{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T20:48:51Z","timestamp":1762980531075,"version":"3.44.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T00:00:00Z","timestamp":1572912000000},"content-version":"am","delay-in-days":461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007726","name":"Shahid Bahonar University of Kerman","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007726","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003968","name":"Iran National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004787","name":"The Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.ijbiomac.2018.04.077","type":"journal-article","created":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T17:53:25Z","timestamp":1523728405000},"page":"1241-1248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Label-free colorimetric sensor for sensitive detection of choline based on DNAzyme-choline oxidase coupling"],"prefix":"10.1016","volume":"115","author":[{"given":"Nasrin","family":"Nikzad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Karami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2018.04.077_bb0005","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jcis.2015.10.014","article-title":"Nano interfaced biosensor for detection of choline in triple negative breast cancer cells","volume":"462","author":"Thiagarajan","year":"2016","journal-title":"J. Colloid Sci."},{"key":"10.1016\/j.ijbiomac.2018.04.077_bb0010","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.talanta.2015.06.037","article-title":"A facile and practical biosensor for choline based on manganese dioxide nanoparticles synthesized in-situ at the surface of electrode by one-step electrodeposition","volume":"146","author":"Yu","year":"2016","journal-title":"Talanta"},{"issue":"5","key":"10.1016\/j.ijbiomac.2018.04.077_bb0015","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s12264-011-1523-5","article-title":"The effects of dietary choline","volume":"27","author":"Biasi","year":"2011","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.ijbiomac.2018.04.077_bb0020","series-title":"Handbook of Neurochemistry and Molecular Neurobiology","first-page":"443","article-title":"Choline and its products acetylcholine and phosphatidylcholine","author":"Wurtman","year":"2009"},{"issue":"11\u221212","key":"10.1016\/j.ijbiomac.2018.04.077_bb0025","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s00604-013-1027-2","article-title":"Optical choline sensor based on a water-soluble fluorescent conjugated polymer and an enzyme-coupled assay","volume":"180","author":"Li","year":"2013","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.ijbiomac.2018.04.077_bb0030","article-title":"Dietary intake and plasma levels of choline and betaine in children with autism spectrum disorders","volume":"2013","author":"Hamlin","year":"2013","journal-title":"Autism Res. Treat."},{"issue":"1","key":"10.1016\/j.ijbiomac.2018.04.077_bb0035","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3945\/an.114.007955","article-title":"Choline, its potential role in nonalcoholic fatty liver disease, and the case for human and bacterial genes","volume":"7","author":"Sherriff","year":"2016","journal-title":"Adv. Nutr."},{"issue":"7","key":"10.1016\/j.ijbiomac.2018.04.077_bb0040","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.3390\/ijms17071148","article-title":"Potential metabolic biomarkers to identify interstitial lung abnormalities","volume":"17","author":"Tan","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.ijbiomac.2018.04.077_bb0045","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11306-016-1084-8","article-title":"Integration of targeted metabolomics and transcriptomics identifies deregulation of phosphatidylcholine metabolism in Huntington's disease peripheral blood samples","volume":"12","author":"Mastrokolias","year":"2016","journal-title":"Metabolomics"},{"issue":"3","key":"10.1016\/j.ijbiomac.2018.04.077_bb0050","doi-asserted-by":"crossref","DOI":"10.7124\/bc.000925","article-title":"Development of amperometric biosensor for choline determination","volume":"32","author":"Kucherenko","year":"2016","journal-title":"Biopolym. Cell"},{"issue":"1","key":"10.1016\/j.ijbiomac.2018.04.077_bb0055","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.bios.2012.02.008","article-title":"Label-free colorimetric sensor for ultrasensitive detection of heparin based on color quenching of gold nanorods by graphene oxide","volume":"34","author":"Fu","year":"2012","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.ijbiomac.2018.04.077_bb0060","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0009-8981(77)90465-X","article-title":"A new enzymatic method for determination of serum choline-containing phospholipids","volume":"79","author":"Takayama","year":"1977","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"10.1016\/j.ijbiomac.2018.04.077_bb0065","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0003-2670(98)00413-9","article-title":"Determination of choline-containing phospholipids in serum with a fiber-optic biosensor","volume":"374","author":"Marazuela","year":"1998","journal-title":"Anal. Chim. Acta"},{"issue":"14","key":"10.1016\/j.ijbiomac.2018.04.077_bb0070","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.clinbiochem.2008.06.010","article-title":"Specific, rapid, and sensitive enzymatic measurement of sphingomyelin, phosphatidylcholine and lysophosphatidylcholine in serum and lipid extracts","volume":"41","author":"Hidaka","year":"2008","journal-title":"Clin. Biochem."},{"issue":"3","key":"10.1016\/j.ijbiomac.2018.04.077_bb0075","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ymeth.2013.07.013","article-title":"Factors influencing the performance of G-quadruplex DNAzyme-based sensors","volume":"64","author":"Kong","year":"2013","journal-title":"Methods"},{"issue":"1","key":"10.1016\/j.ijbiomac.2018.04.077_bb0080","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.aca.2011.08.050","article-title":"Peroxidase-mimicking DNAzymes for biosensing applications: a review","volume":"707","author":"Kosman","year":"2011","journal-title":"Anal. Chim. Acta"},{"issue":"14","key":"10.1016\/j.ijbiomac.2018.04.077_bb0085","doi-asserted-by":"crossref","first-page":"6148","DOI":"10.1021\/ac100940v","article-title":"Positive effects of ATP on G-quadruplex-hemin DNAzyme-mediated reactions","volume":"82","author":"Kong","year":"2010","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2018.04.077_bb0090","series-title":"DNAzyme-functionalized Gold Nanoparticles for Biosensing, Biosensors Based on Aptamers and Enzymes","first-page":"93","author":"Xiang","year":"2013"},{"issue":"4","key":"10.1016\/j.ijbiomac.2018.04.077_bb0095","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/1074-5521(94)90014-0","article-title":"A DNA enzyme that cleaves RNA","volume":"1","author":"Breaker","year":"1994","journal-title":"Chem. Biol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2018.04.077_bb0100","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.talanta.2009.07.010","article-title":"Peroxidase activity\u2013structure relationship of the intermolecular four-stranded G-quadruplex\u2013hemin complexes and their application in Hg2+ ion detection","volume":"80","author":"Kong","year":"2009","journal-title":"Talanta"},{"issue":"2","key":"10.1016\/j.ijbiomac.2018.04.077_bb0105","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2478\/s11532-011-0152-1","article-title":"Optimization study of the catalytic activity of DNAzymes based on telomeric G-quadruplexes","volume":"10","author":"Kosman","year":"2012","journal-title":"Open Chem."},{"key":"10.1016\/j.ijbiomac.2018.04.077_bb0110","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bios.2018.02.020","article-title":"An innovative paradigm of methods in microRNAs detection: highlighting DNAzymes, the illuminators","volume":"107","author":"Mahdiannasser","year":"2018","journal-title":"Biosens. Bioelectron."},{"issue":"3","key":"10.1016\/j.ijbiomac.2018.04.077_bb0115","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1021\/ac902421u","article-title":"Ag+ and cysteine quantitation based on G-quadruplex-hemin DNAzymes disruption by Ag+","volume":"82","author":"Zhou","year":"2010","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2018.04.077_bb0120","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.aca.2012.02.015","article-title":"Colorimetric detection of cholesterol with G-quadruplex-based DNAzymes and ABTS2\u2212","volume":"724","author":"Li","year":"2012","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.ijbiomac.2018.04.077_bb0125","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.aca.2016.01.041","article-title":"Colorimetric detection of sodium ion in serum based on the G-quadruplex conformation related DNAzyme activity","volume":"912","author":"Sun","year":"2016","journal-title":"Anal. Chim. Acta"},{"issue":"5","key":"10.1016\/j.ijbiomac.2018.04.077_bb0130","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/bip.21135","article-title":"Characterization of the G-quadruplex structure of a catalytic DNA with peroxidase activity","volume":"91","author":"Kong","year":"2009","journal-title":"Biopolymers"},{"key":"10.1016\/j.ijbiomac.2018.04.077_bb0135","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.aca.2014.11.031","article-title":"Synthetic multivalent DNAzymes for enhanced hydrogen peroxide catalysis and sensitive colorimetric glucose detection","volume":"856","author":"Yang","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.ijbiomac.2018.04.077_bb0140","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1039\/B808986H","article-title":"Spectral relative standard deviation: a practical benchmark in metabolomics","volume":"134","author":"Parsons","year":"2009","journal-title":"Analyst"},{"issue":"2","key":"10.1016\/j.ijbiomac.2018.04.077_bb0145","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s12247-012-9144-8","article-title":"Determination of the confidence interval of the relative standard deviation using convolution","volume":"8","author":"Gao","year":"2013","journal-title":"J. Pharm. Innov."},{"issue":"10","key":"10.1016\/j.ijbiomac.2018.04.077_bb0150","doi-asserted-by":"crossref","DOI":"10.1002\/bip.23028","article-title":"Structural and functional study of a simple, rapid and label-free DNAzyme-based DNA biosensor for optimization activity","volume":"107","author":"Shahbazi","year":"2017","journal-title":"Biopolymers"},{"issue":"33","key":"10.1016\/j.ijbiomac.2018.04.077_bb0155","doi-asserted-by":"crossref","first-page":"7817","DOI":"10.1021\/bi9006786","article-title":"General peroxidase activity of G-quadruplex-hemin complexes and its application in ligand screening","volume":"48","author":"Cheng","year":"2009","journal-title":"Biochemistry"},{"issue":"31","key":"10.1016\/j.ijbiomac.2018.04.077_bb0160","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.1039\/b805565c","article-title":"G-quadruplex-based DNAzyme for facile colorimetric detection of thrombin","author":"Li","year":"2008","journal-title":"Chem. Commun."},{"issue":"2","key":"10.1016\/j.ijbiomac.2018.04.077_bb0165","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0731-7085(03)00648-4","article-title":"Determination of choline containing phospholipids in serum, bile and amniotic fluids by the derivative enzymatic\u2013spectrophotometric method","volume":"35","author":"Campanella","year":"2004","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1-2","key":"10.1016\/j.ijbiomac.2018.04.077_bb0170","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00604-010-0418-x","article-title":"Spectrophotometric detection of lead (II) ion using unimolecular peroxidase-like deoxyribozyme","volume":"171","author":"Wang","year":"2010","journal-title":"Microchim. Acta"},{"issue":"38","key":"10.1016\/j.ijbiomac.2018.04.077_bb0175","doi-asserted-by":"crossref","first-page":"7861","DOI":"10.1039\/C7TB01589E","article-title":"Choline sensing based on in situ polymerization of aniline on the surface of upconverting nanoparticles","volume":"5","author":"Li","year":"2017","journal-title":"J. Mater. Chem. B"},{"issue":"2","key":"10.1016\/j.ijbiomac.2018.04.077_bb0180","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.snb.2005.10.030","article-title":"Amperometric aqueous sol\u2013gel biosensor for low-potential stable choline detection at multi-wall carbon nanotube modified platinum electrode","volume":"115","author":"Song","year":"2006","journal-title":"Sensors Actuators B Chem."},{"issue":"4","key":"10.1016\/j.ijbiomac.2018.04.077_bb0185","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/uog.5256","article-title":"Reliability, repeatability and reproducibility: analysis of measurement errors in continuous variables","volume":"31","author":"Bartlett","year":"2008","journal-title":"Ultrasound Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2018.04.077_bb0190","doi-asserted-by":"crossref","DOI":"10.4103\/2229-5186.79345","article-title":"Methods for the determination of limit of detection and limit of quantitation of the analytical methods","volume":"2","author":"Shrivastava","year":"2011","journal-title":"Chron. Young Sci."},{"issue":"7","key":"10.1016\/j.ijbiomac.2018.04.077_bb0195","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1002\/elan.201400694","article-title":"Amperometric biosensor for choline based on gold screen-printed electrode modified with electrochemically-deposited silica biocomposite","volume":"27","author":"Mazurenko","year":"2015","journal-title":"Electroanalysis"},{"key":"10.1016\/j.ijbiomac.2018.04.077_bb0200","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.snb.2014.07.125","article-title":"A novel electrochemiluminescence choline biosensor based on biofunctional AMs-ChO biocomposite","volume":"204","author":"Wu","year":"2014","journal-title":"Sensors Actuators B Chem."},{"issue":"1","key":"10.1016\/j.ijbiomac.2018.04.077_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/EBC20150001","article-title":"Introduction to biosensors","volume":"60","author":"Bhalla","year":"2016","journal-title":"Essays Biochem."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813018303337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813018303337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T04:42:04Z","timestamp":1756788124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813018303337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":41,"alternative-id":["S0141813018303337"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.04.077","relation":{},"ISSN":["0141-8130"],"issn-type":[{"type":"print","value":"0141-8130"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Label-free colorimetric sensor for sensitive detection of choline based on DNAzyme-choline oxidase coupling","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.04.077","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}