{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T06:42:11Z","timestamp":1794465731565,"version":"4.9.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671205"],"award-info":[{"award-number":["81671205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.ijbiomac.2018.10.212","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T11:08:25Z","timestamp":1541156905000},"page":"460-468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["CXCL12 has therapeutic value in facial nerve injury and promotes Schwann cells autophagy and migration via PI3K-AKT-mTOR signal pathway"],"prefix":"10.1016","volume":"124","author":[{"given":"Dekun","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianchi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinda","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0005","doi-asserted-by":"crossref","first-page":"686","DOI":"10.12968\/hmed.2016.77.12.686","article-title":"Causes and management of facial nerve palsy","volume":"77","author":"Spencer","year":"2016","journal-title":"Br. J. Hosp. Med. (Lond.)"},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17122101","article-title":"Peripheral nerve injury: stem cell therapy and peripheral nerve transfer","volume":"17","author":"Sullivan","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0015","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.expneurol.2012.06.010","article-title":"Re-expression of N-cadherin in remyelinating lesions of experimental inflammatory demyelination","volume":"237","author":"Hochmeister","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0020","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/glia.22367","article-title":"Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions","volume":"60","author":"Clarner","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0025","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.expneurol.2012.02.018","article-title":"Cuprizone-induced demyelination in the rat cerebral cortex and thyroid hormone effects on cortical remyelination","volume":"235","author":"Silvestroff","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0030","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.expneurol.2008.06.017","article-title":"Reduced NGF secretion by Schwann cells under the high glucose condition decreases neurite outgrowth of DRG neurons","volume":"213","author":"Tosaki","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0035","first-page":"177","article-title":"Schwann cells promote neurite outgrowth of dorsal root ganglion neurons through secretion of nerve growth factor","volume":"49","author":"Hu","year":"2011","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0040","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1523\/JNEUROSCI.2661-13.2014","article-title":"Combination of engineered Schwann cell grafts to secrete neurotrophin and chondroitinase promotes axonal regeneration and locomotion after spinal cord injury","volume":"34","author":"Kanno","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0045","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.neulet.2017.01.031","article-title":"Syntaxin-4 and SNAP23 act as exocytic SNAREs to release NGF from cultured Schwann cells","volume":"653","author":"Lin","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0050","doi-asserted-by":"crossref","first-page":"8316","DOI":"10.1038\/s41598-018-26704-x","article-title":"Hepatocyte growth factor (HGF) promotes peripheral nerve regeneration by activating repair Schwann cells","volume":"8","author":"Ko","year":"2018","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.ijbiomac.2018.10.212_bb0055","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1007\/s11064-018-2535-6","article-title":"Up-regulation of Cdc37 contributes to Schwann cell proliferation and migration after sciatic nerve crush","volume":"43","author":"Liu","year":"2018","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0060","doi-asserted-by":"crossref","first-page":"8198365","DOI":"10.1155\/2018\/8198365","article-title":"MicroRNA mediated regulation of Schwann cell migration and proliferation in peripheral nerve injury","volume":"2018","author":"Sohn","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0065","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.cyto.2015.05.004","article-title":"Role of SDF-1 (CXCL12) in regulating hematopoietic stem and progenitor cells traffic into the liver during extramedullary hematopoiesis induced by G-CSF, AMD3100 and PHZ","volume":"76","author":"Mendt","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0070","doi-asserted-by":"crossref","first-page":"11068","DOI":"10.1073\/pnas.1006375107","article-title":"Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis","volume":"107","author":"Carbajal","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0075","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.expneurol.2013.06.017","article-title":"Stromal derived growth factor-1 (CXCL12) modulates synaptic transmission to immature neurons during post-ischemic cerebral repair","volume":"248","author":"Ardelt","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0080","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1007\/s12035-015-9203-5","article-title":"Activation and regulation of NLRP3 inflammasome by intrathecal application of SDF-1a in a spinal cord injury model","volume":"53","author":"Zendedel","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0085","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/j.jocn.2015.03.048","article-title":"Nimodipine-mediated re-myelination after facial nerve crush injury in rats","volume":"22","author":"Tang","year":"2015","journal-title":"J. Clin. Neurosci."},{"issue":"1","key":"10.1016\/j.ijbiomac.2018.10.212_bb0090","first-page":"13","article-title":"Experimental study of the facial nerve paralysis induced by herpes simplex virus type 1 infection in mice","volume":"41","author":"Wang","year":"2006","journal-title":"Chin. J. Otorhinolaryngol. Head Neck Surg."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0095","first-page":"3119","article-title":"CXCL12 induces migration of Schwann cells via p38 MAPK and autocrine of CXCL12 by the CXCR4 receptor","volume":"11","author":"Gao","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0100","first-page":"1163","article-title":"Applied methods instead of autologous nerve transplantation in the reconstruction of nerve injuries on the hand","volume":"158","author":"Biro","year":"2017","journal-title":"Orv. Hetil."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0105","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/glia.22451","article-title":"Increased miR-195 aggravates neuropathic pain by inhibiting autophagy following peripheral nerve injury","volume":"61","author":"Shi","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0110","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1083\/jcb.201503019","article-title":"Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves","volume":"210","author":"Gomez-Sanchez","year":"2015","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0115","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s12031-015-0672-9","article-title":"Autophagy promotes peripheral nerve regeneration and motor recovery following sciatic nerve crush injury in rats","volume":"58","author":"Huang","year":"2016","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0120","doi-asserted-by":"crossref","first-page":"E8072","DOI":"10.1073\/pnas.1710566114","article-title":"Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury","volume":"114","author":"Brosius Lutz","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0125","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1242\/jcs.188490","article-title":"Autophagy in adhesion and migration","volume":"129","author":"Kenific","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0130","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s12031-018-1056-8","article-title":"Schwann-cell autophagy, functional recovery, and scar reduction after peripheral nerve repair","volume":"64","author":"Ko","year":"2018","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0135","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.molimm.2017.04.010","article-title":"IL-37 induces autophagy in hepatocellular carcinoma cells by inhibiting the PI3K\/AKT\/mTOR pathway","volume":"87","author":"Li","year":"2017","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0140","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.4049\/jimmunol.1402503","article-title":"IL-33 is required for disposal of unnecessary cells during ovarian atresia through regulation of autophagy and macrophage migration","volume":"194","author":"Wu","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0145","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.biomaterials.2014.12.006","article-title":"Autophagy in SDF-1alpha-mediated DPSC migration and pulp regeneration","volume":"44","author":"Yang","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2018.10.212_bb0150","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1080\/15548627.2017.1356977","article-title":"Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition","volume":"13","author":"Kim","year":"2017","journal-title":"Autophagy"}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813018338765?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813018338765?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:43:45Z","timestamp":1785775425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813018338765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":30,"alternative-id":["S0141813018338765"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.10.212","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CXCL12 has therapeutic value in facial nerve injury and promotes Schwann cells autophagy and migration via PI3K-AKT-mTOR signal pathway","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.10.212","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}