{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:59:09Z","timestamp":1793228349288,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.ijbiomac.2019.03.019","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T01:55:48Z","timestamp":1551664548000},"page":"928-937","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"special_numbering":"C","title":["Synthesis, characterization and application of copper oxide chitosan nanocomposite for green regioselective synthesis of [1,2,3]triazoles"],"prefix":"10.1016","volume":"130","author":[{"given":"Khaled D.","family":"Khalil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed M.","family":"Riyadh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sobhi M.","family":"Gomha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0005","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s002679900098","article-title":"The pollution prevention act of 1990: a policy whose time has come or symbolic legislation","volume":"22","author":"Burnett","year":"1998","journal-title":"Environ. Manag."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0010","series-title":"Multicomponent Reactions","author":"Zhu","year":"2005"},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0015","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1016\/j.tet.2010.01.084","article-title":"Water as the reaction medium for multicomponent reactions based on boronic acid","volume":"66","author":"Candeias","year":"2010","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0020","doi-asserted-by":"crossref","first-page":"6619","DOI":"10.3390\/molecules15096619","article-title":"Green one pot solvent-free synthesis of pyrano[2,3-c]-pyrazoles and pyrazolo[1,5-a]pyrimidines","volume":"15","author":"Al-Matar","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0025","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0731-7085(01)00575-1","article-title":"Comparative study of the enantiomeric resolution of chiral antifungal drugs econazole, miconazole and sulconazole by HPLC on various cellulose chiral columns in normal phase mode","volume":"27","author":"Aboul-Enein","year":"2002","journal-title":"J. Pharm. & Biomed Anal."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0030","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.talanta.2004.06.012","article-title":"Determination of tadalafil in pharmaceutical preparation by HPLC using monolithic silica column","volume":"65","author":"Aboul-Enein","year":"2005","journal-title":"Talanta"},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0035","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/elps.201300222","article-title":"Advances in chiral separations by non-aqueous capillary electrophoresis in pharmaceutical and biomedical analysis","volume":"35","author":"Ali","year":"2014","journal-title":"Electrophoresis"},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0040","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/bmc.220","article-title":"Entioseparation of some clinically used drugs by HPLC using cellulose tris(3,5-dichlorophenylcarbamate) chiral stationary phase","volume":"17","author":"Ali","year":"2003","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0045","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1080\/00397910701396906","article-title":"D,L-proline catalyzed one-pot synthesis of pyrans and pyrano[2,3-c]pyrazole derivatives by a grinding method under solvent-free conditions","volume":"37","author":"Gou","year":"2007","journal-title":"Synth. Commun."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0050","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.3390\/molecules17044300","article-title":"Organocatalysis in synthesis: l-proline as an enantioselective catalyst in the synthesis of pyrans and thiopyrans","volume":"17","author":"Elnagdi","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0055","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3390\/80700541","article-title":"Microwave assisted synthesis, part 1: rapid solventless synthesis of 3-substituted coumarins and benzocoumarins by microwave irradiation of the corresponding enaminones","volume":"8","author":"Al-Zaydi","year":"2003","journal-title":"Molecules"},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0060","series-title":"Encyclopedia of Surface and Colloid Science","first-page":"136","author":"Gupta","year":"2002"},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0065","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0045-6535(02)00085-1","article-title":"Speciation of arsenic and chromium metal ions by reversed phase high performance liquid chromatography","volume":"48","author":"Ali","year":"2002","journal-title":"Chemosphere"},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0070","doi-asserted-by":"crossref","first-page":"10409","DOI":"10.1080\/19443994.2015.1041164","article-title":"Removal of secbumeton herbicide from water on composite nano adsorbent","volume":"57","author":"Ali","year":"2016","journal-title":"Desal. & Water Treat."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molliq.2017.11.163","article-title":"Artificial neural network modelling of amido black dye sorption on iron composite nanomaterial: kinetics and thermodynamics studies","volume":"250","author":"Ali","year":"2018","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0080","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1007\/s10593-016-1815-9","article-title":"Synthesis and anticancer activity of arylazothiazoles and 1,3,4-thiadiazoles using chitosan-grafted-poly(4-vinylpyridine) as a novel copolymer basic catalyst","volume":"51","author":"Gomha","year":"2015","journal-title":"Chem. Heterocycl. Compds."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0085","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1039\/C5CY01034A","article-title":"A novel, efficient, and recyclable biocatalyst for Michael addition reactions and its iron(III) complex as promoter for alkyl oxidation reactions","volume":"6","author":"Khalil","year":"2016","journal-title":"Catal. Sci. Technol."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0090","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1021\/ol202718d","article-title":"CuO-promoted construction of N-2-aryl-substituted-1,2,3-triazoles via azide-chalcone oxidative cycloaddition and post-triazole arylation","volume":"14","author":"Zhang","year":"2012","journal-title":"Org. Lett."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0095","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.ijbiomac.2018.11.155","article-title":"Preparation and characterization of chitosan\/polyacrylic acid\/copper nanocomposites and their impact on onion production","volume":"123","author":"Abd El-Aziz","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0100","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ijbiomac.2019.01.145","article-title":"Chitosan capped copper oxide\/copper nanoparticles encapsulated microbial resistant nanocomposite films","volume":"128","author":"Jayaramudu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0105","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.ijbiomac.2018.01.092","article-title":"Chitosan-coated cotton cloth supported copper nanoparticles for toxic dye reduction","volume":"111","author":"Awais","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0110","first-page":"539","article-title":"Synthesis and biological activity of 1,2,3-triazoles, Abstracts, 55th Southeast Regional Meeting of the American Chemical Society, Atlanta, GA, United States","volume":"16\u201319","author":"Neill","year":"2003","journal-title":"November"},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0115","doi-asserted-by":"crossref","first-page":"72937","DOI":"10.1039\/C5RA12856K","article-title":"Inhibitory potential of some chalcones on cathepsins B, H and L","volume":"5","author":"Garg","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0120","first-page":"332","article-title":"Synthesis of pyrimidine incorporated piperazine derivatives and their antimicrobial activity","volume":"76","author":"Thriveni","year":"2014","journal-title":"Indian J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0125","first-page":"359","article-title":"Synthesis and biological evaluation of certain new pyrazoline derivatives","volume":"23","author":"Sudheendra","year":"2007","journal-title":"Oriental J. Chem."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0130","first-page":"755","article-title":"Spectrophotometric analysis of bovine serum albumin in presence of synthesized 1-(2\u2032-furyl)-3(substitutedphenyl)-2-propen-1-ones","volume":"2","author":"Raghav","year":"2011","journal-title":"Res. J. Pharm. Biol. Chem. Sci."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0135","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s12272-010-0501-1","article-title":"Antimicrobial activity of new 4,6-disubstituted pyrimidine, pyrazoline, and pyran derivatives","volume":"33","author":"Ramiz","year":"2010","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0140","first-page":"65","article-title":"Synthesis and antimicrobial activities of new triazoles","volume":"18","author":"Tirlapur","year":"2008","journal-title":"Indian J. Heterocycl. Chem."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0145","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.arabjc.2013.04.027","article-title":"Design, synthesis and pharmacological evaluation of some novel derivatives of 1-{[3-(furan-2-yl)-5-phenyl-4,5-dihydro-1,2-oxazol-4-yl]methyl}-4-methyl piperazine","volume":"10","author":"Kumar","year":"2017","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0150","first-page":"23","article-title":"Novel 1, 3, 4-trisubstituted pyrazole derivatives: design, synthesis and biological evaluation as anti-inflammatory\/antimicrobial agents","volume":"22","author":"Abdel-Ghany","year":"2008","journal-title":"Alex. J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0155","doi-asserted-by":"crossref","first-page":"6780","DOI":"10.1016\/j.bmc.2009.02.052","article-title":"Solution-phase parallel synthesis of substituted chalcones and their antiparasitary activity against Giardia lamblia","volume":"17","author":"Montes-Avila","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0160","doi-asserted-by":"crossref","unstructured":"D.P. Singh, B.K. Allam, R.; Singh, K.N. Singh, V.P. Singh, A binuclear Cu(I) complex as a novel catalyst towards the direct synthesis of N-2-aryl-substituted-1,2,3-triazoles from chalcones, RSC Adv. 6 (2016) 15518\u201315524.","DOI":"10.1039\/C5RA27907K"},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0165","doi-asserted-by":"crossref","first-page":"6231","DOI":"10.1007\/s11164-016-2457-3","article-title":"Synthesis of N-2-aryl-substituted 1,2,3-triazoles mediated by magnetic and recoverable CuFe2O4 nanoparticles","volume":"42","author":"Dong","year":"2016","journal-title":"Res. Chem. Intermed."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0170","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0022-0248(02)01571-3","article-title":"Preparation of CuO nanoparticles by microwave irradiation","volume":"244","author":"Wang","year":"2002","journal-title":"J. Crystal Growth"},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0175","first-page":"1179","article-title":"Synthesis of metal oxides nanoparticles under microwave radiation","volume":"94","author":"Pulit-Prociak","year":"2015","journal-title":"Przemysl. Chem."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0180","series-title":"Metal oxide nanoparticles","author":"Corr","year":"2014"},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0185","doi-asserted-by":"crossref","first-page":"(11 pages)","DOI":"10.1155\/2013\/737831","article-title":"Microwave-assisted synthesis of mixed metal-oxide nanoparticles","volume":"2013","author":"Verma","year":"2013","journal-title":"J. Nanopart."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0190","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.stam.2007.07.001","article-title":"Microwave-assisted route for synthesis of nanosized metal oxides","volume":"8","author":"Lagashetty","year":"2007","journal-title":"Sci. Technol. Adv. Mater."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0195","first-page":"410","article-title":"Application of spectroscopic methods for structural analysis of chitin and chitosan","volume":"77","author":"Al Sagheer","year":"2009","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0200","first-page":"5050","article-title":"From copper nanocrystalline to CuO nanoneedle array: synthesis, growth mechanism, and properties","volume":"111","author":"Liu","year":"2007","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0205","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1021\/bm200193u","article-title":"Interplay between structure and dynamics in chitosan films investigated with solid-state NMR, dynamic mechanical analysis, and X-ray diffraction","volume":"12","author":"Gartner","year":"2011","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0210","doi-asserted-by":"crossref","first-page":"7419","DOI":"10.1039\/c3ra22485f","article-title":"An improved iron-mediated synthesis of N-2-aryl substituted 1,2,3-triazoles","volume":"3","author":"Kamal","year":"2013","journal-title":"RSC Adv."},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0215","doi-asserted-by":"crossref","first-page":"8156","DOI":"10.1016\/j.tet.2012.07.080","article-title":"Recyclable clay supported Cu(II) catalyzed tandem one-pot synthesisof 1-aryl-1,2,3-triazoles","volume":"68","author":"Mohammed","year":"2012","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ijbiomac.2019.03.019_bb0220","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jorganchem.2013.10.005","article-title":"Copper catalyzed synthesis of 1-aryl-1,2,3-triazoles from aryl iodides, alkynes, and sodium azide","volume":"749","author":"Chen","year":"2014","journal-title":"J. Organometal. Chem."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813019308621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813019308621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:38:03Z","timestamp":1785775083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813019308621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":44,"alternative-id":["S0141813019308621"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.03.019","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis, characterization and application of copper oxide chitosan nanocomposite for green regioselective synthesis of [1,2,3]triazoles","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.03.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}