{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:32:13Z","timestamp":1793507533920,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88881.191812\/2018-01"],"award-info":[{"award-number":["88881.191812\/2018-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["406163\/2018-9"],"award-info":[{"award-number":["406163\/2018-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.ijbiomac.2020.05.171","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T01:43:50Z","timestamp":1590371030000},"page":"299-307","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Immunoprotection against lethal effects of Crotalus durissus snake venom elicited by synthetic epitopes trapped in liposomes"],"prefix":"10.1016","volume":"161","author":[{"given":"Patr\u00edcia","family":"D. Vaz de Melo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2521-1114","authenticated-orcid":false,"given":"Sabrina","family":"de Almeida Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3800-8801","authenticated-orcid":false,"given":"Priscila","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1154-4308","authenticated-orcid":false,"given":"Ra\u00edssa","family":"Medina Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9294-5922","authenticated-orcid":false,"given":"Andreza","family":"Alves Belo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo A.","family":"Machado-de-\u00c1vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Costal-Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanete","family":"T. Soccol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7698-3811","authenticated-orcid":false,"given":"Clara","family":"Guerra-Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonides","family":"Rezende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9390-7207","authenticated-orcid":false,"given":"Carlos","family":"Chavez-Olortegui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ijbiomac.2020.05.171_bb0010","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1021\/pr9008749","article-title":"Snake venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal in South America","volume":"9","author":"Calvete","year":"2010","journal-title":"J. Proteome Res."},{"issue":"5","key":"10.1016\/j.ijbiomac.2020.05.171_bb0015","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1021\/pr901042p","article-title":"Snake venomic of Crotalus durissus terrificus-correlation with pharmacological activities","volume":"9","author":"Georgieva","year":"2010","journal-title":"J. Proteome Res."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.05.171_bb0020","first-page":"23","article-title":"Intraspecific variation in the venoms of the South American rattlesnake (Crotalus durissus terrificus)","volume":"127","author":"Francischetti","year":"2000","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.05.171_bb0025","first-page":"337","article-title":"Geographic and ontogenic variability in the venom of the neotropical rattlesnake Crotalus durissus: pathophysiological and therapeutic implications","volume":"50","author":"Saravia","year":"2002","journal-title":"Rev. Biol. Trop."},{"issue":"9","key":"10.1016\/j.ijbiomac.2020.05.171_bb0030","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.jprot.2010.06.001","article-title":"Snake venomics and antivenomics of Crotalus durissus subspecies from Brazil: assessment of geographic variation and its implication on snakebite management","volume":"73","author":"Boldrini-Fran\u00e7a","year":"2010","journal-title":"J. Proteome"},{"key":"10.1016\/j.ijbiomac.2020.05.171_bb0035","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.toxicon.2015.01.006","article-title":"Neuromuscular effects of venoms and crotoxin-like proteins from Crotalus durissus ruruima and Crotalus durissus cumanensis","volume":"96","author":"Cavalcante","year":"2015","journal-title":"Toxicon"},{"key":"10.1016\/j.ijbiomac.2020.05.171_bb0040","doi-asserted-by":"crossref","DOI":"10.1186\/s40409-017-0118-7","article-title":"Antivenomics as a tool to improve the neutralizing capacity of the crotalic antivenom: a study with crotamine","volume":"23","author":"Teixeira-Ara\u00fajo","year":"2017","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.ijbiomac.2020.05.171_bb0045","series-title":"Animais Pe\u00e7onhentos Reconhecimento, Distribui\u00e7\u00e3o Geogr\u00e1fica, Produ\u00e7\u00e3o de Soros E Tratamento Dos Envenenamentos","first-page":"91","article-title":"Produ\u00e7\u00e3o de soros antipe\u00e7onhentos e caracter\u00edsticas imunol\u00f3gicas de cada soro","author":"S\u00f6rensen","year":"1990"},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.05.171_bb0050","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0041-0101(96)00134-1","article-title":"Effect of Crotalus venom on the humoral and cellular immune response","volume":"35","author":"Cardoso","year":"1997","journal-title":"Toxicon"},{"issue":"13\u201314","key":"10.1016\/j.ijbiomac.2020.05.171_bb0055","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1080\/15287391003745069","article-title":"New nanostructured silica adjuvant (SBA-15) employed to produce antivenom in young sheep using Crotalus durissus terrificus and Apis mellifera venoms detoxified by cobalt-60","volume":"73","author":"Junior","year":"2010","journal-title":"J. Toxicol. Environ. Heal. - Part A Curr. Issues"},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.05.171_bb0060","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1051\/jbio\/2009043","article-title":"Guidelines for the production, control and regulation of snake antivenom immunoglobulins","volume":"204","author":"Chippaux","year":"2010","journal-title":"Biol. Aujourdhui"},{"key":"10.1016\/j.ijbiomac.2020.05.171_bb0065","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.molimm.2018.10.019","article-title":"Identification of a linear B-cell epitope in the catalytic domain of bothropasin, a metalloproteinase from Bothrops jararaca snake venom","volume":"104","author":"Molina Molina","year":"2018","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ijbiomac.2020.05.171_bb0070","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.vaccine.2009.11.039","article-title":"In vivo protection against Tityus serrulatus scorpion venom by antibodies raised against a discontinuous synthetic epitope","volume":"28","author":"Duarte","year":"2010","journal-title":"Vaccine"},{"issue":"42","key":"10.1016\/j.ijbiomac.2020.05.171_bb0075","doi-asserted-by":"crossref","first-page":"9217","DOI":"10.1016\/S0040-4020(01)85612-X","article-title":"Spot-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support","volume":"48","author":"Frank","year":"1992","journal-title":"Tetrahedron"},{"issue":"3","key":"10.1016\/j.ijbiomac.2020.05.171_bb0080","first-page":"151","article-title":"Improved performances of spot multiple peptide synthesis","volume":"9","author":"Molina","year":"1996","journal-title":"Pept. Res."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.05.171_bb0085","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0304-4165(99)00211-1","article-title":"Biochemical characterization of two crotamine isoforms isolated by a single step RP-HPLC from Crotalus durissus terrificus (South American rattlesnake) venom and their action on insulin secretion by pancreatic islets","volume":"1474","author":"Toyama","year":"2000","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"issue":"2","key":"10.1016\/j.ijbiomac.2020.05.171_bb0090","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1021\/bi00402a036","article-title":"Crotoxin, a phospholipase A2 neurotoxin from the South American rattlesnake Crotalus durissus terrificus: purification of several isoforms and comparison of their molecular structure and of their biological activities","volume":"27","author":"Faure","year":"1988","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.05.171_bb0095","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.ijbiomac.2020.05.171_bb0100","first-page":"429","article-title":"Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-Sepharose","volume":"15","author":"Ey","year":"1978","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ijbiomac.2020.05.171_bb0105","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-1-59745-324-0_3","article-title":"Antibody purification: ammonium sulfate fractionation or gel filtration","volume":"588","author":"Grodzki","year":"2010","journal-title":"Methods Mol. Biol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2020.05.171_bb0110","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0041-0101(96)00119-5","article-title":"An enzyme-linked immunosorbent assay (ELISA) that discriminates between the venoms of Brazilian Bothrops species and Crotalus durissus","volume":"35","author":"Ch\u00e1vez-Ol\u00f3rtegui","year":"1997","journal-title":"Toxicon"},{"issue":"10","key":"10.1016\/j.ijbiomac.2020.05.171_bb0115","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1107\/S0907444913018003","article-title":"Structure of the polypeptide crotamine from the Brazilian rattlesnake Crotalus durissus terrificus","volume":"69","author":"Coronado","year":"2013","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"issue":"3","key":"10.1016\/j.ijbiomac.2020.05.171_bb0120","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/prot.21980","article-title":"Insights into the role of oligomeric state on the biological activities of crotoxin: crystal structure of a tetrameric phospholipase A2 formed by two isoforms of crotoxin B from Crotalus durissus terrificus venom","volume":"72","author":"Marchi-Salvador","year":"2008","journal-title":"Proteins Struct. Funct. Bioinforma"},{"key":"10.1016\/j.ijbiomac.2020.05.171_bb0125","series-title":"The PyMOL Molecular Graphics System, Version 1.8","author":"DeLano","year":"2014"},{"issue":"6","key":"10.1016\/j.ijbiomac.2020.05.171_bb0130","first-page":"315","article-title":"Automated multiple peptide synthesis","volume":"5","author":"Gausepohl","year":"1992","journal-title":"Pept. Res."},{"issue":"2\u20133","key":"10.1016\/j.ijbiomac.2020.05.171_bb0135","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11168-006-9004-0","article-title":"Alignment as the basis for successful communication","volume":"4","author":"Pickering","year":"2006","journal-title":"Res. Lang. Comput."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.05.171_bb0140","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/msb.2011.75","article-title":"Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega","volume":"7","author":"Sievers","year":"2011","journal-title":"Mol. Syst. Biol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.05.171_bb0145","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/pro.3290","article-title":"Clustal Omega for making accurate alignments of many protein sequences","volume":"27","author":"Sievers","year":"2018","journal-title":"Protein Sci."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.05.171_bb0150","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/02652048409031535","article-title":"Preparation of liposomes containing factor VIII for oral treatment of haemophilia","volume":"1","author":"Kirby","year":"1984","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.ijbiomac.2020.05.171_bb0155","series-title":"Probit Analysis","author":"Finney","year":"1971"},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.05.171_bb0160","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1124\/mol.112.078188","article-title":"Crotamine pharmacology revisited: novel insights based on the inhibition of KV channels","volume":"82","author":"Peigneur","year":"2012","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2020.05.171_bb0165","series-title":"Snakebite Envenoming. Nature Reviews. Disease Primers","author":"Guti\u00e9rrez","year":"2017"},{"key":"10.1016\/j.ijbiomac.2020.05.171_bb0170","series-title":"da Sa\u00fade M. Manual de diagn\u00f3stico e tratamento de acidentes por animais pe\u00e7onhentos","author":"Minist\u00e9rio da Sa\u00fade","year":"2001"},{"issue":"6","key":"10.1016\/j.ijbiomac.2020.05.171_bb0175","article-title":"Animais pe\u00e7onhentos no Brasil: biologia, cl\u00ednica e terap\u00eautica dos acidentes","volume":"45","author":"Cardoso","year":"2003","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"issue":"3","key":"10.1016\/j.ijbiomac.2020.05.171_bb0180","first-page":"75","article-title":"R\u00e9pteis brasileiros: lista de esp\u00e9cies","volume":"4","author":"B\u00e9rnils","year":"2015","journal-title":"Herpetol. Bras."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.05.171_bb0185","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1124\/mol.112.078188","article-title":"Crotamine pharmacology revisited: novel insights based on the inhibition of KV channels","volume":"82","author":"Peigneur","year":"2012","journal-title":"Mol. Pharmacol."},{"issue":"9","key":"10.1016\/j.ijbiomac.2020.05.171_bb0190","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1590\/S0100-879X2000000900017","article-title":"Crotoxin, the major toxin from the rattlesnake Crotalus durissus terrificus, inhibits 3H-choline uptake in guinea pig ileum","volume":"33","author":"Kattah","year":"2000","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"2","key":"10.1016\/j.ijbiomac.2020.05.171_bb0195","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jmb.2011.07.027","article-title":"Crystal structure of crotoxin reveals key residues involved in the stability and toxicity of this potent heterodimeric \u03b2-neurotoxin","volume":"412","author":"Faure","year":"2011","journal-title":"J. Mol. Biol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2020.05.171_bb0200","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1073\/pnas.75.2.600","article-title":"Search for relationships among the hemolytic, phospholipipolytic, and neurotoxic activities of snake venoms","volume":"75","author":"Jeng","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.ijbiomac.2020.05.171_bb0205","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1432-1033.1979.tb13278.x","article-title":"Postsynaptic effects of crotoxin and of its isolated subunits","volume":"99","author":"Bon","year":"1979","journal-title":"Eur. J. Biochem."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.05.171_bb0210","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1472-6807-7-82","article-title":"Characterization of a human coagulation factor Xa-binding site on Viperidae snake venom phospholipases A2 by affinity binding studies and molecular bioinformatics","volume":"7","author":"Faure","year":"2007","journal-title":"BMC Struct. Biol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.05.171_bb0215","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.toxicon.2012.02.007","article-title":"Snake venom Lys49 myotoxins: from phospholipases A 2 to non-enzymatic membrane disruptors","volume":"60","author":"Lomonte","year":"2012","journal-title":"Toxicon"},{"issue":"6","key":"10.1016\/j.ijbiomac.2020.05.171_bb0220","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.ajhg.2011.11.004","article-title":"Biallelic mutations in PLA2G5, encoding group v phospholipase A 2, cause benign fleck retina","volume":"89","author":"Sergouniotis","year":"2011","journal-title":"Am. J. Hum. Genet."},{"issue":"5480","key":"10.1016\/j.ijbiomac.2020.05.171_bb0225","doi-asserted-by":"crossref","DOI":"10.1038\/252252a0","article-title":"Liposomes as immunological adjuvants","volume":"252","author":"Allison","year":"1974","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.ijbiomac.2020.05.171_bb0230","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1016\/j.vaccine.2012.01.070","article-title":"Design considerations for liposomal vaccines: influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens","volume":"30","author":"Watson","year":"2012","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.05.171_bb0235","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1096\/fasebj.9.1.7821757","article-title":"Antigenic peptides","volume":"9","author":"Dyson","year":"1995","journal-title":"FASEB J."},{"key":"10.1016\/j.ijbiomac.2020.05.171_bb0240","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.jprot.2011.06.019","article-title":"Research strategies to improve snakebite treatment: challenges and progress","volume":"74","author":"Harrison","year":"2011","journal-title":"J. Proteome"},{"issue":"11","key":"10.1016\/j.ijbiomac.2020.05.171_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10110452","article-title":"Innovative immunization strategies for antivenom development","volume":"10","author":"Berm\u00fadez-M\u00e9ndez","year":"2018","journal-title":"Toxins"}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813020333328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813020333328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T08:12:15Z","timestamp":1758874335000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813020333328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":48,"alternative-id":["S0141813020333328"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.05.171","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunoprotection against lethal effects of Crotalus durissus snake venom elicited by synthetic epitopes trapped in liposomes","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.05.171","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}