{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:05:15Z","timestamp":1792602315588,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51772233"],"award-info":[{"award-number":["51772233"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012239","name":"Hubei Technological Innovation Special Fund","doi-asserted-by":"publisher","award":["2019ACA130"],"award-info":[{"award-number":["2019ACA130"]}],"id":[{"id":"10.13039\/501100012239","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.ijbiomac.2020.05.161","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T11:17:10Z","timestamp":1590146230000},"page":"101-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"special_numbering":"C","title":["An injectable bioactive magnesium phosphate cement incorporating carboxymethyl chitosan for bone regeneration"],"prefix":"10.1016","volume":"160","author":[{"given":"Ling","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kezhou","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changtian","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingteng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglian","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ijbiomac.2020.05.161_bb0005","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1002\/jbm.a.36719","article-title":"Fabrication of alginate modified brushite cement impregnated with antibiotic: mechanical, thermal, and biological characterizations","volume":"107","author":"Dabiri","year":"2019","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"9","key":"10.1016\/j.ijbiomac.2020.05.161_bb0010","doi-asserted-by":"crossref","first-page":"5744","DOI":"10.3390\/ma8095273","article-title":"Biodegradable materials for bone repair and tissue engineering applications","volume":"8","author":"Sheikh","year":"2015","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0015","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.actbio.2017.11.033","article-title":"Magnesium-based bioceramics in orthopedic applications","volume":"66","author":"Nabiyouni","year":"2018","journal-title":"Acta Biomater."},{"issue":"7","key":"10.1016\/j.ijbiomac.2020.05.161_bb0020","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/adma.201403354","article-title":"Natural-based nanocomposites for bone tissue engineering and regenerative medicine: a review","volume":"27","author":"Pina","year":"2015","journal-title":"Adv. Mater."},{"issue":"7","key":"10.1016\/j.ijbiomac.2020.05.161_bb0025","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1021\/acsbiomaterials.6b00056","article-title":"Magnesium phosphate cement systems for hard tissue applications: a review","volume":"2","author":"Ostrowski","year":"2016","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0030","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jmbbm.2018.12.004","article-title":"Magnesium phosphate based cement with improved setting, strength and cytocompatibility properties by adding Ca(H2PO4)2\u00b7H2O and citric acid","volume":"91","author":"Yu","year":"2019","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2019.110448","article-title":"Fabrication of the antibiotic-releasing gelatin\/PMMA bone cement","volume":"183","author":"Chen","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0040","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jmbbm.2019.02.026","article-title":"Citric acid enhances the physical properties, cytocompatibility and osteogenesis of magnesium calcium phosphate cement","volume":"94","author":"Wang","year":"2019","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.05.161_bb0045","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3390\/ma10040334","article-title":"Calcium phosphate bioceramics: a review of their history, structure, properties, coating technologies and biomedical applications","volume":"10","author":"Eliaz","year":"2017","journal-title":"Materials"},{"issue":"13","key":"10.1016\/j.ijbiomac.2020.05.161_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/ma12132119","article-title":"Development and bone regeneration capacity of premixed magnesium phosphate cement pastes","volume":"12","author":"Ewald","year":"2019","journal-title":"Materials (Basel)"},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.05.161_bb0055","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/rb\/rbw024","article-title":"Preparation and characterization of a degradable magnesium phosphate bone cement","volume":"3","author":"Yu","year":"2016","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0060","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.actbio.2018.01.035","article-title":"Bone regeneration capacity of magnesium phosphate cements in a large animal model","volume":"69","author":"Kanter","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0065","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cemconcomp.2019.05.003","article-title":"Experimental study on the deformation characteristics of magnesium potassium phosphate cement paste at early hydration ages","volume":"103","author":"Jianming","year":"2019","journal-title":"Cem. Concr. Compos."},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0070","article-title":"Chitosan and its oligosaccharides, a promising option for sustainable crop production- a review","volume":"227","author":"Mukhtar","year":"2020","journal-title":"Carbohydr. Polym."},{"issue":"9","key":"10.1016\/j.ijbiomac.2020.05.161_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/biom9090470","article-title":"Progress in the development of chitosan-based biomaterials for tissue engineering and regenerative medicine","volume":"9","author":"Sultankulov","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0080","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.ijbiomac.2017.07.087","article-title":"Chitosan as a bioactive polymer: processing, properties and applications","volume":"105","author":"Muxika","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"issue":"Pt B","key":"10.1016\/j.ijbiomac.2020.05.161_bb0085","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.ijbiomac.2018.09.131","article-title":"Carboxymethyl chitosan: properties and biomedical applications","volume":"120","author":"Shariatinia","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"10","key":"10.1016\/j.ijbiomac.2020.05.161_bb0090","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1039\/C5TB02782A","article-title":"A carboxymethyl chitosan and peptide-decorated polyetheretherketone ternary biocomposite with enhanced antibacterial activity and osseointegration as orthopedic\/dental implants","volume":"4","author":"Xu","year":"2016","journal-title":"J. Mater. Chem. B"},{"issue":"2","key":"10.1016\/j.ijbiomac.2020.05.161_bb0095","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s10529-014-1697-9","article-title":"Biodegradable composite scaffolds of bioactive glass\/chitosan\/carboxymethyl cellulose for hemostatic and bone regeneration","volume":"37","author":"Chen","year":"2015","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0100","series-title":"Test Methods for Water Requirement of Normal Consistency, Setting Time and Soundness of the Portland Cement","author":"Chinese Standard GB\/T1346-2011","year":"2011"},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0105","series-title":"Compressive Strength of Test Specimens, BS EN 12390-3","article-title":"Testing hardened concrete","author":"British Standard Institution","year":"2009"},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0110","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ijbiomac.2018.04.045","article-title":"Polycaprolactone\/carboxymethyl chitosan nanofibrous scaffolds for bone tissue engineering application","volume":"115","author":"Sharifi","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0115","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ijbiomac.2020.04.038","article-title":"O-Carboxymethylated chitosan; a promising tool with in-vivo anti-inflammatory and analgesic properties in albino rats","volume":"156","author":"Adnan","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"44","key":"10.1016\/j.ijbiomac.2020.05.161_bb0120","doi-asserted-by":"crossref","first-page":"26270","DOI":"10.1074\/jbc.270.44.26270","article-title":"Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+","volume":"270","author":"Mould","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.05.161_bb0125","article-title":"Synthesis of hierarchical structured MgO by sol-gel method","volume":"2","author":"Tamilselvi","year":"2013","journal-title":"Nano Bull."},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2016.11.019","article-title":"Critical review: injectability of calcium phosphate pastes and cements","volume":"50","author":"O\u2019Neill","year":"2017","journal-title":"Acta Biomater."},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.05.161_bb0135","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/3\/4\/044105","article-title":"Injectable bioactive calcium-magnesium phosphate cement for bone regeneration","volume":"3","author":"Wu","year":"2008","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0140","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.actbio.2018.09.002","article-title":"Hydration mechanism of a calcium phosphate cement modified with phytic acid","volume":"80","author":"Hurle","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0145","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1177\/0954411918796048","article-title":"Evaluation of Setting Time and Compressive Strength of a New Bone Cement Precursor Powder Containing Mg-Na-Ca","volume":"232","author":"Esnaashary","year":"2018","journal-title":"Proc. Inst. Mech. Eng. H."},{"issue":"18","key":"10.1016\/j.ijbiomac.2020.05.161_bb0150","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1016\/S0142-9612(03)00125-X","article-title":"The exothermal behavior in the hydration process of calcium phosphate cement","volume":"24","author":"Liu","year":"2003","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.ijbiomac.2020.05.161_bb0155","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0014-5793(99)01486-6","article-title":"Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins","volume":"461","author":"Samali","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0160","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.msec.2018.09.039","article-title":"Incorporation of chitosan-alginate complex into injectable calcium phosphate cement system as a bone graft material","volume":"94","author":"Lee","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0165","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.msec.2017.05.017","article-title":"Scaffolds for bone tissue engineering: state of the art and new perspectives","volume":"78","author":"Roseti","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0170","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.msec.2018.10.083","article-title":"Tuning the properties of magnesium phosphate-based bone cements: effect of powder to liquid ratio and aqueous solution concentration","volume":"95","author":"Gelli","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"issue":"8","key":"10.1016\/j.ijbiomac.2020.05.161_bb0175","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1002\/jbm.b.33160","article-title":"Injectable citrate-modified Portland cement for use in vertebroplasty","volume":"102","author":"Wynn-Jones","year":"2014","journal-title":"J Biomed Mater Res B Appl Biomater"},{"issue":"3","key":"10.1016\/j.ijbiomac.2020.05.161_bb0180","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s10856-010-4220-4","article-title":"Formation and properties of magnesium-ammonium-phosphate hexahydrate biocements in the Ca-Mg-PO4 system","volume":"22","author":"Vorndran","year":"2011","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0185","article-title":"Injectable and bioactive bone cement with moderate setting time and temperature by using borosilicate bio-glass incorporated magnesium phosphate","author":"Li","year":"2019","journal-title":"Biomed. Mater."},{"issue":"2","key":"10.1016\/j.ijbiomac.2020.05.161_bb0190","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/iej.12123","article-title":"Magnesium phosphate cements for endodontic applications with improved long-term sealing ability","volume":"47","author":"Mestres","year":"2014","journal-title":"Int. Endod. J."},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0195","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.actbio.2015.04.011","article-title":"Recommendation for modifying current cytotoxicity testing standards for biodegradable magnesium-based materials","volume":"21","author":"Wang","year":"2015","journal-title":"Acta Biomater."},{"issue":"6","key":"10.1016\/j.ijbiomac.2020.05.161_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19061746","article-title":"The \u201cmagnesium sacrifice\u201d strategy enables PMMA bone cement partial biodegradability and osseointegration potential","volume":"19","author":"Zhai","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"49","key":"10.1016\/j.ijbiomac.2020.05.161_bb0205","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1098\/rsif.2009.0559","article-title":"Development of magnesium calcium phosphate biocement for bone regeneration","volume":"7","author":"Jia","year":"2010","journal-title":"J. R. Soc. Interface"},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.05.161_bb0210","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.actbio.2009.10.021","article-title":"Phase composition, mechanical performance and in vitro biocompatibility of hydraulic setting calcium magnesium phosphate cement","volume":"6","author":"Klammert","year":"2010","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0215","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.carbpol.2016.05.049","article-title":"A review of chitosan and its derivatives in bone tissue engineering","volume":"151","author":"LogithKumar","year":"2016","journal-title":"Carbohydr. Polym."},{"issue":"32","key":"10.1016\/j.ijbiomac.2020.05.161_bb0220","doi-asserted-by":"crossref","first-page":"17860","DOI":"10.1039\/C8RA00383A","article-title":"Enhanced bioactivity and osteoinductivity of carboxymethyl chitosan\/nanohydroxyapatite\/graphene oxide nanocomposites","volume":"8","author":"Yu","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.ijbiomac.2020.05.161_bb0225","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.colsurfb.2018.01.022","article-title":"Tuning surface properties of bone biomaterials to manipulate osteoblastic cell adhesion and the signaling pathways for the enhancement of early osseointegration","volume":"164","author":"Chen","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813020333134?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813020333134?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T05:54:08Z","timestamp":1762235648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813020333134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":45,"alternative-id":["S0141813020333134"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.05.161","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An injectable bioactive magnesium phosphate cement incorporating carboxymethyl chitosan for bone regeneration","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.05.161","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}