{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:06:06Z","timestamp":1778285166642,"version":"3.51.4"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T00:00:00Z","timestamp":1518048000000},"content-version":"vor","delay-in-days":283,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/23236-4"],"award-info":[{"award-number":["2011\/23236-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/02734-9"],"award-info":[{"award-number":["2012\/02734-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["23038.000823\/201121"],"award-info":[{"award-number":["23038.000823\/201121"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["310395\/2014-3"],"award-info":[{"award-number":["310395\/2014-3"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["476932\/2012-2"],"award-info":[{"award-number":["476932\/2012-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.ijbiomac.2017.01.131","type":"journal-article","created":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T00:45:12Z","timestamp":1486169112000},"page":"436-446","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Isolation and characterization of a novel metalloprotease inhibitor from Bothrops alternatus snake serum"],"prefix":"10.1016","volume":"98","author":[{"given":"Tatiana Z.","family":"Palacio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norival A.","family":"Santos-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Cesar","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Junior","given":"Rui S.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedito","family":"Barraviera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suely V.","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0005","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.toxicon.2009.11.020","article-title":"Snakebite envenoming from a global perspective: towards an integrated approach","volume":"56","author":"Guti\u00e9rrez","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0010","author":"World Health Organization (WHO)"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0015","doi-asserted-by":"crossref","DOI":"10.1186\/1678-9199-20-7","article-title":"Current challenges for confronting the public health problem of snakebite envenoming in Central America","volume":"20","author":"Guti\u00e9rrez","year":"2014","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40409-015-0011-1","article-title":"Epidemiology of envenomations by terrestrial venomous animals in Brazil based on case reporting: from obvious facts to contingencies","volume":"21","author":"Chippaux","year":"2015","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0025","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1678-9199-19-29","article-title":"The international view of envenoming in Brazil: myths and realities","volume":"19","author":"Bochner","year":"2013","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0030","unstructured":"Funda\u00e7\u00e3o Nacional de Sa\u00fade, Manual de Diagn\u00f3stico e Tratamento de Acidentes por Animais Pe\u00e7onhentos, 2\u00aa ed., Minist\u00e9rio da Sa\u00fade, Bras\u00edlia, (2001)."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0035","first-page":"55","article-title":"Mudan\u00e7as na classifica\u00e7\u00e3o de serpentes pe\u00e7onhentas brasileiras e suas implica\u00e7\u00f5es na literatura m\u00e9dica","volume":"81","author":"Bernarde","year":"2011","journal-title":"Gazeta M\u00e9dica da Bahia"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0040","series-title":"Animal Toxins: State of the Art \u2212Perspectives in Health and Biotechnology","first-page":"750","author":"Lima","year":"2009"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0045","first-page":"147","article-title":"Purifica\u00e7\u00e3o de uma enzima fibrinogenol\u00edtica da pe\u00e7onha da serpente Bothrops alternatus","volume":"19","author":"Costa","year":"2003","journal-title":"Biosci. J."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0050","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.toxicon.2009.11.006","article-title":"Isolation and characterization of a new serine protease with thrombin-like activity (TLBm) from the venom of the snake Bothrops marajoensis","volume":"55","author":"Vilca-Quispe","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0055","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.toxicon.2005.02.012","article-title":"Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases","volume":"45","author":"Fox","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0060","first-page":"1","article-title":"Metalloproteases","volume":"21.4","author":"Nagase","year":"2001","journal-title":"Curr. Protoc. Protein Sci."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0065","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1111\/j.1742-4658.2008.06466.x","article-title":"Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom complexity","volume":"275","author":"Fox","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0070","first-page":"328","article-title":"Snake venom metalloproteases \u2212 structure and function of catalytic and disintegrin domains: comp","volume":"142","author":"Ramos","year":"2006","journal-title":"Biochem. Physiol. C: Toxicol. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0075","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.jprot.2011.03.026","article-title":"Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases","volume":"74","author":"Escalante","year":"2011","journal-title":"J. Proteom."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0080","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0304-4165(00)00022-2","article-title":"Isolation and characterization of DM40 and DM43, two snake venom metalloproteinase inhibitors from Didelphis marsupialis serum","volume":"1474","author":"Neves-Ferreira","year":"2000","journal-title":"Biochim. Biophys. Acta: Gen. Subj."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0085","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.toxicon.2003.08.006","article-title":"PO41, a snake venom metalloproteinase inhibitor isolated from Philander opossum serum","volume":"42","author":"Jurgilas","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0090","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.toxicon.2005.02.028","article-title":"Natural inhibitors of snake venom hemorrhagic metalloproteinases","volume":"45","author":"Perales","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0095","doi-asserted-by":"crossref","first-page":"7717","DOI":"10.1073\/pnas.89.16.7717","article-title":"How the mongoose can fight the snake\u2014the binding-site of the mongoose acetylcholine-receptor","volume":"89","author":"Barchan","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0100","series-title":"Handbook of Venoms and Toxins of Reptiles","first-page":"259","article-title":"Natural inhibitors: innate immunity to snake venoms","author":"Neves-Ferreira","year":"2010"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0105","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/0041-0101(91)90191-S","article-title":"Natural anti-snake venom proteins","volume":"29","author":"Domont","year":"1991","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0110","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/S0041-0101(98)00137-8","article-title":"Snake envenomation and protective natural endogenous proteins: a mini review of the recent developments (1991\u20131997)","volume":"36","author":"Thwin","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0115","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0041-0101(01)00274-4","article-title":"Endogenous inhibitors of snake venom phospholipases A(2) in the blood plasma of snakes","volume":"40","author":"Fortes-Dias","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0120","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.toxicon.2003.11.007","article-title":"Natural phospholipase A(2) myotoxin inhibitor proteins from snakes, mammals and plants","volume":"42","author":"Lizano","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0125","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1080\/08923970802279019","article-title":"Inhibitors of snake venoms and development of new therapeutics","volume":"30","author":"Sanchez","year":"2008","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0130","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/0005-2795(72)90328-5","article-title":"Purification and characterization of an antihemorrhagic factor in the serum of Trimeresurus flavoviridis, a crotalid","volume":"285","author":"Omori-Satoh","year":"1972","journal-title":"Biochim. Biophys. Protein Struct."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0135","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0005-2795(77)90243-4","article-title":"Antihemorrhagic factor as a proteinase inhibitor isolated from the serum of Trimeresurus flavoviridis","volume":"495","author":"Omori-Satoh","year":"1977","journal-title":"Biochim. Biophys. Acta Protein Struct."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0140","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1046\/j.1432-1327.2001.02199.x","article-title":"BJ46a a snake venom metalloproteinase inhibitor\u2014isolation, characterization, cloning and insights into its mechanism of action","volume":"268","author":"Valente","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0145","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.toxicon.2007.09.007","article-title":"Properties and cDNA cloning of antihemorrhagic factors in sera of Chinese and Japanese mamushi (Gloydius blomhoffi)","volume":"51","author":"Aoki","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0150","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.toxicon.2005.09.003","article-title":"Properties and cDNA cloning of an antihemorrhagic factor (HSF) purified from the serum of Trimeresurus flavoviridis","volume":"46","author":"Deshimaru","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0155","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.toxicon.2004.06.002","article-title":"A new hemorrhagic metalloprotease from Bothrops jararacussu snake venom: isolation and biochemical characterization","volume":"44","author":"Mazzi","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0160","series-title":"Proceedings of the XI Congress of the Pan American Section of the International Society on Toxinology and the XII Congress of the Brazilian Society of Toxinology, Nov 3\u20138","article-title":"Isolation and characterization of a serine protease from Bothrops jararaca snake venom","author":"Carone","year":"2013"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0165","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during assembly of the head of bacteriophage T4","volume":"1970","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0170","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0003-2697(74)90034-7","article-title":"Measurement of protein by spectrophotometry at 205nm","volume":"59","author":"Scopes","year":"1974","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0175","doi-asserted-by":"crossref","first-page":"43","DOI":"10.7883\/yoken1952.13.43","article-title":"Studies on the quantitative method for determination of hemorrhagic activity of Habu snake venom","volume":"13","author":"Kondo","year":"1960","journal-title":"Jpn. J. Med. Sci. Biol."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0180","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0041-0101(92)90855-Y","article-title":"Pharmacological and enzymatic effects of the snakes venoms of Antioquia and Choco (Colombia)","volume":"30","author":"Otero","year":"1992","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0185","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0049-3848(73)90082-0","article-title":"The proteolytic action of ancrod on human fibrinogen and its polypeptide chains","volume":"2","author":"Edgar","year":"1973","journal-title":"Thromb. Res."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0190","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1006\/abbi.2000.1958","article-title":"Structural and functional characterization of neuwiedase, a nonhemorrhagic fibrin(ogen)olytic metalloprotease from Bothrops neuwiedi snake venom","volume":"381","author":"Rodrigues","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0195","first-page":"301","article-title":"A study of the fibrin plate assay of fibrinolytic agents \u2212 optimal conditions, reproducibility and precision","volume":"13","author":"Jespersen","year":"1983","journal-title":"Haemostasis"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0200","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S1095-6433(99)00166-X","article-title":"Coagulation and fibrinolysis in capybara (Hydrochaeris hydrochaeris), a close relative of the guinea-pig (Cavia porcellus)","volume":"125","author":"Leit\u00e3o","year":"2000","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0205","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0049-3848(98)00009-7","article-title":"Biochemical characterization of lebetase, a direct-acting fibrinolytic enzyme from Vipera lebetina snake venom","volume":"90","author":"Siigur","year":"1998","journal-title":"Thromb. Res."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0210","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0005-2795(72)90248-6","article-title":"Isoelectric focusing of proteins in polyacrylamide gels","volume":"257","author":"Vesterberg","year":"1972","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0215","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0041-0101(81)90100-8","article-title":"The purification and characterization of an antihemorrhagic factor in opossum (Didelphis virginiana) serum","volume":"19","author":"Menchaca","year":"1981","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0220","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1021\/bi00117a015","article-title":"Isolation from opossum serum of a metalloproteinase inhibitor homologous to human alpha-1\u03b2-glycoprotein","volume":"31","author":"Catanese","year":"1992","journal-title":"Biochemistry"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0225","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/0041-0101(94)90353-0","article-title":"Isolation and partial characterization of an anti-bothropic complex from the serum of South American Didelphidae","volume":"32","author":"Perales","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0230","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.toxicon.2011.08.009","article-title":"Isolation and identification of a snake venom metalloproteinase inhibitor from California ground squirrel (Spermophilus beecheyi) blood sera","volume":"58","author":"Biardi","year":"2011","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0235","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/0304-4165(95)00081-L","article-title":"Isolation, characterization and mode of neutralization of a potent antihemorrhagic factor from the serum of the snake Bothrops asper","volume":"1245","author":"Borkow","year":"1995","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0240","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/oxfordjournals.jbchem.a123944","article-title":"Primary structure of the antihemorrhagic factor in serum of the japanese habu\u2014a snake-venom metalloproteinase inhibitor with a double-headed cystatin domain","volume":"112","author":"Yamakawa","year":"1992","journal-title":"J. Biochem."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0245","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.toxicon.2009.05.018","article-title":"Snake fetuin: isolation and structural analysis of new fetuin family proteins from the sera of venomous snakes","volume":"54","author":"Aoki","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0250","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1042\/bj20031825","article-title":"Evolutionary families of peptidase inhibitors","volume":"378","author":"Rawlings","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0255","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0041-0101(96)00195-X","article-title":"G.B. Domont, Inhibitory properties of the antibothropic complex from the South American opossum (Didelphis marsupialis) serum","volume":"35","author":"Neves-Ferreira","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0260","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.toxicon.2006.11.001","article-title":"Active fragments of the antihemorrhagic protein HSF from serum of habu (Trimeresurus flavoviridis)","volume":"49","author":"Aoki","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0265","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0041-0101(98)00126-3","article-title":"Snake venoms and the hemostatic system","volume":"36","author":"Markland","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0270","series-title":"Handbook of Venoms and Toxins of Reptiles","first-page":"95","article-title":"Snake venom metalloproteinases","author":"Fox","year":"2010"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0275","doi-asserted-by":"crossref","first-page":"e28017","DOI":"10.1371\/journal.pone.0028017","article-title":"Role of collagens and perlecan in microvascular stability: exploring the mechanism of capillary vessel damage by snake venom metalloproteinases","volume":"6","author":"Escalante","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0280","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0163-7258(94)90049-3","article-title":"Hemorrhagic metalloproteinases from snake-venoms","volume":"62","author":"Bjarnason","year":"1994","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0285","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.toxicon.2012.03.018","article-title":"Batroxase, a new metalloproteinase from B. atrox snake venom with strong fibrinolytic activity","volume":"60","author":"Cintra","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.01.131_bib0290","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0041-0101(96)00017-7","article-title":"Insights into the mechanism of haemorrhage caused by snake venom metalloproteinases","volume":"34","author":"Kamiguti","year":"1996","journal-title":"Toxicon"}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813016326083?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813016326083?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T04:46:06Z","timestamp":1655613966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813016326083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":58,"alternative-id":["S0141813016326083"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.01.131","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isolation and characterization of a novel metalloprotease inhibitor from Bothrops alternatus snake serum","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.01.131","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}