{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:00:51Z","timestamp":1791576051473,"version":"4.3.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.ijbiomac.2017.04.012","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T00:02:17Z","timestamp":1491523337000},"page":"153-161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Angiogenenic effects of BpLec, a C-type lectin isolated from Bothrops pauloensis snake venom"],"prefix":"10.1016","volume":"102","author":[{"given":"Let\u00edcia Eulalio","family":"Castanheira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiana Silva","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Natalie Cirilo","family":"Gimenes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Ramos","family":"Deconte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Ant\u00f4nio","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Terra","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Ricardo Goulart","family":"Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana Carla","family":"Tomiosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Santos","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly Aparecida Geraldo","family":"Yoneyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda de Assis","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veridiana de Melo","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0005","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1538-7836.2008.03233.x","article-title":"Scientific and standardization committee communications: classification and nomenclature of snake venom C-type lectins and related proteins","volume":"7","author":"Clemetson","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0010","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.3390\/molecules20033791","article-title":"Lectins with potential for anti-Cancer therapy","volume":"20","author":"Yau","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40409-015-0038-3","article-title":"Snake venom galactoside-binding lectins: a structural and functional overview","volume":"21","author":"Sartim","year":"2015","journal-title":"J. Venom Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0020","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1104\/pp.109.2.347","article-title":"Lectins as plant defense proteins","volume":"109","author":"Peumans","year":"1995","journal-title":"Plant Physiol."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0025","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0304-4165(02)00308-2","article-title":"Animal lectins: a historical introduction and overview","volume":"1572","author":"Kilpatrick","year":"2002","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0030","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.toxicon.2006.08.006","article-title":"Structure-function inferences based on molecular modeling, sequence-based methods and biological data analysis of snake venom lectins","volume":"48","author":"Abreu","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0035","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1590\/S1678-91992007000400009","article-title":"C-Type lectin from Bothrops jararacussu venom can adhere to extracellular matrix proteins and induce the rolling of leukocytes","volume":"13","author":"Elifio-Esposito","year":"2007","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0040","first-page":"90","article-title":"Galectins in tumor angiogenesis","volume":"2","author":"Griffioen","year":"2014","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0045","first-page":"235","article-title":"Galectin expression in cancer diagnosis and prognosis: a systematic review","volume":"1855","author":"Thijssen","year":"2015","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0050","first-page":"963596","article-title":"Glycoconjugates and related molecules in human vascular endothelial cells","volume":"2013","author":"Sasaki","year":"2013","journal-title":"Int. J. Vasc. Med."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0055","doi-asserted-by":"crossref","first-page":"203639","DOI":"10.1155\/2014\/203639","article-title":"Antitumoral activity of snake venom proteins: new trends in cancer therapy","volume":"2014","author":"Calderon","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0060","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2174\/1568026615666150225113402","article-title":"Snake venom derived molecules in tumor angiogenesis and its application in cancer therapy; an overview","volume":"15","author":"Dhananjaya","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0065","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/jcp.20935","article-title":"Lebectin, a Macrovipera lebetina venom-derived C-type lectin, inhibits angiogenesis both in vitro and in vivo","volume":"211","author":"Pilorget","year":"2007","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0070","doi-asserted-by":"crossref","first-page":"862","DOI":"10.3390\/toxins4100862","article-title":"Vixapatin (VP12), a C-type lectin-protein from Vipera xantina palestinae venom: characterization as a novel anti-angiogenic compound","volume":"4","author":"Momic","year":"2012","journal-title":"Toxins (Basel)."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0075","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1182\/blood-2003-07-2483","article-title":"Aggretin, a snake venom-derived endothelial integrin alpha 2 beta 1 agonist, induces angiogenesis via expression of vascular endothelial growth factor","volume":"103","author":"Chung","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0080","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.bbrc.2008.02.091","article-title":"Agglucetin, a tetrameric C-type lectin-like venom protein, regulates endothelial cell survival and promotes angiogenesis by activating integrin alphavbeta3 signaling","volume":"369","author":"Wang","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0085","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijbiomac.2012.11.018","article-title":"Biochemical and functional characterization of a C-type lectin (BpLec) from Bothrops pauloensis snake venom","volume":"54","author":"Castanheira","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0090","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ijbiomac.2014.11.035","article-title":"Insights into anti-parasitism induced by a C-type lectin from Bothrops pauloensis venom on Toxoplasma gondii","volume":"74","author":"Castanheira","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0095","doi-asserted-by":"crossref","first-page":"26235","DOI":"10.1074\/jbc.M112.381483","article-title":"Rhinocetin, a venom-derived integrin-specific antagonist inhibits collagen-induced platelet and endothelial cell functions","volume":"287","author":"Vaiyapuri","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0100","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.4049\/jimmunol.147.7.2122","article-title":"Murine endothelioma cell lines transformed by polyoma middle T oncogene as target for and producers of cytokines","volume":"147","author":"Bussolino","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0105","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0110","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ijbiomac.2014.08.050","article-title":"Biochemical properties of a new PI SVMP from Bothrops pauloensis: inhibition of cell adhesion and angiogenesis","volume":"72","author":"Ach\u00ea","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0115","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1124\/mol.59.5.1333","article-title":"Rhodostomin a snake venom disintegrin, inhibits angiogenesis elicited by basic fibroblast growth factor and suppresses tumor growth by a selective alpha(v)beta(3) blockade of endothelial cells","volume":"59","author":"Yeh","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.biopha.2009.03.003","article-title":"Atorvastatin inhibits inflammatory angiogenesis in mice through down regulation of VEGF, TNF-alpha and TGF-beta1","volume":"64","author":"Ara\u00fajo","year":"2010","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0125","first-page":"510","article-title":"An in vivo quantitative angiogenesis model using tumor cells entrapped in alginate","volume":"62","author":"Plunkett","year":"1990","journal-title":"Lab. Invest."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0130","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1172\/JCI200420997","article-title":"Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis","volume":"114","author":"Phillips","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0135","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1524-475X.2008.00381.x","article-title":"Mechanisms of wound healing responses in lupus-prone New Zealand White mouse strain","volume":"16","author":"Campos","year":"2008","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0140","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.lfs.2007.05.003","article-title":"Tumor growth, angiogenesis and inflammation in mice lacking receptors for platelet activating factor (PAF)","volume":"81","author":"Ferreira","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0145","doi-asserted-by":"crossref","first-page":"832649","DOI":"10.1155\/2015\/832649","article-title":"Endothelial progenitor cells in tumor angiogenesis: another brick in the wall","volume":"2015","author":"Mar\u00e7ola","year":"2015","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0150","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.semcancer.2005.05.004","article-title":"Matrigel: basement membrane matrix with biological activity","volume":"15","author":"Kleinman","year":"2005","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0155","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2172-12-10","article-title":"Human neutrophil migration and activation by BJcuL, a galactose binding lectin purified from Bothrops jararacussu venom","volume":"12","author":"Elifio-Esposito","year":"2011","journal-title":"BMC. Immunol."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0160","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.toxicon.2014.08.062","article-title":"The lectin BJcuL induces apoptosis through TRAIL expression, caspase cascade activation and mitochondrial membrane permeability in a human colon adenocarcinoma cell line","volume":"90","author":"Damasio","year":"2014","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0165","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.toxicon.2016.12.007","article-title":"Structural and binding studies of a C-type galactose-binding lectin from Bothrops jararacussu snake venom","volume":"126","author":"Sartim","year":"2017","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0170","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.toxicon.2014.10.007","article-title":"DisBa-01 inhibits angiogenesis, inflammation and fibrogenesis of sponge-induced-fibrovascular tissue in mice","volume":"92","author":"Cassini-Vieira","year":"2014","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0175","first-page":"1","article-title":"Anti-stromal treatment together with chemotherapy targets multiple signalling pathways in pancreatic adenocarcinoma","volume":"1","author":"Carapu\u00e7a","year":"2016","journal-title":"J. Pathol."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0180","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1681\/ASN.2011040367","article-title":"Inhibition of integrin \u03b12\u03b21 ameliorates glomerular injury","volume":"23","author":"Borza","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0185","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.taap.2013.03.002","article-title":"Identification of inhibitors of \u03b12\u03b21 integrin, members of C-lectin type proteins, in Echis sochureki venom","volume":"269","author":"Jakubowski","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0190","first-page":"823","article-title":"Interleukin-4 stimulates collagen synthesis by normal and scleroderma fibroblasts in dermal equivalents","volume":"37","author":"Fertin","year":"1991","journal-title":"Cell. Mol. Biol."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0195","doi-asserted-by":"crossref","first-page":"791","DOI":"10.3109\/01902149509050842","article-title":"Molecular mechanisms of antifibrotic effect of interferon-(in bleomycin-mouse model of lung fibrosis: downregulation of TGF\u03b2 and procollagen I and III gene expression","volume":"21","author":"Gurujeyalakshmi","year":"1995","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0200","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1146\/annurev-pathol-020712-163930","article-title":"Host responses in tissue repair and fibrosis","volume":"8","author":"Duffield","year":"2013","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0205","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1093\/glycob\/cwu061","article-title":"Galatrox is a C-type lectin in Bothrops atrox snake venom that selectively binds LacNAc-terminated glycans and can induce acute inflammation","volume":"24","author":"Sartim","year":"2014","journal-title":"Glycobiology"},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0210","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/jcp.20458","article-title":"Activation of human endothelial cells by tumor necrosis factor-alpha results in profound changes in the expression of glycosylation-related genes","volume":"206","author":"Garc\u00eda-Vallejo","year":"2006","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0215","first-page":"30037","article-title":"Bjcul, A snake venom lectin, modulates monocyte-derived macrophages to a pro-Inflammatory profile In Vitro","volume":"2333","author":"Dias-Netipanyi","year":"2016","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0220","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.lfs.2009.01.023","article-title":"Cilostazol and pentoxifylline decrease angiogenesis, inflammation, and fibrosis in sponge-induced intraperitoneal adhesion in mice","volume":"84","author":"Mendes","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.ijbiomac.2017.04.012_bib0225","doi-asserted-by":"crossref","first-page":"182703","DOI":"10.1093\/ecam\/nep197","article-title":"Brazilian green propolis inhibits inflammatory angiogenesis in a murine sponge model","volume":"2011","author":"de Moura","year":"2011","journal-title":"Evid. Based. Complement. Alternat. Med."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813017303240?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813017303240?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T21:30:56Z","timestamp":1692739856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813017303240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":45,"alternative-id":["S0141813017303240"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.04.012","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angiogenenic effects of BpLec, a C-type lectin isolated from Bothrops pauloensis snake venom","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}