{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T09:35:47Z","timestamp":1794562547333,"version":"4.9.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","award":["PI18\/00343"],"award-info":[{"award-number":["PI18\/00343"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015755","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015755","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["BFU2016-78232-P"],"award-info":[{"award-number":["BFU2016-78232-P"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2017-83265-R"],"award-info":[{"award-number":["SAF2017-83265-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022532","name":"Centro Nacional de Biotecnolog\u00eda","doi-asserted-by":"publisher","award":["PRB3-ISCIII"],"award-info":[{"award-number":["PRB3-ISCIII"]}],"id":[{"id":"10.13039\/501100022532","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022532","name":"Centro Nacional de Biotecnolog\u00eda","doi-asserted-by":"publisher","award":["PT17\/0019"],"award-info":[{"award-number":["PT17\/0019"]}],"id":[{"id":"10.13039\/501100022532","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003339","name":"Consejo Superior de Investigaciones Cient\u00edficas","doi-asserted-by":"publisher","award":["202020E079"],"award-info":[{"award-number":["202020E079"]}],"id":[{"id":"10.13039\/501100003339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CPII13\/00017"],"award-info":[{"award-number":["CPII13\/00017"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013248","name":"Family Process Institute","doi-asserted-by":"publisher","award":["BES-2017-080739"],"award-info":[{"award-number":["BES-2017-080739"]}],"id":[{"id":"10.13039\/100013248","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.ijbiomac.2020.07.235","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T21:31:21Z","timestamp":1596231081000},"page":"1693-1703","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":233,"special_numbering":"C","title":["Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening"],"prefix":"10.1016","volume":"164","author":[{"given":"Olga","family":"Abian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ortega-Alarcon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Jimenez-Alesanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ceballos-Laita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh T.","family":"Reyburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Rizzuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Velazquez-Campoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ijbiomac.2020.07.235_bb0005","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A novel coronavirus from patients with pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijbiomac.2020.07.235_bb0010","author":"W.H.O. (WHO)"},{"issue":"10223","key":"10.1016\/j.ijbiomac.2020.07.235_bb0015","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ijbiomac.2020.07.235_bb0020","series-title":"Supporting the Health Care Workforce During the COVID-19 Global Epidemic","author":"Adams","year":"2020"},{"key":"10.1016\/j.ijbiomac.2020.07.235_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117839","article-title":"Coronaviruses pathogenesis, comorbidities and multi-organ damage - a review","volume":"255","author":"Renu","year":"2020","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.07.235_bb0030","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41392-020-0191-1","article-title":"Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2","volume":"5","author":"Catanzaro","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"issue":"2","key":"10.1016\/j.ijbiomac.2020.07.235_bb0035","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/jebm.12395","article-title":"An introduction to economic studies, health emergencies, and COVID-19","volume":"13","author":"Clarke","year":"2020","journal-title":"J. Evid. Based Med."},{"key":"10.1016\/j.ijbiomac.2020.07.235_bb0040","doi-asserted-by":"crossref","DOI":"10.1111\/febs.15375","article-title":"A guide to COVID-19: a global pandemic caused by the novel coronavirus SARS-CoV-2","author":"Atzrodt","year":"2020","journal-title":"FEBS J."},{"issue":"5","key":"10.1016\/j.ijbiomac.2020.07.235_bb0045","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1128\/AAC.00976-10","article-title":"Combinatorial approaches to the prevention and treatment of HIV-1 infection","volume":"55","author":"Pirrone","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.07.235_bb0050","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd.2018.168","article-title":"Drug repurposing: progress, challenges and recommendations","volume":"18","author":"Pushpakom","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.07.235_bb0055","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41591-020-0820-9","article-title":"The proximal origin of SARS-CoV-2","volume":"26","author":"Andersen","year":"2020","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.ijbiomac.2020.07.235_bb0060","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41577-020-0311-8","article-title":"The trinity of COVID-19: immunity, inflammation and intervention","volume":"20","author":"Tay","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.07.235_bb0065","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.3390\/jcm9041225","article-title":"The COVID-19 pandemic: a comprehensive review of taxonomy, genetics, epidemiology, diagnosis, treatment, and control","volume":"9","author":"Helmy","year":"2020","journal-title":"J. Clin. Med."},{"issue":"23","key":"10.1016\/j.ijbiomac.2020.07.235_bb0070","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1835675100","article-title":"The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor","volume":"100","author":"Yang","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"9","key":"10.1016\/j.ijbiomac.2020.07.235_bb0075","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1111\/febs.12222","article-title":"Autoprocessing mechanism of severe acute respiratory syndrome coronavirus 3C-like protease (SARS-CoV 3CLpro) from its polyproteins","volume":"280","author":"Muramatsu","year":"2013","journal-title":"FEBS J."},{"key":"10.1016\/j.ijbiomac.2020.07.235_bb0080","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.virusres.2015.05.018","article-title":"Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus","volume":"208","author":"Wu","year":"2015","journal-title":"Virus Res."},{"issue":"5","key":"10.1016\/j.ijbiomac.2020.07.235_bb0085","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/cbic.202000047","article-title":"Learning from the past: possible urgent prevention and treatment options for severe acute respiratory infections caused by 2019-nCoV","volume":"21","author":"Morse","year":"2020","journal-title":"Chembiochem. Eur. J. Chem. Biol."},{"issue":"9","key":"10.1016\/j.ijbiomac.2020.07.235_bb0090","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.1021\/acs.jmedchem.9b01828","article-title":"\u03b1-Ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication: structure-based design, synthesis, and activity assessment","volume":"63","author":"Zhang","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ijbiomac.2020.07.235_bb0095","first-page":"1","article-title":"Identification of chymotrypsin-like protease inhibitors of SARS-CoV-2 via integrated computational approach","author":"Khan","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.07.235_bb0100","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bmc.2013.11.041","article-title":"Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings","volume":"22","author":"Lee","year":"2014","journal-title":"Bioorg. Med. Chem."},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.07.235_bb0105","first-page":"862","article-title":"Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate","volume":"318","author":"Kuo","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6489","key":"10.1016\/j.ijbiomac.2020.07.235_bb0110","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.abb3405","article-title":"Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved \u03b1-ketoamide inhibitors","volume":"368","author":"Zhang","year":"2020","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.ijbiomac.2020.07.235_bb0115","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"14","key":"10.1016\/j.ijbiomac.2020.07.235_bb0120","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B","article-title":"Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function","volume":"19","author":"Morris","year":"1998","journal-title":"J. Comput. Chem."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.07.235_bb0125","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1758-2946-4-17","article-title":"Avogadro: an advanced semantic chemical editor, visualization, and analysis platform","volume":"4","author":"Hanwell","year":"2012","journal-title":"J. Cheminform."},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.07.235_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23040894","article-title":"Identification by molecular docking of homoisoflavones from Leopoldia comosa as ligands of estrogen receptors","volume":"23","author":"Grande","year":"2018","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.07.235_bb0135","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s13238-010-0044-8","article-title":"Three-dimensional domain swapping as a mechanism to lock the active conformation in a super-active octamer of SARS-CoV main protease","volume":"1","author":"Zhang","year":"2010","journal-title":"Protein Cell"},{"key":"10.1016\/j.ijbiomac.2020.07.235_bb0140","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-59745-367-7_3","article-title":"Defining the stability of multimeric proteins","volume":"490","author":"Shriver","year":"2009","journal-title":"Methods Mol. Biol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.07.235_bb0145","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0006-3495(92)81899-4","article-title":"Theoretical analysis of Lumry-Eyring models in differential scanning calorimetry","volume":"61","author":"Sanchez-Ruiz","year":"1992","journal-title":"Biophys. J."},{"issue":"17","key":"10.1016\/j.ijbiomac.2020.07.235_bb0150","doi-asserted-by":"crossref","first-page":"4906","DOI":"10.1021\/bi0361766","article-title":"Identification of novel inhibitors of the SARS coronavirus main protease 3CLpro","volume":"43","author":"Bacha","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.ijbiomac.2020.07.235_bb0155","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ab.2006.07.027","article-title":"Thermofluor-based high-throughput stability optimization of proteins for structural studies","author":"Ericsson","year":"2006","journal-title":"Anal. Biochem."},{"issue":"6","key":"10.1016\/j.ijbiomac.2020.07.235_bb0160","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1177\/108705710100600609","article-title":"High-density miniaturized thermal shift assays as a general strategy for drug discovery","volume":"6","author":"Pantoliano","year":"2001","journal-title":"J. Biomol. Screen."},{"issue":"7","key":"10.1016\/j.ijbiomac.2020.07.235_bb0165","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1529\/biophysj.108.134973","article-title":"A quantitative model of thermal stabilization and destabilization of proteins by ligands","volume":"95","author":"Cimmperman","year":"2008","journal-title":"Biophys. J."},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.07.235_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms8040503","article-title":"Small molecule inhibitors of the response regulator ArsR exhibit bactericidal activity against Helicobacter pylori","volume":"8","author":"Gonz\u00e1lez","year":"2020","journal-title":"Microorganisms"},{"issue":"18","key":"10.1016\/j.ijbiomac.2020.07.235_bb0175","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1089\/ars.2018.7658","article-title":"Redox- and ligand binding-dependent conformational ensembles in the human apoptosis-inducing factor regulate its pro-life and cell death functions","volume":"30","author":"Villanueva","year":"2019","journal-title":"Antioxid. Redox Signal."},{"issue":"18","key":"10.1016\/j.ijbiomac.2020.07.235_bb0180","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1021\/ac00217a020","article-title":"Resolution of multicomponent fluorescence emission using frequency-dependent phase angle and modulation spectra","volume":"62","author":"Lakowicz","year":"1990","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2020.07.235_bb0185","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0079-6468(08)70097-3","article-title":"Isothermal titration calorimetry in drug discovery","author":"Ward","year":"2001","journal-title":"Prog. Med. Chem."},{"issue":"4","key":"10.1016\/j.ijbiomac.2020.07.235_bb0190","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/17460441.2017.1297418","article-title":"A look at ligand binding thermodynamics in drug discovery","volume":"12","author":"Claveria-Gimeno","year":"2017","journal-title":"Expert. Opin. Drug Discov."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.07.235_bb0195","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-47746-9","article-title":"Identifying potential novel drugs against Helicobacter pylori by targeting the essential response regulator HsrA","volume":"9","author":"Gonz\u00e1lez","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijbiomac.2020.07.235_bb0200","first-page":"130","article-title":"Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis","author":"Santofimia-Castano","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijbiomac.2020.07.235_bb0205","doi-asserted-by":"crossref","DOI":"10.1038\/srep39732","article-title":"Identification of a drug targeting an intrinsically disordered protein involved in pancreatic adenocarcinoma","volume":"7","author":"Neira","year":"2017","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.ijbiomac.2020.07.235_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159002","article-title":"Inhibition of pig phosphoenolpyruvate carboxykinase isoenzymes by 3-mercaptopicolinic acid and novel inhibitors","volume":"11","author":"Hidalgo","year":"2016","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.ijbiomac.2020.07.235_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069773","article-title":"Allosteric inhibitors of the NS3 protease from the hepatitis C virus","volume":"8","author":"Abian","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.ijbiomac.2020.07.235_bb0220","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1172\/JCI34355","article-title":"Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria","volume":"118","author":"Pey","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"11","key":"10.1016\/j.ijbiomac.2020.07.235_bb0225","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1021\/cb900166q","article-title":"Discovery of specific flavodoxin inhibitors as potential therapeutic agents against Helicobacter pylori infection","volume":"4","author":"Cremades","year":"2009","journal-title":"ACS Chem. Biol."},{"issue":"23","key":"10.1016\/j.ijbiomac.2020.07.235_bb0230","doi-asserted-by":"crossref","first-page":"24765","DOI":"10.1074\/jbc.M311744200","article-title":"Dissection study on the severe acute respiratory syndrome 3C-like protease reveals the critical role of the extra domain in dimerization of the enzyme: defining the extra domain as a new target for design of highly specific protease inhibitors","volume":"279","author":"Shi","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.ijbiomac.2020.07.235_bb0235","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.1038\/s41467-019-13686-1","article-title":"Engineering protein assemblies with allosteric control via monomer fold-switching","volume":"10","author":"Campos","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijbiomac.2020.07.235_bb0240","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1006\/jmbi.1997.1613","article-title":"The conformational equilibrium of human growth hormone","volume":"1998","author":"Kasimova","year":"1998","journal-title":"J Mol Biol"},{"issue":"13","key":"10.1016\/j.ijbiomac.2020.07.235_bb0245","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.2174\/1389450117666160201110449","article-title":"Biophysical screening for identifying pharmacological chaperones and inhibitors against conformational and infectious diseases","volume":"17","author":"Velazquez-Campoy","year":"2016","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ijbiomac.2020.07.235_bb0250","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S1359-6446(05)03386-6","article-title":"Ligand efficiency indices as guideposts for drug discovery","author":"Abad-Zapatero","year":"2005","journal-title":"Drug Discov. Today"},{"issue":"6","key":"10.1016\/j.ijbiomac.2020.07.235_bb0255","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1111\/cbdd.13604","article-title":"Characteristics of flavonoids as potent MERS-CoV 3C-like protease inhibitors","volume":"94","author":"Jo","year":"2019","journal-title":"Chem. Biol. Drug Des."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813020339970?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813020339970?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:06:00Z","timestamp":1788296760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813020339970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":51,"alternative-id":["S0141813020339970"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.07.235","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.07.235","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}