{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:00:48Z","timestamp":1792450848297,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.ijbiomac.2015.05.027","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T15:12:08Z","timestamp":1432566728000},"page":"504-510","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["SjAPI-2 is the first member of a new neurotoxin family with Ascaris-type fold and KCNQ1 inhibitory activity"],"prefix":"10.1016","volume":"79","author":[{"given":"Jing","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuangeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weishan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingliang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0210","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0005-2795(68)90030-5","volume":"154","author":"Fraefel","year":"1968","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0215","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1110\/ps.9.5.976","volume":"9","author":"Cierpicki","year":"2000","journal-title":"Protein Sci."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0220","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0969-2126(00)00067-8","volume":"2","author":"Grasberger","year":"1994","journal-title":"Structure"},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0225","doi-asserted-by":"crossref","first-page":"e57529","DOI":"10.1371\/journal.pone.0057529","volume":"8","author":"Chen","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0230","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ijbiomac.2014.08.010","volume":"72","author":"Liu","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0235","doi-asserted-by":"crossref","first-page":"e60201","DOI":"10.1371\/journal.pone.0060201","volume":"8","author":"Chen","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0240","doi-asserted-by":"crossref","first-page":"13813","DOI":"10.1074\/jbc.M112.343996","volume":"287","author":"Chen","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0245","doi-asserted-by":"crossref","first-page":"e27548","DOI":"10.1371\/journal.pone.0027548","volume":"6","author":"Zhao","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0250","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.2174\/138161208785777441","volume":"14","author":"Mouhat","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0255","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1038\/srep04509","volume":"4","author":"Rashid","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0260","doi-asserted-by":"crossref","first-page":"e00873","DOI":"10.7554\/eLife.00873","volume":"2","author":"Swartz","year":"2013","journal-title":"Elife"},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0265","author":"Yang","year":"2014","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0270","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/jbt.21538","volume":"28","author":"Yang","year":"2014","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0275","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbrc.2014.03.101","volume":"447","author":"Chen","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0280","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0165-6147(99)01398-X","volume":"20","author":"Tytgat","year":"1999","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0285","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.toxicon.2003.11.029","volume":"43","author":"Giangiacomo","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0290","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.bcp.2008.07.008","volume":"76","author":"Abdel-Mottaleb","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0295","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1124\/mol.112.078006","volume":"82","author":"Varga","year":"2012","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0300","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BFb0035552","volume":"140","author":"Tenenholz","year":"2000","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0305","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cbpc.2006.12.004","volume":"146","author":"Batista","year":"2007","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0310","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1016\/S0006-3495(03)70028-9","volume":"84","author":"Zhang","year":"2003","journal-title":"Biophys. J."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0315","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.toxicon.2013.05.010","volume":"71","author":"Peigneur","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0320","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.bcp.2004.10.018","volume":"69","author":"Nirthanan","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0325","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1042\/bj20031860","volume":"378","author":"Mouhat","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0330","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev.genom.9.081307.164356","volume":"10","author":"Fry","year":"2009","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0335","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/0006-291X(90)92145-P","volume":"170","author":"Lambert","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0340","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00018-007-7370-x","volume":"65","author":"Diego-Garcia","year":"2008","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0345","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nsb0496-317","volume":"3","author":"Tudor","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0350","doi-asserted-by":"crossref","first-page":"9124","DOI":"10.1074\/jbc.M109.071266","volume":"285","author":"Rangaraju","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0355","author":"Chhabra","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0360","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1042\/BJ20041705","volume":"388","author":"Chagot","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0365","doi-asserted-by":"crossref","first-page":"23766","DOI":"10.1074\/jbc.C500064200","volume":"280","author":"Bayrhuber","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0370","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1096\/fj.06-7229com","volume":"21","author":"Vacher","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0375","doi-asserted-by":"crossref","first-page":"e3414","DOI":"10.1371\/journal.pone.0003414","volume":"3","author":"Yuan","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0380","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bcp.2011.03.023","volume":"82","author":"Peigneur","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0385","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1161\/HYPERTENSIONAHA.111.01076","volume":"62","author":"Liu","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0390","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1124\/mol.112.078188","volume":"82","author":"Peigneur","year":"2012","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0395","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1007\/s00018-008-8573-5","volume":"65","author":"St Pierre","year":"2008","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0400","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.toxicon.2009.11.010","volume":"56","author":"Rodriguez de la Vega","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0405","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tree.2012.10.020","volume":"28","author":"Casewell","year":"2013","journal-title":"Trends Ecol. Evol."},{"key":"10.1016\/j.ijbiomac.2015.05.027_bib0410","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/S0006-3495(93)81200-1","volume":"65","author":"Goldstein","year":"1993","journal-title":"Biophys. J."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813015003682?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813015003682?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T06:08:41Z","timestamp":1537596521000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813015003682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":41,"alternative-id":["S0141813015003682"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2015.05.027","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SjAPI-2 is the first member of a new neurotoxin family with Ascaris-type fold and KCNQ1 inhibitory activity","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2015.05.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}