{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:48:18Z","timestamp":1791589698236,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Natural Science Foundation of Guangdong","award":["S2011030005257"],"award-info":[{"award-number":["S2011030005257"]}]},{"name":"Youth Science and Technology Foundation Programs of Guangdong Medical University","award":["XK1418"],"award-info":[{"award-number":["XK1418"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.ijbiomac.2016.12.039","type":"journal-article","created":{"date-parts":[[2016,12,18]],"date-time":"2016-12-18T07:26:24Z","timestamp":1482045984000},"page":"442-450","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Protective effect of Anoectochilus roxburghii polysaccharide against CCl 4 -induced oxidative liver damage in mice"],"prefix":"10.1016","volume":"96","author":[{"given":"Zhenguo","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunwen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meizhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0005","doi-asserted-by":"crossref","first-page":"6228","DOI":"10.1038\/onc.2008.300","article-title":"Nf-Kappab signaling, liver disease and hepatoprotective agents","volume":"27","author":"Sun","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0010","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.bbrc.2015.03.031","article-title":"Hepatoprotective effect of phosphatidylcholine against carbon tetrachloride liver damage in mice","volume":"460","author":"Na","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0015","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1134\/S1990750814040039","article-title":"Hepatoprotective properties of taurine during carbon tetrachloride intoxication","volume":"8","author":"Haretskaya","year":"2014","journal-title":"Biochem. (Moscow) Suppl. Ser. B: Biomed. Chem."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0020","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0163-7258(89)90050-8","article-title":"Mechanisms of carbon tetrachloride toxicity","volume":"43","author":"Recknagel","year":"1989","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0025","doi-asserted-by":"crossref","first-page":"14833","DOI":"10.1039\/C4DT02065K","article-title":"Theoretical insights into the reductive metabolism of Ccl4 by cytochrome P450 enzymes and the ccl4-dependent suicidal inactivation of P450","volume":"43","author":"Li","year":"2014","journal-title":"Dalton Trans. (Cambridge, England: 2003)"},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0030","doi-asserted-by":"crossref","first-page":"e92515","DOI":"10.1371\/journal.pone.0092515","article-title":"Involvement of the tnf and fasl produced by cd11b kupffer cells\/macrophages in ccl4-induced acute hepatic injury","volume":"9","author":"Sato","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0035","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.foodchem.2013.11.058","article-title":"Hepatoprotective effects of fermented Curcuma longa L. on carbon tetrachloride-induced oxidative stress in rats","volume":"151","author":"Kim","year":"2014","journal-title":"Food Chem."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0040","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.ijbiomac.2014.09.066","article-title":"Antioxidant and protective effect of inulin and catechin grafted inulin against ccl4-induced liver injury","volume":"72","author":"Liu","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0045","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s40064-016-1894-1","article-title":"The hepatocurative effects of Cynara scolymus L. leaf extract on carbon tetrachloride-induced oxidative stress and hepatic injury in rats","volume":"5","author":"Colak","year":"2016","journal-title":"SpringerPlus"},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0050","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/j.jff.2013.07.006","article-title":"The prebiotic arabinogalactan of anoectochilus formosanus prevents ovariectomy-induced osteoporosis in mice","volume":"5","author":"Yang","year":"2013","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0055","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.etp.2012.02.003","article-title":"Antihyperglycemic and antioxidant activity of water extract from anoectochilus roxburghii in experimental diabetes","volume":"65","author":"Cui","year":"2013","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0060","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.phymed.2004.01.016","article-title":"Antitumor and immunostimulating effects of anoectochilus formosanus hayata","volume":"13","author":"Tseng","year":"2006","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0065","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jep.2015.12.002","article-title":"The renal protective effects of anoectochilus roxburghii polysaccharose on diabetic mice induced by high-fat diet and streptozotocin","volume":"178","author":"Li","year":"2016","journal-title":"J.Ethnopharmacol"},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0070","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/ptr.1057","article-title":"Hepatoprotective and antihyperliposis activities of in vitro cultured anoectochilus formosanus","volume":"17","author":"Du","year":"2003","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0075","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.phymed.2004.02.008","article-title":"Aqueous extract of anoectochilus formosanus attenuate hepatic fibrosis induced by carbon tetrachloride in rats","volume":"12","author":"Shih","year":"2005","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0080","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/ptr.2025","article-title":"The hepatoprotective activity of kinsenoside from anoectochilus formosanus","volume":"21","author":"Wu","year":"2007","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0085","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.jep.2011.03.040","article-title":"Kinsenoside, a high yielding constituent from anoectochilus formosanus inhibits carbon tetrachloride induced kupffer cells mediated liver damage","volume":"135","author":"Hsieh","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0090","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.taap.2009.11.005","article-title":"Protective action of the immunomodulator ginsan against carbon tetrachloride-Induced liver injury via control of oxidative stress and the inflammatory response","volume":"242","author":"Shim","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0095","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.ijbiomac.2014.09.056","article-title":"Purification, antioxidant and immunological activities of polysaccharides from actinidia chinensis roots","volume":"72","author":"Zhang","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0100","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.ijbiomac.2012.09.002","article-title":"Antioxidant and hepatoprotective potential of endo-polysaccharides from hericium erinaceus grown on tofu whey","volume":"51","author":"Zhang","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0105","doi-asserted-by":"crossref","first-page":"8590","DOI":"10.1021\/jf3018832","article-title":"Characterization and prebiotic activity of aqueous extract and indigestible polysaccharide from anoectochilus formosanus","volume":"60","author":"Yang","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0110","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/S0300-9084(86)80187-0","article-title":"The glucomannan system from aloe vahombe (Liliaceae). iii. Comparative studies on the glucomannan components isolated from the leaves","volume":"68","author":"Vilkas","year":"1986","journal-title":"Biochimie"},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0115","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1021\/ac60111a017","article-title":"Colorimetric method for determination of sugars and related substances","volume":"28","author":"DuBois","year":"1956","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0120","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0003-2697(85)90190-3","article-title":"Mechanism of dye response and interference in the bradford protein assay","volume":"151","author":"Compton","year":"1985","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0125","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.carbpol.2015.04.028","article-title":"Extraction optimization, characterization and antioxidant activity in vitro of polysaccharides from mulberry (Morus alba L.) leaves","volume":"128","author":"Yuan","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0130","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.carbpol.2012.02.045","article-title":"Isolation, purification and antioxidant activities of polysaccharides from grifola frondosa","volume":"89","author":"Chen","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0135","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.carbpol.2010.08.023","article-title":"A comparative study on the antioxidant activities of an acidic polysaccharide and various solvent extracts derived from herbal houttuynia cordata","volume":"83","author":"Tian","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0140","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases","volume":"28","author":"Reitman","year":"1957","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0145","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ijbiomac.2011.12.023","article-title":"Optimization of polysaccharides from panax japonicus C.A. meyer by rsm and its anti-oxidant activity","volume":"50","author":"Wang","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0150","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.foodchem.2007.05.031","article-title":"Structural characterization of water-soluble polysaccharides from opuntia monacantha cladodes in relation to their anti-glycated activities","volume":"105","author":"Zhao","year":"2007","journal-title":"Food Chem."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0155","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0144-8617(02)00259-X","article-title":"Use of Ft-Ir spectroscopy as a tool for the analysis of polysaccharide food additives","volume":"51","author":"\u010cern\u00e1","year":"2003","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0160","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.carbpol.2010.03.010","article-title":"Medium optimization, preliminary characterization and antioxidant activity in vivo of mycelial polysaccharide from phellinus baumii pil\u00e1t","volume":"81","author":"Luo","year":"2010","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0165","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.carbpol.2010.02.011","article-title":"Antioxidant activities of water-soluble polysaccharide extracted from mung bean (Vigna radiata L.) hull with ultrasonic assisted treatment","volume":"81","author":"Lai","year":"2010","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0170","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.ijbiomac.2014.09.007","article-title":"Characterization and antioxidant activities of the polysaccharides from radix cyathulae officinalis kuan","volume":"72","author":"Han","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0175","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.carbpol.2011.09.032","article-title":"Optimization of extraction, preliminary characterization and hepatoprotective effects of polysaccharides from stachys floridana schuttl. Ex Benth","volume":"87","author":"Ma","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0180","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/bjp.2008.338","article-title":"The antioxidant activity of chondroitin-4-sulphate, in carbon tetrachloride-induced acute hepatitis in mice involves Nf-kappab and caspase activation","volume":"155","author":"Campo","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0185","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.foodchem.2009.03.073","article-title":"Protective effect of selenium-polysaccharides from the mycelia of coprinus comatus on alloxan-induced oxidative stress in mice","volume":"117","author":"Yu","year":"2009","journal-title":"Food Chem."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0190","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0016-5085(19)34537-8","article-title":"Serum enzyme changes as evidence of liver reaction to oral alcohol","volume":"49","author":"Goldberg","year":"1965","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0195","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0163-7258(89)90050-8","article-title":"Mechanisms of carbon tetrachloride toxicity","volume":"43","author":"Recknagel","year":"1989","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0009-8981(01)00393-X","article-title":"Methods for monitoring oxidative stress, lipid peroxidation and oxidation resistance of lipoproteins","volume":"306","author":"Abuja","year":"2001","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0205","first-page":"412","article-title":"Biology of disease: free radicals and tissue injury","volume":"47","author":"Freeman","year":"1982","journal-title":"Lab. Invest."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0210","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1016\/j.fct.2010.07.013","article-title":"Protective potential of royal jelly against carbon tetrachloride induced-Toxicity and changes in the serum sialic acid levels","volume":"48","author":"Cemek","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0215","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00709-014-0653-9","article-title":"Improved callus induction, shoot regeneration, and salt stress tolerance in arabidopsis overexpressing superoxide dismutase from potentilla atrosanguinea","volume":"252","author":"Shafi","year":"2015","journal-title":"Protoplasma"},{"key":"10.1016\/j.ijbiomac.2016.12.039_bib0220","doi-asserted-by":"crossref","first-page":"24407","DOI":"10.1074\/jbc.M701589200","article-title":"Catalase takes part in rat liver mitochondria oxidative stress defense","volume":"282","author":"Salvi","year":"2007","journal-title":"J. Biol. Chem."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014181301631220X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014181301631220X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T13:30:06Z","timestamp":1568640606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014181301631220X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":44,"alternative-id":["S014181301631220X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2016.12.039","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect of Anoectochilus roxburghii polysaccharide against CCl4-induced oxidative liver damage in mice","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2016.12.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}