{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:32:04Z","timestamp":1793035924251,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005283","name":"Funda\u00e7\u00e3o Cearense de Apoio ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.ijbiomac.2019.09.207","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T11:52:38Z","timestamp":1573473158000},"page":"841-852","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Dioclea violacea lectin modulates the gentamicin activity against multi-resistant strains and induces nefroprotection during antibiotic exposure"],"prefix":"10.1016","volume":"146","author":[{"given":"Valdenice F.","family":"Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.J.","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L.F.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dnane V.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla R.","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L.E.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno A.M.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanius","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ala M.","family":"Leme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Bondan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda T.","family":"Borges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda S.","family":"Cutrim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis C.N.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique D.M.","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudener S.","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2019.09.207_b0005","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/nm1145","article-title":"Antibacterial resistance worldwide: causes, challenges and responses","volume":"10","author":"Levy","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0010","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0891-5520(05)70392-5","article-title":"Antimicrobial resistance in staphylococci. Epidemiology, molecular mechanisms, and clinical relevance","volume":"11","author":"Maranan","year":"1997","journal-title":"Infect. Dis. Clin. North. Am."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0015","doi-asserted-by":"crossref","first-page":"a027029","DOI":"10.1101\/cshperspect.a027029","article-title":"Aminoglycosides: an overview","volume":"6","author":"Krause","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0020","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/07388550802262197","article-title":"Microbial biosynthesis and applications of gentamicin: a critical appraisal","volume":"28","author":"Kumar","year":"2008","journal-title":"Crit. Rev. Biotechnol."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0025","doi-asserted-by":"crossref","first-page":"8399","DOI":"10.1073\/pnas.0803164105","article-title":"Genetic dissection of the biosynthetic route to gentamicin A2 by heterologous expression of its minimal gene set","volume":"105","author":"Park","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0030","doi-asserted-by":"crossref","first-page":"347","DOI":"10.4103\/0300-1652.193861","article-title":"Gentamicin-mediated ototoxicity and nephrotoxicity: A clinical trial study","volume":"57","author":"Saleh","year":"2016","journal-title":"Niger. Med J."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0035","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1590\/S0102-76382006000400015","article-title":"Aminoglycoside nephrotoxicity","volume":"21","author":"Oliveira","year":"2006","journal-title":"Rev. Bras. Cir. Cardiovasc."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0040","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.4155\/fmc.13.80","article-title":"Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections","volume":"5","author":"Labby","year":"2013","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0045","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1039\/C5MD00344J","article-title":"Mechanisms of resistance to aminoglycoside antibiotics: overview and perspectives","author":"Garneau-Tsodikova","year":"2016","journal-title":"Med. Chem. Comm."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0050","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0735-2689(98)00365-7","article-title":"Plant lectins: a composite of several distinct families of structurally and evolutionary related proteins with diverse biological roles","volume":"17","author":"Van Damme","year":"1998","journal-title":"CRC Crit. Rev. Plant Sci."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0055","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.rvsc.2014.01.005","article-title":"Antiproliferative effect of Canavalia brasiliensis lectin on B16F10 cells","volume":"96","author":"Silva","year":"2014","journal-title":"Res. Veterin. Sci."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0060","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.procbio.2013.12.020","article-title":"Mannose-specific legume lectin from the seeds of Dolichos lablab (FRIL) stimulates inflammatory and hypernociceptive processes in mice","volume":"49","author":"Teixeira","year":"2014","journal-title":"Process Biochem."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0065","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ijbiomac.2017.01.092","article-title":"Structural studies of a vasorelaxant lectin from Dioclea reflexa Hook seeds: crystal structure, molecular docking and dynamics","volume":"98","author":"Pinto-Junior","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0070","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.pbb.2014.03.008","article-title":"Antidepressant-like effect of Canavalia brasiliensis (ConBr) lectin in mice: Evidence for the involvement of the glutamatergic system","volume":"122","author":"Rieger","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0075","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.micpath.2018.08.027","article-title":"Antimicrobial potential of Alpinia purpurata lectin (ApuL): Growth inhibitory action, synergistic effects in combination with antibiotics, and antibiofilm activity","volume":"124","author":"Ferreira","year":"2018","journal-title":"Microbial Pathogen."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0080","doi-asserted-by":"crossref","first-page":"e869","DOI":"10.1002\/mbo3.869","article-title":"Looking for alternative treatments for bovine and caprine mastitis: evaluation of the potential of Calliandra surinamensis leaf pinnulae lectin (CasuL), both alone and in combination with antibiotics","author":"Proc\u00f3pio","year":"2019","journal-title":"Microbiologyopen"},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0085","first-page":"23","article-title":"Isolation and partial characterization of a lectin from Dioclea violacea Benth seeds","volume":"8","author":"Moreira","year":"1996","journal-title":"Revista Brasileira de Fisiologia Vegetal, Brasil"},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0090","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.ijbiomac.2018.08.106","article-title":"Anti-glioma properties of DVL, a lectin purified from Dioclea viol\u00e1cea","volume":"120","author":"Nascimento","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0095","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.biochi.2018.12.007","article-title":"Dioclea violacea lectin ameliorates inflammation in the temporomandibular joint of rats by suppressing intercellular adhesion molecule-1 expression","volume":"158","author":"Clemente-Napimoga","year":"2019","journal-title":"Biochimie"},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0100","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.biocel.2013.01.012","article-title":"Crystal structure of Dioclea violacea lectin and a comparative study of vasorelaxant properties with Dioclea rostrata lectin","volume":"45","author":"Bezerra","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0105","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0110","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1104\/pp.59.5.783","article-title":"Purification and partial characterization of a lectin from Phaseolus vulgaris","volume":"59","author":"Moreira","year":"1977","journal-title":"Plant Physiol."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0115","series-title":"Principles of Fluorescence Spectroscopy","author":"Lakowicz","year":"2006"},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0120","series-title":"Twenty Second Informational Supplement (2012)","article-title":"Performance standards for antimicrobial susceptibility testing","author":"CLSI\u2013Clinical and Laboratory Standards Institute","year":"2012"},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0125","first-page":"9","article-title":"Herbal therapy associated with antibiotic therapy: potentiation of the antibiotic activity against methicillin-resistant Staphylococcus aureus by Turnera ulmifolia L","volume":"8","author":"Coutinho","year":"2009","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0130","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0021-9258(18)65610-8","article-title":"A microcolorimetric determination of creatine in urine by the Jaffe reaction","volume":"208","author":"Taussky","year":"1954","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0135","series-title":"Methods of Enzymatic Analysis","first-page":"435","year":"1985"},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0140","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1093\/clinchem\/35.11.2233","article-title":"An improved pyrogallol red-molybdate method for determining total urinary protein","volume":"35","author":"Orsonneau","year":"1989","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0145","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0076-6879(94)33021-2","article-title":"Ferrous ion oxidation in presence of ferric ion indicator xylenol orange for measurement of hydroperoxides","volume":"233","author":"Wolff","year":"1994","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0150","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1021\/acschembio.5b01070","article-title":"Structural analysis of the tobramycin and gentamicin clinical resistome reveals limitations for next-generation aminoglycoside design","volume":"20","author":"Bassenden","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0155","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1021\/jm051197e","article-title":"MolDock: a new technique for high accuracy molecular docking","volume":"49","author":"Thomsen","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0160","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1107\/S0907444994003112","article-title":"Project Number 4, The CCP4 suite: programs for crystallography","volume":"50","author":"Computational","year":"1994","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0165","unstructured":"W. Delano, The Pymol Molecular Graphics System, 2002."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0170","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/jemt.22407","article-title":"New sensitive detection method for lectin hemagglutination using microscopy","volume":"77","author":"Adamov\u00e1","year":"2014","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0175","article-title":"The galactose-binding lectin isolated from Vatairea macrocarpa seeds enhances the effect of antibiotics against Staphylococcus aureus-resistant strain","author":"Santos","year":"2019","journal-title":"Probiot. Antimicrob. Proteins"},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0180","doi-asserted-by":"crossref","first-page":"12082","DOI":"10.1074\/jbc.273.20.12082","article-title":"Diocleinae lectins are a group of proteins with conserved binding sites for the core trimannoside of asparagine-linked oligosaccharides and differential specificities for complex carbohydrates","volume":"273","author":"Dam","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0185","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1590\/S0074-02762002000700017","article-title":"Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases","volume":"97","author":"Holetz","year":"2002","journal-title":"Mem\u00f3rias do Inst. Oswaldo Cruz."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0190","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00203-018-1613-0","article-title":"Lectin-based detection of Escherichia coli and Staphylococcus aureus by flow cytometry","volume":"201","author":"Hendrickson","year":"2019","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0195","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1590\/S1678-91992010000300016","article-title":"Purification and biological effects of a C-type lectin isolated from Bothrops moojeni","volume":"16","author":"Barbosa","year":"2010","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0200","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.ijantimicag.2018.09.005","article-title":"Predicting antibiotic combination effects on the selection of resistant Staphylococcus aureus: In vitro model studies with linezolid and gentamicin","volume":"52","author":"Zinner","year":"2018","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0205","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1126\/science.aaj2191","article-title":"Antibiotic tolerance facilitates the evolution of resistance","volume":"355","author":"Levin-Reisman","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0210","first-page":"170","article-title":"Markers of renal function tests","volume":"2","author":"Gowda","year":"2010","journal-title":"N. Am. J. Med."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0215","doi-asserted-by":"crossref","first-page":"e12836","DOI":"10.1111\/jfbc.12836","article-title":"Combinational effect of curcumin and metformin against gentamicin-induced nephrotoxicity: Involvement of antioxidative, anti-inflammatory and antiapoptotic pathway","volume":"43","author":"Cao","year":"2019","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0220","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.tox.2005.07.007","article-title":"Protective effect of lycopene on gentamicin-induced oxidative stress and nephrotoxicity in rats","volume":"215","author":"Karahan","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0225","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3109\/08860229909085109","article-title":"Oxidant mechanisms in gentamicin nephrotoxicity","volume":"21","author":"Walker","year":"1999","journal-title":"Ren. Fail."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0230","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1742-7843.2011.00728.x","article-title":"Experimental gentamicin nephrotoxicity and agents that modify it: a mini-review of recent research","volume":"109","author":"Ali","year":"2011","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0235","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/toxsci\/kfq267","article-title":"An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin","volume":"119","author":"Quiros","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0240","doi-asserted-by":"crossref","first-page":"280","DOI":"10.5935\/0101-2800.20140041","article-title":"Evaluation of the cisplatin nephrotoxicity using the urinary neutrophil gelatinase-associated lipocalin (NGAL) in patients with head and neck cancer","volume":"36","author":"Peres","year":"2014","journal-title":"J. Bras. Nefrol."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0245","first-page":"2573","article-title":"Dioclea violacea lectin ameliorates oxidative stress and renal dysfunction in an experimental model of acute kidney injury","volume":"7","author":"Freitas","year":"2015","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0250","doi-asserted-by":"crossref","first-page":"161","DOI":"10.5935\/0101-2800.20160025","article-title":"Priming prevent nephrotoxic acute renal failure through stimulation of antioxidant defense mechanism","volume":"38","author":"Duarte","year":"2016","journal-title":"Brazil. J. Nephrol."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2011.02.022","article-title":"Preconditioning induced by gentamicin protects against acute kidney injury: the role of prostaglandins but not nitric oxide","volume":"253","author":"Pessoa","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0260","first-page":"2003","article-title":"Oxidative stress, mitochondrial damage and neurodegenerative diseases","volume":"8","author":"Guo","year":"2013","journal-title":"Neural Regen Res."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0265","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1128\/AAC.33.6.797","article-title":"Aminoglycoside-induced hearing loss in humans","volume":"33","author":"Brummett","year":"1989","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0270","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1128\/AAC.43.5.1003","article-title":"Aminoglycosides: nephrotoxicity","volume":"43","author":"Mingeot-Leclercq","year":"1999","journal-title":"Antimicrob. Agents. Chemother."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0275","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/pro.359","article-title":"Computational model of hepatitis B virus DNA polymerase: molecular dynamics and docking to understand resistant mutations","volume":"19","author":"Daga","year":"2010","journal-title":"Protein Sci."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0280","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.abb.2014.11.003","article-title":"CRLI induces vascular smooth muscle relaxation and suggests a dual mechanism of eNOS activation by legume lectins via muscarinic receptors and shear stress","volume":"565","author":"Rocha","year":"2015","journal-title":"Arch Biochem. Biophys."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0285","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ijbiomac.2017.08.023","article-title":"Canavalia bonariensis lectin: Molecular bases of glycoconjugates interaction and antiglioma potential","volume":"106","author":"Cavada","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.09.207_b0290","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.ijbiomac.2014.08.031","article-title":"Structural basis of ConM binding with resveratrol, an anti-inflammatory and antioxidant polyphenol","volume":"72","author":"Rocha","year":"2015","journal-title":"Int. J. Biol. Macromol."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014181301934989X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014181301934989X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:56:32Z","timestamp":1758873392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014181301934989X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":58,"alternative-id":["S014181301934989X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.09.207","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dioclea violacea lectin modulates the gentamicin activity against multi-resistant strains and induces nefroprotection during antibiotic exposure","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.09.207","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}