{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T20:18:47Z","timestamp":1782245927584,"version":"3.54.5"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research","doi-asserted-by":"publisher","award":["37(1665)\/15\/EMR-II"],"award-info":[{"award-number":["37(1665)\/15\/EMR-II"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University Grant Commission"},{"DOI":"10.13039\/100010390","name":"Saint Louis University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010390","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Science and Technology, Government of India","award":["SR\/FST\/LSI-541\/2012"],"award-info":[{"award-number":["SR\/FST\/LSI-541\/2012"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.ijbiomac.2017.08.082","type":"journal-article","created":{"date-parts":[[2017,8,19]],"date-time":"2017-08-19T12:50:14Z","timestamp":1503147014000},"page":"840-850","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Biological evaluation of p-toluene sulphonylhydrazone as carbonic anhydrase IX inhibitors: An approach to fight hypoxia-induced tumors"],"prefix":"10.1016","volume":"106","author":[{"given":"Aarfa","family":"Queen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvez","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danish","family":"Idrees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Azam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Imtaiyaz","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ijbiomac.2017.08.082_bib0005","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.ijbiomac.2017.08.082_bib0010","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nrc3599","article-title":"Cancer drug resistance: an evolving paradigm","volume":"13","author":"Holohan","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ijbiomac.2017.08.082_bib0015","series-title":"Carbonic Anhydrase: its Inhibitors and Activators","author":"Supuran","year":"2004"},{"issue":"9","key":"10.1016\/j.ijbiomac.2017.08.082_bib0020","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2174\/156802607780636690","article-title":"Carbonic anhydrases as drug targets-an overview","volume":"7","author":"Supuran","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"issue":"2","key":"10.1016\/j.ijbiomac.2017.08.082_bib0025","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1080\/07391102.2016.1149097","article-title":"Effect of pH on structure, function, and stability of mitochondrial carbonic anhydrase VA","volume":"35","author":"Idrees","year":"2017","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"6","key":"10.1016\/j.ijbiomac.2017.08.082_bib0030","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/j.bmc.2012.04.044","article-title":"Structure, function and applications of carbonic anhydrase isozymes","volume":"21","author":"Imtaiyaz Hassan","year":"2013","journal-title":"Bioorg. Med. Chem."},{"issue":"1","key":"10.1016\/j.ijbiomac.2017.08.082_bib0035","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11030-016-9714-7","article-title":"Design, synthesis, in silico and biological evaluation of novel 2-(4-(4-substituted piperazin-1-yl)benzylidene)hydrazine carboxamides","volume":"21","author":"Kumari","year":"2017","journal-title":"Mol. Divers."},{"issue":"2","key":"10.1016\/j.ijbiomac.2017.08.082_bib0040","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.bbapap.2009.07.027","article-title":"Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target","volume":"1804","author":"De Simone","year":"2010","journal-title":"Biochim. Biophys. Acta (BBA)-Proteins Proteomics"},{"issue":"10","key":"10.1016\/j.ijbiomac.2017.08.082_bib0045","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","article-title":"Interfering with pH regulation in tumours as a therapeutic strategy","volume":"10","author":"Neri","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.ijbiomac.2017.08.082_bib0050","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1158\/0008-5472.CAN-08-2470","article-title":"Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH","volume":"69","author":"Chiche","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.ijbiomac.2017.08.082_bib0055","series-title":"Carbonic Anhydrase IX as an Imaging and Therapeutic Target for Tumors and Metastases, Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications","first-page":"221","author":"Tafreshi","year":"2014"},{"issue":"2","key":"10.1016\/j.ijbiomac.2017.08.082_bib0060","doi-asserted-by":"crossref","first-page":"159","DOI":"10.4161\/cc.3.2.618","article-title":"Hypoxia inducible carbonic anhydrase IX, marker of tumour: hypoxia, survival pathway and therapy target","volume":"3","author":"Potter","year":"2004","journal-title":"ABBV Cell Cycle"},{"key":"10.1016\/j.ijbiomac.2017.08.082_bib0065","series-title":"Carbonic Anhydrase IX: from Biology to Therapy, Hypoxia and Cancer","first-page":"121","author":"Pastorekova","year":"2014"},{"issue":"4","key":"10.1016\/j.ijbiomac.2017.08.082_bib0070","doi-asserted-by":"crossref","first-page":"442","DOI":"10.2174\/156652409788167087","article-title":"Hypoxia and radiation therapy: past history, ongoing research, and future promise","volume":"9","author":"Rockwell","year":"2009","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.ijbiomac.2017.08.082_bib0075","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jmgm.2016.01.006","article-title":"Design and synthesis of a novel class of carbonic anhydrase-IX inhibitor 1-(3-(phenyl\/4-fluorophenyl)-7-imino-3H-[1,2,3]triazolo[4,5d]pyrimidin 6(7H)yl)urea","volume":"64","author":"Kumari","year":"2016","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.ijbiomac.2017.08.082_bib0080","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1146\/annurev.med.53.082901.103929","article-title":"Mechanisms of cancer drug resistance","volume":"53","author":"Gottesman","year":"2002","journal-title":"Annu. Rev. Med."},{"issue":"3","key":"10.1016\/j.ijbiomac.2017.08.082_bib0085","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3109\/21691401.2013.794352","article-title":"New coumarin derivatives as carbonic anhydrase inhibitors","volume":"42","author":"Karata\u015f","year":"2014","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2017.08.082_bib0090","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1021\/acs.jmedchem.5b01720","article-title":"Thioxocoumarins show an alternative carbonic anhydrase inhibition mechanism compared to coumarins","volume":"59","author":"Ferraroni","year":"2015","journal-title":"J. Med. Chem."},{"issue":"5","key":"10.1016\/j.ijbiomac.2017.08.082_bib0095","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0960-894X(03)00029-5","article-title":"Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates\/sulfamides with isozymes I, II and IV","volume":"13","author":"Casini","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"12","key":"10.1016\/j.ijbiomac.2017.08.082_bib0100","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1016\/j.bmcl.2010.05.009","article-title":"Carbonic anhydrase inhibitors","volume":"20","author":"Supuran","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"15","key":"10.1016\/j.ijbiomac.2017.08.082_bib0105","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1021\/jm0501073","article-title":"Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors","volume":"48","author":"Cecchi","year":"2005","journal-title":"J. Med. Chem."},{"issue":"7","key":"10.1016\/j.ijbiomac.2017.08.082_bib0110","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1021\/ml500140t","article-title":"Carbonic anhydrase inhibitors: design, synthesis, and biological evaluation of novel sulfonyl semicarbazide derivatives","volume":"5","author":"Pichake","year":"2014","journal-title":"ACS Med. Chem. Lett."},{"issue":"2","key":"10.1016\/j.ijbiomac.2017.08.082_bib0115","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","article-title":"Carbonic anhydrase inhibitors","volume":"23","author":"Supuran","year":"2003","journal-title":"Med. Res. Rev."},{"issue":"1","key":"10.1016\/j.ijbiomac.2017.08.082_bib0120","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3109\/14756366.2013.879656","article-title":"Synthesis and biological activity of novel thiourea derivatives as carbonic anhydrase inhibitors","volume":"30","author":"Korkmaz","year":"2015","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"6","key":"10.1016\/j.ijbiomac.2017.08.082_bib0125","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.bmc.2012.09.027","article-title":"Synthesis of 1, 4-bis (indolin-1-ylmethyl) benzene derivatives and their structure-activity relationships for the interaction of human carbonic anhydrase isoforms I and II","volume":"21","author":"Talaz","year":"2013","journal-title":"Bioorg. Med. Chem."},{"issue":"7","key":"10.1016\/j.ijbiomac.2017.08.082_bib0130","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1021\/ml500140t","article-title":"Carbonic anhydrase inhibitors: design, synthesis, and biological evaluation of novel sulfonyl semicarbazide derivatives","volume":"5","author":"Pichake","year":"2014","journal-title":"ACS Med. Chem. Lett."},{"issue":"22","key":"10.1016\/j.ijbiomac.2017.08.082_bib0135","doi-asserted-by":"crossref","first-page":"7219","DOI":"10.1016\/j.bmc.2015.10.018","article-title":"New natural product carbonic anhydrase inhibitors incorporating phenol moieties","volume":"23","author":"Karioti","year":"2015","journal-title":"Bioorg. Med. Chem."},{"issue":"20","key":"10.1016\/j.ijbiomac.2017.08.082_bib0140","doi-asserted-by":"crossref","first-page":"5384","DOI":"10.1016\/j.bmcl.2006.07.060","article-title":"Synthesis of N1-arylidene-N2-quinolyl-and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains","volume":"16","author":"Gemma","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ijbiomac.2017.08.082_bib0145","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ejmech.2014.01.023","article-title":"Design, synthesis and biological evaluation of 3-[4-(7-chloro-quinolin-4-yl)-piperazin-1-yl]-propionic acid hydrazones as antiprotozoal agents","volume":"75","author":"Inam","year":"2014","journal-title":"Eur. J. Med. Chem."},{"issue":"7","key":"10.1016\/j.ijbiomac.2017.08.082_bib0150","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0223-5234(03)00138-7","article-title":"Synthesis and anticancer evaluation of some new hydrazone derivatives of 2, 6-dimethylimidazo [2,1-b][1,3,4] thiadiazole-5-carbohydrazide","volume":"38","author":"Terzioglu","year":"2003","journal-title":"Eur. J. Med. Chem."},{"issue":"2","key":"10.1016\/j.ijbiomac.2017.08.082_bib0155","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.bmc.2005.08.012","article-title":"Synthesis and in vitro antitumoral activity of new hydrazinopyrimidine-5-carbonitrile derivatives","volume":"14","author":"Cocco","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ijbiomac.2017.08.082_bib0160","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ejmech.2014.02.026","article-title":"Anticancer activity of new coumarin substituted hydrazide\u2013hydrazone derivatives","volume":"76","author":"Nasr","year":"2014","journal-title":"Eur. J. Med. Chem."},{"issue":"21","key":"10.1016\/j.ijbiomac.2017.08.082_bib0165","doi-asserted-by":"crossref","first-page":"6343","DOI":"10.1021\/jm060232u","article-title":"Synthesis, structure- activity relationships, and antitumor studies of 2-benzoxazolyl hydrazones derived from alpha-(N)-acyl heteroaromatics","volume":"49","author":"Easmon","year":"2006","journal-title":"J. Med. Chem."},{"issue":"5","key":"10.1016\/j.ijbiomac.2017.08.082_bib0170","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1007\/s00044-016-1543-9","article-title":"Synthesis and antimicrobial evaluation of hydrazones derived from 4-methylbenzenesulfonohydrazide in aqueous medium","volume":"25","author":"Ghiya","year":"2016","journal-title":"Med. Chem. Res."},{"issue":"17","key":"10.1016\/j.ijbiomac.2017.08.082_bib0175","doi-asserted-by":"crossref","first-page":"4629","DOI":"10.1016\/j.bmc.2014.07.022","article-title":"Synthesis and antifungal activity of substituted salicylaldehyde hydrazones, hydrazides and sulfohydrazides","volume":"22","author":"Backes","year":"2014","journal-title":"Bioorg. Med. Chem."},{"issue":"5","key":"10.1016\/j.ijbiomac.2017.08.082_bib0180","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/cbdd.12898","article-title":"Design, synthesis, and biological evaluation of pyrimidine derivatives as potential inhibitors of human calcium\/calmodulin-dependent protein kinase IV","volume":"89","author":"Jameel","year":"2017","journal-title":"Chem. Biol. Drug Des."},{"issue":"16","key":"10.1016\/j.ijbiomac.2017.08.082_bib0185","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ijbiomac.2017.08.082_bib0190","series-title":"Discovery Studio Modeling Environment","author":"DSBIOVIA","year":"2013"},{"key":"10.1016\/j.ijbiomac.2017.08.082_bib0195","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1080\/07391102.2016.1179596","article-title":"GdmCl-induced unfolding studies of human carbonic anhydrase IX: a combined spectroscopic and MD simulation approach","volume":"35","author":"Prakash","year":"2017","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.ijbiomac.2017.08.082_bib0200","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.ijbiomac.2016.10.073","article-title":"Characterization of folding intermediates during urea-induced denaturation of human carbonic anhydrase II","volume":"95","author":"Dar","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2017.08.082_bib0205","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ijbiomac.2016.12.024","article-title":"Binding studies and biological evaluation of beta-carotene as a potential inhibitor of human calcium\/calmodulin-dependent protein kinase IV","volume":"96","author":"Naz","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.ijbiomac.2017.08.082_bib0210","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.bbrc.2009.06.064","article-title":"Antibody-specific detection of CAIX in breast and prostate cancers","volume":"386","author":"Li","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1\u20132","key":"10.1016\/j.ijbiomac.2017.08.082_bib0215","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jim.2003.08.011","article-title":"Monoclonal antibodies generated in carbonic anhydrase IX-deficient mice recognize different domains of tumour-associated hypoxia-induced carbonic anhydrase IX","volume":"282","author":"Zat'ovicova","year":"2003","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.ijbiomac.2017.08.082_bib0220","article-title":"Modified annexin V\/propidium iodide apoptosis assay for accurate assessment of cell death","volume":"50","author":"Rieger","year":"2011","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ijbiomac.2017.08.082_bib0225","first-page":"e3491","article-title":"Analysis of cell cycle position in mammalian cells","volume":"59","author":"Cecchini","year":"2012","journal-title":"JoVE J. Visualized Exp."},{"issue":"7","key":"10.1016\/j.ijbiomac.2017.08.082_bib0230","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrgastro.2009.89","article-title":"Pancreatic cancer: molecular pathogenesis and new therapeutic targets","volume":"6","author":"Wong","year":"2009","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2017.08.082_bib0235","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1089\/ars.2013.5212","article-title":"Alpha-mangostin: a dietary antioxidant derived from the pericarp of Garcinia mangostana L. inhibits pancreatic tumor growth in xenograft mouse model","volume":"21","author":"Hafeez","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ijbiomac.2017.08.082_bib0240","article-title":"Evidence of vanillin binding to CAMKIV explains the anti-cancer mechanism in human hepatic carcinoma and neuroblastoma cells","author":"Naz","year":"2017","journal-title":"Mol. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.ijbiomac.2017.08.082_bib0245","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1747-0285.2007.00553.x","article-title":"Structural model of human PSA: a target for prostate cancer therapy","volume":"70","author":"Hassan","year":"2007","journal-title":"Chem. Biol. Drug Des."},{"issue":"12","key":"10.1016\/j.ijbiomac.2017.08.082_bib0250","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/psc.911","article-title":"Structure-guided design of peptidic ligand for human prostate specific antigen","volume":"13","author":"Hassan","year":"2007","journal-title":"J. Pept. Sci."},{"issue":"3","key":"10.1016\/j.ijbiomac.2017.08.082_bib0255","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1080\/07391102.2015.1046934","article-title":"Curcumin specifically binds to the human calcium-calmodulin-dependent protein kinase IV: fluorescence and molecular dynamics simulation studies","volume":"34","author":"Hoda","year":"2016","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"9","key":"10.1016\/j.ijbiomac.2017.08.082_bib0260","doi-asserted-by":"crossref","first-page":"899","DOI":"10.2174\/1568026616999150918145640","article-title":"Editorial. Recent advances in the structure-based drug design and discovery","volume":"16","author":"Hassan","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"issue":"1 Pt. 1","key":"10.1016\/j.ijbiomac.2017.08.082_bib0265","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.gene.2015.09.062","article-title":"Large scale analysis of the mutational landscape in beta-glucuronidase: a major player of mucopolysaccharidosis type VII","volume":"576","author":"Khan","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.ijbiomac.2017.08.082_bib0270","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ijbiomac.2015.12.072","article-title":"Current updates on computer aided protein modeling and designing","volume":"85","author":"Khan","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"issue":"7","key":"10.1016\/j.ijbiomac.2017.08.082_bib0275","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1080\/07391102.2016.1189359","article-title":"Effect of pH on the stability of hemochromatosis factor E: a combined spectroscopic and molecular dynamics simulation-based study","volume":"35","author":"Khan","year":"2017","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"Pt. A","key":"10.1016\/j.ijbiomac.2017.08.082_bib0280","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.ijbiomac.2016.09.087","article-title":"Ubiquitin-associated domain of MARK4 provides stability at physiological pH","volume":"93","author":"Naz","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2017.08.082_bib0285","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jmgm.2015.10.009","article-title":"PKR-inhibitor binds efficiently with human microtubule affinity-regulating kinase 4","volume":"62","author":"Naz","year":"2015","journal-title":"J. Mol. Graph. Model."},{"issue":"9","key":"10.1016\/j.ijbiomac.2017.08.082_bib0290","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.2174\/1568026615666150825143307","article-title":"Current advances in the identification and characterization of putative drug and vaccine targets in the bacterial genomes","volume":"16","author":"Shahbaaz","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"issue":"4","key":"10.1016\/j.ijbiomac.2017.08.082_bib0295","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1504\/IJCBDD.2011.044404","article-title":"Discovering a potent small molecule inhibitor for gankyrin using de novo drug design approach","volume":"4","author":"Thakur","year":"2011","journal-title":"Int. J. Comput. Biol. Drug Des."},{"issue":"1","key":"10.1016\/j.ijbiomac.2017.08.082_bib0300","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4103\/0976-9668.107260","article-title":"Search of potential inhibitor against New Delhi metallo-beta-lactamase 1 from a series of antibacterial natural compounds","volume":"4","author":"Thakur","year":"2013","journal-title":"J. Nat. Sci. Biol. Med."},{"issue":"24","key":"10.1016\/j.ijbiomac.2017.08.082_bib0305","doi-asserted-by":"crossref","first-page":"36666","DOI":"10.18632\/oncotarget.9134","article-title":"Targeting carbonic anhydrase IX improves the anti-cancer efficacy of mTOR inhibitors","volume":"7","author":"Faes","year":"2016","journal-title":"Oncotarget"}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813017325904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813017325904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:03:04Z","timestamp":1758870184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813017325904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":61,"alternative-id":["S0141813017325904"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.08.082","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biological evaluation of p-toluene sulphonylhydrazone as carbonic anhydrase IX inhibitors: An approach to fight hypoxia-induced tumors","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.08.082","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}