05770.x","volume":"86","author":"Mabey.","year":"1991","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0145","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0141-8130(00)00118-5","volume":"27","author":"Sabnis.","year":"2000","journal-title":"Int. J. Biol. Macromol."},{"issue":"1\u20132","key":"10.1016\/j.ijbiomac.2014.11.014_bib0150","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ijpharm.2009.07.023","volume":"382","author":"Tahara","year":"2009","journal-title":"Int. J. Pharm."},{"issue":"5","key":"10.1016\/j.ijbiomac.2014.11.014_bib0155","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.ejps.2012.01.002","volume":"45","author":"Zhang.","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.ijbiomac.2014.11.014_bib0160","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ejps.2005.01.016","volume":"25","author":"Ribeiro","year":"2005","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0165","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.colsurfb.2006.09.012","volume":"53","author":"Sarmento.","year":"2006","journal-title":"Colloids Surf., B: Biointerfaces"},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0170","unstructured":"L.N. David and M.C. Michael. Lehninger Principles of Biochemistry. fourth ed. pp. 84."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0175","first-page":"440","volume":"45","author":"Yu.","year":"1999","journal-title":"J. Wuhan Univ. Nat. Sci. Ed."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0180","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1180\/claymin.1997.032.4.09","volume":"32","author":"Frost.","year":"1997","journal-title":"Clay Miner."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0185","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1346\/CCMN.1997.0450407","volume":"45","author":"Frost.","year":"1997","journal-title":"Clay Miner."},{"issue":"9","key":"10.1016\/j.ijbiomac.2014.11.014_bib0190","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/S1386-1425(00)00223-7","volume":"56A","author":"Frost","year":"2000","journal-title":"Spectrochim. Acta, A: Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0195","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1002\/(SICI)1097-4628(19990624)72:13<1721::AID-APP8>3.0.CO;2-V","volume":"72","author":"Knaul.","year":"1999","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0200","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1042\/bj20021747","volume":"373","author":"Emilia.","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0205","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0168-3659(01)00379-0","volume":"75","author":"Zhou.","year":"2001","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.ijbiomac.2014.11.014_bib0210","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ijpharm.2009.10.008","volume":"390","author":"Gaumet.","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0215","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/S0264-410X(98)00077-2","volume":"16","author":"Jabbal-Gill.","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0220","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.vaccine.2003.09.044","volume":"22","author":"Maytal","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0225","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.0818-9641.2004.01280.x","volume":"82","author":"Moschos","year":"2004","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.ijbiomac.2014.11.014_bib0230","doi-asserted-by":"crossref","first-page":"9026","DOI":"10.1016\/j.vaccine.2011.09.033","volume":"29","author":"Nand.","year":"2011","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.ijbiomac.2014.11.014_bib0235","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1021\/mp900004b","volume":"6","author":"Aditya","year":"2009","journal-title":"Mol. Pharmaceutics"}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813014007624?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813014007624?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T17:42:16Z","timestamp":1566063736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813014007624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":47,"alternative-id":["S0141813014007624"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2014.11.014","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunopotentiating nano-chitosan as potent vaccine carter for efficacious prophylaxis of filarial antigens","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2014.11.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}