{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:11:58Z","timestamp":1786990318862,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81502008"],"award-info":[{"award-number":["81502008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fujian Health Department","award":["2015-CX-2"],"award-info":[{"award-number":["2015-CX-2"]}]},{"name":"Fujian Province Health Education Union Scientific","award":["WKJ-FI-21"],"award-info":[{"award-number":["WKJ-FI-21"]}]},{"name":"Natural Science Foundation of Fujian","award":["2016J05188"],"award-info":[{"award-number":["2016J05188"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.ijbiomac.2017.03.123","type":"journal-article","created":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T14:45:41Z","timestamp":1490280341000},"page":"718-728","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["The over expression of long non-coding RNA ANRIL promotes epithelial-mesenchymal transition by activating the ATM-E2F1 signaling pathway in pancreatic cancer: An in vivo and in vitro study"],"prefix":"10.1016","volume":"102","author":[{"given":"Shi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Qiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-Zhi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Xing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Nan","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao-Lin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Hong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Feng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ijbiomac.2017.03.123_bib0005","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/ng.1032","article-title":"Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia","volume":"44","author":"Quesada","year":"2012","journal-title":"Nat. Genet."},{"issue":"10","key":"10.1016\/j.ijbiomac.2017.03.123_bib0010","first-page":"961","article-title":"BRAF mutations in hairy-cell leukemia","volume":"365","author":"Pardanani","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"16","key":"10.1016\/j.ijbiomac.2017.03.123_bib0015","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1056\/NEJMoa1407222","article-title":"Chimeric antigen receptor T cells for sustained remissions in leukemia","volume":"371","author":"Maude","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.ijbiomac.2017.03.123_bib0020","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/nm.2415","article-title":"Stem cell gene expression programs influence clinical outcome in human leukemia","volume":"17","author":"Eppert","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijbiomac.2017.03.123_bib0025","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-1-60761-404-3_9","article-title":"Manipulation of neutrophil-like HL-60 cells for the study of directed cell migration","volume":"591","author":"Millius","year":"2010","journal-title":"Methods Mol. Biol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2017.03.123_bib0030","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.bbapap.2010.01.002","article-title":"Expression proteomics of acute promyelocytic leukaemia cells treated with methotrexate","volume":"1804","author":"Agarwal","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"10","key":"10.1016\/j.ijbiomac.2017.03.123_bib0035","doi-asserted-by":"crossref","first-page":"e7363","DOI":"10.1371\/journal.pone.0007363","article-title":"Phagocytosis of Streptococcus pyogenes by all-trans retinoic acid-differentiated HL-60 cells: roles of azurophilic granules and NADPH oxidase","volume":"4","author":"Nordenfelt","year":"2009","journal-title":"PLoS One"},{"issue":"15","key":"10.1016\/j.ijbiomac.2017.03.123_bib0040","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1016\/j.ejca.2012.01.028","article-title":"TIS21\/BTG2\/PC3 enhances downregulation of c-Myc during differentiation of HL-60 cells by activating Erk1\/2 and inhibiting Akt in response to all-trans-retinoic acid","volume":"48","author":"Imran","year":"2012","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ijbiomac.2017.03.123_bib0045","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1756-8722-4-20","article-title":"Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663","volume":"4","author":"Jian","year":"2011","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.ijbiomac.2017.03.123_bib0050","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/978-1-60761-691-7_11","article-title":"Cell fusion-induced reprogramming","volume":"636","author":"Do","year":"2010","journal-title":"Methods Mol. Biol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2017.03.123_bib0055","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.semcancer.2010.02.001","article-title":"Cancer as a reprogramming-like disease: implications in tumor development and treatment","volume":"20","author":"Castellanos","year":"2010","journal-title":"Semin. Cancer Biol."},{"issue":"10","key":"10.1016\/j.ijbiomac.2017.03.123_bib0060","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.2174\/1389450116666150907102717","article-title":"Cancer a problem of developmental biology; scientific evidence for reprogramming and differentiation therapy","volume":"17","author":"Sell","year":"2016","journal-title":"Curr. Drug Targets"},{"issue":"1","key":"10.1016\/j.ijbiomac.2017.03.123_bib0065","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5115\/acb.2014.47.1.28","article-title":"Distribution of CD10-positive epithelial and mesenchymal cells in human mid-term fetuses: a comparison with CD34 expression","volume":"47","author":"Kim","year":"2014","journal-title":"Anat. Cell Biol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2017.03.123_bib0070","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.cellsig.2013.02.006","article-title":"Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway","volume":"25","author":"Wan","year":"2013","journal-title":"Cell. Signal."},{"issue":"1","key":"10.1016\/j.ijbiomac.2017.03.123_bib0075","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1158\/1535-7163.MCT-14-0492","article-title":"Long noncoding RNA ANRIL promotes non-small cell lung cancer cell proliferation and inhibits apoptosis by silencing KLF2 and P21 expression","volume":"14","author":"Nie","year":"2015","journal-title":"Mol. Cancer Ther."},{"issue":"8","key":"10.1016\/j.ijbiomac.2017.03.123_bib0080","doi-asserted-by":"crossref","first-page":"801","DOI":"10.4161\/cc.5.8.2638","article-title":"Oncogenes and the DNA damage response: Myc and E2F1 engage the ATM signaling pathway to activate p53 and induce apoptosis","volume":"5","author":"Hong","year":"2006","journal-title":"ABBV Cell Cycle"},{"issue":"3","key":"10.1016\/j.ijbiomac.2017.03.123_bib0085","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10456-016-9506-9","article-title":"CD34 expression modulates tube-forming capacity and barrier properties of peripheral blood-derived endothelial colony-forming cells (ECFCs)","volume":"19","author":"Tasev","year":"2016","journal-title":"Angiogenesis"},{"issue":"3","key":"10.1016\/j.ijbiomac.2017.03.123_bib0090","first-page":"145","article-title":"Drug resistance associated properties of blasts subpopulations with different CD34 expression in childhood acute lymphoblastic leukemia (ALL)","volume":"33","author":"Shman","year":"2011","journal-title":"Exp. Oncol."},{"key":"10.1016\/j.ijbiomac.2017.03.123_bib0095","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13000-015-0247-7","article-title":"Increased expression of the long non-coding RNA ANRIL promotes lung cancer cell metastasis and correlates with poor prognosis","volume":"10","author":"Lin","year":"2015","journal-title":"Diagn. Pathol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2017.03.123_bib0100","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.3892\/mmr.2016.5409","article-title":"ANRIL is associated with the survival rate of patients with colorectal cancer, and affects cell migration and invasion in vitro","volume":"14","author":"Sun","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"3","key":"10.1016\/j.ijbiomac.2017.03.123_bib0105","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1349-7006.2009.01440.x","article-title":"Irrespective of CD34 expression, lineage-committed cell fraction reconstitutes and re-establishes transformed Philadelphia chromosome-positive leukemia in NOD\/SCID\/IL-2Rgammac-\/- mice","volume":"101","author":"Tanizaki","year":"2010","journal-title":"Cancer Sci."},{"issue":"1","key":"10.1016\/j.ijbiomac.2017.03.123_bib0110","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.stem.2010.06.004","article-title":"Reprogramming of T cells from human peripheral blood","volume":"7","author":"Loh","year":"2010","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/j.ijbiomac.2017.03.123_bib0115","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.cell.2009.01.023","article-title":"Oct4-induced pluripotency in adult neural stem cells","volume":"136","author":"Kim","year":"2009","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.ijbiomac.2017.03.123_bib0120","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.ijbiomac.2017.03.123_bib0125","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/nbt.1502","article-title":"Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2","volume":"26","author":"Huangfu","year":"2008","journal-title":"Nat. Biotechnol."},{"issue":"11","key":"10.1016\/j.ijbiomac.2017.03.123_bib0130","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1038\/nbt.1503","article-title":"Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes","volume":"26","author":"Aasen","year":"2008","journal-title":"Nat. Biotechnol."},{"issue":"6","key":"10.1016\/j.ijbiomac.2017.03.123_bib0135","doi-asserted-by":"crossref","first-page":"e11373","DOI":"10.1371\/journal.pone.0011373","article-title":"Derivation of induced pluripotent stem cells from human peripheral blood T lymphocytes","volume":"5","author":"Brown","year":"2010","journal-title":"PLoS One"},{"issue":"37","key":"10.1016\/j.ijbiomac.2017.03.123_bib0140","doi-asserted-by":"crossref","first-page":"15720","DOI":"10.1073\/pnas.0908450106","article-title":"Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells","volume":"106","author":"Sun","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"22","key":"10.1016\/j.ijbiomac.2017.03.123_bib0145","doi-asserted-by":"crossref","first-page":"5476","DOI":"10.1182\/blood-2009-02-204800","article-title":"Generation of induced pluripotent stem cells from human blood","volume":"113","author":"Loh","year":"2009","journal-title":"Blood"},{"issue":"5858","key":"10.1016\/j.ijbiomac.2017.03.123_bib0150","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1126\/science.1152092","article-title":"Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin","volume":"318","author":"Hanna","year":"2007","journal-title":"Science"},{"issue":"36","key":"10.1016\/j.ijbiomac.2017.03.123_bib0155","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1016\/j.biomaterials.2006.06.017","article-title":"Surface-aminated electrospun nanofibers enhance adhesion and expansion of human umbilical cord blood hematopoietic stem\/progenitor cells","volume":"27","author":"Chua","year":"2006","journal-title":"Biomaterials"}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813016327660?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813016327660?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T23:44:00Z","timestamp":1568936640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813016327660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":31,"alternative-id":["S0141813016327660"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.03.123","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The over expression of long non-coding RNA ANRIL promotes epithelial-mesenchymal transition by activating the ATM-E2F1 signaling pathway in pancreatic cancer: An in vivo and in vitro study","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.03.123","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}