{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T17:28:00Z","timestamp":1794331680692,"version":"4.9.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31670978\/31370991\/21676041"],"award-info":[{"award-number":["31670978\/31370991\/21676041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.ijbiomac.2019.09.189","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T12:01:29Z","timestamp":1571918489000},"page":"985-997","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":264,"special_numbering":"C","title":["Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation"],"prefix":"10.1016","volume":"145","author":[{"given":"Wenfang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeren","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongyi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kedong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2019.09.189_b0005","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.biomaterials.2018.04.027","article-title":"Combinational strategy for high-performance cancer chemotherapy","volume":"171","author":"Qin","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0010","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ijbiomac.2019.04.062","article-title":"Physicochemical, scavenging and anti-proliferative analyses of polysaccharides extracted from psyllium (Plantago ovata Forssk) husk and seeds","volume":"133","author":"Patel","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0015","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.carbpol.2019.01.064","article-title":"Polysaccharides as potential anticancer agents \u2013 a review of their progress","volume":"210","author":"Khan","year":"2019","journal-title":"Carbohyd. Polym."},{"issue":"11","key":"10.1016\/j.ijbiomac.2019.09.189_b0020","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1039\/c2fo10279j","article-title":"Antitumor activity of mushroom polysaccharides: a review","volume":"3","author":"Ren","year":"2012","journal-title":"Food Funct."},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0025","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.foodhyd.2016.03.030","article-title":"Recent advances in bioactive polysaccharides from Lycium barbarum L., Zizyphus jujuba Mill, Plantago spp., and Morus spp.: structures and functionalities","volume":"60","author":"Xie","year":"2016","journal-title":"Food Hydrocolloid."},{"issue":"5","key":"10.1016\/j.ijbiomac.2019.09.189_b0030","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/CEJ.0000000000000204","article-title":"Ganoderma: insights into anticancer effects","volume":"25","author":"Kladar","year":"2015","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0035","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.ijbiomac.2018.12.268","article-title":"Apoptosis of human gastric carcinoma MGC-803 cells induced by a novel Astragalus membranaceus polysaccharide via intrinsic mitochondrial pathways","volume":"126","author":"Yu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"11","key":"10.1016\/j.ijbiomac.2019.09.189_b0040","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ijbiomac.2013.09.016","article-title":"Antitumor and immunomodulatory activity of Astragalus membranaceus polysaccharides in H22 tumor-bearing mice","volume":"62","author":"Yang","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.ijbiomac.2019.09.189_b0045","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1007\/s12032-011-0068-9","article-title":"Astragalus polysaccharide injection integrated with vinorelbine and cisplatin for patients with advanced non-small cell lung cancer: effects on quality of life and survival","volume":"29","author":"Guo","year":"2012","journal-title":"Med. Oncol."},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0050","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.msec.2019.01.025","article-title":"Anti-tumor potential of astragalus polysaccharides on breast cancer cell line mediated by macrophage activation","volume":"98","author":"Li","year":"2019","journal-title":"Mater. Sci. Eng. C-Mater."},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0055","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ijbiomac.2018.04.049","article-title":"Composition characterization, antioxidant capacities and anti-proliferative effects of the polysaccharides isolated from Trametes lactinea (Berk.) Pat","volume":"115","author":"He","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2019.09.189_b0060","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3390\/cells8040297","article-title":"Deubiquitinase DUB3 regulates cell cycle progression via stabilizing cyclin a for proliferation of non-small cell lung cancer cells","volume":"8","author":"Hu","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0065","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.biomaterials.2018.06.020","article-title":"Nanoformulated ABT-199 to effectively target Bcl-2 at mitochondrial membrane alleviates airway inflammation by inducing apoptosis","volume":"192","author":"Tian","year":"2019","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.09.189_b0070","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.cell.2018.09.007","article-title":"Immune checkpoint inhibition overcomes ADCP-induced immunosuppression by macrophages","volume":"175","author":"Su","year":"2018","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.ijbiomac.2019.09.189_b0075","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.ijbiomac.2014.05.045","article-title":"Anti-tumor and macrophage activation induced by alkali-extracted polysaccharide from Pleurotus ostreatus","volume":"69","author":"Kong","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2019.09.189_b0080","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ccr.2013.11.011","article-title":"Hepatic RIG-I predicts survival and interferon-\u03b1 therapeutic response in hepatocellular carcinoma","volume":"25","author":"Jin","year":"2014","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.ijbiomac.2019.09.189_b0085","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.foodchem.2009.05.069","article-title":"Polysaccharides from Turbinaria conoides: structural features and antioxidant capacity","volume":"118","author":"Chattopadhyay","year":"2010","journal-title":"Food Chem."},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0090","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.ijbiomac.2017.11.059","article-title":"Purification, molecular properties, structural characterization, and immunomodulatory activities of water soluble polysaccharides from Sargassum angustifolium","volume":"109","author":"Borazjani","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.09.189_b0095","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3390\/molecules22020257","article-title":"\u03b2-Glucans: relationships between modification, conformation and functional activities","volume":"22","author":"Qiang","year":"2017","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.ijbiomac.2019.09.189_b0100","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2174\/0929867003374705","article-title":"Immunomodulation and anti-cancer activity of polysaccharide-protein complexes","volume":"7","author":"Ooi","year":"2000","journal-title":"Curr. Med. Chem."},{"issue":"25","key":"10.1016\/j.ijbiomac.2019.09.189_b0105","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ijbiomac.2014.05.005","article-title":"Exopolysaccharides from lactic acid bacteria: structural analysis, molecular weight effect on immunomodulation","volume":"68","author":"Surayot","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.ijbiomac.2019.09.189_b0110","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nnano.2008.30","article-title":"Nanoparticle-mediated cellular response is size-dependent","volume":"3","author":"Jiang","year":"2008","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0115","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ijbiomac.2018.04.059","article-title":"The structure changes of water-soluble polysaccharides in papaya during ripening","volume":"115","author":"John","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0120","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.carbpol.2016.12.068","article-title":"Preparation, complexation mechanism and properties of nano-complexes of Astragalus polysaccharide and amphiphilic chitosan derivatives","volume":"161","author":"Lai","year":"2017","journal-title":"Carbohyd. Polym."},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.09.189_b0125","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ijbiomac.2013.12.002","article-title":"Structural features and biological activities of the polysaccharides from Astragalus membranaceus","volume":"64","author":"Jin","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2019.09.189_b0130","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.carbpol.2011.04.020","article-title":"Structural analysis and anti-tumor activity comparison of polysaccharides from Astragalus","volume":"85","author":"Zhu","year":"2011","journal-title":"Carbohyd. Polym."},{"issue":"1","key":"10.1016\/j.ijbiomac.2019.09.189_b0135","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.phymed.2005.09.002","article-title":"Immunostimulatory principles from yrenoidosa\u2014Part 1: Isolation and biological assessment in vitro","volume":"14","author":"Kralovec","year":"2007","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0140","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3389\/fphys.2019.00418","article-title":"Astragalus and ginseng polysaccharides improve developmental, intestinal morphological, and immune functional characters of weaned piglets","volume":"10","author":"Yang","year":"2019","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.09.189_b0145","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/cancers11020128","article-title":"Karnofsky performance status as a predictive factor for cancer-related fatigue treatment with Astragalus polysaccharides (PG2) injection-a double blind, multi-center, randomized phase IV study","volume":"11","author":"Wang","year":"2019","journal-title":"Cancers"},{"issue":"47","key":"10.1016\/j.ijbiomac.2019.09.189_b0150","doi-asserted-by":"crossref","first-page":"7079","DOI":"10.3748\/wjg.v18.i47.7079","article-title":"Astragalus polysaccharides can regulate cytokine and P-glycoprotein expression in H22 tumor-bearing mice","volume":"18","author":"Tian","year":"2012","journal-title":"World J. Gastroentero."},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0155","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.fct.2018.07.044","article-title":"Licochalcone A from licorice root, an inhibitor of human hepatoma cell growth via induction of cell apoptosis and cell cycle arrest","volume":"120","author":"Wang","year":"2018","journal-title":"Food Chem. Toxicol."},{"issue":"7015","key":"10.1016\/j.ijbiomac.2019.09.189_b0160","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/nature03095","article-title":"Targeted cancer therapy","volume":"432","author":"Sawyers","year":"2004","journal-title":"Nature"},{"issue":"6835","key":"10.1016\/j.ijbiomac.2019.09.189_b0165","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/35077213","article-title":"Proliferation, cell cycle and apoptosis in cancer","volume":"411","author":"Evan","year":"2001","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.09.189_b0170","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.3390\/ijms16022942","article-title":"A time to kill: targeting apoptosis in cancer","volume":"16","author":"Koff","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0175","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.carbpol.2017.01.062","article-title":"Selective estrogen receptor modulator: a novel polysaccharide from Sparganii Rhizoma induces apoptosis in breast cancer cells","volume":"163","author":"Wu","year":"2017","journal-title":"Carbohyd. Polym."},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0180","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ijbiomac.2018.10.169","article-title":"Ginger polysaccharides induced cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells","volume":"123","author":"Wang","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.09.189_b0185","first-page":"90","article-title":"Measuring apoptosis by microscopy and flow cytometry","volume":"61","author":"Henry","year":"2013","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0190","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.carbpol.2019.03.059","article-title":"Purification of an acidic polysaccharide from Suaeda salsa plant and its anti-tumor activity by activating mitochondrial pathway in MCF-7 cells","volume":"215","author":"Liu","year":"2019","journal-title":"Carbohyd. Polym."},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0195","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.procbio.2018.02.014","article-title":"Sulfated polysaccharides from Padina tetrastromatica induce apoptosis in HeLa cells through ROS triggered mitochondrial pathway","volume":"68","author":"Jose","year":"2018","journal-title":"Process Biochem."},{"issue":"1","key":"10.1016\/j.ijbiomac.2019.09.189_b0200","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrm2308","article-title":"The BCL-2 protein family: opposing activities that mediate cell death","volume":"9","author":"Youle","year":"2008","journal-title":"Nat. Rev. Mol. Cell Bio."},{"issue":"7","key":"10.1016\/j.ijbiomac.2019.09.189_b0205","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nrm2434","article-title":"Cytochrome c: functions beyond respiration","volume":"9","author":"Ow","year":"2008","journal-title":"Nat. Rev. Mol. Cell Bio."},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0210","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ijbiomac.2018.10.077","article-title":"Purification and characterization a polysaccharide from Hedyotis diffusa and its apoptosis inducing activity toward human lung cancer cell line A549","volume":"122","author":"Lin","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"8","key":"10.1016\/j.ijbiomac.2019.09.189_b0215","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jep.2015.12.060","article-title":"TLR-4 may mediate signaling pathways of Astragalus polysaccharide RAP induced cytokine expression of RAW264.7 cells","volume":"179","author":"Wei","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0220","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.biopha.2018.01.140","article-title":"Astragalus polysaccharide enhanced antitumor effects of Apatinib in gastric cancer AGS cells by inhibiting AKT signalling pathway","volume":"100","author":"Wu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0225","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.carbpol.2015.05.079","article-title":"Structure-function relationships of immunostimulatory polysaccharides: a review","volume":"132","author":"Ferreira","year":"2015","journal-title":"Carbohyd. Polym."},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0230","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.carbpol.2018.04.100","article-title":"Dose matters: direct killing or immunoregulatory effects of natural polysaccharides in cancer treatment","volume":"195","author":"Pang","year":"2018","journal-title":"Carbohyd. Polym."},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0235","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.ijbiomac.2015.10.083","article-title":"Anti-tumor and immunomodulatory activity of selenium (Se)-polysaccharide from Se-enriched Grifola frondosa","volume":"82","author":"Mao","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"issue":"8","key":"10.1016\/j.ijbiomac.2019.09.189_b0240","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.4049\/jimmunol.0803989","article-title":"Induction of tumor cell apoptosis or necrosis by conditional expression of cell death proteins: analysis of cell death pathways and in vitro immune stimulatory potential","volume":"182","author":"Lohmann","year":"2009","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2019.09.189_b0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0162-3109(99)00124-1","article-title":"The immunostimulating activities of anti-tumor polysaccharide from K1 capsular (polysaccharide) antigen isolated from Klebsiella pneumoniae","volume":"46","author":"Ho","year":"2000","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0250","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.ijbiomac.2018.06.153","article-title":"Synthesis and evaluation of a novel water-soluble high Se-enriched Astragalus polysaccharide nanoparticles","volume":"118","author":"Meng","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.09.189_b0255","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ijbiomac.2018.01.168","article-title":"Antitumor activity and underlying mechanism of Sargassum fusiforme polysaccharides in CNE-bearing mice","volume":"112","author":"Fan","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"10","key":"10.1016\/j.ijbiomac.2019.09.189_b0260","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.2217\/nnm-2018-0390","article-title":"Immunoactive polysaccharide functionalized gold nanocomposites promote dendritic cell stimulation and antitumor effects","volume":"14","author":"Pang","year":"2019","journal-title":"Nanomedicine"},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.09.189_b0265","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.canlet.2012.04.003","article-title":"DNA damage induces the IL-6\/STAT3 signaling pathway, which has anti-senescence and growth-promoting functions in human tumors","volume":"323","author":"Yun","year":"2012","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.ijbiomac.2019.09.189_b0270","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.carbpol.2013.12.002","article-title":"Antitumor and immunomodulatory effects of a water-soluble polysaccharide from Lilii Bulbus in mice","volume":"102","author":"Sun","year":"2014","journal-title":"Carbohyd. Polym."},{"issue":"15","key":"10.1016\/j.ijbiomac.2019.09.189_b0275","doi-asserted-by":"crossref","first-page":"8633","DOI":"10.1073\/pnas.96.15.8633","article-title":"CD4+ T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-?","volume":"96","author":"Mumberg","year":"1999","journal-title":"P. Natl. Acad. Sci. USA"}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014181301936369X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014181301936369X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:50:53Z","timestamp":1758873053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014181301936369X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":55,"alternative-id":["S014181301936369X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.09.189","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.09.189","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}