{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:54:20Z","timestamp":1793228060292,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"International Collaboration of Department of Science and Technology in Jilin Province","award":["20180414065GH"],"award-info":[{"award-number":["20180414065GH"]}]},{"name":"Bethune Plan of Department of Medicine in Jilin University"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.ijbiomac.2019.09.185","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T12:36:08Z","timestamp":1571920568000},"page":"944-949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"special_numbering":"C","title":["Codonopsis lanceolata polysaccharide CLPS alleviates high fat\/high sucrose diet-induced insulin resistance via anti-oxidative stress"],"prefix":"10.1016","volume":"145","author":[{"given":"Yandong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehai","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2019.09.185_b0005","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.phymed.2017.12.028","article-title":"Codonopsis lanceolata extract prevents hypertension in rats","volume":"39","author":"Han","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0010","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/ptr.5553","article-title":"Codonopsis lanceolata: a review of its therapeutic potentials","volume":"30","author":"Hossen","year":"2016","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0015","doi-asserted-by":"crossref","first-page":"4663","DOI":"10.3390\/nu6114663","article-title":"Codonopsis lanceolata extract prevents diet-induced obesity in C57BL\/6 mice","volume":"6","author":"Lee","year":"2014","journal-title":"Nutrients"},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0020","doi-asserted-by":"crossref","first-page":"e1200","DOI":"10.3390\/nu9111200","article-title":"Codonopsis lanceolata water extract increases hepatic insulin sensitivity in rats with experimentally-induced type 2 diabetes","volume":"9","author":"Jeong","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0025","doi-asserted-by":"crossref","first-page":"e210297","DOI":"10.1155\/2013\/210297","article-title":"Antiobesity effect of Codonopsis lanceolata in high-calorie\/high-fat-diet-induced obese rats","volume":"2013","author":"Choi","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0030","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ijbiomac.2017.05.093","article-title":"Codonopsis lanceolata polysaccharide CLPS inhibits melanoma metastasis via regulating integrin signaling","volume":"103","author":"Liu","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0035","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrm2327","article-title":"Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes","volume":"9","author":"Muoio","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0040","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/nature05482","article-title":"Mechanisms linking obesity to insulin resistance and type 2 diabetes","volume":"444","author":"Kahn","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0045","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.lfs.2016.02.002","article-title":"Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies","volume":"148","author":"Rani","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0050","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1152\/physrev.00024.2006","article-title":"Disordered lipid metabolism and the pathogenesis of insulin resistance","volume":"87","author":"Savage","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0055","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.cca.2015.07.009","article-title":"Natural Nrf2 activators in diabetes","volume":"448","author":"Jim\u00e9nez-Osorio","year":"2015","journal-title":"Clin. Chim. Acta."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0060","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.abb.2014.12.012","article-title":"The Keap1-Nrf2 system and diabetes mellitus","volume":"566","author":"Uruno","year":"2015","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0065","doi-asserted-by":"crossref","first-page":"e4826724","DOI":"10.1155\/2017\/4826724","article-title":"The Nrf2\/Keap1\/ARE pathway and oxidative stress as a therapeutic target in type II diabetes mellitus","volume":"2017","author":"David","year":"2017","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0070","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1038\/s41591-018-0222-4","article-title":"Gut microbiota and intestinal FXR mediate the clinical benefits of metformin","volume":"24","author":"Sun","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0075","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.ijbiomac.2014.09.060","article-title":"A polysaccharide extract of mulberry leaf ameliorates hepatic glucose metabolism and insulin signaling in rats with type 2 diabetes induced by high fat-diet and streptozotocin","volume":"72","author":"Ren","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0080","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.ijbiomac.2016.03.028","article-title":"Schisandra polysaccharide increased glucose consumption by up-regulating the expression of GLUT-4","volume":"87","author":"Jin","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0085","first-page":"567","article-title":"Oxidative stress, insulin signaling, and diabetes, Free Radic","volume":"50","author":"Rains","year":"2011","journal-title":"Biol, Med."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0090","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1089\/ars.2005.7.1553","article-title":"Proposed mechanisms for the induction of insulin resistance by oxidative stress","volume":"7","author":"Bloch-Damti","year":"2005","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0095","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2337\/db06-S002","article-title":"Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction","volume":"55","author":"Morino","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0100","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.freeradbiomed.2008.04.029","article-title":"Fatty acids as modulators of the cellular production of reactive oxygen species","volume":"45","author":"Sch\u00f6nfeld","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0105","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/MED.0b013e3283444b09","article-title":"Obesity, insulin resistance and free fatty acids","volume":"18","author":"Boden","year":"2011","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0110","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1210\/er.2001-0039","article-title":"Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes","volume":"23","author":"Evans","year":"2002","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0115","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0076-6879(02)48630-2","article-title":"Redox potential of GSH\/GSSG couple: Assay and biological significance","volume":"348","author":"Jones","year":"2002","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0120","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.numecd.2009.06.002","article-title":"A novel component of the metabolic syndrome: the oxidative stress","volume":"20","author":"Hopps","year":"2010","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0125","doi-asserted-by":"crossref","first-page":"e1600433","DOI":"10.1002\/mnfr.201600433","article-title":"A mix of apple pomace polysaccharide improves mitochondrial function and reduces oxidative stress in the liver of high-fat diet-induced obese mice","volume":"61","author":"Chen","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0130","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1128\/MCB.00225-13","article-title":"The Keap1-Nrf2 system prevents onset of diabetes mellitus","volume":"33","author":"Uruno","year":"2013","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0135","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.redox.2013.06.001","article-title":"Glucose availability is a decisive factor for Nrf2-mediated gene expression","volume":"1","author":"Heiss","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0140","doi-asserted-by":"crossref","first-page":"e145641","DOI":"10.1155\/2014\/145641","article-title":"Dietary Lycium barbarum polysaccharide induces Nrf2\/ARE pathway and ameliorates insulin resistance induced by high-fat via activation of PI3K\/AKT signaling","volume":"2014","author":"Yang","year":"2014","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0145","doi-asserted-by":"crossref","first-page":"e4050","DOI":"10.3390\/ijms19124050","article-title":"Fucoidan alleviates acetaminophen-induced hepatotoxicity via oxidative stress inhibition and Nrf2 translocation","volume":"19","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0150","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.ijbiomac.2018.08.148","article-title":"Polysaccharide FMP-1 from Morchella esculenta attenuates cellular oxidative damage in human alveolar epithelial A549 cells through PI3K\/AKT\/Nrf2\/HO-1 pathway","volume":"120","author":"Li","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0155","doi-asserted-by":"crossref","first-page":"e1111","DOI":"10.3390\/nu9101111","article-title":"Dietary anthocyanins and insulin resistance: When food becomes a medicine","volume":"9","author":"Belwal","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.ijbiomac.2019.09.185_b0160","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2174\/157339911794940729","article-title":"Antioxidants in the treatment of diabetes","volume":"7","author":"Golbidi","year":"2011","journal-title":"Curr. Diabetes Rev."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813019358234?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813019358234?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:50:29Z","timestamp":1758873029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813019358234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":32,"alternative-id":["S0141813019358234"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.09.185","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Codonopsis lanceolata polysaccharide CLPS alleviates high fat\/high sucrose diet-induced insulin resistance via anti-oxidative stress","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.09.185","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}