{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T15:32:00Z","timestamp":1794238320372,"version":"4.9.0"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["31820103010"],"award-info":[{"award-number":["31820103010"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["31530056"],"award-info":[{"award-number":["31530056"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["31871773"],"award-info":[{"award-number":["31871773"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1604206"],"award-info":[{"award-number":["2018YFC1604206"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015601","name":"Collaborative Innovationcenter of Food Safety and Quality Control in Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.ijbiomac.2020.07.191","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T02:47:21Z","timestamp":1595386041000},"page":"884-891","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":241,"special_numbering":"C","title":["The role of MUC2 mucin in intestinal homeostasis and the impact of dietary components on MUC2 expression"],"prefix":"10.1016","volume":"164","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixiao","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0005","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1007\/s00018-011-0822-3","article-title":"Composition and functional role of the mucus layers in the intestine","volume":"68","author":"Johansson","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0010","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1038\/ajg.2010.281","article-title":"Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria","volume":"105","author":"Png","year":"2010","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0015","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1053\/j.gastro.2006.04.020","article-title":"Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection","volume":"131","author":"Van der Sluis","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0020","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3390\/pathogens2010055","article-title":"Goblet cells and mucins: role in innate defense in enteric infections","volume":"2","author":"Kim","year":"2013","journal-title":"Pathogens"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0025","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1042\/BJ20102066","article-title":"Function of the CysD domain of the gel-forming MUC2 mucin","volume":"436","author":"Ambort","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0030","doi-asserted-by":"crossref","first-page":"47248","DOI":"10.1074\/jbc.M208483200","article-title":"The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment","volume":"277","author":"Godl","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0035","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1016\/j.jmb.2016.02.010","article-title":"The densely O-glycosylated MUC2 mucin protects the intestine and provides food for the commensal bacteria","volume":"428","author":"Arike","year":"2016","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0040","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1177\/0884533608329231","article-title":"Unraveling mechanisms of action of probiotics","volume":"24","author":"Sherman","year":"2009","journal-title":"Nutr. Clin. Pract."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0045","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrmicro2538","article-title":"Mucin dynamics and enteric pathogens","volume":"9","author":"McGuckin","year":"2011","journal-title":"Nat. Rev. Microbiol"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0050","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.physiol.70.113006.100638","article-title":"Regulated airway goblet cell mucin secretion","volume":"70","author":"Davis","year":"2008","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0055","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1007\/s00253-016-7322-1","article-title":"Implication of sortase-dependent proteins of Streptococcus thermophilus in adhesion to human intestinal epithelial cell lines and bile salt tolerance","volume":"100","author":"Kebouchi","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0060","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1046\/j.1440-1711.2003.t01-1-01163.x","article-title":"mRNA of MUC2 is stimulated by IL-4, IL-13 or TNF-\u03b1 through a mitogen-activated protein kinase pathway in human colon cancer cells","volume":"81","author":"Iwashita","year":"2003","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0065","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s00383-002-0855-7","article-title":"Probiotics up-regulate MUC-2 mucin gene expression in a Caco-2 cell-culture model","volume":"18","author":"Mattar","year":"2002","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0070","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1053\/j.gastro.2009.06.044","article-title":"The Ets-Domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium","volume":"137","author":"Gregorieff","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0075","first-page":"941","article-title":"Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR\/PKC\/Ras\/ERK\/CREB, PI3K\/Akt\/I\u03baB\/NF-\u03baB and p38\/MSK1\/CREB pathways and negative JNK\/c-Jun\/AP-1 pathway","volume":"36","author":"Lee","year":"2010","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0080","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3390\/toxins11020132","article-title":"Modulation of mucin (MUC2, MUC5AC and MUC5B) mRNA expression and protein production and secretion in Caco-2\/HT29-MTX co-cultures following exposure to individual and combined aflatoxin M1 and ochratoxin A","volume":"11","author":"Huang","year":"2019","journal-title":"Toxins."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0085","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1002\/jat.3655","article-title":"Endoplasmic reticulum stress is involved in the T-2 toxin-induced apoptosis in goat endometrium epithelial cells","volume":"38","author":"Yi","year":"2018","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0090","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/mnfr.201500005","article-title":"Deoxynivalenol inhibits the expression by goblet cells of intestinal mucins through a PKR and MAP kinase dependent repression of the resistin-like molecule \u03b2","volume":"59","author":"Pinton","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0095","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.biopha.2019.01.007","article-title":"Bisphenol A inhibits mucin 2 secretion in intestinal goblet cells through mitochondrial dysfunction and oxidative stress","volume":"111","author":"Zhao","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0100","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S1665-2681(19)31012-9","article-title":"PGE2 induces MUC2 and MUC5AC expression in human intrahepatic biliary epithelial cells via EP4\/p38MAPK activation","volume":"12","author":"Yang","year":"2013","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0105","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0008-8749(03)00059-5","article-title":"LPS up-regulates mucin and cytokine mRNA expression and stimulates mucin and cytokine secretion in goblet cells","volume":"221","author":"Smirnova","year":"2003","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0110","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/glycob\/9.1.13","article-title":"Mucin secretion by the human colon cell line LS174T is regulated by bile salts","volume":"9","author":"Klinkspoor","year":"1999","journal-title":"Glycobiology"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0115","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1042\/BJ20082222","article-title":"The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection","volume":"420","author":"Burger-van Paassen","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0120","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1183\/09031936.96.09030542","article-title":"Nucleotide-induced mucin release from primary hamster tracheal surface epithelial cells involves the P2u purinoceptor","volume":"9","author":"Kim","year":"1996","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0125","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1042\/bj3230521","article-title":"Stimulation of mucin exocytosis from human epithelial cells by nitric oxide: evidence for a cGMP-dependent and a cGMP-independent pathway","volume":"323","author":"Branka","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0130","first-page":"G949","article-title":"Vasoactive intestinal peptide upregulates MUC2 intestinal mucin via CREB\/ATF1","volume":"289","author":"Hokari","year":"2005","journal-title":"Am. J. Physiol.-Gastr"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0135","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s00011-003-1171-y","article-title":"Effects of activation of polymorphonuclear leukocytes on airway goblet cell mucin release in a co-culture system","volume":"52","author":"Kim","year":"2003","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0140","doi-asserted-by":"crossref","first-page":"164","DOI":"10.15252\/embr.201439263","article-title":"The composition of the gut microbiota shapes the colon mucus barrier","volume":"16","author":"Jakobsson","year":"2015","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0145","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1080\/19490976.2015.1086057","article-title":"The colonic mucus protection depends on the microbiota","volume":"6","author":"Rodr\u00edguez-Pi\u00f1eiro","year":"2015","journal-title":"Gut Microbes"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0150","doi-asserted-by":"crossref","first-page":"G315","DOI":"10.1152\/ajpgi.00265.2006","article-title":"The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells","volume":"292","author":"Caballero-Franco","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/1829632","article-title":"Protective effects of benzoic acid, bacillus coagulans, and oregano oil on intestinal injury caused by enterotoxigenic Escherichia coli in weaned piglets","volume":"2018","author":"Pu","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0160","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1016\/S0016-5085(17)30687-X","article-title":"Bifidobacterium dentium upregulates intestinal SERT via the JNK pathway and stimulates serotonin release","volume":"152","author":"Engevik","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0165","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.lwt.2016.08.021","article-title":"Interaction between putative probiotic Lactobacillus strains of Indian gut origin and Salmonella: impact on intestinal barrier function","volume":"84","author":"Rokana","year":"2017","journal-title":"LWT - Food Sci Technol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0170","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1136\/gut.52.10.1442","article-title":"Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E1 and E2 production by intestinal myofibroblasts","volume":"52","author":"Willemsen","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022459","article-title":"Stromal IFN-\u03b3R-signaling modulates goblet cell function during Salmonella Typhimurium infection","volume":"6","author":"Songhet","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0180","doi-asserted-by":"crossref","first-page":"5718","DOI":"10.1073\/pnas.95.10.5718","article-title":"Activation of NF-\u03baB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells","volume":"95","author":"Li","year":"1998","journal-title":"Proc. Natl. Acad. Sci"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0185","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00203-008-0358-6","article-title":"Listeria monocytogenes internalins bind to the human intestinal mucin MUC2","volume":"190","author":"Lind\u00e9n","year":"2008","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000902","article-title":"Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa","volume":"6","author":"Bergstrom","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0195","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1128\/IAI.01078-13","article-title":"EatA, an immunogenic protective antigen of enterotoxigenic Escherichia coli, degrades intestinal mucin","volume":"82","author":"Kumar","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0200","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00399-18","article-title":"SslE (YghJ), a cell-associated and secreted lipoprotein of neonatal septicemic Escherichia coli, induces Toll-like receptor 2-dependent macrophage activation and proinflammation through NF-\u03baB and MAP kinase signaling","volume":"86","author":"Tapader","year":"2018","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0205","doi-asserted-by":"crossref","first-page":"e12717","DOI":"10.1111\/cmi.12717","article-title":"The StcE metalloprotease of enterohaemorrhagic Escherichia coli reduces the inner mucus layer and promotes adherence to human colonic epithelium ex vivo","volume":"19","author":"Hews","year":"2017","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0210","doi-asserted-by":"crossref","first-page":"14636","DOI":"10.1074\/jbc.M113.459479","article-title":"Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB)","volume":"288","author":"van der Post","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0215","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1099\/mic.0.26086-0","article-title":"Haemagglutinin\/protease expression and mucin gel penetration in El Tor biotype Vibrio cholerae","volume":"149","author":"Silva","year":"2003","journal-title":"Microbiology"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0220","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1002\/jcb.26569","article-title":"Molecular dynamics insights into the structure, function, and substrate binding mechanism of mucin desulfating sulfatase of gut microbe Bacteroides fragilis","volume":"119","author":"Praharaj","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0225","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1074\/jbc.M111.277384","article-title":"\u03b1-N-acetylgalactosaminidase from infant-associated bifidobacteria belonging to novel glycoside hydrolase family 129 is implicated in alternative mucin degradation pathway","volume":"287","author":"Kiyohara","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0230","first-page":"G510","article-title":"Human Clostridium difficile infection: altered mucus production and composition","volume":"308","author":"Engevik","year":"2014","journal-title":"Am. J. Physiol.-Gastr. L."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0235","doi-asserted-by":"crossref","first-page":"S","DOI":"10.1016\/S0016-5085(18)31072-2","article-title":"1057-Bifidobacterium dentium increases Muc2 synthesis and activates autophagy to promote mucin release","volume":"154","author":"Engevik","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016876","article-title":"The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes","volume":"6","author":"van Passel","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0245","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1016\/j.febslet.2010.04.045","article-title":"Mining metagenomic data for novel domains: BACON, a new carbohydrate-binding module","volume":"584","author":"Mello","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0250","doi-asserted-by":"crossref","first-page":"71456","DOI":"10.18632\/oncotarget.16886","article-title":"MUC2 mucin deficiency alters inflammatory and metabolic pathways in the mouse intestinal mucosa","volume":"8","author":"Tadesse","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0255","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1006\/bbrc.1996.1039","article-title":"Quantitative analysis of MUC2 synthesis in ulcerative colitis","volume":"224","author":"Tytgat","year":"1996","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0260","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1002\/ibd.21625","article-title":"Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation","volume":"17","author":"Larsson","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/431231","article-title":"Mucosal barrier in ulcerative colitis and Crohn\u2019s disease","volume":"2013","author":"Dorofeyev","year":"2013","journal-title":"Gastroent. Res. Pract"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0270","first-page":"79","article-title":"Mucins and inflammatory bowel disease","volume":"90","author":"Shirazi","year":"2000","journal-title":"QJM"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0275","first-page":"100655","article-title":"Decreased expression of MUC2 due to a decrease in the expression of lectins and apoptotic defects in colitis patients","volume":"19","author":"Wibowo","year":"2019","journal-title":"BB Rep"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0280","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1097\/MEG.0000000000000707","article-title":"Mucin gene expression in the intestine of ulcerative colitis patients: a systematic review and meta-analysis","volume":"28","author":"Niv","year":"2016","journal-title":"Eur. J. Gastroen. Hepatol"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0285","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/(SICI)1096-9896(199907)188:3<304::AID-PATH375>3.0.CO;2-A","article-title":"Defective post-transcriptional processing of MUC2 mucin in ulcerative colitis and in Crohn's disease increases detectability of the MUC2 protein core","volume":"188","author":"Hanski","year":"1999","journal-title":"J. Pathol."},{"issue":"33","key":"10.1016\/j.ijbiomac.2020.07.191_bb0290","doi-asserted-by":"crossref","first-page":"6016","DOI":"10.3748\/wjg.v23.i33.6016","article-title":"Dextran sodium sulfate colitis murine model: an indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis","author":"Eichele","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0295","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.3748\/wjg.v16.i32.4089","article-title":"Altered expression of MUC2 and MUC5AC in progression of colorectal carcinoma","volume":"16","author":"Bu","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0300","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3892\/ol.2016.4672","article-title":"Differential expression of mucins in middle eastern patients with colorectal cancer","volume":"12","author":"Al-Khayal","year":"2016","journal-title":"Oncol. Lett"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0305","first-page":"251","article-title":"Loss of MUC2 expression correlates with progression along the adenoma-carcinoma sequence pathway as well as de novo carcinogenesis in the colon","volume":"22","author":"Mizoshita","year":"2007","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0310","first-page":"1909","article-title":"Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis","volume":"6","author":"Biemer-H\u00fcttmann","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0315","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1136\/jcp.2006.039552","article-title":"Prognostic significance of mucins in colorectal cancer with different DNA mismatch-repair status","volume":"60","author":"Lugli","year":"2007","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0320","doi-asserted-by":"crossref","first-page":"192","DOI":"10.2307\/3273265","article-title":"Further studies on duodenal mucus as a factor in age resistance of chickens to parasitism","volume":"34","author":"Frick","year":"1948","journal-title":"J. Parasitol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0325","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.0141-9838.2004.00715.x","article-title":"Immune-mediated alteration in gut physiology and its role in host defence in nematode infection","volume":"26","author":"Khan","year":"2004","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0330","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1053\/j.gastro.2010.01.045","article-title":"Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection","volume":"138","author":"Hasnain","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0335","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1023\/A:1010622125040","article-title":"Coordinated Muc2 and Muc3 mucin gene expression in Trichinella spiralis infection in wild-type and cytokine-deficient mice","volume":"46","author":"Shekels","year":"2001","journal-title":"Digest Dis. Sci."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0340","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1128\/IAI.00854-13","article-title":"The mucin Muc2 limits pathogen burdens and epithelial barrier dysfunction during Salmonella enterica serovar Typhimurium colitis","volume":"81","author":"Zarepour","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0345","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.virol.2005.03.039","article-title":"Homeostasis and function of goblet cells during rotavirus infection in mice","volume":"337","author":"Boshuizen","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0350","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029094","article-title":"MicroRNA-449a overexpression, reduced NOTCH1 signals and scarce goblet cells characterize the small intestine of celiac patients","volume":"6","author":"Capuano","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0355","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1095-6433(00)00183-5","article-title":"Short chain fatty acids but not lactate or succinate stimulate mucus release in the rat colon","volume":"125","author":"Shimotoyodome","year":"2000","journal-title":"CBP Mol. Integr. Physiol"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0360","doi-asserted-by":"crossref","first-page":"12396","DOI":"10.1073\/pnas.1407597111","article-title":"Microbial-induced meprin \u03b2 cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus","volume":"111","author":"Andr\u00e9","year":"2014","journal-title":"Proc. Natl. Acad. Sci"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0365","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ejphar.2013.06.006","article-title":"The changes induced by cyclophosphamide in intestinal barrier and microflora in mice","volume":"714","author":"Yang","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0370","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1039\/C4FO01191K","article-title":"Dietary squid ink polysaccharide induces goblet cells to protect small intestine from chemotherapy induced injury","volume":"6","author":"Zuo","year":"2015","journal-title":"Food Funct."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0375","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.carbpol.2018.11.002","article-title":"Dendrobium huoshanense polysaccharide regionally regulates intestinal mucosal barrier function and intestinal microbiota in mice","volume":"206","author":"Xie","year":"2019","journal-title":"Carbohydr. Polym"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0380","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ijbiomac.2017.02.074","article-title":"Apple polysaccharide inhibits microbial dysbiosis and chronic inflammation and modulates gut permeability in HFD-fed rats","volume":"99","author":"Wang","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0385","first-page":"1","article-title":"Changes in the mucus barrier during Cisplatin-induced intestinal mucositis in rats","volume":"2013","author":"Yamamoto","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0390","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jff.2018.08.023","article-title":"Polysaccharide extracted from Enteromorpha ameliorates Cisplastin-induced small intestine injury in mice","volume":"49","author":"Ren","year":"2018","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0395","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1093\/jn\/137.6.1442","article-title":"A deficiency or excess of dietary threonine reduces protein synthesis in jejunum and skeletal muscle of young pigs","volume":"137","author":"Wang","year":"2007","journal-title":"J. Nutr."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0400","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cbpa.2008.12.002","article-title":"A moderate threonine deficiency differently affects protein metabolism in tissues of early-weaned piglets","volume":"152","author":"Hamard","year":"2009","journal-title":"CBP Mol. Integr. Physiol"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0405","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1093\/jn\/136.6.1558","article-title":"Specific amino acids increase mucin synthesis and microbiota in dextran sulfate sodium-treated rats","volume":"136","author":"Magali","year":"2006","journal-title":"J. Nutr."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0410","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.aninu.2016.05.004","article-title":"Leucine increases mucin 2 and occludin production in LS174T cells partially via PI3K-Akt-mTOR pathway","volume":"2","author":"Mao","year":"2016","journal-title":"Anim. Nutr"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0415","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.intimp.2015.10.003","article-title":"Catechin-7-O-\u03b2-d-glucopyranoside isolated from the seed of Phaseolus calcaratus Roxburgh ameliorates experimental colitis in rats","volume":"29","author":"Kook","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0420","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.fct.2012.12.018","article-title":"In vitro anti-inflammatory effect of apigenin in the Helicobacter pylori-infected gastric adenocarcinoma cells","volume":"53","author":"Wang","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0425","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/fsn3.818","article-title":"Effects of chlorogenic acid, epicatechin gallate, and quercetin on mucin expression and secretion in the Caco-2\/HT29-MTX cell model","volume":"7","author":"Volstatova","year":"2016","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0430","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.nut.2009.03.009","article-title":"Influence of dietary resveratrol on early and late molecular markers of 1,2-dimethylhydrazine-induced colon carcinogenesis","volume":"25","author":"Sengottuvelan","year":"2009","journal-title":"Nutr"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0435","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1177\/0148607112463076","article-title":"Cranberry proanthocyanidins improve the gut mucous layer morphology and function in mice receiving elemental enteral nutrition","volume":"37","author":"Pierre","year":"2013","journal-title":"JPEN J. Parenter. Enteral Nutr."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0440","doi-asserted-by":"crossref","first-page":"9253","DOI":"10.1038\/srep09253","article-title":"Phytonutrient diet supplementation promotes beneficial Clostridia species and intestinal mucus secretion resulting in protection against enteric infection","volume":"5","author":"Wlodarska","year":"2015","journal-title":"Sci. Rep.-UK"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0445","first-page":"47","article-title":"The effects of herbal plants on Mucin 2 gene expression and performance in ascetic broilers","volume":"8","author":"Sangani","year":"2014","journal-title":"IJVM"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0450","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/jn\/120.10.1179","article-title":"Alteration of gastrointestinal mucin by fiber feeding in rats","volume":"120","author":"Satchithanandam","year":"1990","journal-title":"J. Nutr."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0455","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.cell.2016.10.043","article-title":"A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility","volume":"167","author":"Desai","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0460","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.clnu.2010.05.005","article-title":"The combination of fructooligosaccharides and resistant starch shows prebiotic additive effects in rats","volume":"29","author":"Rodr\u00edguez-Cabezas","year":"2010","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0465","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nrmicro3050","article-title":"The abundance and variety of carbohydrate-active enzymes in the human gut microbiota","volume":"11","author":"Kaoutari","year":"2013","journal-title":"Nat. Rev. Microbiol"},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0470","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1024\/0300-9831.74.5.355","article-title":"Vitamin A deficiency aggravates rotavirus infection in CD-1 mice through extensive involvement of the gut","volume":"74","author":"Reifen","year":"2004","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0475","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jnutbio.2008.01.002","article-title":"Bacterial population and innate immunity-related genes in rat gastrointestinal tract are altered by vitamin A-deficient diet","volume":"20","author":"Amit-Romach","year":"2009","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0480","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1080\/09540105.2017.1313202","article-title":"Inorganic or organic zinc and MUC-2, IgA, IL-17, TGF-\u03b24 gene expression and sIgA secretion in broiler chickens","volume":"28","author":"Levkut","year":"2017","journal-title":"Food Agric. Immunol."},{"key":"10.1016\/j.ijbiomac.2020.07.191_bb0485","first-page":"421","article-title":"Nano-selenium activates Mucin gene expression in intestinal crypt cells","volume":"7","author":"Gowri","year":"2018","journal-title":"J. Pharm. Innov."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813020339507?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813020339507?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:58:21Z","timestamp":1788296301000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813020339507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":97,"alternative-id":["S0141813020339507"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.07.191","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of MUC2 mucin in intestinal homeostasis and the impact of dietary components on MUC2 expression","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.07.191","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}