{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:25:20Z","timestamp":1793744720745,"version":"4.6.1"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007787","name":"National Research Centre","doi-asserted-by":"publisher","award":["11090127"],"award-info":[{"award-number":["11090127"]}],"id":[{"id":"10.13039\/100007787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.ijbiomac.2020.07.133","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T10:45:15Z","timestamp":1595069115000},"page":"1149-1163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":105,"special_numbering":"C","title":["Colchicine mesoporous silica nanoparticles\/hydrogel composite loaded cotton patches as a new encapsulator system for transdermal osteoarthritis management"],"prefix":"10.1016","volume":"164","author":[{"given":"Amina L.","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba","family":"Elmotasem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer A.A.","family":"Salama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0005","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.joca.2018.11.001","article-title":"Osteoarthritis year in review 2018: clinical","volume":"27","author":"Mandl","year":"2018","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0010","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.joca.2015.07.026","article-title":"Osteoarthritis year in review 2015: clinical","volume":"24","author":"Sharma","year":"2016","journal-title":"Osteoarthritis and cartilage \/ OARS, Osteoarthritis Research Society"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0015","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.berh.2008.07.002","article-title":"Osteoarthritis","volume":"22","author":"Das","year":"2008","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0020","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.joca.2013.03.018","article-title":"The epidemiology and impact of pain in osteoarthritis","volume":"21","author":"Neogi","year":"2013","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11926-018-0716-6","article-title":"Peripheral mechanisms contributing to osteoarthritis pain","volume":"20","author":"Syx","year":"2018","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0030","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1053\/joca.2002.0516","article-title":"A randomized controlled trial to evaluate the slow-acting symptom modifying effects of a regimen containing colchicine in a subset of patients with osteoarthritis of the knee","volume":"10","author":"Das","year":"2002","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0035","first-page":"513","article-title":"A double-blind randomized controlled trial appraising the symptom-modifying effects of colchicine on osteoarthritis of the knee","volume":"29","author":"Aran","year":"2011","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0040","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s13063-015-0726-x","article-title":"Colchicine effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): study protocol for a randomized controlled trial","volume":"16","author":"Leung","year":"2015","journal-title":"Trials"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0045","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.joca.2018.01.026","article-title":"Colchicine lack of effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): a randomized controlled trial","volume":"26","author":"Leung","year":"2018","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0050","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.amjmed.2014.12.010","article-title":"Colchicine: old and new","volume":"128","author":"Slobodnick","year":"2015","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0055","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.semarthrit.2015.06.013","article-title":"Colchicine\u2014update on mechanisms of action and therapeutic uses","volume":"45","author":"Leung","year":"2015","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0060","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jddst.2018.10.036","article-title":"Flexible nano-sized lipid vesicles for the transdermal delivery of colchicine; in vitro\/in vivo investigation","volume":"49","author":"El-Feky","year":"2019","journal-title":"Journal of Drug Delivery Science and Technology"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0065","doi-asserted-by":"crossref","first-page":"795","DOI":"10.2147\/DDDT.S158018","article-title":"Transethosomal gels as carriers for the transdermal delivery of colchicine: statistical optimization, characterization, and ex vivo evaluation","volume":"12","author":"Abdulbaqi","year":"2018","journal-title":"Drug design, development and therapy"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0070","first-page":"143","article-title":"A comprehensive investigation of inpatient intravenous colchicine use shows more education is needed","volume":"23","author":"Evans","year":"1996","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0075","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.cclet.2018.10.037","article-title":"Nano-formulations for transdermal drug delivery: a review","volume":"29","author":"Zhou","year":"2018","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0080","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1208\/s12248-008-9078-8","article-title":"Elastic liposomal formulation for sustained delivery of colchicine: in vitro characterization and in vivo evaluation of anti-gout activity","volume":"11","author":"Singh","year":"2009","journal-title":"AAPS J."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0085","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1248\/yakushi.130.397","article-title":"Preparation and in vitro, in vivo characterization of elastic liposomes encapsulating cyclodextrin-colchicine complexes for topical delivery of colchicine","volume":"130","author":"Singh","year":"2010","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0090","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jddst.2017.08.013","article-title":"Fabrication and in-vivo evaluation of lipid nanocarriers based transdermal patch of colchicine","volume":"41","author":"Joshi","year":"2017","journal-title":"Journal of Drug Delivery Science and Technology"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0095","first-page":"262","article-title":"Mesoporous silica materials: from physico-chemical properties to enhanced dissolution of poorly water-soluble drugs","author":"Maleki","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0100","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejpb.2014.11.022","article-title":"Mesoporous silica as topical nanocarriers for quercetin: characterization and in vitro studies","volume":"89","author":"Sapino","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0105","doi-asserted-by":"crossref","first-page":"17041","DOI":"10.1039\/C9NR06303J","article-title":"Transdermal delivery of small interfering RNAs with topically applied mesoporous silica nanoparticles for facile skin cancer treatment","volume":"11","author":"Lio","year":"2019","journal-title":"Nanoscale"},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.07.133_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12010028","article-title":"Silica-polymer composites as the novel antibiotic delivery systems for bone tissue infection","volume":"12","author":"Skwira","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0115","doi-asserted-by":"crossref","first-page":"067","DOI":"10.7324\/JAPS.2015.501211","article-title":"Controlled release of drugs from cellulosic wound bandage using silica microsphere as drug encapsulator module","volume":"5","author":"Hassabo","year":"2015","journal-title":"JAPS"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0120","first-page":"59","article-title":"Metal salts rented in silica microcapsules as inorganic phase change materials for textile usage","volume":"10","author":"Hassabo","year":"2015","journal-title":"Inorganic Chemistry: An Indian Journal"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0125","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jcis.2017.03.080","article-title":"Surface modification of SiO2 coated ZnO nanoparticles for multifunctional cotton fabrics","volume":"498","author":"El-Naggar","year":"2017","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0130","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s00542-015-2776-0","article-title":"Novel nano polymeric system containing biosynthesized core shell silver\/silica nanoparticles for functionalization of cellulosic based material","volume":"22","author":"Mohamed","year":"2016","journal-title":"Microsys. Technol."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0135","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ijbiomac.2016.10.082","article-title":"Laminating of chemically modified silan based nanosols for advanced functionalization of cotton textiles","volume":"95","author":"Mohamed","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0140","article-title":"Composite material based on pullulan\/silane\/ZnO-NPs as pH, thermo-sensitive and antibacterial agent for cellulosic fabrics","volume":"9","author":"Mohamed","year":"2018","journal-title":"Advances in Natural Science: Nanoscience and Nanotechnolgy"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0145","first-page":"139","article-title":"Review of silicon-based materials for cellulosic fabrics with functional applications","volume":"16","author":"Mohamed","year":"2019","journal-title":"Journal of Textiles, Coloration and Polymer Science"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0150","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s42833-019-0002-6","article-title":"Multifunctional magnetic iron oxide nanoparticles: diverse synthetic approaches, surface modifications, cytotoxicity towards biomedical and industrial applications","volume":"1","author":"Natarajan","year":"2019","journal-title":"BMC Materials"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0155","doi-asserted-by":"crossref","first-page":"7008","DOI":"10.1039\/C7TB01217A","article-title":"Gelatin-functionalized mesoporous silica nanoparticles with sustained release properties for intracameral pharmacotherapy of glaucoma","volume":"5","author":"Liao","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0160","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jajs.2017.10.003","article-title":"The Promise of Silicon: bone regeneration and increased bone density","volume":"4","author":"Arora","year":"2017","journal-title":"Journal of Arthroscopy and Joint Surgery"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0165","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.apmt.2017.12.002","article-title":"Self-crosslinking and injectable chondroitin sulfate\/pullulan hydrogel for cartilage tissue engineering","volume":"10","author":"Li","year":"2018","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0170","doi-asserted-by":"crossref","first-page":"7836","DOI":"10.1021\/acsami.8b21967","article-title":"Self-nanoemulsifying electrospun fiber enhancing drug permeation","volume":"11","author":"Xiang","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0175","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3390\/pharmaceutics11030117","article-title":"Effects of silicon compounds on biomineralization, osteogenesis, and hard tissue formation","volume":"11","author":"G\u00f6tz","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0180","doi-asserted-by":"crossref","first-page":"110886","DOI":"10.1016\/j.msec.2020.110886","article-title":"Lubrication and drug release behaviors of mesoporous silica nanoparticles grafted with sulfobetaine-based zwitterionic polymer","volume":"112","author":"Wan","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0185","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ijbiomac.2020.06.110","article-title":"A review on biomacromolecular hydrogel classification and its applications","volume":"162","author":"Sharma","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0190","doi-asserted-by":"crossref","first-page":"110670","DOI":"10.1016\/j.msec.2020.110670","article-title":"Biomimetic organic-inorganic hybrid hydrogel electrospinning periosteum for accelerating bone regeneration","volume":"110","author":"Liu","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0195","doi-asserted-by":"crossref","first-page":"41168","DOI":"10.1021\/acsami.7b13167","article-title":"Inorganic strengthened hydrogel membrane as regenerative periosteum","volume":"9","author":"Xin","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0200","doi-asserted-by":"crossref","first-page":"6840","DOI":"10.1021\/acsami.9b18496","article-title":"Programmed sustained release of recombinant human bone morphogenetic protein-2 and inorganic ion composite hydrogel as artificial Periosteum","volume":"12","author":"Xin","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0205","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/ajcn\/75.5.887","article-title":"Dietary silicon intake and absorption","volume":"75","author":"Jugdaohsingh","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0210","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201604634","article-title":"Degradability and clearance of silicon, organosilica, silsesquioxane, silica mixed oxide, and mesoporous silica nanoparticles","volume":"29","author":"Croissant","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0215","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201700831","article-title":"Mesoporous silica and organosilica nanoparticles: physical chemistry, biosafety, delivery strategies, and biomedical applications","volume":"7","author":"Croissant","year":"2018","journal-title":"Advanced Healthcare Materials"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0220","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.biomaterials.2009.09.060","article-title":"The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function","volume":"31","author":"Huang","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0225","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ijpharm.2016.12.018","article-title":"Enhancement of 8-methoxypsoralen topical delivery via nanosized niosomal vesicles: formulation development, in vitro and in vivo evaluation of skin deposition","volume":"517","author":"Kassem","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0230","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ijpharm.2018.05.038","article-title":"In vitro and in vivo evaluation of an oral sustained release hepatoprotective caffeine loaded w\/o Pickering emulsion formula - containing wheat germ oil and stabilized by magnesium oxide nanoparticles","volume":"547","author":"Elmotasem","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0235","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jddst.2018.01.017","article-title":"Mannosylated gelatin nanoparticles of licorice for use in tuberculosis: formulation, in vitro evaluation, in vitro cell uptake, in vivo pharmacokinetics and in vivo anti-tubercular efficacy","volume":"45","author":"Viswanathan","year":"2018","journal-title":"Journal of Drug Delivery Science and Technology"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0240","series-title":"Standard Test Methods for Stiffness of Fabrics","author":"ASTM Standard Test Method (ASTM D1388 \u2212 14e1)","year":"2016"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0245","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2174\/156720108785915005","article-title":"Design and evaluation of chitosan films for transdermal delivery of glimepiride","volume":"5","author":"Ammar","year":"2008","journal-title":"Curr Drug Deliv"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.111024","article-title":"Permeation kinetics of active drugs through lanolin-based artificial membranes","volume":"192","author":"Alonso","year":"2020","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0255","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejps.2017.05.045","article-title":"Ex vivo skin permeation and penetration of nonivamide from and in vivo skin tolerability of film-forming formulations containing porous silica","volume":"106","author":"Heck","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajps.2019.09.003","article-title":"A stepwise optimization strategy to formulate in situ gelling formulations comprising fluconazole-hydroxypropyl-beta-cyclodextrin complex loaded niosomal vesicles and Eudragit nanoparticles for enhanced antifungal activity and prolonged ocular delivery","author":"Elmotasem","year":"2020","journal-title":"Asian Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0265","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ijpharm.2015.07.010","article-title":"Tri\/tetra-block co-polymeric nanocarriers as a potential ocular delivery system of lornoxicam: in-vitro characterization, and in-vivo estimation of corneal permeation","volume":"492","author":"Salama","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0270","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1292\/jvms.65.1195","article-title":"Sodium iodoacetate-induced experimental osteoarthritis and associated pain model in rats","volume":"65","author":"Kobayashi","year":"2003","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0275","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3923\/ijp.2016.329.339","article-title":"Study of the protective effects of flaxseed oil on ethanol induced gastric mucosal lesions in non ovariectomized and ovariectomized rats","volume":"12","author":"Ibrahim","year":"2016","journal-title":"International Journal of Pharmacology"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/7840687","article-title":"Low-temperature production of genuinely amorphous carbon from highly reactive nanoacetylide precursors","volume":"2016","author":"Judai","year":"2016","journal-title":"J. Chem."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0285","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/1521-3935(20000901)201:14<1701::AID-MACP1701>3.0.CO;2-V","article-title":"Synthesis of a novel N-selective ester functionalized chitin derivative and water-soluble carboxyethylchitin","volume":"201","author":"Aoi","year":"2000","journal-title":"Macromol. Chem. Phys."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0290","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.carbpol.2006.05.025","article-title":"Oxidation of sodium alginate and characterization of the oxidized derivatives","volume":"67","author":"Gomez","year":"2007","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0295","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1021\/bp010070p","article-title":"Degradation of partially oxidized alginate and its potential application for tissue engineering","volume":"17","author":"Bouhadir","year":"2001","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0300","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1021\/bm025567h","article-title":"Evaluation of chain stiffness of partially oxidized polyguluronate","volume":"3","author":"Lee","year":"2002","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0305","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1039\/C8TB02547A","article-title":"Progress in self-healing hydrogels assembled by host-guest interactions: preparation and biomedical applications","volume":"7","author":"Jin","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s42833-019-0007-1","article-title":"Emerging functional materials based on chemically designed molecular recognition","volume":"2","author":"Chen","year":"2020","journal-title":"BMC Materials"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0315","doi-asserted-by":"crossref","first-page":"6297","DOI":"10.1002\/adfm.201601612","article-title":"Proteoid dynamers with tunable properties","volume":"26","author":"Liu","year":"2016","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0320","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s42833-019-0005-3","article-title":"Dual functional \u03b2-peptide polymer-modified resin beads for bacterial killing and endotoxin adsorption","volume":"1","author":"Qian","year":"2019","journal-title":"BMC Materials"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0325","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.foodhyd.2012.04.002","article-title":"Preparation and characterization of pullulan chitosan and pullulan carboxymethyl chitosan blended films","volume":"30","author":"Wu","year":"2013","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0330","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijpharm.2017.07.058","article-title":"Mesoporous silica nanoparticles as a promising skin delivery system for methotrexate","volume":"530","author":"Sapino","year":"2017","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.07.133_bb0335","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ijpharm.2016.07.024","article-title":"Thermoresponsive mesoporous silica nanoparticles as a carrier for skin delivery of quercetin","volume":"511","author":"Ugazio","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0340","doi-asserted-by":"crossref","first-page":"6703","DOI":"10.1021\/acsnano.7b01023","article-title":"Super-cationic carbon quantum dots synthesized from spermidine as an eye drop formulation for topical treatment of bacterial keratitis","volume":"11","author":"Jian","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119961","article-title":"Dually functional hollow ceria nanoparticle platform for intraocular drug delivery: a push beyond the limits of static and dynamic ocular barriers toward glaucoma therapy","volume":"243","author":"Luo","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0350","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0378-5173(89)90306-2","article-title":"A simple equation for the description of solute release. III. Coupling of diffusion and relaxation","volume":"57","author":"Peppas","year":"1989","journal-title":"Int. J. Pharm."},{"issue":"7","key":"10.1016\/j.ijbiomac.2020.07.133_bb0355","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1023\/A:1018931210396","article-title":"Zero-order drug release from hydrocolloid matrices","volume":"10","author":"M\u00f6ckel","year":"1993","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0360","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijbiomac.2020.01.073","article-title":"Kinetics and controlled release of lidocaine from novel carrageenan and alginate-based blend hydrogels","volume":"147","author":"Rasool","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119411","article-title":"Nanotechnology based blended chitosan-pectin hybrid for safe and efficient consolidative antiemetic and neuro-protective effect of meclizine hydrochloride in chemotherapy induced emesis","volume":"584","author":"Salama","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0370","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/art.1780400917","article-title":"Mono-iodoacetate-induced experimental osteoarthritis: a dose-response study of loss of mobility, morphology, and biochemistry","volume":"40","author":"Guingamp","year":"1997","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0375","doi-asserted-by":"crossref","first-page":"454","DOI":"10.4103\/0971-5916.159296","article-title":"Effect of alcoholic extract of Entada pursaetha DC on monosodium iodoacetate-induced osteoarthritis pain in rats","volume":"141","author":"Kumari","year":"2015","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0380","doi-asserted-by":"crossref","first-page":"46","DOI":"10.21608\/bvmj.2017.29987","article-title":"Biochemical studies on the effect of curcumin in experimentally induced osteoarthritis in rats","volume":"33","author":"El-senosi","year":"2017","journal-title":"Benha Veterinary Medical Journal"},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0385","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00232-011-9404-4","article-title":"Colchicine modulates oxidative stress in serum and neutrophil of patients with Behcet disease through regulation of Ca(2)(+) release and antioxidant system","volume":"244","author":"Korkmaz","year":"2011","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0390","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1053\/joca.2001.0472","article-title":"Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors","volume":"9","author":"Janusz","year":"2001","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ijbiomac.2020.07.133_bb0395","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3390\/ijms17020249","article-title":"Antinociceptive and anti-inflammatory effects of zerumbone against mono-iodoacetate-induced arthritis","volume":"17","author":"Chien","year":"2016","journal-title":"Int. J. Mol. Sci."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813020338824?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813020338824?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:49:48Z","timestamp":1788295788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813020338824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":79,"alternative-id":["S0141813020338824"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.07.133","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Colchicine mesoporous silica nanoparticles\/hydrogel composite loaded cotton patches as a new encapsulator system for transdermal osteoarthritis management","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.07.133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}