{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T10:47:22Z","timestamp":1793011642117,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673557"],"award-info":[{"award-number":["81673557"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1703110"],"award-info":[{"award-number":["U1703110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Program of Guangdong Province","award":["2014A050503067"],"award-info":[{"award-number":["2014A050503067"]}]},{"name":"Science and Technology Program of Guangdong Province","award":["2015A020211032"],"award-info":[{"award-number":["2015A020211032"]}]},{"name":"Education Program of Guangdong Province","award":["2017KZDXM048"],"award-info":[{"award-number":["2017KZDXM048"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.ijbiomac.2018.08.082","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T23:19:06Z","timestamp":1534547946000},"page":"170-179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"PA","title":["Investigation of inulins from the roots of Morinda officinalis for potential therapeutic application as anti-osteoporosis agent"],"prefix":"10.1016","volume":"120","author":[{"given":"Keming","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinluan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9209-6630","authenticated-orcid":false,"given":"Chunyan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0005","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/jbmr.5650020206","article-title":"The effect of ovariectomy and 17beta-estradiol on bone histomorphometry in growing rats","volume":"2","author":"Turner","year":"1987","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0010","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1056\/NEJM200105103441904","article-title":"Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis","volume":"344","author":"Neer","year":"2001","journal-title":"New. Engl. J. Med."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0015","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1053\/sarh.2001.16648","article-title":"Osteoporosis therapies for rheumatoid arthritis patients: minimizing gastrointestinal side effects","volume":"30","author":"Sewell","year":"2001","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0020","first-page":"482","article-title":"Investigation on germplasm resources of Morinda officinalis How","volume":"18","author":"Zhang","year":"2016","journal-title":"Mod. Chin. Med."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0025","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1248\/bpb.28.1915","article-title":"Antinociceptive anti-inflammatory effect of monotropein isolated from the root of Morinda officinalis","volume":"28","author":"Choi","year":"2005","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0030","first-page":"109","article-title":"Antidepressant effect of inulin-type oligosaccharides from Morinda officinalis How in mice","volume":"10","author":"Cai","year":"1996","journal-title":"Chin. J. Pharmacol. Toxicol."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0035","first-page":"112","article-title":"Protective effect of Morinda officinalis polysaccharides on bone degeneration in the aged rats","volume":"6","author":"Wang","year":"2011","journal-title":"Int. J. Phys. Sci."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0040","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ijbiomac.2008.06.008","article-title":"Protective effect of polysaccharides from Morinda officinalis on bone loss in ovariectomized rats","volume":"43","author":"Zhu","year":"2008","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0045","first-page":"4570","article-title":"Effects of Morinda root polysaccharide and its extract on the activity of osteoblast cultured in vitro","volume":"11","author":"Li","year":"2007","journal-title":"J. Clin. Rehab. Tissue Eng. Res."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0050","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/0043-1354(73)90090-0","article-title":"Determination of carbohydrate in lake sediment by a modified phenol-sulfuric acid method","volume":"7","author":"Liu","year":"1973","journal-title":"Water Res."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0055","doi-asserted-by":"crossref","first-page":"13230","DOI":"10.1021\/jf2031617","article-title":"Kudzu (Pueraria lobata) vine ethanol extracts improve ovariectomy-induced bone loss in female mice","volume":"59","author":"Tanaka","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0060","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1016\/j.biomaterials.2007.03.003","article-title":"The effect of 3-hydroxybutyrate on the in vitro differentiation of murine osteoblast MC3T3-E1 and in vivo bone formation in ovariectomized rats","volume":"28","author":"Zhao","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0065","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0070","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.foodchem.2010.02.028","article-title":"Comparison of the water-soluble carbohydrate composition and fructan structures of Agave tequilana plants of different ages","volume":"122","author":"Arrizon","year":"2010","journal-title":"Food Chem."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0008-6215(93)80055-J","article-title":"Avoiding oxidative degradation during sodium hydroxide\/methyl iodide-mediated carbohydrate methylation in dimethyl sulfoxide","volume":"245","author":"Needs","year":"1993","journal-title":"Carbohydr. Res."},{"issue":"2013","key":"10.1016\/j.ijbiomac.2018.08.082_bb0080","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.carbpol.2013.06.011","article-title":"Chemical modification, antioxidant and \u03b1-amylase inhibitory activities of corn silk polysaccharides","volume":"98","author":"Chen","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0085","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.diff.2016.04.004","article-title":"Effects of sodium tri- and hexameta-phosphate in vitro osteoblastic differentiation in periodontal ligament and osteoblasts, and in vivo bone regeneration","volume":"92","author":"Bae","year":"2016","journal-title":"Differentiation"},{"issue":"2016","key":"10.1016\/j.ijbiomac.2018.08.082_bb0090","article-title":"The mechanism of a chitosan-collagen composite film used as biomaterial support for MC3T3-E1 cell differentiation","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0095","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.yexcr.2015.02.009","article-title":"Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs\u2013G protein signaling in osteoblasts","volume":"333","author":"Wattanachanya","year":"2015","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bone.2015.01.003","article-title":"Glucose-dependent insulinotropic polypeptide (GIP) directly affects collagen fibril diameter and collagen cross-linking in osteoblast cultures","volume":"74","author":"Mieczkowska","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0105","doi-asserted-by":"crossref","first-page":"5548","DOI":"10.1039\/C6TB01109H","article-title":"Osteogenic and angiogenic activities of silicon-incorporated TiO2 nanotube arrays","volume":"4","author":"Bai","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2014.05.044","article-title":"Epigenetic landscape during osteoblastogenesis defines a differentiation-dependent Runx2 promoter region","volume":"550","author":"Tai","year":"2014","journal-title":"Gene"},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0115","article-title":"Scavenger receptor class B, type I (Scarb1) deficiency promotes osteoblastogenesis but stunts terminal osteocyte differentiation","volume":"2","author":"Martineau","year":"2014","journal-title":"Phys. Rep."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0120","doi-asserted-by":"crossref","first-page":"7928","DOI":"10.1016\/j.biomaterials.2010.06.055","article-title":"Mineralized human primary osteoblast matrices as a model system to analyse interactions of prostate cancer cells with the bone microenvironment","volume":"31","author":"Reichert","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0125","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1006\/bbrc.2002.6510","article-title":"Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts","volume":"291","author":"Viereck","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0130","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","article-title":"Osteoprotegerin: a novel secreted protein involved in the regulation of bone density","volume":"89","author":"Simonet","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0135","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.carbpol.2011.01.016","article-title":"Extraction of polysaccharides from Morinda officinalis by response surface methodology and effect of the polysaccharides on bone-related genes","volume":"85","author":"Zhu","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0140","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.indcrop.2013.03.024","article-title":"An analysis of the influence of growth periods on physical appearance, and acemannan and elemental distribution of Aloe vera L. gel","volume":"48","author":"Ray","year":"2013","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0145","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.carbpol.2015.08.067","article-title":"Structural characterization and antioxidant activity of a novel heteropolysaccharide from the submerged fermentation mycelia of Ganoderma capense","volume":"134","author":"Huang","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0150","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.carbpol.2014.11.034","article-title":"Structural characterization and antioxidant activity of a heteropolysaccharide from Ganoderma capense","volume":"121","author":"Yi","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0155","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0144-8617(00)00151-X","article-title":"FT-IR study of plant cell wall model compounds: pectic polysaccharides and hemicelluloses","volume":"43","author":"Ka\u010dur\u00e1kov\u00e1","year":"2000","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0160","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.indcrop.2017.07.018","article-title":"Structural characterization of a novel oligosaccharide from Achyranthes bidentata and its anti-osteoporosis activities","volume":"108","author":"Wang","year":"2017","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0165","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/j.carres.2004.07.020","article-title":"NMR characterisation of inulin-type fructooligosaccharides as the major water-soluble carbohydrates from Matricaria maritima (L.)","volume":"339","author":"C\u00e9rantola","year":"2004","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0170","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0008-6215(91)84123-V","article-title":"New features of plant-fructan structure revealed by methylation analysis and carbon-13 n.m.r. spectroscopy","volume":"217","author":"Carpita","year":"1991","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0175","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0008-6215(84)85131-9","article-title":"Determination of the structures of trisaccharides by 13C-N.M.R. spectroscopy","volume":"126","author":"Bradbury","year":"1984","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0180","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jff.2016.11.033","article-title":"An inulin-type fructan isolated from Artemisia japonica and its anti-arthritic effects","volume":"29","author":"Li","year":"2017","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0185","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0008-6215(91)84115-U","article-title":"Proton and carbon chemical-shift assignments for 6-kestose and neokestose from two-dimensional n.m.r. measurements","volume":"217","author":"Liu","year":"1991","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0190","first-page":"22","article-title":"Biochemical characterization of Aspergillus awamori exoinulinase: substrate binding characteristics and regioselectivity of hydrolysis","volume":"1650","author":"Kulminskaya","year":"2003","journal-title":"BBA-Biomembranes"},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0195","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1021\/bi00508a053","article-title":"Preparation and circular dichroism analysis of sodium hyaluronate oligosaccharides and chondroitin","volume":"20","author":"Cowman","year":"1981","journal-title":"Biochemistry"},{"key":"10.1016\/j.ijbiomac.2018.08.082_bb0200","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0008-6215(94)00235-5","article-title":"Induced circular dichroism study of the aqueous solution complexation of cello-oligosaccharides and related polysaccharides with aromatic dyes","volume":"265","author":"Engle","year":"1994","journal-title":"Carbohydr. Res."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813018326886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813018326886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:10:41Z","timestamp":1758870641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813018326886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":40,"alternative-id":["S0141813018326886"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.08.082","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of inulins from the roots of Morinda officinalis for potential therapeutic application as anti-osteoporosis agent","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.08.082","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}