{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T01:33:55Z","timestamp":1789781635405,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.ijbiomac.2020.04.216","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T20:37:31Z","timestamp":1588106251000},"page":"85-93","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Large-scale mtDNA deletions as genetic biomarkers for susceptibility to male infertility: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"158","author":[{"given":"Mohammad","family":"Karimian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faezeh","family":"Babaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2020.04.216_bb0005","first-page":"1167","article-title":"Androgen receptor (AR)-CAG trinucleotide repeat length and idiopathic male infertility: a case-control trial and a meta-analysis","volume":"17","author":"Mobasseri","year":"2018","journal-title":"EXCLI J."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.04.216_bb0010","doi-asserted-by":"crossref","DOI":"10.1111\/and.12805","article-title":"Association of the c.-9C> T and c. 368A> G transitions in H2BFWT gene with male infertility in an Iranian population","volume":"50","author":"Rafatmanesh","year":"2018","journal-title":"Andrologia"},{"key":"10.1016\/j.ijbiomac.2020.04.216_bb0015","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.mito.2017.01.001","article-title":"Mitochondria in teleost spermatozoa","volume":"34","author":"Ulloa-Rodr\u00edguez","year":"2017","journal-title":"Mitochondrion"},{"issue":"2","key":"10.1016\/j.ijbiomac.2020.04.216_bb0020","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/j.1939-4640.2000.tb02093.x","article-title":"A role for mitochondrial DNA review and sperm survival","volume":"21","author":"St John","year":"2000","journal-title":"J. Androl."},{"issue":"2","key":"10.1016\/j.ijbiomac.2020.04.216_bb0025","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1365-2605.2011.01218.x","article-title":"The role of mitochondria in energy production for human sperm motility","volume":"35","author":"Piomboni","year":"2012","journal-title":"Int. J. Androl."},{"issue":"3","key":"10.1016\/j.ijbiomac.2020.04.216_bb0030","doi-asserted-by":"crossref","DOI":"10.1111\/and.12627","article-title":"Sperm mitochondrial DNA deletion in Iranian infertiles with asthenozoospermia","volume":"49","author":"Bahrehmand Namaghi","year":"2017","journal-title":"Andrologia"},{"issue":"2","key":"10.1016\/j.ijbiomac.2020.04.216_bb0035","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3390\/cells8020100","article-title":"Mitochondrial DNA integrity: role in health and disease","volume":"8","author":"Sharma","year":"2019","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.ijbiomac.2020.04.216_bb0040","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1002\/jcb.27492","article-title":"Comparison of large-scale deletions of the sperm mitochondrial DNA in normozoospermic and asthenoteratozoospermic men","volume":"120","author":"Gholinezhad","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.04.216_bb0045","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1095\/biolreprod52.4.729","article-title":"Mitochondrial deoxyribonucleic acid 4977-bp deletion is associated with diminished fertility and motility of human sperm","volume":"52","author":"Kao","year":"1995","journal-title":"Biol. Reprod."},{"issue":"7","key":"10.1016\/j.ijbiomac.2020.04.216_bb0050","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/molehr\/4.7.657","article-title":"Multiple deletions of mitochondrial DNA are associated with the decline of motility and fertility of human spermatozoa","volume":"4","author":"Kao","year":"1998","journal-title":"Mol. Hum. Reprod."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.04.216_bb0055","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1046\/j.1365-2605.1998.00093.x","article-title":"Semen levels of mitochondrial DNA deletions in men attending an infertility clinic do not correlate with phenotype","volume":"21","author":"Cummins","year":"1998","journal-title":"Int. J. Androl."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.04.216_bb0060","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/molehr\/7.1.103","article-title":"Men with oligoasthenoteratozoospermia harbour higher numbers of multiple mitochondrial DNA deletions in their spermatozoa, but individual deletions are not indicative of overall aetiology","volume":"7","author":"St John","year":"2001","journal-title":"Mol. Hum. Reprod."},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.04.216_bb0065","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1080\/24701394.2017.1331347","article-title":"Association of sperm mitochondrial DNA deletions with male infertility in an Iranian population","volume":"29","author":"Talebi","year":"2018","journal-title":"Mitochondrial DNA Part A"},{"issue":"7","key":"10.1016\/j.ijbiomac.2020.04.216_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000100","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"6","author":"Liberati","year":"2009","journal-title":"PLoS Med."},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.04.216_bb0075","first-page":"213","article-title":"Associations of MTHFR DNMT3b 4977 bp deletion in mtDNA and GSTM1 deletion, and aberrant CpG island hypermethylation of GSTM1 in non-obstructive infertility in Indian men","volume":"13","author":"Dhillon","year":"2007","journal-title":"MHR: Basic science of reproductive medicine"},{"issue":"7","key":"10.1016\/j.ijbiomac.2020.04.216_bb0080","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/gepi.20410","article-title":"STrengthening the REporting of genetic association studies (STREGA)\u2014an extension of the STROBE statement","volume":"33","author":"Little","year":"2009","journal-title":"Genetic Epidemiology: The Official Publication of the International Genetic Epidemiology Society"},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.04.216_bb0085","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel","year":"1959","journal-title":"J. Natl. Cancer Inst."},{"issue":"3","key":"10.1016\/j.ijbiomac.2020.04.216_bb0090","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control. Clin. Trials"},{"issue":"7109","key":"10.1016\/j.ijbiomac.2020.04.216_bb0095","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"Bmj"},{"key":"10.1016\/j.ijbiomac.2020.04.216_bb0100","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","author":"Begg","year":"1994","journal-title":"Biometrics"},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.04.216_bb0105","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4103\/0974-1208.178635","article-title":"Association of large scale 4977-bp \u201ccommon\u201d deletions in sperm mitochondrial DNA with asthenozoospermia and oligoasthenoteratozoospermia","volume":"9","author":"Ambulkar","year":"2016","journal-title":"Journal of human reproductive sciences"},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.04.216_bb0110","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3109\/19401736.2013.796512","article-title":"Large scale deletions of the mitochondrial DNA in astheno, asthenoterato and oligoasthenoterato-spermic men","volume":"25","author":"Hosseinzadeh Colagar","year":"2014","journal-title":"Mitochondrial DNA"},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.04.216_bb0115","first-page":"453","article-title":"A novel large-scale deletion of the mitochondrial DNA of spermatozoa of men in North Iran","volume":"8","author":"Gholinezhad Chari","year":"2015","journal-title":"International Journal of Fertility & Sterility"},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.04.216_bb0120","first-page":"3","article-title":"Sperm mitochondrial DNA 15bp deletion of cytochrome c oxidase subunit III is significantly associated with human male infertility in Pakistan","volume":"66","author":"Mughal","year":"2016","journal-title":"JPMA. The Journal of the Pakistan Medical Association"},{"issue":"3","key":"10.1016\/j.ijbiomac.2020.04.216_bb0125","doi-asserted-by":"crossref","first-page":"928","DOI":"10.3906\/sag-1606-52","article-title":"Male infertility is significantly associated with multiple deletions in an 8.7-kb segment of sperm mtDNA in Pakistan","volume":"47","author":"Mughal","year":"2017","journal-title":"Turkish journal of medical sciences"},{"issue":"2","key":"10.1016\/j.ijbiomac.2020.04.216_bb0130","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4103\/0970-1591.40606","article-title":"Mitochondrial DNA mutations in etiopathogenesis of male infertility","volume":"24","author":"Shamsi","year":"2008","journal-title":"Indian journal of urology: IJU: journal of the Urological Society of India"},{"issue":"2","key":"10.1016\/j.ijbiomac.2020.04.216_bb0135","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s13237-017-0209-4","article-title":"Role of nuclear and mitochondrial genes in human male infertility: a review","volume":"60","author":"Pal","year":"2017","journal-title":"Nucleus"},{"issue":"8","key":"10.1016\/j.ijbiomac.2020.04.216_bb0140","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nrurol.2017.69","article-title":"Oxidative stress and male infertility","volume":"14","author":"Bisht","year":"2017","journal-title":"Nature Reviews Urology"},{"issue":"8","key":"10.1016\/j.ijbiomac.2020.04.216_bb0145","doi-asserted-by":"crossref","DOI":"10.1111\/and.13012","article-title":"Reactive oxygen species impact on sperm DNA and its role in male infertility","volume":"50","author":"Bui","year":"2018","journal-title":"Andrologia"},{"key":"10.1016\/j.ijbiomac.2020.04.216_bb0150","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1177\/153537020222700901","article-title":"Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging","volume":"227","author":"Lee","year":"2002","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.ijbiomac.2020.04.216_bb0155","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1590\/S1677-55382007000500002","article-title":"Clinical relevance of oxidative stress and sperm chromatin damage in male infertility: an evidence based analysis","volume":"33","author":"Sikka","year":"2007","journal-title":"International Braz J Urol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.04.216_bb0160","doi-asserted-by":"crossref","first-page":"583","DOI":"10.4103\/1008-682X.153303","article-title":"Redox regulation of mammalian sperm capacitation","volume":"17","author":"O\u2019Flaherty","year":"2015","journal-title":"Asian Journal of Andrology"},{"issue":"10","key":"10.1016\/j.ijbiomac.2020.04.216_bb0165","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2174\/0929867053764635","article-title":"Metals, toxicity and oxidative stress","volume":"12","author":"Valko","year":"2005","journal-title":"Curr. Med. Chem."},{"issue":"2","key":"10.1016\/j.ijbiomac.2020.04.216_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1071\/RD15325","article-title":"Causes and consequences of oxidative stress in spermatozoa","volume":"28","author":"Aitken","year":"2016","journal-title":"Reprod. Fertil. Dev."},{"issue":"3","key":"10.1016\/j.ijbiomac.2020.04.216_bb0175","first-page":"168","article-title":"The 3243 MELAS mutation in a pedigree with MERRF","volume":"35","author":"Folger\u00f8","year":"1995","journal-title":"Eur. Neurol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2020.04.216_bb0180","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2605.2005.00515.x","article-title":"The impact of mitochondrial genetics on male infertility","volume":"28","author":"St John","year":"2005","journal-title":"Int. J. Androl."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.04.216_bb0185","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.rbmo.2018.10.004","article-title":"Sperm mitochondrial DNA measures and semen parameters among men undergoing fertility treatment","volume":"38","author":"Wu","year":"2019","journal-title":"Reprod. BioMed. Online"},{"key":"10.1016\/j.ijbiomac.2020.04.216_bb0190","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/molehr\/3.9.811","article-title":"Oligoasthenospermia associated with multiple mitochondrial DNA rearrangements","volume":"3","author":"Patrick","year":"1997","journal-title":"Mol. Hum. Reprod."},{"issue":"2","key":"10.1016\/j.ijbiomac.2020.04.216_bb0195","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1006\/bbrc.1998.9651","article-title":"Long PCR analysis of human gamete mtDNA suggests defective mitochondrial maintenance in spermatozoa and supports the bottleneck theory for oocytes","volume":"252","author":"Reynier","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813020330828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813020330828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T21:21:25Z","timestamp":1786569685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813020330828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":39,"alternative-id":["S0141813020330828"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.04.216","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Large-scale mtDNA deletions as genetic biomarkers for susceptibility to male infertility: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.04.216","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}