{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:44:25Z","timestamp":1777383865215,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T00:00:00Z","timestamp":1565740800000},"content-version":"vor","delay-in-days":286,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Conselho Nacional de Pesquisa\/CNPq","award":["446480\/2014-2"],"award-info":[{"award-number":["446480\/2014-2"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa de Minas Gerais\/FAPEMIG","award":["APQ-02238-14"],"award-info":[{"award-number":["APQ-02238-14"]}]},{"DOI":"10.13039\/501100004933","name":"Instituto Nacional de Ci\u00eancia e Tecnologia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004933","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.ijbiomac.2018.08.051","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T22:48:01Z","timestamp":1533941281000},"page":"1179-1187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Inflammation, angiogenesis and fibrogenesis are differentially modulated by distinct domains of the snake venom metalloproteinase jararhagin"],"prefix":"10.1016","volume":"119","author":[{"given":"Bruno Antonio","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone Ramos","family":"Deconte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francyelle Borges Rosa","family":"de Moura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana Carla","family":"Tomiosso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia Bianca","family":"Clissa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Passos","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda de Assis","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0005","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.toxicon.2006.07.008","article-title":"Bothrops jararaca venom gland transcriptome: analysis of the gene expression pattern","volume":"48","author":"Cidade","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0010","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1002\/pmic.201100287","article-title":"Bothrops jararaca venom proteome rearrangement upon neonate to adult transition","volume":"11","author":"Zelanis","year":"2011","journal-title":"Proteomics"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0015","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0300-9084(00)01163-9","article-title":"Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage","volume":"82","author":"Guti\u00e9rrez","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0020","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1111\/j.1742-4658.2008.06466.x","article-title":"Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom complexity","volume":"275","author":"Fox","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0025","doi-asserted-by":"crossref","first-page":"22869","DOI":"10.1016\/S0021-9258(18)50027-2","article-title":"Purification, cloning and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom, insights into the disintegrin gene family","volume":"267","author":"Paine","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0030","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0003-9861(02)00598-2","article-title":"Evidence for heterogeneous forms of the snake venom metalloproteinase jararhagin: a factor contributing to snake venom variability","volume":"409","author":"Moura-da-Silva","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0035","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.toxicon.2012.03.026","article-title":"Jararhagin, a hemorrhagic snake venom metalloproteinase from Bothrops jararaca","volume":"60","author":"Moura-da-Silva","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0040","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.toxicon.2006.02.001","article-title":"Importance of jararhagin disintegrin-like and cysteine-rich domains in the early events of local inflammatory response","volume":"47","author":"Clissa","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2005.06.007","article-title":"Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: in vitro and in vivo gene expression analysis of the effects of the toxin","volume":"441","author":"Gallagher","year":"2005","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0050","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1002\/eji.200324475","article-title":"Inflammatory pathogenesis of snake venom metalloproteinase induced skin necrosis","volume":"33","author":"Laing","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0055","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/S0041-0101(01)00131-3","article-title":"The effect of jararhagin, a metalloproteinase from Bothrops jararaca venom, on pro-inflammatory cytokines released by murine peritoneal adherent cells","volume":"39","author":"Clissa","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0060","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1023\/A:1014465611487","article-title":"Importance of metalloproteinases and macrophages in viper snake envenomation-induced local inflammation","volume":"26","author":"Costa","year":"2002","journal-title":"Inflammation"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0065","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.toxicon.2004.08.009","article-title":"Jararhagin, a snake venom metalloproteinase-disintegrin, stimulates epithelial cell migration in an in vitro restitution model","volume":"44","author":"Costa","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0070","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0049-3848(01)00216-X","article-title":"Selective recognition of alpha(2)beta(1) integrin by Jararhagin, a metalloproteinase\/disintegrin from Bothrops jararaca venom","volume":"102","author":"Moura-da-Silva","year":"2001","journal-title":"Thromb. Res."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0075","first-page":"755","article-title":"Quantitative in-vivo studies on angiogenesis in a rat sponge model","volume":"68","author":"Andrade","year":"1987","journal-title":"Br. J. Exp. Pathol."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0080","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.toxicon.2012.02.005","article-title":"Sponge implant in Swiss mice as a model for studying loxoscelism","volume":"59","author":"Pereira","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0085","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.toxicon.2014.10.007","article-title":"DisBa-01 inhibits angiogenesis, inflammation and fibrogenesis of sponge-induced-fibrovascular tissue in mice","volume":"92","author":"Cassini-Vieira","year":"2014","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0090","first-page":"302","article-title":"Angiogenic activity of PAF and inhibition of blood flow by Bothrops jararaca venom in a mouse sponge model","volume":"61","author":"Vieira","year":"1992","journal-title":"EXS"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0095","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.toxicon.2014.03.003","article-title":"Apoptosis, mast cell degranulation and collagen breakdown in the pathogenesis of loxoscelism in subcutaneously implanted sponges","volume":"84","author":"Pereira","year":"2014","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.biopha.2009.03.003","article-title":"Atorvastatin inhibits inflammatory angiogenesis in mice through down regulation of VEGF, TNF-\u03b1 and TGF-\u03b21","volume":"64","author":"Ara\u00fajo","year":"2010","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0105","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.peptides.2016.10.002","article-title":"Ts14 from Tityus serrulatus boosts angiogenesis and attenuates inflammation and collagen deposition in sponge-induced granulation tissue in mice","volume":"98","author":"Cassini-Vieira","year":"2017","journal-title":"Peptides"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0110","first-page":"1","article-title":"iNOS activity modulates inflammation, angiogenesis, and tissue fibrosis in polyether-polyurethane synthetic implants","author":"Cassini-Vieira","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0115","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0120","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0041-0101(96)00193-6","article-title":"Inhibition of the hemorrhagic activity of Bothrops asper venom by a novel neutralizing mixture","volume":"35","author":"Borkow","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0125","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0041-0101(85)90380-0","article-title":"Neutralization of proteolytic and hemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom","volume":"23","author":"Guti\u00e9rrez","year":"1985","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep16877","article-title":"Trypanosoma cruzi P21: a potential novel target for chagasic cardiomyopathy therapy","volume":"5","author":"Teixeira","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0135","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.mvr.2011.08.011","article-title":"Genetic background determines mouse strain differences in inflammatory angiogenesis","volume":"82","author":"Marques","year":"2011","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0140","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ijbiomac.2017.04.012","article-title":"Angiogenenic effects of BpLec, a C-type lectin isolated from Bothrops pauloensis snake venom","volume":"102","author":"Castanheira","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0145","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1006\/bbrc.1994.1706","article-title":"A 28-kDa protein with disintegrin-like structure (Jararhagin-C) purified from Bothrops jararaca venom inhibits collagen- and ADP-induced platelet aggregation","volume":"201","author":"Usami","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0150","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.toxicon.2012.09.005","article-title":"The continuing saga of snake venom disintegrins","volume":"62","author":"Calvete","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0155","doi-asserted-by":"crossref","first-page":"532","DOI":"10.2174\/1389203716666150515125002","article-title":"Disintegrins from snake venoms and their applications in cancer research and therapy","volume":"16","author":"Macedo","year":"2015","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0160","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.toxicon.2012.07.004","article-title":"Gene expression of inflammatory mediators induced by jararhagin on endothelial cells","volume":"60","author":"Lopes","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0165","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.toxicon.2015.06.024","article-title":"Jararhagin-induced mechanical hyperalgesia depends on TNF-\u03b1, IL-1\u03b2 and NF\u03baB in mice","volume":"103","author":"Ferraz","year":"2015","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0170","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1186\/1472-6882-14-446","article-title":"Antiproliferative effect of the jararhagin toxin on B16F10 murine melanoma","volume":"14","author":"Maria","year":"2014","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0175","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1042\/bj3200635","article-title":"Inhibition of collagen-induced platelet aggregation as the result of cleavage of \u03b12\u03b21-integrin by the snake venom metalloproteinase jararhagin","volume":"2","author":"Kamiguti","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0180","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s10456-015-9477-2","article-title":"The pathogenic role of angiogenesis in rheumatoid arthritis","volume":"18","author":"Elshabrawy","year":"2015","journal-title":"Angiogenesis"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0185","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0190","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00726-010-0689-x","article-title":"Physiology and pathophysiology of matrix metalloproteases","volume":"41","author":"Klein","year":"2011","journal-title":"Amino Acids"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0195","doi-asserted-by":"crossref","first-page":"10830","DOI":"10.1021\/bi901656f","article-title":"Updated biological roles for matrix metalloproteinases and new \u201cintracellular\u201d substrates revealed by degradomics","volume":"48","author":"Butler","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0200","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0041-008X(03)00337-5","article-title":"Pulmonary hemorrhage induced by jararhagin, a metalloproteinase from Bothrops jararaca snake venom","volume":"193","author":"Escalante","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0205","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1515\/BC.2005.044","article-title":"The snake venom metalloproteases berythractivase and jararhagin activate endothelial cells","volume":"386","author":"Schattner","year":"2005","journal-title":"Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0210","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s10495-005-2945-1","article-title":"Jararhagin, a snake venom metalloproteinase, induces a specialized form of apoptosis (anoikis) selective to endothelial cells","volume":"10","author":"Tanjoni","year":"2005","journal-title":"Apoptosis"},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0215","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.1016\/j.febslet.2008.10.034","article-title":"Activation of leukocyte rolling by the cysteine-rich domain and the hyper-variable region of HF3, a snake venom hemorrhagic metalloproteinase","volume":"582","author":"Menezes","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0220","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000339613","article-title":"Wound repair and regeneration","volume":"49","author":"Reinke","year":"2012","journal-title":"Eur. Surg. Res."},{"issue":"17","key":"10.1016\/j.ijbiomac.2018.08.051_bb0225","first-page":"1","article-title":"Macrophages, wound healing, and fibrosis: recent insights","volume":"20","author":"Smigiel","year":"2018","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0230","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.4049\/jimmunol.175.8.5390","article-title":"TGF-\u03b2 and Smad3 signaling link inflammation to chronic fibrogenesis","volume":"175","author":"Bonniaud","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0235","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-\u03b2 signaling and the fibrotic response","volume":"18","author":"Leask","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.ijbiomac.2018.08.051_bb0240","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.biochi.2007.11.009","article-title":"Collagen binding is a key factor for the hemorrhagic activity of snake venom metalloproteinases","volume":"90","author":"Moura-da-Silva","year":"2008","journal-title":"Biochimie"}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014181301831972X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014181301831972X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:22:42Z","timestamp":1758871362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014181301831972X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":48,"alternative-id":["S014181301831972X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.08.051","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammation, angiogenesis and fibrogenesis are differentially modulated by distinct domains of the snake venom metalloproteinase jararhagin","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.08.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}