{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:06:17Z","timestamp":1793066777809,"version":"4.5.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Minist\u00e8re de l\"Enseignement Sup\u00e9rieur de la Recherche et de la Technologie","award":["LR11IPT08"],"award-info":[{"award-number":["LR11IPT08"]}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Action en R\u00e9gion de Coop\u00e9ration Universitaire et Scientifique"},{"name":"PHC Utique","award":["17G0811"],"award-info":[{"award-number":["17G0811"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.ijbiomac.2018.05.230","type":"journal-article","created":{"date-parts":[[2018,6,2]],"date-time":"2018-06-02T11:53:33Z","timestamp":1527940413000},"page":"790-799","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Targeting \u03b11 inserted domain (I) of \u03b11\u03b21 integrin by Lebetin 2 from M. lebetina transmediterranea venom decreased tumorigenesis and angiogenesis"],"prefix":"10.1016","volume":"117","author":[{"given":"Maram","family":"Morjen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houcemeddine","family":"Othman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaineb","family":"Abdelkafi-Koubaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erij","family":"Messadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jed","family":"Jebali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"El Ayeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najet Srairi","family":"Abid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Luis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naziha","family":"Marrakchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0005","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0010","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00441-009-0834-6","article-title":"Integrins","volume":"339","author":"Barczyk","year":"2010","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0015","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.matbio.2013.10.011","article-title":"Signalling pathways linking integrins with cell cycle progression","volume":"34","author":"Moreno-Layseca","year":"2014","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0020","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1126\/science.285.5430.1028","article-title":"Integrin signaling","volume":"285","author":"Giancotti","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0025","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.molcel.2008.11.018","article-title":"Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces","volume":"32","author":"Zhu","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0030","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1242\/jcs.188672","article-title":"The integrin-collagen connection\u2014a glue for tissue repair?","volume":"129","author":"Zeltz","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0035","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0092-8674(00)80622-4","article-title":"Structural basis of collagen recognition by integrin \u03b12\u03b21","volume":"101","author":"Emsley","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0040","doi-asserted-by":"crossref","first-page":"35139","DOI":"10.1074\/jbc.M112.358648","article-title":"Enhancing integrin \u03b11 inserted (I) domain affinity to ligand potentiates integrin \u03b11\u03b21-mediated down-regulation of collagen synthesis","volume":"287","author":"Shi","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0045","doi-asserted-by":"crossref","first-page":"36796","DOI":"10.1074\/jbc.M113.480251","article-title":"The structure of integrin \u03b11I domain in complex with a collagen-mimetic peptide","volume":"288","author":"Chin","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0050","doi-asserted-by":"crossref","first-page":"12311","DOI":"10.1074\/jbc.272.19.12311","volume":"272","author":"Calderwood","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0055","doi-asserted-by":"crossref","first-page":"22811","DOI":"10.1016\/S0021-9258(17)31717-9","article-title":"The role of the I domain in ligand binding of the human integrin alpha 1 beta 1","volume":"269","author":"Kern","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0060","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1074\/jbc.275.1.35","article-title":"The collagen-binding A-domains of integrins \u03b11\u03b21 and \u03b12\u03b21 recognize the same specific amino acid sequence, GFOGER, in native (triple-helical) collagens","volume":"275","author":"Knight","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0065","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nrd3266","article-title":"Integrins as therapeutic targets: lessons and opportunities","volume":"9","author":"Cox","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0070","doi-asserted-by":"crossref","first-page":"154","DOI":"10.7150\/thno\/v01p0154","article-title":"Integrin targeted therapeutics","volume":"1","author":"Millard","year":"2011","journal-title":"Theranostics"},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0075","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.2174\/138161207782023793","article-title":"Anti-angiogenesis and RGD-containing snake venom disintegrins","volume":"13","author":"Swenson","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0080","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2174\/1568006043335880","article-title":"Disintegrins","volume":"4","author":"McLane","year":"2004","journal-title":"Curr. Drug Targets Cardiovasc. Haematol. Disord."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0085","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1042\/bj20030373","article-title":"The alpha2beta1 integrin inhibitor rhodocetin binds to the A domain of the integrin alpha2 subunit proximal to the collagen-binding site","volume":"376","author":"Eble","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0090","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/jcp.20935","article-title":"Lebectin, a Macrovipera lebetina venom-derived C-type lectin, inhibits angiogenesis both in vitro and in vivo","volume":"211","author":"Pilorget","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0095","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.matbio.2007.01.001","article-title":"Lebectin and lebecetin, two C-type lectins from snake venom, inhibit a5b1 and aV-containing integrins","volume":"26","author":"Sarray","year":"2007","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0100","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.matbio.2009.03.007","article-title":"MVL-PLA2, a phospholipase A2 from Macrovipera lebetina transmediterranea venom inhibits tumor cells adhesion and migration","volume":"28","author":"Bazaa","year":"2009","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0105","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/labinvest.2009.137","article-title":"CC-PLA2-1 and CC-PLA2-2, two Cerastes cerastes venom derived phospholipases A2, inhibit angiogenesis both in vitro and in vivo","volume":"90","author":"Kessentini-Zouari","year":"2010","journal-title":"Lab. Investig."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0110","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.matbio.2012.11.015","article-title":"PIVL, a new serine protease inhibitor from Macrovipera lebetina transmediterranea venom, impairs motility of human glioblastoma cells","volume":"32","author":"Morjen","year":"2013","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0115","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.mvr.2014.08.006","article-title":"PIVL, a snake venom Kunitz-type serine protease inhibitor, inhibits in vitro and in vivo angiogenesis","volume":"95","author":"Morjen","year":"2014","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0120","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/0014-5793(96)00774-0","article-title":"Novel anti-platelet aggregation polypeptides from Vipera lebetina venom: isolation and characterization","volume":"392","author":"Barbouche","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0125","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.toxicon.2010.12.001","article-title":"Natriuretic peptide drug leads from snake venom","volume":"59","author":"Vink","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0130","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.toxicon.2008.08.014","article-title":"Renal and vascular effects of the natriuretic peptide isolated from Crotalus durissus cascavella venom","volume":"52","author":"Evangelista","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162632","article-title":"Lebetin 2, a snake venom-derived natriuretic peptide, attenuates acute myocardial ischemic injury through the modulation of mitochondrial permeability transition pore at the time of reperfusion","volume":"11","author":"Tourki","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0140","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.2174\/0929867321666140205140152","article-title":"Atrial natriuretic peptide: a magic bullet for cancer therapy targeting Wnt signaling and cellular pH regulators","volume":"21","author":"Serafino","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0145","doi-asserted-by":"crossref","first-page":"5693","DOI":"10.21873\/anticanres.11152","article-title":"Heart peptide hormones: adjunct and primary treatments of cancer","volume":"36","author":"Vesely","year":"2016","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0150","first-page":"445","article-title":"Elimination of up to 80% of human pancreatic adenocarcinomas in athymic mice by cardiac hormones","volume":"21","author":"Vesely","year":"2007","journal-title":"In Vivo"},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0155","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1365-2362.2008.01978.x","article-title":"Cardiac hormones and urodilatin eliminate up to 86% of human small-cell lung carcinomas in mice","volume":"38","author":"Eichelbaum","year":"2008","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0160","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1365-2362.2005.01444.x","article-title":"Four peptide hormones decrease the number of human breast adenocarcinoma cells","volume":"35","author":"Vesely","year":"2005","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0165","doi-asserted-by":"crossref","first-page":"13928","DOI":"10.1016\/S0021-9258(19)49658-0","article-title":"A new member of the natriuretic family is present in the venom of the green mamba (Dendroaspis angusticeps)","volume":"267","author":"Schweitz","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0170","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.canlet.2007.02.015","article-title":"Four cardiac hormones eliminate four-fold more human glioblastoma cells than green mamba snake peptide","volume":"254","author":"Vesely","year":"2007","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0175","first-page":"207","article-title":"Lebetin peptides: potent platelet aggregation inhibitors","volume":"31","author":"Marrakchi","year":"2001","journal-title":"Haemostasis"},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0180","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/S0041-0101(98)00118-4","article-title":"Anti-platelet activity of the peptides composing the lebetin 1 family, a new class of inhibitors of platelet aggregation","volume":"36","author":"Barbouche","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0185","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1247\/csf.13.281","article-title":"Novel purification of vitronectin from human plasma by heparin affinity chromatography","volume":"13","author":"Yatohgo","year":"1988","journal-title":"Cell Struct. Funct."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0190","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1158\/0008-5472.CAN-05-3885","article-title":"Antiangiogenic concentrations of vinflunine increase the interphase microtubule dynamics and decrease the motility of endothelial cells","volume":"66","author":"Pourroy","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0195","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1006\/bbrc.1998.8536","article-title":"Effect of microtubule disruption on cell adhesion and spreading","volume":"246","author":"Kadi","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0200","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1242\/jcs.111.20.3119","article-title":"Integrin ligation and PKC activation are required for migration of colon carcinoma cells","volume":"111","author":"Rigot","year":"1998","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0205","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1016\/j.ajpath.2011.01.013","article-title":"Interleukin-1beta inhibition prevents choroidal neovascularization and does not exacerbate photoreceptor degeneration","volume":"178","author":"Lavalette","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0210","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0076-6879(08)02007-7","article-title":"The aortic ring model of angiogenesis","volume":"443","author":"Aplin","year":"2008","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0215","first-page":"13","article-title":"Focal adhesion a focal point in current cell biology and molecular medicine","volume":"1","author":"Wu","year":"2007","journal-title":"Cell Adhes. Migr."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0220","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1083\/jcb.200909003","article-title":"Plasticity of cell migration: a multiscale tuning model","volume":"188","author":"Friedl","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0225","doi-asserted-by":"crossref","first-page":"6165","DOI":"10.1007\/s00253-016-7610-9","article-title":"Snake venom toxins: toxicity and medicinal applications","volume":"100","author":"Chan","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0230","first-page":"31","article-title":"Medical and diagnostic applications of snake venom proteomes","volume":"2","author":"Mukherjee","year":"2011","journal-title":"J. Protein Proteome"},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0235","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10585-005-1262-y","article-title":"Role of integrin receptors for fibronectin, collagen and laminin in the regulation of ovarian carcinoma functions in response to a matrix microenvironment","volume":"22","author":"Ahmed","year":"2005","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0240","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1128\/MCB.01476-06","article-title":"Integrin \u03b11\u03b21 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation","volume":"27","author":"Chen","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0245","doi-asserted-by":"crossref","first-page":"10931","DOI":"10.1016\/S0021-9258(19)49853-0","article-title":"Angiogenesis","volume":"267","author":"Folkman","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0250","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0065-230X(08)60716-2","article-title":"Role of VEGF-flt receptor system in normal and tumor angiogenesis","volume":"67","author":"Shibuya","year":"1995","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0255","doi-asserted-by":"crossref","first-page":"132641","DOI":"10.1155\/2010\/132641","article-title":"Tumor angiogenesis: insights and innovations","volume":"2010","author":"Nussenbaum","year":"2010","journal-title":"J. Oncol."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0260","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.2174\/138161207782023766","article-title":"KTS and RTS-disintegrins: anti-angiogenic viper venom peptides specifically targeting the alpha 1 beta 1 integrin","volume":"13","author":"Calvete","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0265","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/386671a0","article-title":"Mechanisms of angiogenesis","volume":"386","author":"Risau","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0270","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0070-2153(04)64009-9","article-title":"Integrins and angiogenesis","volume":"64","author":"Stupack","year":"2004","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0275","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1091\/mbc.e09-07-0591","article-title":"Vascular endothelial growth factor: much more than an angiogenesis factor","volume":"21","author":"Senger","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0280","doi-asserted-by":"crossref","first-page":"534758","DOI":"10.1155\/2015\/534758","article-title":"Rho\/MRTF-A-induced integrin expression regulates angiogenesis in differentiated multipotent mesenchymal stem cells","volume":"2015","author":"Zhang","year":"2015","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0285","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/BJ20081403","article-title":"Structural requirements of KTS-disintegrins for inhibition of \u03b11\u03b21 integrin","volume":"417","author":"Brown","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0290","first-page":"2020","article-title":"Obtustatin: a potent selective inhibitor of alpha1beta1 integrin in vitro and angiogenesis in vivo","volume":"63","author":"Marcinkiewicz","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0295","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.febslet.2004.10.050","article-title":"Structural determinants of the selectivity of KTS-disintegrins for the alpha1beta1 integrin","volume":"577","author":"Kisiel","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0300","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1038\/labinvest.3700350","article-title":"Lebestatin, a disintegrin from Macrovipera venom, inhibits integrin-mediated cell adhesion, migration and angiogenesis","volume":"85","author":"Olfa","year":"2005","journal-title":"Lab. Investig."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0305","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/0092-8674(93)90575-B","article-title":"A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b\/CD18) is essential for ligand binding","volume":"72","author":"Michishita","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0310","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/j.1432-1033.1996.00732.x","article-title":"The A-domain of integrin a2 binds specifically to a range of collagens but is not a general receptor for the collagenous motif","volume":"241","author":"Tuckwell","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0315","doi-asserted-by":"crossref","first-page":"7962","DOI":"10.1074\/jbc.M312912200","article-title":"Jararhagin-derived RKKH peptides induce structural changes in \u03b11I domain of human integrin \u03b11\u03b21","volume":"279","author":"Nymalm","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0320","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1073\/pnas.0407234102","article-title":"Hypertension in mice lacking the proatrial natriuretic peptide convertase corin","volume":"102","author":"Chan","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0325","first-page":"3813","article-title":"Atrial natriuretic peptide and long acting natriuretic peptide inhibit MEK 1\/2 activation in human prostate cancer cells","volume":"27","author":"Sun","year":"2007","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0330","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.bbadis.2012.02.016","article-title":"Anti-proliferative effect of atrial natriuretic peptide on colorectal cancer cells: evidence for an Akt-mediated cross-talk between NHE-1 activity and Wnt\/beta-catenin signaling","volume":"1822","author":"Serafino","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ijbiomac.2018.05.230_bb0335","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3892\/ol.2011.247","article-title":"Association between brain natriuretic peptide and distant metastases in advanced non-small cell lung cancer patients","volume":"2","author":"Masago","year":"2011","journal-title":"Oncol. Lett."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813018320798?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813018320798?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:15:03Z","timestamp":1758870903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813018320798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":67,"alternative-id":["S0141813018320798"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.05.230","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting \u03b11 inserted domain (I) of \u03b11\u03b21 integrin by Lebetin 2 from M. lebetina transmediterranea venom decreased tumorigenesis and angiogenesis","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.05.230","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}