{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:22:59Z","timestamp":1787311379588,"version":"build-2736575974"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"International Cooperation Projects of Guangdong Provincial Science and Technology","award":["2015A050502013"],"award-info":[{"award-number":["2015A050502013"]}]},{"name":"Zhejiang Provincial Natural Science and Foundation of China","award":["LGF19E030001"],"award-info":[{"award-number":["LGF19E030001"]}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["QTJ17012"],"award-info":[{"award-number":["QTJ17012"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wenzhou Institute of Biomaterial and Engineering","award":["WIBEZD2017010-03"],"award-info":[{"award-number":["WIBEZD2017010-03"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.ijbiomac.2019.07.152","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T11:55:53Z","timestamp":1564055753000},"page":"933-949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":83,"special_numbering":"C","title":["5-hydroxymethylfurfural-embedded poly (vinyl alcohol)\/sodium alginate hybrid hydrogels accelerate wound healing"],"prefix":"10.1016","volume":"138","author":[{"given":"Fanhui","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conghui","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bae Hoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7193","key":"10.1016\/j.ijbiomac.2019.07.152_bb0005","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nature07039","article-title":"Wound repair and regeneration","volume":"453","author":"Gurtner","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ijbiomac.2019.07.152_bb0010","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jep.2017.06.006","article-title":"Achillea asiatica extract and its active compounds induce cutaneous wound healing","volume":"206","author":"Dorjsembe","year":"2017","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2019.07.152_bb0015","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1021\/acsami.5b09853","article-title":"Bioglass activated skin tissue engineering constructs for wound healing","volume":"8","author":"Yu","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"265","key":"10.1016\/j.ijbiomac.2019.07.152_bb0020","doi-asserted-by":"crossref","first-page":"265sr6","DOI":"10.1126\/scitranslmed.3009337","article-title":"Wound repair and regeneration: mechanisms, signaling, and translation","volume":"6","author":"Eming","year":"2014","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.07.152_bb0025","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00441-016-2434-6","article-title":"MiR-1908 promotes scar formation post-burn wound healing by suppressing ski-mediated inflammation and fibroblast proliferation","volume":"366","author":"Xie","year":"2016","journal-title":"Cell Tissue Res."},{"issue":"2015","key":"10.1016\/j.ijbiomac.2019.07.152_bb0030","article-title":"Application of Antrodia camphorata promotes rat's wound healing in vivo and facilitates fibroblast cell proliferation in vitro","author":"Amin","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"5","key":"10.1016\/j.ijbiomac.2019.07.152_bb0035","doi-asserted-by":"crossref","first-page":"822","DOI":"10.2337\/diacare.21.5.822","article-title":"Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers. A phase III randomized placebo-controlled double-blind study","volume":"21","author":"Wieman","year":"1998","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.07.152_bb0040","first-page":"A18","article-title":"Optimizing the moist wound healing environment","volume":"23","author":"Cullen","year":"2015","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.ijbiomac.2019.07.152_bb0045","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ijbiomac.2012.09.031","article-title":"Development of novel alginate based hydrogel films for wound healing applications","volume":"52","author":"Pereira","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.07.152_bb0050","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.carbpol.2017.08.130","article-title":"In vitro and in vivo evaluation of effectiveness of a novel TEMPO-oxidized cellulose nanofiber-silk fibroin scaffold in wound healing","volume":"177","author":"Shefa","year":"2017","journal-title":"Carbohydr. Polym."},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.07.152_bb0055","article-title":"Hydrogel dressings for treating pressure ulcers","author":"Dumville","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"issue":"5","key":"10.1016\/j.ijbiomac.2019.07.152_bb0060","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.ijbiomac.2011.08.010","article-title":"Photocrosslinkable biodegradable responsive hydrogels as drug delivery systems","volume":"49","author":"Almeida","year":"2011","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2019.07.152_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arabjc.2014.07.005","article-title":"Crosslinked poly(vinyl alcohol) hydrogels for wound dressing applications: a review of remarkably blended polymers","volume":"8","author":"Kamoun","year":"2015","journal-title":"Arab. J. Chem."},{"issue":"5","key":"10.1016\/j.ijbiomac.2019.07.152_bb0070","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1002\/jbm.b.32694","article-title":"A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications","volume":"100b","author":"Baker","year":"2012","journal-title":"J Biomed Mater Res B"},{"issue":"1","key":"10.1016\/j.ijbiomac.2019.07.152_bb0075","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.arabjc.2013.12.003","article-title":"Poly (vinyl alcohol)-alginate physically crosslinked hydrogel membranes for wound dressing applications: characterization and bio-evaluation","volume":"8","author":"Kamoun","year":"2015","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.ijbiomac.2019.07.152_bb0080","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.carbpol.2017.08.070","article-title":"Nanohybrid hydrogels of laponite: PVA-alginate as a potential wound healing material","volume":"176","author":"Golafshan","year":"2017","journal-title":"Carbohydr. Polym."},{"issue":"1\u20132","key":"10.1016\/j.ijbiomac.2019.07.152_bb0085","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ijpharm.2008.03.021","article-title":"Development of polyvinyl alcohol-sodium alginate gel-matrix-based wound dressing system containing nitrofurazone","volume":"359","author":"Kim","year":"2008","journal-title":"Int. J. Pharm."},{"issue":"9","key":"10.1016\/j.ijbiomac.2019.07.152_bb0090","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1177\/0885328218816526","article-title":"Breathable hydrogel dressings containing natural antioxidants for management of skin disorders","volume":"33","author":"Comotto","year":"2019","journal-title":"J. Biomater. Appl."},{"issue":"68","key":"10.1016\/j.ijbiomac.2019.07.152_bb0095","doi-asserted-by":"crossref","first-page":"42900","DOI":"10.1039\/C7RA07555C","article-title":"Glucuronoxylan-mediated silver nanoparticles: green synthesis, antimicrobial and wound healing applications","volume":"7","author":"Muhammad","year":"2017","journal-title":"RSC Adv."},{"issue":"7","key":"10.1016\/j.ijbiomac.2019.07.152_bb0100","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1007\/s11626-017-0150-5","article-title":"Interaction of silver and gold nanoparticles in mammalian cancer: as real topical bullet for wound healing - a comparative study","volume":"53","author":"Sivakumar","year":"2017","journal-title":"In Vitro Cellular & Developmental Biology-Animal"},{"issue":"6","key":"10.1016\/j.ijbiomac.2019.07.152_bb0105","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00217-014-2297-6","article-title":"The anti-inflammatory and wound healing properties of honey","volume":"239","author":"Hadagali","year":"2014","journal-title":"Eur. Food Res. Technol."},{"issue":"7","key":"10.1016\/j.ijbiomac.2019.07.152_bb0110","doi-asserted-by":"crossref","first-page":"60","DOI":"10.7897\/2230-8407.087118","article-title":"Analysis of Manuka (Leptospermum scoparium) honey and development of Chitosan-Manuka honey film for wound dressing applications","volume":"8","author":"L","year":"2017","journal-title":"International Research Journal of Pharmacy"},{"issue":"49","key":"10.1016\/j.ijbiomac.2019.07.152_bb0115","doi-asserted-by":"crossref","first-page":"11865","DOI":"10.1021\/jf403280n","article-title":"Hydroxymethylfurfural: a possible emergent cause of honey bee mortality?","volume":"61","author":"Zirbes","year":"2013","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.07.152_bb0120","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.intimp.2014.10.028","article-title":"5-Hydroxymethylfurfural, an antioxidant agent from Alpinia oxyphylla Miq. improves cognitive impairment in a beta(1-42) mouse model of Alzheimer's disease","volume":"23","author":"Liu","year":"2014","journal-title":"Int. Immunopharmacol."},{"issue":"44","key":"10.1016\/j.ijbiomac.2019.07.152_bb0125","doi-asserted-by":"crossref","first-page":"25021","DOI":"10.1039\/C8RA03980A","article-title":"Experimental study of the protective effect of mesosilica-supported 5-hydroxymethylfurfural on UV-induced aging of human dermal fibroblasts","volume":"8","author":"Niu","year":"2018","journal-title":"RSC Adv."},{"issue":"7","key":"10.1016\/j.ijbiomac.2019.07.152_bb0130","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/ptr.3351","article-title":"5-Hydroxymethylfurfural from black garlic extract prevents TNF alpha-induced monocytic cell adhesion to HUVECs by suppression of vascular cell adhesion molecule-1 expression, reactive oxygen species generation and NF-kappa B activation","volume":"25","author":"Kim","year":"2011","journal-title":"Phytother. Res."},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.07.152_bb0135","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3390\/molecules24020275","article-title":"5-Hydroxymethylfurfural mitigates lipopolysaccharide-stimulated inflammation via suppression of MAPK, NF-kappaB and mTOR activation in RAW 264.7 cells","volume":"24","author":"Kong","year":"2019","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.ijbiomac.2019.07.152_bb0140","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1021\/la4047148","article-title":"Synthesis of monodisperse, quasi-spherical silver nanoparticles with sizes defined by the nature of silver precursors","volume":"30","author":"Li","year":"2014","journal-title":"Langmuir"},{"issue":"1","key":"10.1016\/j.ijbiomac.2019.07.152_bb0145","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bbagen.2018.10.010","article-title":"Biomedical potential of chitosan-silver nanoparticles with special reference to antioxidant, antibacterial, hemolytic and in vivo cutaneous wound healing effects","volume":"1863","author":"Hajji","year":"2019","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.ijbiomac.2019.07.152_bb0150","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.msec.2018.08.027","article-title":"Effect of silver nanoparticles in the induction of apoptosis on human hepatocellular carcinoma (HepG2) cell line","volume":"93","author":"Ahmadian","year":"2018","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"issue":"1","key":"10.1016\/j.ijbiomac.2019.07.152_bb0155","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3177\/jnsv.63.35","article-title":"5-HMF attenuates liver fibrosis in CCl4-plus-alcohol-induced mice by suppression of oxidative stress","volume":"63","author":"Han","year":"2017","journal-title":"J. Nutr. Sci. Vitaminol. (Tokyo)"},{"issue":"22","key":"10.1016\/j.ijbiomac.2019.07.152_bb0160","first-page":"1722","article-title":"5-hydroxymethyl-2-furfural prolongs survival and inhibits oxidative stress in a mouse model of forebrain ischemia","volume":"7","author":"Ya","year":"2012","journal-title":"Neural Regen. Res."},{"issue":"4\u20135","key":"10.1016\/j.ijbiomac.2019.07.152_bb0165","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.addr.2011.01.005","article-title":"Skin tissue engineering--in vivo and in vitro applications","volume":"63","author":"Groeber","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.ijbiomac.2019.07.152_bb0170","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/0022034509359125","article-title":"Factors affecting wound healing","volume":"89","author":"Guo","year":"2010","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.ijbiomac.2019.07.152_bb0175","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2147\/CWCMR.S64905","article-title":"Safety and efficacy of Becaplermin gel in the treatment of diabetic foot ulcers","volume":"1","author":"Bowlby","year":"2014","journal-title":"Chronic Wound Care Management and Research"},{"issue":"1","key":"10.1016\/j.ijbiomac.2019.07.152_bb0180","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13065-018-0408-3","article-title":"5-Hydroxymethylfurfural (HMF) levels in honey and other food products: effects on bees and human health","volume":"12","author":"Shapla","year":"2018","journal-title":"Chem Cent J"},{"issue":"3","key":"10.1016\/j.ijbiomac.2019.07.152_bb0185","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jare.2017.01.005","article-title":"A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings","volume":"8","author":"Kamoun","year":"2017","journal-title":"J. Adv. Res."},{"issue":"3","key":"10.1016\/j.ijbiomac.2019.07.152_bb0190","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1037\/a0035302","article-title":"From stress to inflammation and major depressive disorder: a social signal transduction theory of depression","volume":"140","author":"Slavich","year":"2014","journal-title":"Psychol. Bull."},{"issue":"3","key":"10.1016\/j.ijbiomac.2019.07.152_bb0195","doi-asserted-by":"crossref","first-page":"100","DOI":"10.17795\/jjnpp-9487","article-title":"Evidence for clinical use of honey in wound healing as an anti-bacterial, anti-inflammatory anti-oxidant and anti-viral agent: a review","volume":"8","author":"Yaghoobi","year":"2013","journal-title":"Jundishapur J Nat Pharm Prod"},{"issue":"5","key":"10.1016\/j.ijbiomac.2019.07.152_bb0200","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1007\/s13197-017-2525-8","article-title":"Protective effects of tetrahydrocurcumin (THC) on fibroblast and melanoma cell lines in vitro: it's implication for wound healing","volume":"54","author":"Trivedi","year":"2017","journal-title":"J. Food Sci. Technol."},{"issue":"8","key":"10.1016\/j.ijbiomac.2019.07.152_bb0205","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.semcdb.2012.08.011","article-title":"Mesenchymal-epithelial interactions during hair follicle morphogenesis and cycling","volume":"23","author":"Sennett","year":"2012","journal-title":"Semin. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.07.152_bb0210","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.tcb.2014.10.001","article-title":"Understanding fibroblast heterogeneity in the skin","volume":"25","author":"Driskell","year":"2015","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ijbiomac.2019.07.152_bb0215","first-page":"373","article-title":"Silver nanoparticles\/chitosan oligosaccharide\/poly(vinyl alcohol) nanofiber promotes wound healing by activating TGFbeta1\/Smad signaling pathway","volume":"11","author":"Li","year":"2016","journal-title":"Int. J. Nanomedicine"}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813019347683?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813019347683?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T08:03:34Z","timestamp":1723190614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813019347683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":43,"alternative-id":["S0141813019347683"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.07.152","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"5-hydroxymethylfurfural-embedded poly (vinyl alcohol)\/sodium alginate hybrid hydrogels accelerate wound healing","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.07.152","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}