{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:29:47Z","timestamp":1786681787264,"version":"build-2736575974"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["SERB\/F\/108\/2013"],"award-info":[{"award-number":["SERB\/F\/108\/2013"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007179","name":"ACTREC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007179","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.ijbiomac.2021.03.040","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T23:57:15Z","timestamp":1615507035000},"page":"97-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Loss of GSK-3\u03b2 mediated phosphorylation in HtrA2 contributes to uncontrolled cell death with Parkinsonian phenotype"],"prefix":"10.1016","volume":"180","author":[{"given":"Kakoli","family":"Bose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Wagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasudha","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubhankar","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aasna L.","family":"Parui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Puja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snehal Pandav","family":"Mudrale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyamindra S.","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod B.","family":"Gai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Sarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0005","first-page":"S21","article-title":"Prevalence of Parkinson\u2019s disease in Europe: a collaborative study of population-based cohorts","volume":"54","author":"de Rijk","year":"2000","journal-title":"Neurologic Diseases in the Elderly Research Group. Neurology"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0010","doi-asserted-by":"crossref","first-page":"5765","DOI":"10.1073\/pnas.1814909116","article-title":"Parkinson\u2019s disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration","volume":"116","author":"Chen","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0015","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.1111\/febs.12335","article-title":"The hallmarks of Parkinson\u2019s disease","volume":"280","author":"Antony","year":"2013","journal-title":"FEBS J."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0020","doi-asserted-by":"crossref","first-page":"a009399","DOI":"10.1101\/cshperspect.a009399","article-title":"\u03b1-Synuclein in Parkinson's disease","volume":"2","author":"Stefanis","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0025","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1136\/jmg.2008.063917","article-title":"Parkin and PINK1 mutations in early-onset Parkinson\u2019s disease: comprehensive screening in publicly available cases and control","volume":"46","author":"Brooks","year":"2009","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0030","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S1474-4422(19)30320-5","article-title":"Identification of novel risk loci, causal insights, and heritable risk for Parkinson\u2019s disease: a meta-analysis of genome-wide association studies","volume":"18","author":"Nalls","year":"2019","journal-title":"The Lancet Neurology"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0035","doi-asserted-by":"crossref","first-page":"104782","DOI":"10.1016\/j.nbd.2020.104782","article-title":"Genetics of Parkinson\u2019s disease: an introspection of its journey towards precision medicine","volume":"137","author":"Bandres-Ciga","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0040","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nrn1868","article-title":"Expanding insights of mitochondrial dysfunction in Parkinson\u2019s disease","volume":"7","author":"Abou-Sleiman","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0045","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1093\/hmg\/ddi215","article-title":"Loss of function mutations in the gene encoding Omi\/HtrA2 in Parkinson\u2019s disease","volume":"14","author":"Strauss","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0050","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1074\/jbc.M109721200","article-title":"Identification of Omi\/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction","volume":"277","author":"Hegde","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0055","doi-asserted-by":"crossref","first-page":"49417","DOI":"10.1074\/jbc.M308659200","article-title":"Binding specificity and regulation of the serine protease and PDZ domains of HtrA2\/Omi","volume":"278","author":"Martins","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0060","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S1097-2765(01)00341-0","article-title":"A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death","volume":"8","author":"Suzuki","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0065","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1074\/jbc.M109891200","article-title":"HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins","volume":"277","author":"Verhagen","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0070","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/sj.cdd.4401343","article-title":"Mitochondrial protease Omi\/HtrA2 enhances caspase activation through multiple pathways","volume":"11","author":"Suzuki","year":"2004","journal-title":"Cell Death & Differentiation"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0075","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.1046\/j.1432-1327.2000.01589.x","article-title":"Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response","volume":"267","author":"Gray","year":"2000","journal-title":"European journal of biochemistry\/FEBS"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0080","doi-asserted-by":"crossref","first-page":"9848","DOI":"10.1128\/MCB.24.22.9848-9862.2004","article-title":"Neuroprotective role of the reaper-related serine protease HtrA2\/Omi revealed by targeted deletion in mice","volume":"24","author":"Martins","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0085","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/humu.20713","article-title":"Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease","volume":"29","author":"Bogaerts","year":"2008","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0090","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1093\/hmg\/ddn096","article-title":"Sequencing analysis of OMI\/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls","volume":"17","author":"Simon-Sanchez","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0095","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/hmg\/ddv485","article-title":"Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2","volume":"25","author":"Casadei","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0100","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00439-011-1041-6","article-title":"Novel variant Pro143Ala in HTRA2 contributes to Parkinson\u2019s disease by inducing hyperphosphorylation of HTRA2 protein in mitochondria","volume":"130","author":"Lin","year":"2011","journal-title":"Hum. Genet."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0105","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.brainres.2011.02.037","article-title":"Genetic variations of Omi\/HTRA2 in Chinese patients with Parkinson\u2019s disease","volume":"1385","author":"Wang","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0110","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3389\/fneur.2020.00524","article-title":"Genetic architecture of Parkinson\u2019s disease in the Indian population: harnessing genetic diversity to address critical gaps in Parkinson\u2019s disease research","volume":"11","author":"Rajan","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0115","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4103\/0028-3886.132338","article-title":"Molecular analysis of alpha-synuclein gene in Parkinson\u2019s disease in North Karnataka, India","volume":"62","author":"Kadakol","year":"2014","journal-title":"Neurol. India"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0120","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1136\/jmedgenet-2016-103922","article-title":"Deficiency of HTRA2\/Omi is associated with infantile neurodegeneration and 3-methylglutaconic aciduria","volume":"53","author":"Mandel","year":"2016","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0125","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/bdr2.1717","article-title":"3-Methylglutaconic aciduria type VIII in an Indian neonate","volume":"112","author":"Sreedhara","year":"2020","journal-title":"Birth Defects Research"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0130","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1073\/pnas.1019277108","article-title":"Signal integration by DegS and RseB governs the &#963; E-mediated envelope stress response in Escherichia coli","volume":"108","author":"Chaba","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0135","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0378-1119(95)00406-V","article-title":"Site-directed mutagenesis of the HtrA (DegP) serine protease, whose proteolytic activity is indispensable for Escherichia coli survival at elevated temperatures","volume":"163","author":"Skorko-Glonek","year":"1995","journal-title":"Gene"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0140","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1093\/brain\/awn179","article-title":"Subthalamic nucleus stimulation-induced regional blood flow responses correlate with improvement of motor signs in Parkinson disease","volume":"131","author":"Karimi","year":"2008","journal-title":"Brain: a journal of neurology"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0145","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1096\/fj.13-227256","article-title":"Intricate structural coordination and domain plasticity regulate activity of serine protease HtrA2","volume":"27","author":"Chaganti","year":"2013","journal-title":"FASEB journal: official publication of the Federation of American Societies for Experimental Biology"},{"issue":"5","key":"10.1016\/j.ijbiomac.2021.03.040_bb0150","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181072","article-title":"Structural basis of inactivation of human counterpart of mouse motor neuron degeneration 2 mutant in serine protease HtrA2","volume":"38","author":"Wagh","year":"2018","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0155","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1111\/febs.12799","article-title":"Dual regulatory switch confers tighter control on HtrA2 proteolytic activity","volume":"281","author":"Singh","year":"2014","journal-title":"FEBS J."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0160","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1107\/S0907444909047337","article-title":"Xds. Acta crystallographica","volume":"66","author":"Kabsch","year":"2010","journal-title":"Section D, Biological crystallography"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0165","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1107\/S0907444910045749","article-title":"Overview of the CCP4 suite and current developments. Acta crystallographica","volume":"67","author":"Winn","year":"2011","journal-title":"Section D, Biological crystallography"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0170","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nsb795","article-title":"Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2\/Omi","volume":"9","author":"Li","year":"2002","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055416","article-title":"Allosteric regulation of serine protease HtrA2 through novel non-canonical substrate binding pocket","volume":"8","author":"Bejugam","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0180","first-page":"866","article-title":"Assessing the performance of the molecular mechanics\/Poisson Boltzmann surface area and molecular mechanics\/generalized Born surface area methods","volume":"32","author":"Hou","year":"2011","journal-title":"II. The accuracy of ranking poses generated from docking. J Comput Chem"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0185","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/pro.3289","article-title":"PDBsum: structural summaries of PDB entries","volume":"27","author":"Laskowski","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0190","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1-2","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0195","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/BF00938315","article-title":"A stochastic steepest-descent algorithm","volume":"59","author":"Wardi","year":"1988","journal-title":"J. Optim. Theory Appl."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0200","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/00268977200100031","article-title":"NpT-ensemble Monte Carlo calculations for binary liquid mixtures","volume":"23","author":"McDonald","year":"1972","journal-title":"Mol. Phys."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0205","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0210","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1212\/WNL.17.5.427","article-title":"Parkinsonism: onset, progression and mortality","volume":"17","author":"Hoehn","year":"1967","journal-title":"Neurology"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0215","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1021\/ct700119m","article-title":"Clustering molecular dynamics trajectories: 1. Characterizing the performance of different clustering algorithms","volume":"3","author":"Shao","year":"2007","journal-title":"Journal of Chemical Theory and Computation"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0220","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/cdd.2008.7","article-title":"HtrA2 enhances the apoptotic functions of p73 on bax","volume":"15","author":"Marabese","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0225","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11910-018-0829-3","article-title":"Mitochondrial dysfunction in Parkinson\u2019s disease: new mechanistic insights and therapeutic perspectives","volume":"18","author":"Park","year":"2018","journal-title":"Current neurology and neuroscience reports"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0230","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12935-015-0231-z","article-title":"Etoposide induces cell death via mitochondrial-dependent actions of p53","volume":"15","author":"Jamil","year":"2015","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0235","first-page":"361","article-title":"MitoSOX-based flow cytometry for detecting mitochondrial ROS","volume":"2","author":"Kauffman","year":"2016","journal-title":"React Oxyg Species (Apex)"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0240","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/ncb1644","article-title":"The mitochondrial protease HtrA2 is regulated by Parkinson\u2019s disease-associated kinase PINK1","volume":"9","author":"Plun-Favreau","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0245","doi-asserted-by":"crossref","first-page":"D261","DOI":"10.1093\/nar\/gkr1122","article-title":"PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse","volume":"40","author":"Hornbeck","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0250","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1093\/nar\/gkg584","article-title":"Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs","volume":"31","author":"Obenauer","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0255","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1002\/pmic.200300771","article-title":"Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence","volume":"4","author":"Blom","year":"2004","journal-title":"Proteomics"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0260","doi-asserted-by":"crossref","first-page":"628","DOI":"10.14336\/AD.2017.0103","article-title":"The biology of aging and Cancer: a brief overview of shared and divergent molecular hallmarks","volume":"8","author":"Aunan","year":"2017","journal-title":"Aging Dis."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0265","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1073\/pnas.68.4.820","article-title":"Mutation and cancer: statistical study of retinoblastoma","volume":"68","author":"Knudson","year":"1971","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0270","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1097\/NEN.0b013e31818809f4","article-title":"Accumulation of HtrA2\/Omi in neuronal and glial inclusions in brains with \u03b1-synucleinopathies","volume":"67","author":"Kawamoto","year":"2008","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0275","doi-asserted-by":"crossref","first-page":"5284","DOI":"10.1038\/s41598-020-62309-z","article-title":"The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2\/Omi","volume":"10","author":"Chung","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0280","first-page":"38","article-title":"Mitochondrial dysfunction in Parkinson\u2019s disease-cause or consequence?","volume":"8","author":"Chen","year":"2019","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0285","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1097\/00001756-200312190-00025","article-title":"Glycogen synthase kinase-3 beta is highly activated in nuclei and mitochondria","volume":"14","author":"Bijur","year":"2003","journal-title":"Neuroreport"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0290","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0006-8993(01)03005-0","article-title":"Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithium","volume":"919","author":"King","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0295","doi-asserted-by":"crossref","first-page":"13262","DOI":"10.1021\/acsami.6b02416","article-title":"Carrier-free, chemophotodynamic dual nanodrugs via self-assembly for synergistic antitumor therapy","volume":"8","author":"Zhang","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0300","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1002\/adma.201600284","article-title":"An injectable self-assembling collagen\u2013gold hybrid hydrogel for combinatorial antitumor photothermal\/photodynamic therapy","volume":"28","author":"Xing","year":"2016","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ijbiomac.2021.03.040_bb0305","doi-asserted-by":"crossref","first-page":"10964","DOI":"10.1073\/pnas.96.20.10964","article-title":"Caspase activation: the induced-proximity model","volume":"96","author":"Salvesen","year":"1999","journal-title":"Proc. Natl. Acad. Sci."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813021005584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813021005584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:11:31Z","timestamp":1786680691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813021005584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":61,"alternative-id":["S0141813021005584"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2021.03.040","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of GSK-3\u03b2 mediated phosphorylation in HtrA2 contributes to uncontrolled cell death with Parkinsonian phenotype","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2021.03.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}