{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:33:48Z","timestamp":1792175628601,"version":"4.4.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","award":["USTP-NTUT-TMU-105-03"],"award-info":[{"award-number":["USTP-NTUT-TMU-105-03"]}],"id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006705","name":"National Taipei University of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006705","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.ijbiomac.2018.12.182","type":"journal-article","created":{"date-parts":[[2018,12,23]],"date-time":"2018-12-23T11:37:06Z","timestamp":1545565026000},"page":"141-150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":147,"special_numbering":"C","title":["Development of mutlifunctional nanoparticles self-assembled from trimethyl chitosan and fucoidan for enhanced oral delivery of insulin"],"prefix":"10.1016","volume":"126","author":[{"given":"Li-Chu","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Ho","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Wei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Cheng","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fwu-Long","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0005","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.addr.2012.10.010","article-title":"Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules","volume":"65","author":"Chen","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0010","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.carbpol.2018.02.084","article-title":"Chitosan nanoparticle antigen uptake in epithelial monolayers can predict mucosal but not systemic in vivo immune response by oral delivery","volume":"190","author":"Cole","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0015","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jconrel.2018.07.018","article-title":"Bilayer polymeric nanocapsules: a formulation approach for a thermostable and adjuvanted E. coli antigen vaccine","volume":"286","author":"Crecente-Campo","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0020","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.carbpol.2017.04.066","article-title":"Alginate coated chitosan core-shell nanoparticles for efficient oral delivery of naringenin in diabetic animals-an in vitro and in vivo approach","volume":"170","author":"Maity","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0025","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ijbiomac.2016.07.024","article-title":"Chitosan-based nano-in-microparticle carriers for enhanced oral delivery and anticancer activity of propolis","volume":"92","author":"Elbaz","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0030","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.carbpol.2017.02.096","article-title":"In vitro evaluation of glycol chitosan based formulations as oral delivery systems for efflux pump inhibition","volume":"166","author":"Mandracchia","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0035","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/j.carbpol.2016.11.072","article-title":"Physico-chemical characterization of succinyl chitosan-stabilized liposomes for the oral co-delivery of quercetin and resveratrol","volume":"157","author":"Caddeo","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0040","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.carbpol.2018.03.080","article-title":"Mutlifunctional nanoparticles prepared from arginine-modified chitosan and thiolated fucoidan for oral delivery of hydrophobic and hydrophilic drugs","volume":"193","author":"Chen","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0045","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ijbiomac.2016.10.012","article-title":"Multilayer micro-dispersing system as oral carriers for co-delivery of doxorubicin hydrochloride and P-gp inhibitor","volume":"94","author":"Feng","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0050","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.ijbiomac.2016.06.015","article-title":"Chitosan based nanoparticles as protein carriers for efficient oral antigen delivery","volume":"91","author":"Gao","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijbiomac.2015.12.064","article-title":"Multilayer sodium alginate beads with porous core containing chitosan based nanoparticles for oral delivery of anticancer drug","volume":"85","author":"Li","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0060","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.carbpol.2016.10.021","article-title":"Mechanism of surface charge triggered intestinal epithelial tight junction opening upon chitosan nanoparticles for insulin oral delivery","volume":"157","author":"Wang","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0065","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.carbpol.2015.09.103","article-title":"Positive\/negative surface charge of chitosan based nanogels and its potential influence on oral insulin delivery","volume":"136","author":"Wang","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0070","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.carbpol.2017.10.066","article-title":"N\u2011mercapto acetyl\u2011N\u2032\u2011octyl\u2011O, N\u2033\u2011glycol chitosan as an efficiency oral delivery system of paclitaxel","volume":"181","author":"Huo","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0075","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ijbiomac.2016.07.019","article-title":"Development of amphoteric alginate\/aminated chitosan coated microbeads for oral protein delivery","volume":"92","author":"Omer","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0080","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.ijbiomac.2018.02.016","article-title":"Eudragit (R) L100-coated mannosylated chitosan nanoparticles for oral protein vaccine delivery","volume":"113","author":"Xu","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0085","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.ijbiomac.2018.04.023","article-title":"Fabrication and characterization of genipin cross-linked chitosan\/gelatin hydrogel for pH-sensitive, oral delivery of metformin with an application of response surface methodology","volume":"114","author":"Ubaid","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0090","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.ijbiomac.2017.04.098","article-title":"Oral delivery of ursolic acid-loaded nanostructured lipid carrier coated with chitosan oligosaccharides: development, characterization, in vitro and in vivo assessment for the therapy of leishmaniasis","volume":"102","author":"Das","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0095","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.carbpol.2016.10.041","article-title":"N,N,N\u2011Trimethyl chitosan: an advanced polymer with myriad of opportunities in nanomedicine","volume":"157","author":"Kulkarni","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0100","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jconrel.2017.09.003","article-title":"Potential of insulin nanoparticle formulations for oral delivery and diabetes treatment","volume":"264","author":"Wong","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0105","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jconrel.2018.03.013","article-title":"N\u2011trimethyl chitosan nanoparticles and CSKSSDYQC peptide: N\u2011trimethyl chitosan conjugates enhance the oral bioavailability of gemcitabine to treat breast cancer","volume":"277","author":"Chen","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0110","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.actbio.2017.02.012","article-title":"Trimethyl chitosan based conjugates for oral and intravenous delivery of paclitaxel","volume":"53","author":"He","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0115","article-title":"Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems","author":"Lin","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0120","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jconrel.2015.12.008","article-title":"Efficient mucus permeation and tight junction opening by dissociable \u201cmucus-inert\u201d agent coated trimethyl chitosan nanoparticles for oral insulin delivery","volume":"222","author":"Liu","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0125","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ijpharm.2017.11.020","article-title":"In-vitro and in-vivo cytotoxicity and efficacy evaluation of novel glycyl\u2011glycine and alanyl\u2011alanine conjugates of chitosan and trimethyl chitosan nano-particles as carriers for oral insulin delivery","volume":"535","author":"Omid","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0130","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/j.xphs.2018.02.004","article-title":"In vitro-in vivo evaluation of an oral ghost drug delivery device for the delivery of salmon calcitonin","volume":"107","author":"Hibbins","year":"2018","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0135","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jconrel.2016.05.015","article-title":"Enhancing insulin oral absorption by using mucoadhesive nanoparticles loaded with LMWP-linked insulin conjugates","volume":"233","author":"Sheng","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201800285","article-title":"Uniform core-shell nanoparticles with thiolated hyaluronic acid coating to enhance oral delivery of insulin","volume":"7","author":"Tian","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0145","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.ijbiomac.2016.03.045","article-title":"New nasal nanocomplex self-assembled from charged biomacromolecules: N,N,N\u2011Trimethyl chitosan and dextran sulfate","volume":"88","author":"Kulkarni","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0150","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.carbpol.2017.09.075","article-title":"GABA(B) receptor ligand-directed trimethyl chitosan\/tripolyphosphate nanoparticles and their pMDI formulation for survivin siRNA pulmonary delivery","volume":"179","author":"Ni","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2017.10.010","article-title":"Enhanced antitumor efficacy of arginine modified amphiphilic nanoparticles co-delivering doxorubicin and iSur-pDNA via the multiple synergistic effect","volume":"150","author":"Song","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0160","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jconrel.2017.07.017","article-title":"Diphtheria toxoid and N\u2011trimethyl chitosan layer-by-layer coated pH-sensitive microneedles induce potent immune responses upon dermal vaccination in mice","volume":"262","author":"Schipper","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0165","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.ijbiomac.2016.05.073","article-title":"Preparation and sustainable release of modified konjac glucomannan\/chitosan nanospheres","volume":"91","author":"Shi","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0170","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.carbpol.2017.11.068","article-title":"pH-responsive selenium nanoparticles stabilized by folate-chitosan delivering doxorubicin for overcoming drug-resistant cancer cells","volume":"181","author":"Luesakul","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0175","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.actbio.2016.10.012","article-title":"Co-delivery of doxorubicin and interleukin-2 via chitosan based nanoparticles for enhanced antitumor efficacy","volume":"47","author":"Wu","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0180","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.biomaterials.2016.12.025","article-title":"BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in, peripheral nerve injury","volume":"121","author":"Lopes","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0185","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1021\/bc800076n","article-title":"Oral delivery of peptide drugs using nanoparticles self-assembled by poly(gamma\u2011glutamic acid) and a chitosan derivative functionalized by trimethylation","volume":"19","author":"Mi","year":"2008","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/md15040113","article-title":"Effects of low-molecular-weight fucoidan and high stability fucoxanthin on glucose homeostasis, lipid metabolism, and liver function in a mouse model of type II diabetes","volume":"15","author":"Lin","year":"2017","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0195","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ijbiomac.2015.11.036","article-title":"In vitro and in vivo hypoglycemic effects of brown algal fucoidans","volume":"82","author":"Shan","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tifs.2017.12.001","article-title":"Bioactive compounds from marine macroalgae and their hypoglycemic benefits","volume":"72","author":"Zhao","year":"2018","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0205","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.phytochem.2013.12.003","article-title":"Alpha-amylase and alpha-glucosidase inhibition is differentially modulated by fucoidan obtained from Fucus vesiculosus and Ascophyllum nodosum","volume":"98","author":"Kim","year":"2014","journal-title":"Phytochemistry"},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0210","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ijbiomac.2018.03.127","article-title":"Physico-chemical characterization and beneficial effects of seaweed sulfated polysaccharide against oxydatif and cellular damages caused by alloxan in diabetic rats","volume":"117","author":"Kolsi","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0215","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.ijbiomac.2014.10.013","article-title":"Fucoidan - a alpha\u2011d\u2011glucosidase inhibitor from Sargassum wightii with relevance to type 2 diabetes mellitus therapy","volume":"72","author":"Kumar","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0220","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.ijbiomac.2015.08.065","article-title":"Fucoidan - an alpha-amylase inhibitor from Sargassum wightii with relevance to NIDDM","volume":"81","author":"Senthil","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0225","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ijbiomac.2015.11.036","article-title":"In vitro and in vivo hypoglycemic effects of brown algal fucoidans","volume":"82","author":"Shan","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0230","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.phanu.2015.02.001","article-title":"Molecular weight and sulfate content modulate the inhibition of \u03b1\u2011amylase by fucoidan relevant for type 2 diabetes management","volume":"3","author":"Kim","year":"2015","journal-title":"PharmaNutrition"},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mnfr.201700136","article-title":"Fucoidan ameliorates pancreatic beta-cell death and impaired insulin synthesis in streptozotocin-treated beta cells and mice via a Sirt-1-dependent manner","volume":"61","author":"Yu","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0240","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ijbiomac.2016.05.081","article-title":"Low molecular weight fucoidan modulates P-selectin and alleviates diabetic nephropathy","volume":"91","author":"Xu","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0245","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.3390\/md12063292","article-title":"The protective effect of fucoidan in rats with streptozotocin-induced diabetic nephropathy","volume":"12","author":"Wang","year":"2014","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0250","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ijbiomac.2018.03.127","article-title":"Physico-chemical characterization and beneficial effects of seaweed sulfated polysaccharide against oxydatif and cellular damages caused by alloxan in diabetic rats","volume":"117","author":"Kolsi","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0255","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.ijbiomac.2018.02.072","article-title":"Low molecular weight fucoidan attenuates liver injury via SIRTI\/AMPK\/PGC1 alpha axis in db\/db mice","volume":"112","author":"Zheng","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0260","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/labinvest.2014.12","article-title":"Low-molecular-weight fucoidan protects endothelial function and ameliorates basal hypertension in diabetic Goto-Kakizaki rats","volume":"94","author":"Cui","year":"2014","journal-title":"Lab. Investig."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/420929","article-title":"Low molecular weight fucoidan alleviates cardiac dysfunction in diabetic Goto-Kakizaki rats by reducing oxidative stress and cardiomyocyte apoptosis","author":"Yu","year":"2014","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0270","first-page":"A203-A203","article-title":"Enhanced taste sensitivities in patients with type 2 diabetes receiving an oral preparation of high-molecular-weightfucoidan: fucose-containing sulfated polysaccharides","volume":"66","author":"Sakai","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0275","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2174\/157341311796196862","article-title":"Preparation and antitumor effect of n-trimethylchitosan\/fucoidan ion-complex submicron particles","volume":"7","author":"Hayashi","year":"2011","journal-title":"Curr. Nanosci."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0280","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/jps.2600821205","article-title":"Effects of insulin and acarbose alone and in combination in the female streptozotocin-induced diabetic rat","volume":"82","author":"Katovich","year":"1993","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0285","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2165\/00044011-200323100-00001","article-title":"Effect of add-on acarbose to insulin therapy in routine clinical practice","volume":"23","author":"Klocke","year":"2003","journal-title":"Clin. Drug Investig."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0290","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1046\/j.1463-1326.1999.00021.x","article-title":"Effect of acarbose on additional insulin therapy in type 2 diabetic patients with late failure of sulphonylurea therapy","volume":"1","author":"Standl","year":"1999","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0295","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s005920050151","article-title":"Effects of combination of insulin and acarbose compared with insulin and gliclazide in type 2 diabetic patients","volume":"36","author":"Guvener","year":"1999","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0300","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.2217\/nnm-2017-0055","article-title":"Development of genipin-crosslinked fucoidan\/chitosan\u2011N\u2011arginine nanogels for preventing helicobacter infection","volume":"12","author":"Lin","year":"2017","journal-title":"Nanomedicine"},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0305","doi-asserted-by":"crossref","first-page":"7449","DOI":"10.1016\/j.actbio.2013.04.009","article-title":"Nanoparticle-induced tight-junction opening for the transport of an anti-angiogenic sulfated polysaccharide across Caco-2 cell monolayers","volume":"9","author":"Yu","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0310","doi-asserted-by":"crossref","first-page":"18275","DOI":"10.1021\/am505441p","article-title":"FRET-based dual-emission and pH-responsive nanocarriers for enhanced delivery of protein across intestinal epithelial cell barrier","volume":"6","author":"Lu","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0315","first-page":"3049","article-title":"Hydrophobic ion pairing of an insulin-sodium deoxycholate complex for oral delivery of insulin","volume":"6","author":"Sun","year":"2011","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijbiomac.2018.12.182_bb0320","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.foodhyd.2012.04.014","article-title":"Characterization of tea catechins-loaded nanoparticles prepared from chitosan and an edible polypeptide","volume":"30","author":"Tang","year":"2013","journal-title":"Food Hydrocoll."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813018354916?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813018354916?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:22:42Z","timestamp":1758871362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813018354916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":64,"alternative-id":["S0141813018354916"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.12.182","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of mutlifunctional nanoparticles self-assembled from trimethyl chitosan and fucoidan for enhanced oral delivery of insulin","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.12.182","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}