{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:40:55Z","timestamp":1793385655562,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Natural Science Foundation of China NSFC-Shandong joint fund","award":["U1406402-5"],"award-info":[{"award-number":["U1406402-5"]}]},{"name":"Basic Research Plan of Qingdao","award":["15-9-1-73-jch"],"award-info":[{"award-number":["15-9-1-73-jch"]}]},{"name":"The Fundamental Research Funds for the Central Universities","award":["201513009"],"award-info":[{"award-number":["201513009"]}]},{"name":"Taishan Scholar Program, China"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.ijbiomac.2017.06.017","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T23:02:17Z","timestamp":1496876537000},"page":"224-231","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"PA","title":["Tough chitosan hydrogel based on purified regeneration and alkaline solvent as biomaterials for tissue engineering applications"],"prefix":"10.1016","volume":"104","author":[{"given":"Shichao","family":"Bi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixian","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiguang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0005","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nmat1092","volume":"3","author":"Luo","year":"2004","journal-title":"Nat. Mater."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0010","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1021\/ma901530r","volume":"43","author":"Shoichet","year":"2009","journal-title":"Macromolecules"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0015","doi-asserted-by":"crossref","first-page":"5243","DOI":"10.1002\/adma.201201522","volume":"24","author":"Shimamoto","year":"2012","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0020","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.progpolymsci.2011.02.001","volume":"36","author":"Dash","year":"2011","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0025","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/adma.201302958","volume":"26","author":"Thiele","year":"2014","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0030","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.carbpol.2010.12.023","volume":"84","author":"Chang","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0035","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1016\/j.biomaterials.2011.03.033","volume":"32","author":"Egawa","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0040","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1021\/am404855q","volume":"6","author":"He","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0045","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.biomaterials.2009.10.040","volume":"31","author":"Liu","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0050","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1039\/c2sm07462a","volume":"8","author":"Nata","year":"2012","journal-title":"Soft Matter"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0055","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1039\/c0jm03075a","volume":"21","author":"Chang","year":"2011","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0060","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nature06619","volume":"452","author":"Ladet","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0065","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1021\/acs.macromol.5b00117","volume":"48","author":"Duan","year":"2015","journal-title":"Macromolecules"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0070","series-title":"Biopolymers Online","author":"Peter","year":"2005"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0075","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.biomaterials.2009.09.102","volume":"31","author":"Strand","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0080","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.eurpolymj.2012.12.009","volume":"49","author":"Croisier","year":"2013","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0085","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jconrel.2007.11.018","volume":"126","author":"Ta","year":"2008","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0090","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/adma.201303233","volume":"26","author":"Annabi","year":"2014","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0095","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1289\/ehp.98106393","volume":"106","author":"Luu","year":"1998","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0100","first-page":"158","volume":"6","author":"Miller","year":"2000","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0105","doi-asserted-by":"crossref","first-page":"7635","DOI":"10.1038\/srep07635","volume":"5","author":"Nie","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0110","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.1039\/C6TB00378H","volume":"4","author":"Bao","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0115","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1021\/bm500827q","volume":"15","author":"He","year":"2014","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0120","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1016\/j.biomaterials.2010.01.068","volume":"31","author":"Kim","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0125","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.actbio.2010.10.023","volume":"7","author":"Ovsianikov","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0130","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1016\/j.biomaterials.2007.02.032","volume":"28","author":"Jin","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0135","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.carbpol.2011.10.017","volume":"87","author":"Spagnol","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0140","doi-asserted-by":"crossref","first-page":"9345","DOI":"10.1021\/ma801110g","volume":"41","author":"Cai","year":"2008","journal-title":"Macromolecules"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0145","doi-asserted-by":"crossref","first-page":"5380","DOI":"10.1002\/anie.201402751","volume":"53","author":"Shi","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0150","author":"Xu","year":"2016","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0155","doi-asserted-by":"crossref","first-page":"8245","DOI":"10.1039\/C4SM01336K","volume":"10","author":"Li","year":"2014","journal-title":"Soft Matter"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0160","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.carbpol.2009.03.031","volume":"78","author":"Fan","year":"2009","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0165","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.carbpol.2013.01.016","volume":"94","author":"Fan","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0170","doi-asserted-by":"crossref","first-page":"12033","DOI":"10.1038\/ncomms12033","volume":"7","author":"Wang","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0175","doi-asserted-by":"crossref","first-page":"4144","DOI":"10.1021\/bm2012295","volume":"12","author":"Krajewska","year":"2011","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0180","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0039-9140(97)00288-9","volume":"45","author":"Tan","year":"1998","journal-title":"Talanta"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0185","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1016\/j.polymer.2014.05.003","volume":"55","author":"Zhao","year":"2014","journal-title":"Polymer"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0190","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.actbio.2016.02.028","volume":"35","author":"Liu","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0195","doi-asserted-by":"crossref","first-page":"43663","DOI":"10.1039\/C6RA04609F","volume":"6","author":"Li","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0200","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.msec.2010.05.003","volume":"30","author":"Meng","year":"2010","journal-title":"Mater. Sci. Eng.: C"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0205","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1021\/bm000036j","volume":"1","author":"Cho","year":"2000","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0210","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.progpolymsci.2007.11.001","volume":"33","author":"Crini","year":"2008","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0215","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.biortech.2007.01.051","volume":"99","author":"Abdou","year":"2008","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0220","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/j.biortech.2006.09.002","volume":"98","author":"Lavall","year":"2007","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0225","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1021\/bm800178b","volume":"9","author":"Fan","year":"2008","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0230","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1021\/bm990017d","volume":"1","author":"Van Den Bulcke","year":"2000","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0235","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1039\/C4TB01806K","volume":"3","author":"He","year":"2015","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0240","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1021\/acs.biomac.5b00928","volume":"16","author":"Huang","year":"2015","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0245","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1021\/acs.macromol.5b02231","volume":"49","author":"You","year":"2016","journal-title":"Macromolecules"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0250","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1021\/bm060094q","volume":"7","author":"Kobayashi","year":"2006","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0255","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0009-9120(89)80031-1","volume":"22","author":"Porstmann","year":"1989","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0260","series-title":"Chitin","author":"Muzzarelli","year":"2013"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0265","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1002\/jbm.a.34106","volume":"100","author":"Gorgieva","year":"2012","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0270","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-1-59259-261-6_16","author":"Muzzarelli","year":"1999","journal-title":"Carbohydr. Biotechnol. protocols"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0275","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.biomaterials.2011.10.059","volume":"33","author":"Vogler","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0280","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.colsurfb.2013.06.002","volume":"111","author":"Lima","year":"2013","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0285","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1021\/bm015531+","volume":"2","author":"Sorlier","year":"2001","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0290","doi-asserted-by":"crossref","first-page":"4236","DOI":"10.1021\/bm3014999","volume":"13","author":"Cheng","year":"2012","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0295","author":"Mu","year":"2010","journal-title":"Macromol. Mater. Eng."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0300","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.progpolymsci.2013.06.001","volume":"38","author":"Okamoto","year":"2013","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.ijbiomac.2017.06.017_bib0305","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.carbpol.2015.09.049","volume":"136","author":"Zhao","year":"2016","journal-title":"Carbohydr. Polym."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813016327647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813016327647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T23:13:30Z","timestamp":1620861210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813016327647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":61,"alternative-id":["S0141813016327647"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.06.017","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tough chitosan hydrogel based on purified regeneration and alkaline solvent as biomaterials for tissue engineering applications","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.06.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}