{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:58:16Z","timestamp":1782413896327,"version":"3.54.5"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"TEQIP-III"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.ijbiomac.2019.12.038","type":"journal-article","created":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T02:03:06Z","timestamp":1576288986000},"page":"42-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Dual property of chitosan blended copolymer membranes: Antidiabetic drug release profile and antimicrobial assay"],"prefix":"10.1016","volume":"145","author":[{"given":"E.","family":"Jaisankar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.E.","family":"Pavithra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjith","family":"Krishna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Thirumarimurugan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja S.","family":"Azarudeen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0005","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/S0264-410X(02)00686-2","article-title":"Chitosan microparticles for mucosal vaccination against diphtheria: oral and nasal efficacy studies in mice","volume":"21","author":"van der Lubben","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0010","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1002\/jctb.5162","article-title":"Antibacterial chitosan\u2013copolymer membranes drug delivery: synthesis, characterization, drug release profile and kinetics","volume":"92","author":"Azarudeen","year":"2017","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0015","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0924-2244(99)00017-5","article-title":"Food applications of chitin and chitosan","volume":"10","author":"Shahidi","year":"1999","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0020","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2174\/157016308786733528","article-title":"New drug delivery systems based on chitosan","volume":"5","author":"Acosta","year":"2008","journal-title":"Current Drug Discov. Tech."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0025","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.carbpol.2007.02.008","article-title":"Novel interpenetrating polymer network microspheres of chitosan and methyl cellulose for controlled release of theophylline","volume":"69","author":"Rokhade","year":"2007","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0030","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1021\/ie00103a019","article-title":"Assessment of chitosan gels for the controlled release of agrochemicals","volume":"29","author":"Dunn","year":"1990","journal-title":"Ind. Eng. Chem. Res."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0035","first-page":"3065","article-title":"Effects of chitosan, pectic acid, lysozyme and chitinase on the growth of several phyto pathogens","volume":"53","author":"Hirano","year":"1989","journal-title":"Agric. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0040","first-page":"1","article-title":"Chitosan - as a biomaterial","volume":"18","author":"Chandy","year":"1990","journal-title":"Biomat. Art. Cells Art. Org."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0045","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/jctb.280490410","article-title":"Metal recovery using chitosan","volume":"49","author":"Onsoyen","year":"1990","journal-title":"J. Chem. Technol. Biotechnol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2019.12.038_bb0050","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/1061186X.2018.1512112","article-title":"Chitosan-based nanoparticles as drug delivery systems: a review on two decades of research","volume":"27","author":"Naskar","year":"2019","journal-title":"J. Drug Target"},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0055","series-title":"Superabsorbent polymers from the cell wall of Zygomycetes fungi","author":"Zamani","year":"2010"},{"issue":"1","key":"10.1016\/j.ijbiomac.2019.12.038_bb0060","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3390\/jfb6010104","article-title":"Chitin, chitosan, and its derivatives for wound healing: old and new materials","volume":"6","author":"Azuma","year":"2015","journal-title":"J. Funct. Biomater."},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.12.038_bb0065","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4103\/0973-8398.154716","article-title":"Biodegradable interpenetrating polymer network hydrogel membranes for controlled release of anticancer drug","volume":"9","author":"Mallikarjuna","year":"2015","journal-title":"Asian J. Pharm."},{"issue":"4","key":"10.1016\/j.ijbiomac.2019.12.038_bb0070","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.actbio.2009.11.001","article-title":"Biodegradable hybrid polymeric membranes for ocular drug delivery","volume":"6","author":"Jain","year":"2010","journal-title":"Acta Biomater."},{"issue":"13","key":"10.1016\/j.ijbiomac.2019.12.038_bb0075","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/0142-9612(92)90119-9","article-title":"Chitosan beads and granules for oral sustained delivery of nifedipine: in vitro studies","volume":"13","author":"Chandy","year":"1992","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.ijbiomac.2019.12.038_bb0080","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1080\/10601320600575231","article-title":"Chitosan\/HPMC polymer blends for developing transdermal drug delivery systems","volume":"43","author":"Siddaramaiah","year":"2006","journal-title":"J. Macromol. Sci. - Pure Appl. Chem."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0085","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jsps.2011.09.004","article-title":"Synthesis and evaluation of chitosan-graft-poly (2-hydroxyethyl methacrylate-co-itaconic acid) as a drug carrier for controlled release of tramadol hydrochloride","volume":"20","author":"Subramanian","year":"2012","journal-title":"Saudi Pharm. J."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0090","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s10853-011-5836-6","article-title":"Characterization of chitosan and polycaprolactone membranes designed for wound repair application","volume":"47","author":"Salgado","year":"2012","journal-title":"J. Mater. Sci."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0095","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1163\/138577210X12634696333479","article-title":"Development and characterization of chitosan based polymeric hydrogel membranes","volume":"13","author":"Ray","year":"2010","journal-title":"Des. Monomers Polym."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0100","doi-asserted-by":"crossref","first-page":"7701","DOI":"10.1039\/C5RA23875G","article-title":"Novel chitosan-based nanobiohybird membranes for wound dressing applications","volume":"6","author":"Moghadas","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0105","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0731-7085(02)00608-8","article-title":"Rapid determination of metformin in human plasma using ion-pair HPLC","volume":"31","author":"Zarghi","year":"2003","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.12.038_bb0110","first-page":"135","article-title":"Estimation and pharmacokinetics of metformin in human volunteers","volume":"41","author":"Bhavesh","year":"2007","journal-title":"Indian J. Pharm. Educ. Res."},{"issue":"3","key":"10.1016\/j.ijbiomac.2019.12.038_bb0115","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1208\/pt040331","article-title":"Controlled release formulation of tramadol hydrogen chloride using hydrophilic and hydrophobic matrix system","volume":"4","author":"Tiwari","year":"2003","journal-title":"AAPS PharmSciTech."},{"issue":"2","key":"10.1016\/j.ijbiomac.2019.12.038_bb0120","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/app.38814","article-title":"Formulation of pH-responsive carboxymethyl chitosan and alginate beads for the oral delivery of insulin","volume":"129","author":"Mukhopadhyay","year":"2013","journal-title":"J. Appl. Polym. Sci."},{"issue":"1","key":"10.1016\/j.ijbiomac.2019.12.038_bb0125","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.carbpol.2013.07.021","article-title":"Polyamidoamine dendrimer conjugated chitosan nanoparticles for the delivery of methotrexate","volume":"98","author":"Leng","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0130","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.desal.2010.10.002","article-title":"Chelating terpolymer resin: synthesis, characterization and its ion-exchange properties","volume":"268","author":"Azarudeen","year":"2011","journal-title":"Desalination"},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0135","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jhazmat.2012.12.047","article-title":"Removal of cations using ion-binding terpolymer involving 2-amino-6-nitro-benzothiazole and thiosemicarbazide with formaldehyde by batch equilibrium technique","volume":"248\u2013249","author":"Ahamed","year":"2013","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0140","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1002\/jctb.4528","article-title":"Heavy and toxic metal ion removal by a novel polymeric ion-exchanger: synthesis, characterization, kinetics and equilibrium studies","volume":"90","author":"Azarudeen","year":"2015","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0145","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s10904-011-9631-2","article-title":"Synthesis, spectral, morphology, thermal degradation kinetics and antibacterial studies of terpolymer metal complexes","volume":"22","author":"Azarudeen","year":"2012","journal-title":"J. Inorg. Organomet. Polym."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0150","doi-asserted-by":"crossref","first-page":"13652","DOI":"10.1039\/c4ra00083h","article-title":"Nanofibrous electroactive scaffolds from a chitosan-grafted-aniline tetramer by electrospinning for tissue engineering","volume":"4","author":"Ma","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0155","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.carbpol.2010.12.038","article-title":"Sustanined release of ketoprofen from fibrous chitosan \u2013 poly (\u0190- caprolactone) membranes","volume":"84","author":"Wang","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0160","series-title":"Polysaccharides I. Advances in Polymer Science","doi-asserted-by":"crossref","DOI":"10.1007\/b136820","article-title":"Chitosan chemistry: relevance to the biomedical sciences","volume":"186","author":"Muzzarelli","year":"2005"},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0165","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijpharm.2006.03.039","article-title":"The delivery of ketoprofen from a system containing ion-exchange fibers","volume":"319","author":"Yu","year":"2006","journal-title":"Int. J. Pharm."},{"issue":"3","key":"10.1016\/j.ijbiomac.2019.12.038_bb0170","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0168-3659(01)00517-X","article-title":"Factors affecting protein release from alginate\u2013chitosan coacervate microcapsules during production and gastric\/intestinal simulation","volume":"77","author":"Vandenberg","year":"2001","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0175","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/898910","article-title":"Preparation and characterization of water-soluble chitosan nanoparticles as protein delivery system","author":"Zhang","year":"2010","journal-title":"J. Nanomater."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0180","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.reactfunctpolym.2006.09.001","article-title":"Carboxymethyl chitosan graft phosphatidylethanolamine: amphiphilic matrices for controlled drug delivery","volume":"67","author":"Prabaharan","year":"2007","journal-title":"React. Funct. Polym."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0185","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0169-409X(01)00112-0","article-title":"Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC)","volume":"48","author":"Siepmann","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"7","key":"10.1016\/j.ijbiomac.2019.12.038_bb0190","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.eurpolymj.2011.02.011","article-title":"Glucose diffusivity and porosity in silica hydrogel based on organo functional silanes","volume":"47","author":"Krupa","year":"2011","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0195","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.carbpol.2010.12.038","article-title":"Sustained release of Ketoprofen from fibrous chitosan-poly(\u03b5-caprolactone) membranes","volume":"84","author":"Wang","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2019.12.038_bb0200","doi-asserted-by":"crossref","DOI":"10.1186\/s11671-016-1669-1","article-title":"Development of novel biocomposite scaffold of chitosan \u2013 gelatin\/nanohydroxyapatite for potential bone tissue engineering applications","volume":"11","author":"Dan","year":"2016","journal-title":"Nanoscale Res. Lett."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813019352742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813019352742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:41:06Z","timestamp":1758872466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813019352742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":40,"alternative-id":["S0141813019352742"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.12.038","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual property of chitosan blended copolymer membranes: Antidiabetic drug release profile and antimicrobial assay","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.12.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}