{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:07:00Z","timestamp":1787242020977,"version":"build-2736575974"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010937","name":"St. John's University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009267","name":"College of Pharmacy and Health Sciences, Lipscomb University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009267","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.ijbiomac.2020.05.146","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T11:28:46Z","timestamp":1589974126000},"page":"128-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Metformin-loaded chitosomes for treatment of malignant pleural mesothelioma \u2013 A rare thoracic cancer"],"prefix":"10.1016","volume":"160","author":[{"given":"Snehal K.","family":"Shukla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineela","family":"Parvathaneni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0005","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1158\/0008-5472.CAN-14-1008","article-title":"Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma","volume":"75","author":"Guo","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jconrel.2015.10.019","article-title":"Advanced therapeutic approach for the treatment of malignant pleural mesothelioma via the intrapleural administration of liposomal pemetrexed","volume":"220","author":"Ando","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0015","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jss.2016.08.031","article-title":"Open access phone triage for veterans with suspected malignant pleural mesothelioma","volume":"207","author":"Siegert","year":"2017","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0020","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1136\/oemed-2015-103074","article-title":"Pleural mesothelioma and lung cancer risks in relation to occupational history and asbestos lung burden","volume":"73","author":"Gilham","year":"2016","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0030","article-title":"Advances in the diagnosis, treatment and prognosis of malignant pleural mesothelioma","volume":"3","author":"Zhang","year":"2015","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0035","author":"Meredith"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0040","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1200\/JCO.2003.11.136","article-title":"Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma","volume":"21","author":"Vogelzang","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0045","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3816\/CLC.2005.n.020","article-title":"Open-label study of pemetrexed alone or in combination with cisplatin for the treatment of patients with peritoneal mesothelioma: outcomes of an expanded access program","volume":"7","author":"J\u00e4nne","year":"2005","journal-title":"Clin. Lung Cancer"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0050","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.ejcts.2009.08.012","article-title":"Intrapleural polymeric films containing cisplatin for malignant pleural mesothelioma in a rat tumour model: a preliminary study","volume":"37","author":"Ampollini","year":"2010","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0055","doi-asserted-by":"crossref","first-page":"S207","DOI":"10.21037\/jtd.2017.10.74","article-title":"Polymeric films loaded with cisplatin for malignant pleural mesothelioma: a pharmacokinetic study in an ovine model","volume":"10","author":"Ampollini","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0060","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1136\/bmj.38415.708634.F7","article-title":"Metformin and reduced risk of cancer in diabetic patients","volume":"330","author":"Evans","year":"2005","journal-title":"BMJ"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0065","article-title":"Metformin reduces the risk of cancer in patients with type 2 diabetes","volume":"97","author":"Kim","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0070","doi-asserted-by":"crossref","first-page":"765","DOI":"10.7314\/APJCP.2013.14.2.765","article-title":"Therapeutic potential of an anti-diabetic drug, metformin: alteration of miRNA expression in prostate cancer cells","volume":"14","author":"Avci","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0075","doi-asserted-by":"crossref","first-page":"896","DOI":"10.18632\/oncotarget.387","article-title":"Metformin: multi-faceted protection against cancer","volume":"2","author":"Del Barco","year":"2011","journal-title":"Oncotarget"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0080","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11010-013-1845-x","article-title":"Metformin reverses multidrug resistance and epithelial-mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells","volume":"386","author":"Qu","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0085","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-017-3300-y","article-title":"Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways","volume":"17","author":"Shimazu","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0090","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1007\/s00125-017-4318-z","article-title":"Metformin: historical overview","volume":"60","author":"Bailey","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0095","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.lungcan.2016.07.020","article-title":"Metformin and survival of people with type 2 diabetes and pleural mesothelioma: a population-based retrospective cohort study","volume":"99","author":"Wu","year":"2016","journal-title":"Lung Cancer"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0100","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/cas.13952","article-title":"Glucose starvation induces resistance to metformin through the elevation of mitochondrial multidrug resistance protein 1","volume":"110","author":"Hwang","year":"2019","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0105","first-page":"171","article-title":"Pharmacokinetics of intrapleural cisplatin for the treatment of malignant pleural effusions","volume":"7","author":"Monjanel-Mouterde","year":"2000","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0110","doi-asserted-by":"crossref","DOI":"10.4155\/tde-2019-0098","article-title":"Utilizing nanotechnology to recuperate sorafenib for lung cancer treatment: challenges and future perspective","author":"Shukla","year":"2020","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0115","doi-asserted-by":"crossref","first-page":"975","DOI":"10.2147\/IJN.S68861","article-title":"Liposomes as nanomedical devices","volume":"10","author":"Bozzuto","year":"2015","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0120","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3390\/pharmaceutics5040542","article-title":"Surface engineering of liposomes for stealth behavior","volume":"5","author":"Nag","year":"2013","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0125","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3390\/pharmaceutics12030206","article-title":"Systematic development and optimization of inhalable pirfenidone liposomes for non-small cell lung cancer treatment","volume":"12","author":"Parvathaneni","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0130","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.addr.2009.11.009","article-title":"Chitosan-based delivery systems for protein therapeutics and antigens","volume":"62","author":"Amidi","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11110559","article-title":"Metformin-encapsulated liposome delivery system: an effective treatment approach against breast cancer","volume":"11","author":"Shukla","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0140","doi-asserted-by":"crossref","first-page":"14341","DOI":"10.1039\/C6NR03256G","article-title":"Recent advances in chitosan-based nanoparticulate pulmonary drug delivery","volume":"8","author":"Islam","year":"2016","journal-title":"Nanoscale"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0145","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3109\/03639045.2010.523425","article-title":"Mucoadhesive liposomal delivery systems: the choice of coating material","volume":"37","author":"Karn","year":"2011","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0150","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.colsurfb.2009.01.010","article-title":"Chitosan-coated liposomes for delivery to lungs by nebulisation","volume":"71","author":"Zaru","year":"2009","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0155","article-title":"Development of chitosan-coated liposome for pulmonary delivery of N-acetylcysteine","author":"Hamedinasab","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0160","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1208\/s12249-013-9926-4","article-title":"Improving oral bioavailability and pharmacokinetics of liposomal metformin by glycerolphosphate-chitosan microcomplexation","volume":"14","author":"Manconi","year":"2013","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0165","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.carbpol.2014.04.038","article-title":"Layer-by-layer assembly of chitosan stabilized multilayered liposomes for paclitaxel delivery","volume":"111","author":"Chen","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0170","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.colsurfb.2016.03.044","article-title":"Inhalable polymer-glycerosomes as safe and effective carriers for rifampicin delivery to the lungs","volume":"143","author":"Melis","year":"2016","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0175","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.2147\/IJN.S166901","article-title":"Hydrophobically modified chitosan nanoliposomes for intestinal drug delivery","volume":"13","author":"Zariwala","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0180","doi-asserted-by":"crossref","first-page":"105149","DOI":"10.1039\/C5RA24032H","article-title":"Nanoincorporation of curcumin in polymer-glycerosomes and evaluation of their in vitro\u2013in vivo suitability as pulmonary delivery systems","volume":"5","author":"Manca","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0185","doi-asserted-by":"crossref","first-page":"29916","DOI":"10.18632\/oncotarget.9171","article-title":"Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity","volume":"7","author":"Mazor","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0190","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1158\/1535-7163.MCT-15-0532","article-title":"Recombinant immunotoxin with T-cell epitope mutations that greatly reduce immunogenicity for treatment of mesothelin-expressing tumors","volume":"14","author":"Mazor","year":"2015","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0195","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.carbpol.2018.09.080","article-title":"Nintedanib-cyclodextrin complex to improve bio-activity and intestinal permeability","volume":"204","author":"Vaidya","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0200","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jconrel.2007.04.011","article-title":"Long-circulating liposome-encapsulated ganciclovir enhances the efficacy of HSV-TK suicide gene therapy","volume":"120","author":"Kajiwara","year":"2007","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0205","article-title":"Interaction between chitosan and mucin: fundamentals and applications","volume":"4","author":"Collado-Gonz\u00e1lez","year":"2019","journal-title":"Biomimetics (Basel)"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0210","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0378-5173(03)00254-0","article-title":"Chitosan-coated liposomes: characterization and interaction with leuprolide","volume":"260","author":"Guo","year":"2003","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0215","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ijbiomac.2019.10.256","article-title":"Chitosan coated liposomes (CCL) containing triamcinolone acetonide for sustained delivery: a potential topical treatment for posterior segment diseases","volume":"143","author":"Khalil","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0220","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.ijpharm.2011.12.019","article-title":"Predicting hydrophilic drug encapsulation inside unilamellar liposomes","volume":"423","author":"Xu","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0225","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.colsurfb.2014.09.029","article-title":"Liposomes as carriers of hydrophilic small molecule drugs: strategies to enhance encapsulation and delivery","volume":"123","author":"Eloy","year":"2014","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0230","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1208\/s12248-017-0142-0","article-title":"Role of in vitro release methods in liposomal formulation development: challenges and regulatory perspective","volume":"19","author":"Solomon","year":"2017","journal-title":"AAPS J."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0235","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nrd1632","article-title":"Recent advances with liposomes as pharmaceutical carriers","volume":"4","author":"Torchilin","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0240","first-page":"311","article-title":"In vitro release of hydrophilic and hydrophobic drugs from liposomal dispersions and gels","volume":"56","author":"Nounou","year":"2006","journal-title":"Acta Pharma."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0245","doi-asserted-by":"crossref","first-page":"8556","DOI":"10.1200\/JCO.2017.35.15_suppl.8556","article-title":"Patterns of metastases in malignant pleural mesothelioma in the modern era: redefining the spread of an old disease","volume":"35","author":"Collins","year":"2017","journal-title":"JCO"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0250","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3390\/pharmaceutics3010107","article-title":"Cell migration and invasion assays as tools for drug discovery","volume":"3","author":"Hulkower","year":"2011","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0255","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0098-2017","article-title":"Drug repurposing in malignant pleural mesothelioma: a breath of fresh air?","volume":"27","author":"Boyer","year":"2018","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0260","first-page":"2030","article-title":"Metformin-induced apoptosis facilitates degradation of the cellular caspase 8 (FLICE)-like inhibitory protein through a caspase-dependent pathway in human renal cell carcinoma A498 cells","volume":"16","author":"Jang","year":"2018","journal-title":"Oncol. Lett."},{"issue":"14","key":"10.1016\/j.ijbiomac.2020.05.146_bb0265","doi-asserted-by":"crossref","first-page":"7192","DOI":"10.3748\/wjg.14.7192","article-title":"Metformin induces apoptosis of pancreatic cancer cells","volume":"14","author":"Wang","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0270","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/bit.26845","article-title":"3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs","volume":"116","author":"Nunes","year":"2019","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0275","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.biotechadv.2016.11.002","article-title":"3D tumor spheroids: an overview on the tools and techniques used for their analysis","volume":"34","author":"Costa","year":"2016","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0280","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.2217\/fon.13.274","article-title":"3D tumor models: history, advances and future perspectives","volume":"10","author":"Benien","year":"2014","journal-title":"Future Oncol."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0285","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.tibtech.2012.12.003","article-title":"Spheroid culture as a tool for creating 3D complex tissues","volume":"31","author":"Fennema","year":"2013","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.ijbiomac.2020.05.146_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118995","article-title":"Development of inhalable quinacrine loaded bovine serum albumin modified cationic nanoparticles: repurposing quinacrine for lung cancer therapeutics","volume":"577","author":"Vaidya","year":"2020","journal-title":"Int. J. Pharm."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813020333006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813020333006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T05:52:37Z","timestamp":1762235557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813020333006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":57,"alternative-id":["S0141813020333006"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.05.146","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metformin-loaded chitosomes for treatment of malignant pleural mesothelioma \u2013 A rare thoracic cancer","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.05.146","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}