{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:27:12Z","timestamp":1791196032848,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21571154"],"award-info":[{"award-number":["21571154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20161315"],"award-info":[{"award-number":["BK20161315"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.ijbiomac.2019.10.271","type":"journal-article","created":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T02:04:00Z","timestamp":1574474640000},"page":"1166-1174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Redox response, antibacterial and drug package capacities of chitosan-\u03b1-lipoic acid conjugates"],"prefix":"10.1016","volume":"154","author":[{"given":"Qiang","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghao","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2019.10.271_b0005","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.foodchem.2018.02.018","article-title":"Extraction of crude chitosans from squid (Illexargentinus) pen by acompressional puffing-pretreatment process and evaluation of their antibacterial activity","volume":"254","author":"Huang","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0010","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1021\/bm700701w","article-title":"Extraction and precipitation of chitosan from cell wall of zygomycetes fungi by dilute sulfuric acid","volume":"8","author":"Zamani","year":"2007","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2018.08.054","article-title":"Immunomodulatory properties of chitosan polymers","volume":"184","author":"Moran","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0020","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.foodchem.2018.04.005","article-title":"Effect of gallic acid\/chitosan coating on fresh pork quality in modified atmosphere packaging","volume":"260","author":"Fang","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0025","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1021\/acs.jafc.7b04528","article-title":"Emerging chitosan-based films for food packaging applications","volume":"66","author":"Wang","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0030","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.foodhyd.2019.04.010","article-title":"Influence of chitosan-coating on the stability and digestion of emulsions stabilized by waxy maize starch crystals","volume":"94","author":"Jo","year":"2019","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0035","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.carbpol.2018.08.070","article-title":"Review on recent progress in chitosan-based hydrogels for waste water treatment application","volume":"201","author":"Pakdel","year":"2018","journal-title":"Carbohydr. Polym"},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0040","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1016\/j.biomaterials.2010.12.033","article-title":"A self-assembling hydrophobically modified chitosan capable of reversible hemostatic action","volume":"32","author":"Dowing","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0045","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.memsci.2014.03.044","article-title":"A study on ionic interactions in chitosan-oxalic acid polymer electrolyte membranes","volume":"463","author":"Fadzallah","year":"2014","journal-title":"J. Membr. Sci."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0050","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.msec.2018.12.119","article-title":"Effects of post-processing methods on chitosan-genipin hydrogel properties","volume":"98","author":"Heimbuck","year":"2019","journal-title":"Mater. Sci. Eng. C."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0055","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.carbpol.2015.09.072","article-title":"Composite chitosan hydrogels for extended release of hydrophobic drugs","volume":"136","author":"Delmar","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0060","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.carbpol.2018.05.073","article-title":"Preparation and properties of chitosan\/guar gum\/nanocrystalline cellulose nanocomposite films","volume":"197","author":"Tang","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0065","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ijbiomac.2018.03.106","article-title":"Supramolecular hydrogel formation between chitosan and hydroxypropyl \u03b2-cyclodextrin via Diels-Alder reaction and its drug delivery","volume":"114","author":"Zhang","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0070","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/adfm.201101979","article-title":"Self-assembled nanoparticles with dual effects of passive tumor targeting and cancer-selective anticancer effects","volume":"22","author":"Won","year":"2012","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0075","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/mabi.200900233","article-title":"Reduction-sensitive reversibly crosslinked biodegradable micelles for triggered release of doxorubicin","volume":"9","author":"Xu","year":"2009","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0080","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.colsurfb.2013.07.056","article-title":"Reduction-degradable PEG-b-PAA-b-PEG triblock copolymer micelles incorporated with MTX for cancer chemotherapy","volume":"112","author":"Sun","year":"2014","journal-title":"Colloid. Surf. B."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0085","doi-asserted-by":"crossref","first-page":"34650","DOI":"10.1021\/acsami.7b10027","article-title":"Methotrexate-camptothecin prodrug nanoassemblies as a versatile nanoplatform for biomodalimaging-guided self-active targeted and synergistic chemotherapy","volume":"9","author":"Li","year":"2017","journal-title":"ACS Appl. Mater. Interf."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0090","doi-asserted-by":"crossref","first-page":"105828","DOI":"10.1016\/j.cemconres.2019.105828","article-title":"Rheological properties of ultra-high-performance concrete-an overview","volume":"124","author":"Khayat","year":"2019","journal-title":"Cement Concr. Res."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0095","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1021\/ma400200y","article-title":"Rheological behavior of environmentally friendly castor oil-based waterborne polyurethane dispersions","volume":"46","author":"Madbouly","year":"2013","journal-title":"Macromolecules"},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0100","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1021\/cr300358b","article-title":"Disulfide-cleavage-triggered chemosensors and their biological applications","volume":"113","author":"Lee","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0105","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1021\/ma202282p","article-title":"Reversible inter-and intra-microgel cross-linking using disulfides","volume":"45","author":"Gaulding","year":"2012","journal-title":"Macromolecules"},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0110","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.carbpol.2018.09.074","article-title":"Disulfide bond reconstruction: a novel approach for grafting of thiolated chitosan onto wool","volume":"203","author":"Zhang","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0115","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1021\/jacs.7b00039","article-title":"1,2-Dithiolane-derived dynamic, covalent materials: cooperative self-assembly and reversible cross-linking","volume":"139","author":"Zhang","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0120","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.carbpol.2019.01.030","article-title":"Comparison of the physicochemical, rheological, and morphologic properties of chitosan from four insects","volume":"209","author":"Luo","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0125","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.foodchem.2017.02.035","article-title":"Functionalities of chitosan conjugated with stearic acid and gallic acidand application of the modified chitosan in stabilizing labile aromacompounds in an oil-in-water emulsion","volume":"228","author":"Yang","year":"2017","journal-title":"Food Chem."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0130","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ijbiomac.2015.05.001","article-title":"Neuropharmacokinetic evaluation of methotrexate-loaded chitosan nanogels","volume":"79","author":"Azadi","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0135","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/j.ijbiomac.2018.07.074","article-title":"Development of antibacterial \u03b5-polylysine\/chitosan hybrid films and the effect on citrus","volume":"118","author":"Li","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0140","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.cej.2018.08.181","article-title":"pH responsive antifouling and antibacterial multilayer films with self-healing performance","volume":"356","author":"Hao","year":"2019","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0145","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.carbpol.2017.12.051","article-title":"Fabrication of cellulose nanowhiskers reinforced chitosan-xylan nanocomposite films with antibacterial and antioxidant activities","volume":"184","author":"Bao","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0150","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.colsurfb.2013.12.007","article-title":"Fabrication and evaluation of the novel reduction-sensitive starch nanoparticles for controlled drug release","volume":"115","author":"Jiang","year":"2014","journal-title":"Colloid Surf. B"},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0155","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.ijbiomac.2017.02.008","article-title":"Influence of chitosan concentration on mechanical and barrier properties of corn starch\/chitosan films","volume":"105","author":"Ren","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0160","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.foodchem.2017.02.035","article-title":"Functionalities of chitosan conjugated with stearic acid and gallic acid and application of the modified chitosan in stabilizing labile aroma compounds in an oil-in-water emulsion","volume":"228","author":"Yang","year":"2017","journal-title":"Food Chem."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0165","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.jpcs.2006.01.004","article-title":"Intercalation of amino acids and oligopeptides into Zn-Al layered doublehydroxide by coprecipitation reaction","volume":"67","author":"Aisawa","year":"2006","journal-title":"J. Phys Chem. Solids."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0170","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jddst.2018.12.020","article-title":"Chaulmoogra oil based methotrexate loaded topical nanoemulsion for the treatment of psoriasis","volume":"49","author":"Rajitha","year":"2019","journal-title":"J. Drug. Deliv. Sci. Tech."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0175","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ijbiomac.2017.10.112","article-title":"Anti-psoriatic and toxicity evaluation of methotrexate loaded chitin nanogel in imiquimod induced mice model","volume":"110","author":"Panonnummal","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0180","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1021\/jf404026f","article-title":"Synthesis, characterization, and antimicrobial activity of kojic acid grafted chitosan oligosaccharide","volume":"62","author":"Liu","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0185","doi-asserted-by":"crossref","first-page":"31391","DOI":"10.1039\/C6RA05501J","article-title":"Reduction-responsive core-crosslinked micelles based on a glycol chitosan\u2013lipoic acid conjugate for triggered release of doxorubicin","volume":"6","author":"Zhou","year":"2016","journal-title":"RSC. Adv."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0190","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.foodhyd.2015.07.030","article-title":"Compositional characterization and rheological properties of an anionic gum from Alyssum homolocarpum seeds","volume":"52","author":"Anvari","year":"2016","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0195","doi-asserted-by":"crossref","first-page":"5817","DOI":"10.1021\/acs.iecr.6b00703","article-title":"Rheology test on shear viscosity of surfactant solution: characteristic time, hysteresis phenomenon, and fitting equation","volume":"55","author":"Xu","year":"2016","journal-title":"Ind. Eng. Chem. Res."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0200","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.foodhyd.2011.03.013","article-title":"Rheological properties of Salecan as a new source of thickening agent","volume":"25","author":"Xiu","year":"2011","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0205","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1016\/j.ijbiomac.2018.09.157","article-title":"Surface treatment for imparting solar-reflective thermal insulating properties to cellulosic paper","volume":"120","author":"Mao","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0210","doi-asserted-by":"crossref","first-page":"10338","DOI":"10.1016\/j.biomaterials.2013.09.064","article-title":"Thermosensitive hydrogels based on polypeptides for localized and sustained delivery of anticancer drugs","volume":"34","author":"Cheng","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0215","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.eurpolymj.2018.11.005","article-title":"A transparent, highly stretchable, self-healing polyurethane based on disulfide bonds","volume":"112","author":"Chang","year":"2019","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0220","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.foodhyd.2010.03.009","article-title":"Flow behaviour, linear viscoelasticity and surface properties of chitosan aqueous solutions","volume":"24","author":"Calero","year":"2010","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0225","doi-asserted-by":"crossref","first-page":"8816","DOI":"10.1021\/ma050922s","article-title":"Investigating linear and nonlinear viscoelastic behavior using model silica-particle-filled polybutadiene","volume":"38","author":"Zhu","year":"2005","journal-title":"Macromolecules"},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0230","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ijpharm.2015.12.036","article-title":"Comparison of the mucoadhesive properties of thiolated polyacrylic acid to thiolated polyallylamine","volume":"498","author":"Duggan","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0235","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.actbio.2015.01.020","article-title":"Thiolated silicone oil: synthesis, gelling and mucoadhesive properties","volume":"16","author":"Partenhauser","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0240","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.foodcont.2015.05.041","article-title":"Antimicrobial effect of lipoic acid against Cronobacter sakazakii","volume":"59","author":"Shi","year":"2016","journal-title":"Food Control."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0245","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.foodchem.2019.01.022","article-title":"Preparation and characterization of multilayer films composed of chitosan, sodium alginate and carboxymethyl chitosan-ZnO nanoparticles","volume":"283","author":"Wang","year":"2019","journal-title":"Food Chem."},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0250","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.polymer.2018.08.077","article-title":"Green and eco-friendly route for the synthesis of Ag@Vitamin B9-LDH hybrid and its chitosan nanocomposites: Characterization and antibacterial activity","volume":"154","author":"Mallakpour","year":"2018","journal-title":"Polymer"},{"key":"10.1016\/j.ijbiomac.2019.10.271_b0255","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jconrel.2019.06.011","article-title":"Graphene-based nanomaterials: the promising active agents forantibiotics- independent antibacterial applications","volume":"307","author":"Xia","year":"2019","journal-title":"J. Control. Release."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813019379966?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813019379966?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T08:08:32Z","timestamp":1758874112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813019379966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":51,"alternative-id":["S0141813019379966"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.10.271","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Redox response, antibacterial and drug package capacities of chitosan-\u03b1-lipoic acid conjugates","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.10.271","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}