{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T14:15:22Z","timestamp":1768486522545,"version":"3.49.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012522","name":"Central Mechanical Engineering Research Institute, Council of Scientific and Industrial Research","doi-asserted-by":"publisher","award":["BSC-0101"],"award-info":[{"award-number":["BSC-0101"]}],"id":[{"id":"10.13039\/501100012522","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.ijbiomac.2018.04.143","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T09:16:16Z","timestamp":1525079776000},"page":"633-647","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Localization of MIF-II on mammalian spermatozoa: A study revealing its structure, function and motility inhibitory pathway"],"prefix":"10.1016","volume":"116","author":[{"given":"Arpita","family":"Bhoumik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0903-0997","authenticated-orcid":false,"given":"Sudipta","family":"Saha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavan V.","family":"Payghan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasanta","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandhya Rekha","family":"Dungdung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0005","series-title":"The Physiology of Reproduction","first-page":"1072","article-title":"The epididymis","author":"Robaire","year":"2006"},{"issue":"2","key":"10.1016\/j.ijbiomac.2018.04.143_bb0010","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/jsap.12020","article-title":"Quality of canine spermatozoa retrieved by percutaneous epididymal sperm aspiration","volume":"54","author":"Varesi","year":"2013","journal-title":"J. Small Anim. Pract."},{"issue":"1","key":"10.1016\/j.ijbiomac.2018.04.143_bb0015","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.fertnstert.2011.10.013","article-title":"Proteomic approach in the identification of fertility pattern in seminal plasma of fertile men","volume":"97","author":"Milardi","year":"2012","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/686253","article-title":"The ethical, legal, and social issues impacted by modern assisted reproductive technologies","volume":"686253","author":"Brezina","year":"2012","journal-title":"Obstet. Gynecol. Int."},{"issue":"4","key":"10.1016\/j.ijbiomac.2018.04.143_bb0035","first-page":"261","article-title":"Evaluation of male infertility","volume":"61","author":"Schlegel","year":"2009","journal-title":"Minerva Ginecol."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0012039","article-title":"Purification and characterization of a sperm motility inhibiting factor from caprine epididymal plasma","volume":"5","author":"Das","year":"2010","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.ijbiomac.2018.04.143_bb0045","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/humupd\/dmn055","article-title":"New insights into epididymal biology and function","volume":"15","author":"Cornwall","year":"2009","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0050","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1586\/epr.09.76","article-title":"Proteomic insights into spermatozoa: critiques, comments and concerns","volume":"6","author":"Baker","year":"2009","journal-title":"Expert Rev. Proteomics."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0055","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/B978-0-12-397944-5.00004-3","article-title":"Sperm patch-clamp","volume":"525","author":"Lishko","year":"2013","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0060","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1745-7262.2007.00282.x","article-title":"Supramolecular organization of the sperm plasma membrane during maturation and capacitation","volume":"9","author":"Jones","year":"2007","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0065","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1751-0147-55-17","article-title":"Morphological and acrosomal changes of canine spermatozoa during epididymal transit","volume":"55","author":"Varesi","year":"2013","journal-title":"Acta Vet. Scand."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0070","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1095\/biolreprod29.5.1241","article-title":"Rat sperm are mechanically immobilized in the caudal epididymis by \u201cImmobilin\u201d a high molecular weight glycoprotein","volume":"29","author":"Usselman","year":"1983","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0075","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1530\/jrf.0.0830169","article-title":"Effects of seminal vesicle fluid components on sperm motility in the house mouse","volume":"83","author":"Peitz","year":"1988","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0080","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/j.1939-4640.1988.tb01069.x","article-title":"Purification and characterization of a sperm motility inhibitor in human seminal plasma","volume":"9","author":"Iwamoto","year":"1988","journal-title":"J. Androl."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0085","first-page":"161","article-title":"A glycoprotein factor in buffalo seminal plasma inhibits sperm forward motility","volume":"3","author":"Mandal","year":"1991","journal-title":"Mol. Androl."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0090","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/mrd.1080310110","article-title":"Purification and characterization of a sperm motility-dynein ATPase inhibitor from boar seminal plasma","volume":"31","author":"Iwamoto","year":"1992","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0095","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1006\/bbrc.1993.1236","article-title":"Purification and characterization of reversible sperm motility inhibitors from porcine seminal plasma","volume":"191","author":"Jeng","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0100","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1095\/biolreprod55.4.813","article-title":"Purification and characterization of the active precursor of a human sperm motility inhibitor secreted by the seminal vesicles: identity with semenogelin","volume":"55","author":"Robert","year":"1996","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0105","first-page":"413","article-title":"Isolation and identification of a novel motility-inhibiting factor from goat cauda sperm plasma membrane","volume":"49","author":"Dungdung","year":"2003","journal-title":"Cell. Mol. Biol."},{"issue":"7","key":"10.1016\/j.ijbiomac.2018.04.143_bb0110","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/molehr\/5.7.618","article-title":"Pentoxifylline-stimulated capacitation and acrosome reaction in hamster spermatozoa: involvement of intracellular signalling molecules","volume":"5","author":"Ain","year":"1999","journal-title":"Mol. Hum. Reprod."},{"issue":"0","key":"10.1016\/j.ijbiomac.2018.04.143_bb0115","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1016\/j.bbadis.2014.07.013","article-title":"Central role of soluble adenylyl cyclase and cAMP in sperm physiology","volume":"18","author":"Buffone","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0120","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/mrd.1120220205","article-title":"Relationship between calcium, cyclic AMP, ATP and intracellular pH and the capacity of hamster spermatozoa to express hyperactivated motility","volume":"22","author":"White","year":"1989","journal-title":"Gamete Res."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0125","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1046\/j.1471-4159.2001.00331.x","article-title":"Nitric oxide regulates adenylyl cyclase activity in rat striatal membranes","volume":"77","author":"Hudson","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0130","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/364450a0","article-title":"Amplification of calcium induced gene transcription by nitric oxide in neuronal cells","volume":"364","author":"Peunova","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0135","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1113\/expphysiol.1993.sp003687","article-title":"Nitric oxide and cardiovascular control","volume":"78","author":"Calver","year":"1993","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0140","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1126\/science.7690156","article-title":"Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase","volume":"261","author":"Karupiah","year":"1993","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.ijbiomac.2018.04.143_bb0145","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/j.1939-4640.2004.tb02784.x","article-title":"Role of nitric oxide concentrations on human sperm motility","volume":"25","author":"Balercia","year":"2004","journal-title":"J. Androl."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0150","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/01.gco.0000193003.58158.4e","article-title":"The role of free radicals and antioxidants in reproduction","volume":"18","author":"Agarwal","year":"2006","journal-title":"Curr. Opin. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2018.04.143_bb0155","first-page":"129","article-title":"Nitric oxide levels and total antioxidant capacity in the seminal plasma of infertile smoking men","volume":"7","author":"Yousefniapasha","year":"2015","journal-title":"Cell J."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0160","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1071\/RD9960931","article-title":"Localization by indirect immunofluorescence of nitric oxide synthase in mouse and human spermatozoa","volume":"8","author":"Herrero","year":"1996","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0165","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S0891-5849(00)00339-7","article-title":"Nitric oxide interacts with the cAMP pathway to modulate capacitation of human spermatozoa","volume":"29","author":"Herrero","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0170","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.fertnstert.2013.03.012","article-title":"Identification of a novel sperm motility-stimulating protein from caprine serum: its characterization and functional significance","volume":"100","author":"Saha","year":"2013","journal-title":"Fert. Steril."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0175","series-title":"Vitro Initiated Sperm Forward Motility in Caput Spermatozoa: Weak and Transient, Androl","first-page":"807","volume":"44","author":"Das","year":"2011"},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0180","series-title":"Laboratory Manual for the examination of human semen and sperm-cervical mucus interaction","author":"WHO","year":"1999"},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0185","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/0005-2795(67)90089-X","article-title":"Isolation and characterization of sheep gammal- and gamma2- immunoglobulins and their polypeptide chains","volume":"147","author":"Harrison","year":"1967","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0190","doi-asserted-by":"crossref","first-page":"314","DOI":"10.4049\/jimmunol.100.2.314","article-title":"Neutralization of matrix lactase dehydrogenase virus by antiglobulin","volume":"100","author":"Notkins","year":"1968","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2018.04.143_bb0195","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1002\/jcp.25958","article-title":"Spermicidal efficacy of VRP, a synthetic cationic antimicrobial peptide, inducing apoptosis and membrane disruption","volume":"233","author":"Ghosh","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0200","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1093\/clinchem\/22.8.1243","article-title":"Enzyme-immunoassay","volume":"22","author":"Wisdom","year":"1976","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0205","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S0015-0282(16)57743-7","article-title":"Nitric oxide inhibition of human sperm motility","volume":"64","author":"Weinberg","year":"1995","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0210","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications","volume":"76","author":"Towbin","year":"1979","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0215","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1152\/ajpendo.00548.2012","article-title":"Ovarian regulation of neuromedin U and its local actions in the ovary, mediated through neuromedin U receptor 2","volume":"304","author":"Lin","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0220","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"issue":"3","key":"10.1016\/j.ijbiomac.2018.04.143_bb0225","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/GCO.0b013e32835213f1","article-title":"Has fertility declined in recent decades?","volume":"24","author":"Yoldemir","year":"2012","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0230","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1095\/biolreprod30.4.913","article-title":"Inhibition of bovine spermatozoa by caudal epididymal fluid: I. Studies of a sperm motilityquiescence factor","volume":"30","author":"Carr","year":"1984","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0235","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1530\/jrf.0.0680275","article-title":"Factors in seminal plasma of bulls that affect the viability and motility of spermatozoa","volume":"68","author":"Bass","year":"1983","journal-title":"J. Reprod. Fertil."},{"issue":"6","key":"10.1016\/j.ijbiomac.2018.04.143_bb0240","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/aja.2013.69","article-title":"Cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis","volume":"15","author":"Xu","year":"2013","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0245","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1042\/BSR20120097","article-title":"Dihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction","volume":"33","author":"Fang","year":"2013","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0250","first-page":"3","article-title":"The role of nitric oxide in the hypothalamic control of LHRH and oxytocin release, sexual behavior and aging of the LHRH and oxytocin neurons","volume":"44","author":"Calka","year":"2006","journal-title":"Folia Histochem. Cytobiol."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0255","first-page":"181","article-title":"Sperm quiescence in cauda epididymis: a mini-review","volume":"3","author":"Verma","year":"2001","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0260","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1749-6632.1984.tb38281.x","article-title":"Characteristics of a seminal plasma inhibitor of sperm motility","volume":"438","author":"de Lamirande","year":"1984","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0265","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/mrd.1080360411","article-title":"Origin of a sperm motility inhibitor from boar seminal plasma","volume":"36","author":"Iwamoto","year":"1993","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0270","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1365-2605.1994.tb01248.x","article-title":"Sperm motility inhibitor from human seminal plasma: presence of a precursor molecule in seminal vesicle fluid and its molecular processing after ejaculation","volume":"17","author":"Robert","year":"1994","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0275","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1139\/o96-072","article-title":"Cyclic AMP phosphodiesterase: a regulator of forward motility initiation during epididymal sperm maturation","volume":"74","author":"Jaiswal","year":"1996","journal-title":"Biochem. Cell Biol."},{"issue":"1\u20132","key":"10.1016\/j.ijbiomac.2018.04.143_bb0280","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1071\/RD05120","article-title":"Moving to the beat: a review of mammalian sperm motility regulation","volume":"18","author":"Turner","year":"2006","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.ijbiomac.2018.04.143_bb0285","series-title":"Knobil and Neill's physiology of Reproduction","first-page":"134","article-title":"The spermatozoon","volume":"1","author":"Toshimori","year":"2014"},{"issue":"3","key":"10.1016\/j.ijbiomac.2018.04.143_bb0290","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1095\/biolreprod.111.091546","article-title":"Lactate dehydrogenase C and energy metabolism in mouse sperm","volume":"85","author":"Odet","year":"2011","journal-title":"Biol. Reprod."},{"issue":"4","key":"10.1016\/j.ijbiomac.2018.04.143_bb0295","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1095\/biolreprod.113.108530","article-title":"Glycolysis and mitochondrial respiration in mouse LDHC-null sperm","volume":"88","author":"Odet","year":"2013","journal-title":"Biol. Reprod."},{"issue":"4","key":"10.1016\/j.ijbiomac.2018.04.143_bb0300","doi-asserted-by":"crossref","first-page":"502","DOI":"10.2164\/jandrol.05185","article-title":"Testis-specific lactate dehydrogenase (LDH-C4; Ldh3) in murine oocytes and preimplantation embryos","volume":"27","author":"Coonrod","year":"2006","journal-title":"J. Androl."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813018305178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813018305178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:10:21Z","timestamp":1758870621000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813018305178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":58,"alternative-id":["S0141813018305178"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.04.143","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Localization of MIF-II on mammalian spermatozoa: A study revealing its structure, function and motility inhibitory pathway","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.04.143","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}