{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:52:19Z","timestamp":1788245539230,"version":"build-2803163510"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.ijbiomac.2018.06.024","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T13:09:00Z","timestamp":1528290540000},"page":"1140-1146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["A novel bactericidal homodimeric PLA2 group-I from Walterinnesia aegyptia venom"],"prefix":"10.1016","volume":"117","author":[{"given":"Abir","family":"Ben Bacha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona Awad","family":"Alonazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Solman","family":"Elshikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Karray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1388-1981(00)00105-0","article-title":"The expanding superfamily of phospholipase A2 enzymes: classification and characterization","volume":"1488","author":"Six","year":"2000","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0010","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0041-0101(89)90013-5","article-title":"A model to explain the pharmacological effects of snake venom phospholipases A2","volume":"27","author":"Kini","year":"1989","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0015","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0003-2697(91)90007-G","article-title":"[1-14C]oleate-labeled autoclaved yeast: a membranous substrate for measuring phospholipase A2 activity in vitro","volume":"193","author":"Harris","year":"1991","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s002040050579","article-title":"Phospholipase A2 inhibitors p-bromophenacyl bromide and arachidonyltrifluoromethyl ketone suppressed interleukin-2 (IL-2) expression in murine primary splenocytes","volume":"73","author":"Ouyang","year":"1999","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0025","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0041-0101(01)00260-4","article-title":"Professor Chen-Yuan Lee, MD (1915\u20132001), Pharmacologist: snake venom research at the Institute of Pharmacology, National Taiwan University","volume":"40","author":"Hawgood","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0030","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/carcin\/24.2.307","article-title":"Inverse association between phospholipase A2 and COX-2 expression during mouse colon tumorigenesis","volume":"24","author":"Dong","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0035","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1365-2672.2006.03161.x","article-title":"Antibacterial activity of snake, scorpion and bee venoms: a comparison with purified venom phospholipase A2 enzymes","volume":"102","author":"PerumalSamy","year":"2007","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0040","doi-asserted-by":"crossref","first-page":"6150","DOI":"10.2174\/0929867311209066150","article-title":"Snake venom phospholipases A2: a novel tool against bacterial diseases","volume":"19","author":"Samy","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0045","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/0041-0101(91)90210-I","article-title":"Antibacterial effects of different snake venoms: purification and characterization of antibacterial proteins from Pseudechis australis (Australian king brown or mulga snake) venom. 1","volume":"29","author":"Stiles","year":"1991","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0050","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/S0041-0101(00)00085-4","article-title":"Antibacterial properties of KwaZulu natal snake venoms","volume":"38","author":"Blaylock","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0055","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1128\/AAC.47.3.965-971.2003","article-title":"Modulation of the activity of secretory phospholipase A2 by antimicrobial peptides","volume":"47","author":"Zhao","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0060","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0041-0101(03)00069-2","article-title":"Contribution of crotoxin for the inhibitory effect of Crotalus durissus terrificus snake venom on macrophage function","volume":"41","author":"Sampaio","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0065","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1042\/BJ20060318","article-title":"Antimicrobial activity of omwaprin, a new member of the waprin family of snake venom proteins","volume":"402","author":"Nair","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0070","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2174\/138920106777950771","article-title":"Novel therapies based on cationic antimicrobial peptides","volume":"7","author":"Anne Pereira","year":"2006","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0075","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1007\/s00018-013-1345-x","article-title":"Snake venoms: attractive antimicrobial proteinaceous compounds for therapeutic purposes","volume":"70","author":"de Oliveira Junior","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0080","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/jbt.21486","article-title":"Purification, characterization, and chemical modification of neurotoxic peptide from Daboia russelii snake venom of India","volume":"27","author":"Venkatesh","year":"2013","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0085","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s40064-016-1690-y","article-title":"Antibacterial activity of an acidic phospholipase A 2 (NN-XIb-PLA 2) from the venom of Naja naja (Indian cobra)","volume":"5","author":"Sudarshan","year":"2016","journal-title":"Springerplus"},{"issue":"2017","key":"10.1016\/j.ijbiomac.2018.06.024_bb0090","first-page":"297","article-title":"Antibacterial activity of isolated immunodominant proteins of Naja naja (Oxiana) venom","volume":"16","author":"Talebimehrdar","year":"2017","journal-title":"J. Pharm. Res."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0095","article-title":"Antibacterial activity of different types of snake venom from the Viperidae family against Staphylococcus aureus","volume":"39","author":"Nascimento Canhas","year":"2017","journal-title":"Acta. Sci. Biol. Sci."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0100","series-title":"Fauna of Saudi Arabia","first-page":"169","article-title":"Snakes of Arabia","author":"Gasperetti","year":"1998"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0105","first-page":"58","article-title":"Survey of the reptilian fauna of the Kingdom of Saudi Arabia. II. The lizard and amphisbaenian fauna of Riyadh province","volume":"24","author":"Al-Sadoon","year":"1998","journal-title":"Bull. Md. Herpetol. Soc."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0110","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0041-0101(97)00062-7","article-title":"Pharmacokinetics of 125I-labelled Walterinnesia aegyptia venom and its specific antivenins: flash absorption and distribution of the venom and its toxin versus slow absorption and distribution of IgG, F (ab\u2032) 2 and F (ab) of the antivenin","volume":"36","author":"Ismail","year":"1998","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0115","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0041-0101(76)90023-4","article-title":"Chromatographic separation of the venom of Egyptian black snake (Walterinnesia aegyptia) and pharmacological characterization of its components","volume":"14","author":"Lee","year":"1976","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0120","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/0041-0101(72)90130-4","article-title":"Does the desert black snake venom inhibit release of acetylcholine from motor nerve endings?","volume":"10","author":"Lee","year":"1972","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0125","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0041-0101(96)00138-9","article-title":"Amino acid sequence of two neurotoxins from the venom of the Egyptian black snake (Walterinnesia aegyptia)","volume":"35","author":"Samejima","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0130","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0041-0101(80)90020-3","article-title":"Isolation of phospholipase A from the venom of the desert black snake Walterinnesia aegyptia","volume":"18","author":"Simon","year":"1980","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0135","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0003-9861(02)00747-6","article-title":"Geographic variations, cloning, and functional analyses of the venom acidic phospholipases A2 of Crotalus viridis viridis","volume":"411","author":"Tsai","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0140","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S1095-6433(97)00475-3","article-title":"The composition of Naja naja venom samples from three districts of West Bengal, India","volume":"119","author":"Mukherjee","year":"1998","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0145","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1476-511X-10-32","article-title":"Purification and biochemical characterization of pancreatic phospholipase A2 from the common stingray Dasyatis pastinaca","volume":"10","author":"Ben Bacha","year":"2011","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0150","first-page":"186","article-title":"Purification and characterization of a phospholipase A2-IIA from common stingray (Dasyatis pastinaca) intestine","volume":"50","author":"Ben Bacha","year":"2013","journal-title":"Indian J. Biochem. Biophys."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0155","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0160","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0165","doi-asserted-by":"crossref","first-page":"7990","DOI":"10.1016\/S0021-9258(18)43377-7","article-title":"A gas-liquid solid phase peptide and protein sequenator","volume":"256","author":"Hewick","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0170","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0076-6879(66)08005-4","article-title":"Analysis of sugars found in glycoproteins","volume":"8","author":"Spiro","year":"1966","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0175","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0041-0101(81)90118-5","article-title":"Effect of modification of one histidine residue on the enzymatic and pharmacological properties of a toxic phospholipase A2 from Naja nigricollis snake venom and less toxic phospholipases A2 from Hemachatushaemachatus and Naja naja atra snake venoms","volume":"19","author":"Condrea","year":"1981","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0180","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1388-1981(00)00033-0","article-title":"Egg yolk lipoproteins as substrates for lipases","volume":"1485","author":"Abousalham","year":"2000","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0185","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/0006-3002(57)90256-1","article-title":"Chromatography of rattle snake venom A separation of three phosphodiesterases","volume":"24","author":"Boman","year":"1957","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0190","first-page":"47","article-title":"Screening methods for anti-bacterial and antiviral agents from higher plants","volume":"6","author":"Berghe","year":"1991","journal-title":"Methods Plant Biochem."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0195","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.18388\/abp.2001_3889","article-title":"Hematological and antifungal properties of temporin A and a cecropin A-temporin A hybrid","volume":"48","author":"Wade","year":"2001","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0200","series-title":"Microbiologia","first-page":"505","author":"Ronald","year":"1990"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0205","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.peptides.2007.02.008","article-title":"A bactericidal homodimeric phospholipases A2 from Bungarus fasciatus venom","volume":"28","author":"Xu","year":"2007","journal-title":"Peptides"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0210","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.toxicon.2009.01.003","article-title":"Two purified and characterized phospholipases A2 from Cerastes cerastes venom, that inhibit cancerous cell adhesion and migration","volume":"53","author":"Zouari-Kessentini","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0215","doi-asserted-by":"crossref","first-page":"6485","DOI":"10.1021\/bi00076a024","article-title":"The divalent cation is obligatory for the binding of ligands to the catalytic site of secreted phospholipase A2","volume":"32","author":"Yu","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0220","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1042\/bj3010503","article-title":"Zinc and barium inhibit the phospholipase A2 from Naja naja atra by different mechanisms","volume":"301","author":"Mezna","year":"1994","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0225","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.procbio.2010.05.027","article-title":"GC\/MS and LC\/MS analysis, and antioxidant and antimicrobial activities of various solvent extracts from Mirabilis jalapa tubers","volume":"45","author":"Hajji","year":"2010","journal-title":"Process Biochem."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0230","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1388-1981(00)00111-6","article-title":"The antibacterial properties of secreted phospholipases A2","volume":"1488","author":"Buckland","year":"2000","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0235","first-page":"452","article-title":"Bactericidal activity of Lys49 and Asp49 myotoxic phospholipases A2 from Bothropsasper snake venom","volume":"253","author":"P\u00e1ramo","year":"1998","journal-title":"FEBS J."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0240","doi-asserted-by":"crossref","first-page":"21505","DOI":"10.1074\/jbc.271.35.21505","article-title":"Cytosolic phospholipase A2 (PLA2), but not secretory PLA2, potentiates hydrogen peroxide cytotoxicity in kidney epithelial cells","volume":"271","author":"Sapirstein","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0245","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.4049\/jimmunol.166.6.4029","article-title":"Bactericidal properties of group IIA and group V phospholipases A2","volume":"166","author":"Gr\u00f6nroos","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0250","series-title":"Phospholipase A2. Basic and Clinical Aspects in Inflammatory Diseases","first-page":"176","article-title":"Toxic effects of phospholipase A2 in vitro","volume":"vol. 24","author":"Nyman","year":"1997"},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0255","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ijbiomac.2013.03.020","article-title":"Purification, characterization and bactericidal activities of phospholipase A2 from the dromedary intestine","volume":"57","author":"Bacha","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.06.024_bb0260","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.abb.2018.03.014","article-title":"Integrin-mediated human glioblastoma cells adhesion, migration and invasion by native and recombinant phospholipases of Scorpio maurus venom glands","volume":"645","author":"Krayem","year":"2018","journal-title":"Arch. Biochem. Biophys."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813018309437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813018309437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:18:14Z","timestamp":1758871094000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813018309437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":52,"alternative-id":["S0141813018309437"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.06.024","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel bactericidal homodimeric PLA2 group-I from Walterinnesia aegyptia venom","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.06.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}