{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:41:37Z","timestamp":1791394897902,"version":"4.3.3"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang province","doi-asserted-by":"publisher","award":["LQ16H310002"],"award-info":[{"award-number":["LQ16H310002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.ijbiomac.2018.12.072","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T03:38:31Z","timestamp":1544585911000},"page":"721-729","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"special_numbering":"C","title":["Preparation and drug release property of tanshinone IIA loaded chitosan-montmorillonite microspheres"],"prefix":"10.1016","volume":"125","author":[{"given":"Chao","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenze","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1548-328X","authenticated-orcid":false,"given":"Guohua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.atherosclerosis.2011.06.041","article-title":"Cardiovascular actions and therapeutic potential of tanshinone IIA","volume":"220","author":"Gao","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0010","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.pharmthera.2007.09.008","article-title":"Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion","volume":"117","author":"Han","year":"2008","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0015","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ejphar.2017.08.041","article-title":"Tanshinone IIA ameliorates apoptosis of myocardiocytes by up-regulation of miR-133 and suppression of Caspase-9","volume":"815","author":"Song","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0020","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/med.20077","article-title":"New developments in the chemistry and biology of the bioactive constituents of Tanshen","volume":"27","author":"Wang","year":"2007","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0025","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s11064-013-1221-y","article-title":"Protective effect of tanshinone IIA against infarct size and increased HMGB1, NFkappaB, GFAP and apoptosis consequent to transient middle cerebral artery occlusion","volume":"39","author":"Wang","year":"2014","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0030","doi-asserted-by":"crossref","first-page":"6893","DOI":"10.1016\/j.biomaterials.2013.05.021","article-title":"The effect of cationic albumin-conjugated PEGylated tanshinone IIA nanoparticles on neuronal signal pathways and neuroprotection in cerebral ischemia","volume":"34","author":"Liu","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0035","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/pcan.2013.38","article-title":"Tanshinone IIA inhibits human prostate cancer cells growth by induction of endoplasmic reticulum stress in vitro and in vivo","volume":"16","author":"Chiu","year":"2013","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0040","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1002\/jcb.24553","article-title":"Tanshinone IIA inhibits breast cancer stem cells growth in vitro and in vivo through attenuation of IL-6\/STAT3\/NF-\u03baB signaling pathways","volume":"114","author":"Lin","year":"2013","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0045","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejps.2015.05.012","article-title":"Tanshinone IIA \u2013 loaded pellets developed for angina chronotherapy: deconvolution-based formulation design and optimization, pharmacokinetic and pharmacodynamic evaluation","volume":"76","author":"Yan","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0050","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.biomaterials.2012.09.058","article-title":"Pharmacokinetics and atherosclerotic lesions targeting effects of tanshinone IIA discoidal and spherical biomimetic high density lipoproteins","volume":"34","author":"Zhang","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0055","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ejps.2015.03.002","article-title":"Enhanced hepatic targeting, biodistribution and antifibrotic efficacy of tanshinone IIA loaded globin nanoparticles","volume":"73","author":"Meng","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0060","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijpharm.2014.09.017","article-title":"TPGS-g-PLGA\/Pluronic F68 mixed micelles for tanshinone IIA delivery in cancer therapy","volume":"476","author":"Zhang","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0065","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.ejpb.2011.11.003","article-title":"Novel tanshinone II A ternary solid dispersion pellets prepared by a single-step technique: in vitro and in vivo evaluation","volume":"80","author":"Li","year":"2012","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0070","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1142\/S0192415X13500146","article-title":"Novel microemulsion of tanshinone IIA, isolated from Salvia miltiorrhiza Bunge, exerts anticancer activity through inducing apoptosis in hepatoma cells","volume":"41","author":"Ma","year":"2013","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0075","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/adhm.201100014","article-title":"A novel microfluidic approach for monodispersed chitosan microspheres with controllable structures","volume":"1","author":"Xu","year":"2012","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0080","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ijpharm.2013.06.055","article-title":"Bioavailability enhancement of glucosamine hydrochloride by chitosan","volume":"455","author":"Qian","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0085","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ejpb.2012.04.007","article-title":"Chitosan-based drug delivery systems","volume":"81","author":"Bernkop-Schn\u00fcrch","year":"2012","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0090","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.carbpol.2017.08.131","article-title":"Chitosan\/kaolin composite porous microspheres with high hemostatic efficacy","volume":"177","author":"Sun","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0095","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.ijbiomac.2017.02.007","article-title":"Encapsulation of testosterone by chitosan nanoparticles","volume":"98","author":"Chanphai","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0100","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.carbpol.2017.08.039","article-title":"Chitosan composite hydrogels reinforced with natural clay nanotubes","volume":"175","author":"Huang","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0105","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.carbpol.2014.09.019","article-title":"Preparation, characterization and in vitro digestibility of gellan and chitosan\u2013gellan microgels","volume":"117","author":"Vilela","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0110","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ijbiomac.2017.07.081","article-title":"Co-immobilization of Pd and Zn nanoparticles in chitosan\/silica membranes for efficient, recyclable catalysts used in Ullmann reaction","volume":"105","author":"Liu","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0115","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1016\/j.molcatb.2016.12.007","article-title":"Dextransucrase immobilized on activated-chitosan particles as a novel biocatalyst","volume":"133","author":"Graebin","year":"2016","journal-title":"J. Mol. Catal. B Enzym."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0120","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ijpharm.2013.03.021","article-title":"Development and evaluation of a novel phytosome-loaded chitosan microsphere system for curcumin delivery","volume":"448","author":"Zhang","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0125","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jddst.2017.03.023","article-title":"Montmorillonite nanoclay as a multifaceted drug-delivery carrier: a review","volume":"39","author":"Jayrajsinh","year":"2017","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0130","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/10601325.2014.864920","article-title":"Preparation, characterization and drug release studies from poly (d, l-lactic acid)\/organoclay nanocomposite films","volume":"51","author":"Stathokostopoulou","year":"2014","journal-title":"J. Macromol. Sci. A"},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0135","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jddst.2016.03.010","article-title":"Development of poly (2-hydroxyethyl methacrylate)\/clay composites as drug delivery systems of paracetamol","volume":"33","author":"Bounabi","year":"2016","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0140","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1007\/s10904-013-9890-1","article-title":"Drug release behavior and antitumor efficiency of 5- ASA loaded chitosan-layered silicate nanocomposites","volume":"23","author":"Salahuddin","year":"2013","journal-title":"J. Inorg. Organomet. Polym. Mater."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0145","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.colsurfb.2013.07.008","article-title":"Evaluation of clay\/poly(l-lactide) microcomposites as anticancer drug, 6-mercaptopurine reservoir through in vitro cytotoxicity, oxidative stress markers and in vivo pharmacokinetics","volume":"112","author":"Kevadiya","year":"2013","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0150","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1177\/0883911514557014","article-title":"Natural alginate biopolymer montmorillonite clay composites for vitamin B2 delivery","volume":"30","author":"Kaygusuz","year":"2015","journal-title":"J. Bioact. Compat. Polym."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0155","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.2147\/IJN.S122747","article-title":"A novel ion-exchange carrier based upon liposome-encapsulated montmorillonite for ophthalmic delivery of betaxolol hydrochloride","volume":"12","author":"Huang","year":"2017","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0160","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ijpharm.2015.06.049","article-title":"Gastroretentive montmorillonite-tetracycline nanoclay for the treatment of Helicobacter pylori infection","volume":"493","author":"Iannuccelli","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0165","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.clay.2011.11.006","article-title":"In vitro biocompatibility and mucoadhesion of montmorillonite chitosan nanocomposite: a new drug delivery","volume":"55","author":"Salcedo","year":"2012","journal-title":"Appl. Clay Sci."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0170","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.colsurfa.2016.12.051","article-title":"Characterization of chitosan\/montmorillonite bionanocomposites by inverse gas chromatography","volume":"516","author":"Bensalema","year":"2017","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0175","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.pnsc.2012.07.008","article-title":"Influence of chitosan characteristics on the properties of biopolymeric chitosan\u2013montmorillonite","volume":"22","author":"Lertsutthiwongn","year":"2012","journal-title":"Prog. Nat. Sci.: Mater. Int."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0180","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.colsurfb.2011.01.030","article-title":"Chitosan microspheres as a delivery system for nasal insufflation","volume":"84","author":"Patil","year":"2011","journal-title":"Colloids Surf. B. Biointerfaces"},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0185","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/ddr.10416","article-title":"Preparation and characterization of drug-loaded chitosan\u2013tripolyphosphate microspheres by spray drying","volume":"64","author":"Desai1","year":"2005","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0190","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.micromeso.2011.11.032","article-title":"Chitosan\u2013montmorillonite bio-based aerogel hybrid microspheres","volume":"152","author":"Ennajih","year":"2012","journal-title":"Microporous Mesoporous Mater."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0195","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijbiomac.2014.04.030","article-title":"Preparation and drug release properties of chitosan\/organomodified palygorskite microspheres","volume":"68","author":"Wu","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0200","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ejps.2016.12.005","article-title":"Phospholipid complex enriched micelles: a novel drug delivery approach for promoting the antidiabetic effect of repaglinide","volume":"99","author":"Kassem","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0205","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0169-409X(01)00112-0","article-title":"Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC)","volume":"48","author":"Siepmann","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0210","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.carbpol.2015.03.064","article-title":"Chitosan-montmorillonite microspheres: a sustainable fertilizer delivery system","volume":"127","author":"dos Santos","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0215","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.carbpol.2016.03.077","article-title":"Insightful understanding of the role of clay topology on the stability of biomimetic hybrid chitosan-clay thin films and CO2-dried porous aerogel microspheres","volume":"146","author":"Frindy","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0220","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.memsci.2007.06.015","article-title":"Crosslinking of chitosan membranes using glutaraldehyde: effect on ion permeability and water absorption","volume":"301","author":"Beppu","year":"2007","journal-title":"J. Membr. Sci."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0225","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.actbio.2008.01.012","article-title":"Drug release behavior of chitosan\u2013montmorillonite nanocomposite hydrogels following electrostimulation","volume":"4","author":"Liu","year":"2008","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0230","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.actbio.2008.08.007","article-title":"Cell proliferation and controlled drug release studies of nanohybrids based on chitosan-g-lactic acid and montmorillonite","volume":"5","author":"Depan","year":"2009","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0235","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.seppur.2015.05.024","article-title":"Swelling\u2013adsorption interactions during mercury and nickel ions removal by chitosan derivatives","volume":"149","author":"Kyzas","year":"2015","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0240","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.clay.2010.07.012","article-title":"Controlled release of ofloxacin from chitosan\u2013montmorillonite hydrogel","volume":"50","author":"Hua","year":"2010","journal-title":"Appl. Clay Sci."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0245","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/jphp.12047","article-title":"Enhanced dissolution and oral bioavailability of tanshinone IIA base by solid dispersion system with low-molecular-weight chitosan","volume":"65","author":"Liu","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0250","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0168-3659(87)90034-4","article-title":"A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs","volume":"5","author":"Ritger","year":"1987","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0255","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ijpharm.2010.12.020","article-title":"Modeling of drug release from bulk-degrading polymers","volume":"418","author":"Lao","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2018.12.072_bb0260","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.colsurfb.2013.11.009","article-title":"Intestinal permeability of oxytetracycline from chitosan-montmorillonite nanocomposites","volume":"117","author":"Salcedo","year":"2014","journal-title":"Colloids Surf. B: Biointerfaces"}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813018358045?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813018358045?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T04:45:39Z","timestamp":1565239539000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813018358045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":52,"alternative-id":["S0141813018358045"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.12.072","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preparation and drug release property of tanshinone IIA loaded chitosan-montmorillonite microspheres","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.12.072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}