{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:22:18Z","timestamp":1787066538028,"version":"build-2736575974"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005071","name":"Shiraz University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003968","name":"Iran National Science foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003968","name":"INSF","doi-asserted-by":"publisher","award":["96008461"],"award-info":[{"award-number":["96008461"]}],"id":[{"id":"10.13039\/501100003968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.ijbiomac.2018.06.136","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T03:37:59Z","timestamp":1530329879000},"page":"1120-1130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"PA","title":["Structural and functional alteration of human \u03b1A-crystallin after exposure to full spectrum solar radiation and preventive role of lens antioxidants"],"prefix":"10.1016","volume":"118","author":[{"given":"Afrooz","family":"Anbaraki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Ghahramani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin O.","family":"Muranov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris I.","family":"Kurganov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Yousefi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0005","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1529\/biophysj.106.082388","article-title":"Singlet oxygen generation by UVA light exposure of endogenous photosensitizers","volume":"91","author":"Baier","year":"2006","journal-title":"Biophys. J."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0010","doi-asserted-by":"crossref","first-page":"J247","DOI":"10.1016\/j.jaut.2009.11.011","article-title":"Light, including ultraviolet","volume":"34","author":"Maverakis","year":"2010","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0015","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1089\/pho.2006.24.179","article-title":"Photochemistry and photobiology of light absorption by living cells","volume":"24","author":"Lubart","year":"2006","journal-title":"Photomed. Laser Surg."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0020","doi-asserted-by":"crossref","first-page":"47379","DOI":"10.1074\/jbc.M107678200","article-title":"Photodynamic therapy-induced apoptosis in epidermoid carcinoma cells reactive oxygen species and mitochondrial inner membrane permeabilization","volume":"276","author":"Lam","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0025","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1096\/fasebj.9.12.7672510","article-title":"Oxidative stress-induced cataract: mechanism of action","volume":"9","author":"Spector","year":"1995","journal-title":"FASEB J."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0030","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3389\/fmicb.2012.00120","article-title":"Concepts and principles of photodynamic therapy as an alternative antifungal discovery platform","volume":"3","author":"Dai","year":"2012","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0035","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1039\/cs9952400019","article-title":"Photosensitizers of the porphyrin and phthalocyanine series for photodynamic therapy","volume":"24","author":"Bonnett","year":"1995","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0040","first-page":"397","article-title":"The mechanism of bilirubin-photosensitized DNA strand breakage in human cells exposed to phototherapy light","volume":"112","author":"Rosenstein","year":"1983","journal-title":"Mutat. Res."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0045","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s11426-008-0046-z","article-title":"Two-photon spectroscopic behaviors and photodynamic effect on the BEL-7402 cancer cells of the new chlorophyll photosensitizer","volume":"51","author":"Zhao","year":"2008","journal-title":"Sci. China B"},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0050","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1039\/b209993d","article-title":"Singlet oxygen (1 \u0394 g) production by pterin derivatives in aqueous solutions","volume":"2","author":"Thomas","year":"2003","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0055","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0190-9622(98)70379-2","article-title":"Photosensitive dermatitis caused by pyridoxine hydrochloride","volume":"39","author":"Murata","year":"1998","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0060","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1046\/j.1523-1747.2003.12414.x","article-title":"Proteins of the extracellular matrix are sensitizers of photo-oxidative stress in human skin cells","volume":"121","author":"Wondrak","year":"2003","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0065","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0304-4165(03)00072-2","article-title":"Advanced glycation endproducts as UVA photosensitizers of tryptophan and ascorbic acid: consequences for the lens","volume":"1621","author":"De La Rochette","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0070","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1011-1344(98)00142-0","article-title":"Photosensitization of thymine nucleobase by benzophenone through energy transfer, hydrogen abstraction and one-electron oxidation","volume":"44","author":"Delatour","year":"1998","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0075","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1751-1097.1985.tb01549.x","article-title":"Photosensitized production of superoxide anion by monochromatic (290\u2013405\u202fnm) ultraviolet irradiation of NADH and NADPH coenzymes","volume":"42","author":"Cunningham","year":"1985","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0080","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/01.ico.0000105827.85025.7f","article-title":"Collagen fiber diameter in the rabbit cornea after collagen crosslinking by riboflavin\/UVA","volume":"23","author":"Wollensak","year":"2004","journal-title":"Cornea"},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0085","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0304-4165(02)00215-5","article-title":"Electron transfer oxidation of tryptophan and tyrosine by triplet states and oxidized radicals of flavin sensitizers: a laser flash photolysis study","volume":"1571","author":"Lu","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0090","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1039\/b504573h","article-title":"Endogenous UVA-photosensitizers: mediators of skin photodamage and novel targets for skin photoprotection","volume":"5","author":"Wondrak","year":"2006","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0095","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3390\/ma6030817","article-title":"Dye sensitizers for photodynamic therapy","volume":"6","author":"Ormond","year":"2013","journal-title":"Materials"},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0100","series-title":"Progress in Phytochemistry","first-page":"183","article-title":"Photosensitizers from plants and their photodynamic action","volume":"Vol. 6","author":"Towers","year":"1980"},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0105","first-page":"241","article-title":"Radiation and the ageing eye","volume":"5","author":"Marshall","year":"1985","journal-title":"Ophthalmic Physiol. Opt."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0110","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1751-1097.1990.tb01738.x","article-title":"Time resolved spectroscopic studies on the intact human lens","volume":"51","author":"Dillon","year":"1990","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0115","first-page":"3237","article-title":"UV filter compounds in human lenses: the origin of 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-\u03b2-d-glucoside","volume":"40","author":"Bova","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0120","first-page":"200","article-title":"Major changes in human ocular UV protection with age","volume":"42","author":"Bova","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0125","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1562\/0031-8655(2001)074<0740:POLPWX>2.0.CO;2","article-title":"Photooxidation of lens proteins with xanthurenic acid: a putative chromophore for cataractogenesis","volume":"74","author":"Roberts","year":"2001","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0130","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1562\/0031-8655(2002)076<0368:ROXAOD>2.0.CO;2","article-title":"Role of xanthurenic acid 8-O-\u03b2-d-glucoside, a novel fluorophore that accumulates in the brunescent human eye lens","volume":"76","author":"Thiagarajan","year":"2002","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0135","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1751-1097.1991.tb01984.x","article-title":"A study of the photodynamic efficiencies of some eye lens constituents","volume":"54","author":"Krishna","year":"1991","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0140","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.freeradbiomed.2007.12.003","article-title":"Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage","volume":"44","author":"Mizdrak","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0145","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1167\/iovs.04-0178","article-title":"Lenticular levels of amino acids and free UV filters differ significantly between normals and cataract patients","volume":"45","author":"Streete","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0150","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1011-1344(00)00014-2","article-title":"Reactivity of monoclonal antibodies against a tryptophan\u2013 riboflavin adduct toward irradiated and non-irradiated bovine-eye-lens protein fractions: an indicator of in vivo visible-light-mediated phototransformations","volume":"55","author":"Mancini","year":"2000","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0155","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1751-1097.2012.01094.x","article-title":"Diurnal variation of ocular exposure to solar ultraviolet radiation based on data from a manikin head","volume":"88","author":"Gao","year":"2012","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0160","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1089\/jop.2000.16.285","article-title":"Ultraviolet radiation and cataract","volume":"16","author":"Balasubramanian","year":"2000","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0165","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1562\/0031-8655(2003)077<0535:SOTIBT>2.0.CO;2","article-title":"Study of the interaction between triplet riboflavin and the \u03b1-, \u03b2H- and \u03b2l-crystallins of the eye lens","volume":"77","author":"Viteri","year":"2003","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0170","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0014-4835(02)00278-6","article-title":"Alpha-crystallin","volume":"76","author":"Horwitz","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0175","first-page":"1278","article-title":"The ageing lens and cataract: a model of normal and pathological ageing","volume":"366","author":"Michael","year":"2011","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0180","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.ijbiomac.2016.06.047","article-title":"Preventive role of lens antioxidant defense mechanism against riboflavin-mediated sunlight damaging of lens crystallins","volume":"91","author":"Anbaraki","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0185","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1016\/j.bbamem.2007.03.015","article-title":"Fluorescence as a method to reveal structures and membrane-interactions of amyloidogenic proteins","volume":"1768","author":"Munishkina","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0190","doi-asserted-by":"crossref","first-page":"15474","DOI":"10.1074\/jbc.273.25.15474","article-title":"Identification of 1, 1\u2032-bi (4-anilino) naphthalene-5, 5\u2032-disulfonic acid binding sequences in \u03b1-crystallin","volume":"273","author":"Sharma","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0195","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jmb.2007.06.060","article-title":"Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human \u03b1A-, \u03b1B- and R120G \u03b1B-crystallins","volume":"372","author":"Meehan","year":"2007","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0200","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1007\/s11011-017-9983-6","article-title":"The effects of lipoic acid on redox status in brain regions and systemic circulation in streptozotocin-induced sporadic Alzheimer's disease model","volume":"33","author":"Erdo\u011fan","year":"2017","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0205","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0006-291X(91)91779-C","article-title":"Fluorometric characterization of dityrosine: complex formation with boric acid and borate ion","volume":"178","author":"Malencik","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0210","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1093\/nar\/gkh371","article-title":"DICHROWEB, an online server for protein secondary structure analyses from circular dichroism spectroscopic data","volume":"32","author":"Whitmore","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0215","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ab.2014.11.016","article-title":"Concomitant Raman spectroscopy and dynamic light scattering for characterization of therapeutic proteins at high concentrations","volume":"472","author":"Zhou","year":"2015","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0220","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.bbapap.2017.02.003","article-title":"The impact of different mutations at Arg54 on structure, chaperone-like activity and oligomerization state of human \u03b1A-crystallin: The pathomechanism underlying congenital cataract-causing mutations R54L, R54P and R54C","volume":"1865","author":"Khoshaman","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0225","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0003-2697(88)90179-0","article-title":"Coomassie blue-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for direct visualization of polypeptides during electrophoresis","volume":"173","author":"Sch\u00e4gger","year":"1988","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0230","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1002\/pro.5560041120","article-title":"How to measure and predict the molar absorption coefficient of a protein","volume":"4","author":"Pace","year":"1995","journal-title":"Protein Sci."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0235","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1751-1097.1981.tb05505.x","article-title":"Photosensitized oxidation in the ocular lens: evidence for photosensitizers endogenous to the human lens","volume":"33","author":"Zigler","year":"1981","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0240","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/S0886-3350(03)00343-2","article-title":"Endothelial cell damage after riboflavin\u2013ultraviolet-a treatment in the rabbit","volume":"29","author":"Wollensak","year":"2003","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-4835(88)90019-X","article-title":"Conformational changes of \u03b2H-crystallin in riboflavin-sensitized photooxidation","volume":"47","author":"Andley","year":"1988","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0250","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/dmrr.1075","article-title":"Diabetic cataracts: mechanisms and management","volume":"26","author":"Obrosova","year":"2010","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0255","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1039\/c1pp05164d","article-title":"Photo-oxidation of proteins","volume":"11","author":"Pattison","year":"2012","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0260","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S1011-1344(01)00208-1","article-title":"Photo-oxidation of proteins and its role in cataractogenesis, J","volume":"63","author":"Davies","year":"2001","journal-title":"Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0265","first-page":"87","article-title":"Ultraviolet damage to the eye revisited: eye-sun protection factor (E-SPF\u00ae), a new ultraviolet protection label for eyewear","volume":"8","author":"Behar-Cohen","year":"2014","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0270","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S1011-1344(01)00196-8","article-title":"Ocular phototoxicity","volume":"64","author":"Roberts","year":"2001","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0275","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2188\/jea.9.6sup_22","article-title":"Geometrical assessment of ocular exposure to environmental UV radiation-implications for ophthalmic epidemiology","volume":"9","author":"Sliney","year":"1999","journal-title":"J. Epidemiol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0280","first-page":"83","article-title":"Ultraviolet radiation albedo of natural surfaces","volume":"16","author":"Chady\u0161iene","year":"2008","journal-title":"J. Environ. Eng. Landsc. Manag."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0285","first-page":"736","article-title":"UV doses worldwide","volume":"81","author":"Godar","year":"2005","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0290","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/ICL.0b013e31821fbf29","article-title":"UV-B exposure to the eye depending on solar altitude","volume":"37","author":"Sasaki","year":"2011","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0295","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/phpp.12022","article-title":"Current status of photoprotection by window glass, automobile glass, window films, and sunglasses","volume":"29","author":"Almutawa","year":"2013","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0300","doi-asserted-by":"crossref","first-page":"e71398","DOI":"10.1371\/journal.pone.0071398","article-title":"Phototoxic action spectrum on a retinal pigment epithelium model of age-related macular degeneration exposed to sunlight normalized conditions","volume":"8","author":"Arnault","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0305","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1039\/c2fo10246c","article-title":"Riboflavin as a photosensitizer. Effects on human health and food quality","volume":"3","author":"Cardoso","year":"2012","journal-title":"Food Funct."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0310","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S1046-2023(02)00204-9","article-title":"Sources and measurement of ultraviolet radiation","volume":"28","author":"Diffey","year":"2002","journal-title":"Methods"},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0315","first-page":"781","article-title":"Physical factors in cataractogenesis: ambient ultraviolet radiation and temperature","volume":"27","author":"Sliney","year":"1986","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0320","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S1542-0124(12)70185-4","article-title":"Antioxidant defenses in the ocular surface","volume":"7","author":"Chen","year":"2009","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0325","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/ICL.0b013e31821ec4f2","article-title":"Role of UV irradiation and oxidative stress in cataract formation. Medical prevention by nutritional antioxidants and metabolic agonists","volume":"37","author":"Varma","year":"2011","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0330","first-page":"758","article-title":"Quantitation of free cysteine in the lens","volume":"34","author":"Veltman","year":"1993","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0335","doi-asserted-by":"crossref","first-page":"5776","DOI":"10.1021\/jp013727y","article-title":"Singlet oxygen generation by 8-methoxypsoralen in deuterium oxide: relaxation rate constants and dependence of the generation efficacy on the oxygen partial pressure","volume":"106","author":"Engl","year":"2002","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0340","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1562\/0031-8655(2000)072<0815:RPAPEA>2.0.CO;2","article-title":"Riboflavin photodegradation and photosensitizing effects are highly dependent on oxygen and ascorbate concentrations","volume":"72","author":"Rochette","year":"2000","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0345","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S1011-1344(01)00208-1","article-title":"Photo-oxidation of proteins and its role in cataractogenesis, J","volume":"63","author":"Davies","year":"2001","journal-title":"Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0350","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/01.ede.0000086881.84657.98","article-title":"Sun exposure as a risk factor for nuclear cataract","volume":"14","author":"Neale","year":"2003","journal-title":"Epidemiology"},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0355","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1039\/c1pp05164d","article-title":"Photo-oxidation of proteins","volume":"11","author":"Pattison","year":"2012","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0360","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ab.2013.09.001","article-title":"Concurrent quantification of tryptophan and its major metabolites","volume":"443","author":"Lesniak","year":"2013","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0365","doi-asserted-by":"crossref","first-page":"450","DOI":"10.2174\/092986612799789396","article-title":"Effect of temperature and ionic strength on structure and chaperone activity of glycated and non-glycated alpha-crystallins","volume":"19","author":"Khalili-Hezarjaribi","year":"2012","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0370","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ab.2006.03.015","article-title":"Methods for enhancing the accuracy and reproducibility of Congo red and thioflavin T assays","volume":"353","author":"Eisert","year":"2006","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0375","series-title":"Metal Ions in Neurological Systems","first-page":"85","article-title":"Beta-amyloid toxicity increases with hydrophobicity in the presence of metal ions","author":"Granzotto","year":"2012"},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0380","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.freeradbiomed.2007.12.003","article-title":"Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage","volume":"44","author":"Mizdrak","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0385","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1023\/A:1015927907418","article-title":"Molecular pathology of dityrosine cross-links in proteins: structural and functional analysis of four proteins","volume":"234","author":"Balasubramanian","year":"2002","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0390","doi-asserted-by":"crossref","first-page":"e111617","DOI":"10.1371\/journal.pone.0111617","article-title":"Modulating the structure of EGFR with UV light: new possibilities in cancer therapy","volume":"9","author":"Correia","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0395","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1021\/bi00537a022","article-title":"Spectroscopic investigations of bovine lens crystallins. 1. Circular dichroism and intrinsic fluorescence","volume":"21","author":"Liang","year":"1982","journal-title":"Biochemistry"},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0400","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0014-4835(88)80010-1","article-title":"Spectroscopic studies on the riboflavin-sensitized conformational changes of calf lens \u03b1-crystallin","volume":"46","author":"Andley","year":"1988","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0405","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1001\/archophthalmol.2008.507","article-title":"Clinical detection of precataractous lens protein changes using dynamic light scattering","volume":"126","author":"Datiles","year":"2008","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0410","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1111\/j.1751-1097.2008.00390.x","article-title":"Measurement of lens protein aggregation in vivo using dynamic light scattering in a guinea pig\/UVA model for nuclear cataract","volume":"84","author":"Simpanya","year":"2008","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0415","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2174\/1389203013381107","article-title":"Chaperone-like activity of alpha-crystallin and other small heat shock proteins","volume":"2","author":"Ganea","year":"2001","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0420","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ijbiomac.2014.10.060","article-title":"Quantification of anti-aggregation activity of UV-irradiated \u03b1-crystallin","volume":"73","author":"Borzova","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0425","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mam.2008.05.005","article-title":"Regulation of glutathione synthesis","volume":"30","author":"Lu","year":"2009","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0430","first-page":"329","article-title":"Photooxidized products of recombinant \u03b1A-crystallin and W9F mutant","volume":"69","author":"Dhir","year":"1999","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.ijbiomac.2018.06.136_bb0435","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1562\/0031-8655(2003)077<0567:PSMOTL>2.0.CO;2","article-title":"Photosensitized structural modifications of the lens protein \u03b1-crystallin: do all modifications impair chaperone-like activity?","volume":"77","author":"Sgarbossa","year":"2003","journal-title":"Photochem. Photobiol."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813018307116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813018307116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:06:09Z","timestamp":1758870369000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813018307116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":87,"alternative-id":["S0141813018307116"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.06.136","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural and functional alteration of human \u03b1A-crystallin after exposure to full spectrum solar radiation and preventive role of lens antioxidants","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.06.136","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}