{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T18:59:45Z","timestamp":1774292385793,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003051","name":"NEDO","doi-asserted-by":"crossref","award":["08C46218d"],"award-info":[{"award-number":["08C46218d"]}],"id":[{"id":"10.13039\/501100003051","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.ijbiomac.2017.05.049","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T17:47:13Z","timestamp":1494870433000},"page":"1532-1538","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"P2","title":["Anti-allergic and Profilaggrin (ProFLG)-mRNA expression modulatory effects of sacran"],"prefix":"10.1016","volume":"105","author":[{"given":"Nlandu R.","family":"Ngatu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Motoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumitsu","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiko Kaneko","family":"Okajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoji","family":"Hirota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taishi","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suni","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Arima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsunori","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayumi","family":"Nojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0005","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1056\/NEJMcp042803","article-title":"Atopic dermatitis","volume":"352","author":"Williams","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0010","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1067\/mai.2000.106484","article-title":"Atopic dermatitis: new insights and opportunities for therapeutic intervention","volume":"105","author":"Leung","year":"2000","journal-title":"J. Allergy Clin. Immnol."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0015","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/jid.2008.280","article-title":"Clinical severity correlates with impaired barrier in filaggrin-related eczema","volume":"129","author":"Nemoto-Hasebe","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0020","doi-asserted-by":"crossref","first-page":"S128","DOI":"10.1016\/j.jaci.2003.09.032","article-title":"Immune mechanisms leading to atopic dermatitis","volume":"112","author":"Novak","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0025","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1172\/JCI21060","article-title":"New insights into atopic dermatitis","volume":"113","author":"Leung","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0030","series-title":"Skin Barrier","first-page":"111","article-title":"Profilaggrin and the fused S100 family of calcium-binding proteins","author":"Presland","year":"2005"},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0035","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/jid.2011.360","article-title":"Profilaggrin, dry skin, and atopic dermatitis risk: size matters","volume":"132","author":"McGrath","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0040","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/ics.12049","article-title":"Filaggrin revisited","volume":"35","author":"Harding","year":"2013","journal-title":"Int. J. Cosmet. Sci."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0045","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/ng.1017","article-title":"Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis","volume":"44","author":"Paternoster","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0050","doi-asserted-by":"crossref","first-page":"58","DOI":"10.2340\/00015555-0748","article-title":"Safety and efficacy of tacrlimus ointment versus pimecrolimus cream in the treatment of patients with atopic dermatitis previously treated with corticosteroids","volume":"90","author":"Kirsner","year":"2010","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0055","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1517\/13543776.2016.1101451","article-title":"Emerging small-molecule compounds for treatment of atopic dermatitis: a review","volume":"26","author":"Vavrova","year":"2016","journal-title":"Expert Opin. Ther. Patents"},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0060","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1021\/ma800307w","article-title":"Supergiant ampholytic sugar chains with imbalanced charge ratio form saline ultra-absorbent hydrogels","volume":"41","author":"Okajima","year":"2008","journal-title":"Macromolecules"},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0065","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1128\/AEM.70.6.3338-3345.2004","article-title":"Establishment of a pure culture of the hitherto uncultured unicellular cyano-bacterium Aphanothece sacrum, and phylogenic position of the organism","volume":"70","author":"Fujishiro","year":"2004","journal-title":"Appl. Environm. Microbiol."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0070","doi-asserted-by":"crossref","first-page":"8526","DOI":"10.1021\/la8036956","article-title":"Cyanobacterial megamolecule sacran efficiently forms LC gels with very heavy metal ions","volume":"25","author":"Okajima","year":"2009","journal-title":"Langmuir"},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0075","article-title":"Anti-allergic effects and immunomodulatory activity of sacran, a bioactive compound from river alga Aphanothece sacrum","volume":"2","author":"Ngatu","year":"2016","journal-title":"Evid.-Based Med. Public Health"},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0080","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jaci.2007.09.015","article-title":"Signal transducer and activator of transcription 1 decoy oligodeoxynucleotide suppression of contact hypersensitivity","volume":"121","author":"Wagner","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0085","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1056\/NEJMra074081","article-title":"Atopic dermatitis","volume":"358","author":"Bieber","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0090","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/all.12632","article-title":"Past, present, and future for biologic intervention in atopic dermatitis","volume":"70","author":"Howell","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0095","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1136\/adc.67.3.277","article-title":"Increased plasma tumor necrosis factor-alpha concentration in atopic dermatitis","volume":"67","author":"Sumitomo","year":"1992","journal-title":"Arch. Dis. Child"},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0100","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jaci.2007.04.031","article-title":"Cytokine modulation of AD filaggrin skin expression","volume":"120","author":"Howell","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0105","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1146\/annurev.immunol.17.1.701","article-title":"The IL-4 receptor: signaling mechanisms and biologic functions","volume":"17","author":"Nelms","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0110","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1002\/eji.200635972","article-title":"IL-4 induces expression of TARC\/CCL17 via two STAT6 binding sites","volume":"36","author":"Wirnsberger","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0115","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/jid.2013.506","article-title":"Crossing barriers; restoring barriers? Filaggrin protein replacement takes a bow","volume":"134","author":"Irvine","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0120","first-page":"428","article-title":"Interleukin 33 is induced by tumor necrosis factor alpha and interferon in keratinocytes and contributes to allergic contact dermatitis","volume":"23","author":"Taniguchi","year":"2013","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0125","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1242\/jcs.033969","article-title":"Filaggrin in the frontline: role in skin barrier function and disease","volume":"122","author":"Sandilands","year":"2009","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0130","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.anai.2011.10.013","article-title":"Anti-inflammatory effects of sacran, a novel polysaccharide from Aphanothece sacrum, on 2,4,6-trinitrochlorobenzene-induced allergic dermatitis in vivo","volume":"108","author":"Ngatu","year":"2012","journal-title":"Ann. Allergy Asthm. Clin. Immunol."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0135","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ijbiomac.2016.09.093","article-title":"Enhancing effect of (-cyclodextrin on wound dressing properties of sacran hydrogel film","volume":"94","author":"Wathoni","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0140","first-page":"9","article-title":"Clinical Evaluation of novel natural poly-saccharides sacran as a skincare material for atopic dermatitis patients","volume":"6","author":"Fukushima","year":"2016","journal-title":"J. Cosmet. Dermatol. Sci. Appl."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0145","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1248\/bpb.b16-00208","article-title":"Anti-inflammatory effects of novel polysaccharide sacran extracted from cyanobacterium aphanothece sacrum in various inflammatory animal models","volume":"39","author":"Motoyama","year":"2016","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0150","first-page":"111","article-title":"Sacran, a natural skin barrier enhancer, improves atopic and contact eczema: case reports","volume":"4","author":"Ngatu","year":"2015","journal-title":"Ann. Phytomed."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0155","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1056\/NEJMoa0906312","article-title":"A large-scale consortium-based genome wide association study of asthma","volume":"363","author":"Moffatt","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijbiomac.2017.05.049_bib0160","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/ng.851","article-title":"Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population","volume":"43","author":"Sun","year":"2011","journal-title":"Nat. Genet."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813017310486?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813017310486?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T02:49:10Z","timestamp":1654224550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813017310486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":32,"alternative-id":["S0141813017310486"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.05.049","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-allergic and Profilaggrin (ProFLG)-mRNA expression modulatory effects of sacran","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.05.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}