{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:02:25Z","timestamp":1792508545327,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100008990","name":"Science and Technology Department of Zhejiang Province","doi-asserted-by":"publisher","award":["2018C02045"],"award-info":[{"award-number":["2018C02045"]}],"id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.ijbiomac.2019.10.035","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T19:43:06Z","timestamp":1573760586000},"page":"829-836","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"special_numbering":"C","title":["Apios americana Medik flowers polysaccharide (AFP) alleviate Cyclophosphamide-induced immunosuppression in ICR mice"],"prefix":"10.1016","volume":"144","author":[{"given":"Qiang","family":"Chu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyi","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lushuang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ijbiomac.2019.10.035_b0005","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.cell.2015.02.010","article-title":"Homeostasis, inflammation, and disease susceptibility","volume":"160","author":"Kotas","year":"2015","journal-title":"Cell"},{"issue":"28","key":"10.1016\/j.ijbiomac.2019.10.035_b0010","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1200\/JCO.2015.60.8448","article-title":"Immune-related adverse events, need for systemic immunosuppression, and effects on survival and time to treatment failure in patients with melanoma treated with ipilimumab at memorial sloan kettering cancer center","volume":"33","author":"Horvat","year":"2015","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"issue":"6","key":"10.1016\/j.ijbiomac.2019.10.035_b0015","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.it.2016.04.003","article-title":"Immune dysfunction as a cause and consequence of malnutrition","volume":"37","author":"Bourke","year":"2016","journal-title":"Trends Immunol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2019.10.035_b0020","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/imr.12555","article-title":"Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells","volume":"278","author":"Palomares","year":"2017","journal-title":"Immunol. Rev."},{"issue":"6","key":"10.1016\/j.ijbiomac.2019.10.035_b0025","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1053\/j.ajkd.2015.01.026","article-title":"Transplant immunology and immunosuppression: core curriculum 2015","volume":"65","author":"Hricik","year":"2015","journal-title":"Am. J. Kidney Dis."},{"issue":"3","key":"10.1016\/j.ijbiomac.2019.10.035_b0030","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nri.2017.131","article-title":"Towards personalized, tumour-specific, therapeutic vaccines for cancer","volume":"18","author":"Hu","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.ijbiomac.2019.10.035_b0035","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1002\/cncr.29244","article-title":"Cancer treatments and their side effects are associated with aggravation of insomnia: results of a longitudinal study","volume":"121","author":"Savard","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.ijbiomac.2019.10.035_b0040","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jns.2016.04.002","article-title":"Can aerobic exercise alleviate flu-like symptoms following interferon beta-1a injections in patients with multiple sclerosis?","volume":"365","author":"Langeskov-Christensen","year":"2016","journal-title":"J. Neurol. Sci."},{"issue":"5","key":"10.1016\/j.ijbiomac.2019.10.035_b0045","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1080\/10715762.2019.1613534","article-title":"Radix Tetrastigma flavonoid ameliorates inflammation and prolongs the lifespan of Caenorhabditis elegans through JNK, p38 and Nrf2 pathways","volume":"53","author":"Li","year":"2019","journal-title":"Free Radic Res"},{"issue":"8","key":"10.1016\/j.ijbiomac.2019.10.035_b0050","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.biotechadv.2015.08.001","article-title":"Discovery and resupply of pharmacologically active plant-derived natural products: a review","volume":"33","author":"Atanasov","year":"2015","journal-title":"Biotechnol. Adv."},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.10.035_b0055","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11101-014-9367-z","article-title":"The pharmaceutical industry and natural products: historical status and new trends","volume":"14","author":"David","year":"2015","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.ijbiomac.2019.10.035_b0060","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.ijbiomac.2019.03.012","article-title":"Apios americana Medikus tuber polysaccharide exerts anti-inflammatory effects by activating autophagy","volume":"130","author":"Chu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2019.10.035_b0065","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3390\/molecules21050559","article-title":"The Traditional medicine and modern medicine from natural products","volume":"21","author":"Yuan","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.ijbiomac.2019.10.035_b0070","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.ijbiomac.2016.06.021","article-title":"Immunomodulatory effects of sulfated polysaccharides of pine pollen on mouse macrophages","volume":"91","author":"Geng","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.10.035_b0075","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.ijbiomac.2019.09.039","article-title":"Tetrastigma hemsleyanum tubers polysaccharide ameliorates LPS-induced inflammation in macrophages and Caenorhabditis elegans","volume":"141","author":"Chu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2019.10.035_b0080","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ni.3123","article-title":"Control of adaptive immunity by the innate immune system","volume":"16","author":"Iwasaki","year":"2015","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2019.10.035_b0085","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3390\/molecules23010232","article-title":"Chemical constituents from apios americana and their inhibitory activity on tyrosinase","volume":"23","author":"Kim","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.ijbiomac.2019.10.035_b0090","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.carbpol.2016.05.062","article-title":"Characterization and development mechanism of Apios americana tuber starch","volume":"151","author":"Yangcheng","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2019.10.035_b0095","doi-asserted-by":"crossref","first-page":"34908EP","DOI":"10.1038\/srep34908","article-title":"Genomics-assisted characterization of a breeding collection of Apios americana, an edible tuberous legume","volume":"6","author":"Belamkar","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.ijbiomac.2019.10.035_b0100","doi-asserted-by":"crossref","first-page":"987","DOI":"10.3390\/molecules20010987","article-title":"Isolation and biochemical characterization of Apios tuber lectin","volume":"20","author":"Kenmochi","year":"2015","journal-title":"Molecules"},{"issue":"12","key":"10.1016\/j.ijbiomac.2019.10.035_b0105","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.4014\/jmb.1508.08017","article-title":"Apios americana Medik Extract Alleviates Lung Inflammation in Influenza Virus H1N1- and Endotoxin-Induced Acute Lung Injury","volume":"25","author":"Sohn","year":"2015","journal-title":"J. Microbiol. Biotechnol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2019.10.035_b0110","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1080\/09168451.2015.1127132","article-title":"Biological activities of unique isoflavones prepared from Apios americana Medik","volume":"80","author":"Kaneta","year":"2016","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.ijbiomac.2019.10.035_b0115","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.fct.2018.12.003","article-title":"Apios americana Medik flowers extract protects PC12 cells against H2O2 induced neurotoxicity via regulating autophagy","volume":"124","author":"Chu","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ijbiomac.2019.10.035_b0120","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.ijbiomac.2018.11.078","article-title":"Apios americana Medik flowers polysaccharide (AFP-2) attenuates H2O2 induced neurotoxicity in PC12 cells","volume":"123","author":"Chu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.10.035_b0125","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jep.2016.08.046","article-title":"Immuno-enhancement effects of Yifei Tongluo Granules on cyclophosphamide-induced immunosuppression in Balb\/c mice","volume":"194","author":"Wang","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.ijbiomac.2019.10.035_b0130","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1039\/C6FO00667A","article-title":"Immunostimulatory activity of glycopeptides from Paecilomyces sinensis under normal and cyclophosphamide induced immunosuppressive conditions in mice models","volume":"7","author":"Zhu","year":"2016","journal-title":"Food Funct."},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.10.035_b0135","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.carbpol.2012.03.029","article-title":"Cordyceps militaris polysaccharides can enhance the immunity and antioxidation activity in immunosuppressed mice","volume":"89","author":"Wang","year":"2012","journal-title":"Carbohydr. Polym."},{"issue":"6","key":"10.1016\/j.ijbiomac.2019.10.035_b0140","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nri3843","article-title":"Fever and the thermal regulation of immunity: the immune system feels the heat","volume":"15","author":"Evans","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2019.10.035_b0145","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jsps.2017.04.006","article-title":"Investigation on the immunomodulatory activities of Sarcodon imbricatus extracts in a cyclophosphamide (CTX)-induced immunosuppressanted mouse model","volume":"25","author":"Meng","year":"2017","journal-title":"Saudi Pharm. J."},{"key":"10.1016\/j.ijbiomac.2019.10.035_b0150","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.dci.2016.04.016","article-title":"Analysis of the function of IL-10 in chickens using specific neutralising antibodies and a sensitive capture ELISA","volume":"63","author":"Wu","year":"2016","journal-title":"Dev. Comp. Immunol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2019.10.035_b0155","first-page":"3633","article-title":"The investigation of immunomodulatory activities of Gloeostereum incaratum polysaccharides in cyclophosphamide-induced immunosuppression mice","volume":"15","author":"Wang","year":"2018","journal-title":"Experim. Therap. Med."},{"issue":"4","key":"10.1016\/j.ijbiomac.2019.10.035_b0160","doi-asserted-by":"crossref","first-page":"4173","DOI":"10.1021\/acsnano.5b00396","article-title":"Multiplex serum cytokine immunoassay using nanoplasmonic biosensor microarrays","volume":"9","author":"Chen","year":"2015","journal-title":"ACS Nano"},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.10.035_b0165","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3390\/molecules23020239","article-title":"Immunomodulatory effect of tremella polysaccharides against cyclophosphamide-induced immunosuppression in mice","volume":"23","author":"Zhou","year":"2018","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.ijbiomac.2019.10.035_b0170","doi-asserted-by":"crossref","first-page":"15674","DOI":"10.1038\/ncomms15674","article-title":"Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus","volume":"8","author":"Pantoja","year":"2017","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.ijbiomac.2019.10.035_b0175","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.carbpol.2012.02.055","article-title":"Chemical characterization and immunostimulatory effects of a polysaccharide from Polygoni Multiflori Radix Praeparata in cyclophosphamide-induced anemic mice","volume":"88","author":"Chen","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2019.10.035_b0180","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.ijbiomac.2013.12.029","article-title":"Chemoprotective effects of Ganoderma atrum polysaccharide in cyclophosphamide-induced mice","volume":"64","author":"Yu","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.10.035_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/747543","article-title":"Innate immune defenses in human tuberculosis: an overview of the interactions betweenmycobacterium tuberculosis and innate immune cells","volume":"2015","author":"Sia","year":"2015","journal-title":"J. Immunol. Res."},{"issue":"6","key":"10.1016\/j.ijbiomac.2019.10.035_b0190","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1164\/rccm.201507-1376OC","article-title":"Flow cytometric analysis of mononuclear phagocytes in nondiseased human lung and lung-draining lymph nodes","volume":"193","author":"Desch","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.10.035_b0195","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.carbpol.2012.06.052","article-title":"A polysaccharide from Sargassum fusiforme protects against immunosuppression in cyclophosphamide-treated mice","volume":"90","author":"Chen","year":"2012","journal-title":"Carbohydr. Polym."},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.10.035_b0200","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1631\/jzus.B1500170","article-title":"Immunomodulatory effect of a formula developed from American ginseng and Chinese jujube extracts in mice","volume":"17","author":"Yu","year":"2016","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"10.1016\/j.ijbiomac.2019.10.035_b0205","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.exppara.2015.04.010","article-title":"Immunological, ionic and biochemical responses in blood serum of the marine fish Trachinotus ovatus to poly-infection by Cryptocaryon irritans","volume":"154","author":"Yin","year":"2015","journal-title":"Exp. Parasitol."},{"issue":"9","key":"10.1016\/j.ijbiomac.2019.10.035_b0210","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1039\/C5FO00389J","article-title":"Raspberry pulp polysaccharides inhibit tumor growth via immunopotentiation and enhance docetaxel chemotherapy against malignant melanoma in vivo","volume":"6","author":"Yang","year":"2015","journal-title":"Food Funct."},{"key":"10.1016\/j.ijbiomac.2019.10.035_b0215","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.fct.2016.11.033","article-title":"Ganoderma atrum polysaccharide ameliorates ROS generation and apoptosis in spleen and thymus of immunosuppressed mice","volume":"99","author":"Li","year":"2017","journal-title":"Food Chem. Toxicol."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813019372642?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813019372642?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:00:11Z","timestamp":1778666411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813019372642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":43,"alternative-id":["S0141813019372642"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.10.035","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apios americana Medik flowers polysaccharide (AFP) alleviate Cyclophosphamide-induced immunosuppression in ICR mice","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.10.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}