{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:39:04Z","timestamp":1790177944122,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100013318","name":"Shanxi Science and Technology Department","doi-asserted-by":"crossref","award":["2015081024"],"award-info":[{"award-number":["2015081024"]}],"id":[{"id":"10.13039\/501100013318","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013318","name":"Shanxi Science and Technology Department","doi-asserted-by":"crossref","award":["20150311020-2, 2015"],"award-info":[{"award-number":["20150311020-2, 2015"]}],"id":[{"id":"10.13039\/501100013318","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003398","name":"Shanxi scholarship council of China","doi-asserted-by":"publisher","award":["2016-073, 2016"],"award-info":[{"award-number":["2016-073, 2016"]}],"id":[{"id":"10.13039\/501100003398","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Department of Human Resource and Social Security of Shanxi Province, China"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.ijbiomac.2017.02.086","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T10:17:07Z","timestamp":1487931427000},"page":"249-257","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Anti-hyperglycemic activity of polysaccharides from calyx of Physalis alkekengi var. franchetii Makino on alloxan-induced mice"],"prefix":"10.1016","volume":"99","author":[{"given":"Yu","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0005","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.carbpol.2007.06.001","article-title":"Structural characterization and hypoglycemic activity of a polysaccharide isolated from the fruit of Physalis alkekengi L","volume":"71","author":"Tong","year":"2008","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0010","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1021\/jf0343130","article-title":"Cell wall polysaccharides from chalkumra (Benincasa hispida) fruit. Part I. Isolation and characterization of pectins","volume":"52","author":"Mazumder","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0015","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0308-8146(01)00282-5","article-title":"Some properties of a polysaccharide preparation that is isolated from the fruit of Cordia abyssinica","volume":"76","author":"Benhura","year":"2002","journal-title":"Food Chem."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0020","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.carbpol.2008.12.020","article-title":"Polysaccharides from fruit calyx of Physalis alkekengi var. franchetii Makino: isolation, purification, structural features and antioxidant activities","volume":"77","author":"Ge","year":"2009","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0025","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.ijbiomac.2015.08.049","article-title":"Anti-diabetic properties of Momordica charantia L. polysaccharide in alloxan-induced diabetic mice","volume":"81","author":"Xu","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0030","unstructured":"International Diabetes federation, IDF diabetes atlas (7th edn). http:\/\/diabetesatlas.org."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0035","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.biopha.2007.07.006","article-title":"Hepatic glucokinase activity is the primary defect in alloxan-induced diabetes of mice","volume":"63","author":"Zhang","year":"2009","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0040","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.foodchem.2008.04.006","article-title":"Purification and characterisation of a hypoglycemic peptide from Momordica charantia L. var. abbreviata Ser","volume":"111","author":"Yuan","year":"2008","journal-title":"Food Chem."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0045","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.yrtph.2014.10.006","article-title":"Purification, characterization and anti-diabetic activity of a polysaccharide from mulberry leaf","volume":"70","author":"Zhang","year":"2014","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0050","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.apjtm.2015.06.013","article-title":"Evaluation of protective effect of cactus peer seed oil (Opuntia ficus-indica L. MILL.) against alloxan-induced diabetes in mice","volume":"8","author":"Berraaouan","year":"2015","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0055","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1042\/BST0360343","article-title":"Oxidative stress: the vulnerable \u03b2-cell","volume":"36","author":"Lenzen","year":"2008","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0060","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.phymed.2012.12.017","article-title":"Evaluation of in vivo anti-hyperglycemic and antioxidant potentials of \u03b1-santalol and sandalwood oil","volume":"20","author":"Misra","year":"2013","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0065","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ijbiomac.2014.01.063","article-title":"Protective effects of polysaccharides from Lilium lancifolium on streptozotocin-induced diabetic mice","volume":"65","author":"Zhang","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0070","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.carbpol.2010.01.038","article-title":"Structure characterization and hypoglycemic activity of a polysaccharide isolated from the fruit of Lycium barbarum L","volume":"80","author":"Zou","year":"2010","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0075","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bcdf.2014.03.003","article-title":"The anti-diabetic potential of polysaccharides extracted from members of the cucurbit family: a review","volume":"3","author":"Simpson","year":"2014","journal-title":"Bioact. Carbohydr. Diet. Fibre"},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0080","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.carbpol.2015.01.068","article-title":"Protective effect of polysaccharides from Opuntia dillenii Haw. fruits on streptozotocin-induced diabetic rats","volume":"124","author":"Gao","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0085","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ijbiomac.2014.09.011","article-title":"Anti-diabetic effects of polysaccharides from Talinum triangulare in streptozotocin (STZ)-induced type 2 diabetic male mice","volume":"72","author":"Xu","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0090","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.ijbiomac.2015.09.037","article-title":"Involvement of the PI3K\/Akt signal pathway in the hypoglycemic effects of tea polysaccharides on diabetic mice","volume":"81","author":"Li","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0095","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.ijbiomac.2012.06.021","article-title":"Composition and bioactivity of polysaccharides from Inula britannica flower","volume":"51","author":"Hong","year":"2012","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0100","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1016\/S0024-3205(03)00594-0","article-title":"In vitro and in vivo protective effect of Ganoderma lucidum polysaccharides on alloxan-induced pancreatic islets damage","volume":"73","author":"Zhang","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0105","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.biopha.2005.07.002","article-title":"A review on the role of antioxidants in the management of diabetes and its complications","volume":"59","author":"Rahimi","year":"2005","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0110","first-page":"199","article-title":"Characterizarion of pumpkin polysaccharides and protective effects on streptozotocin-damaged islet cells","volume":"13","author":"Zhu","year":"2015","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0115","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1172\/JCI10582","article-title":"Signaling pathways in insulin action: molecular targets of insulin resistance","volume":"106","author":"Pessin","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2015.03.011","article-title":"Anti-diabetic efficacy of KICG1338, a novel glycogen synthase kinase-3\u03b2 inhibitor, and its molecular characterization in animal models of type 2 diabetes and insulin resistance","volume":"409","author":"Kim","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0125","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1074\/jbc.274.4.1865","article-title":"Signaling mechanisms that regulate glucose transport","volume":"274","author":"Czech","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0130","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.tem.2011.05.001","article-title":"New insights into insulin resistance in the diabetic heart","volume":"22","author":"Gray","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0135","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.acthis.2013.04.016","article-title":"Chard (Beta vulgaris L. var. cicla) extract ameliorates hyperglycemia by increasing GLUT2 through Akt2 and antioxidant defense in the liver of rats","volume":"116","author":"Gezginci-Oktayoglu","year":"2014","journal-title":"Acta Histochem."},{"key":"10.1016\/j.ijbiomac.2017.02.086_bib0140","doi-asserted-by":"crossref","first-page":"6019","DOI":"10.1021\/acs.jafc.5b01238","article-title":"Effects of D-pinitol on insulin resistance through the PI3K\/Akt signaling pathway in type 2 diabetes mellitus rats","volume":"63","author":"Gao","year":"2015","journal-title":"J. Agric. Food Chem."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813016322917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813016322917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T16:36:23Z","timestamp":1589733383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813016322917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":28,"alternative-id":["S0141813016322917"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.02.086","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-hyperglycemic activity of polysaccharides from calyx of Physalis alkekengi var. franchetii Makino on alloxan-induced mice","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.02.086","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}