{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:57:18Z","timestamp":1788217038217,"version":"build-2803163510"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.ijbiomac.2022.01.064","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T10:51:50Z","timestamp":1642243910000},"page":"332-344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Fenugreek seed mucilage grafted poly methacrylate pH-responsive hydrogel: A promising tool to enhance the oral bioavailability of methotrexate"],"prefix":"10.1016","volume":"202","author":[{"given":"Hafiz Rashid","family":"Hussain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajid","family":"Bashir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Mahmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rai Muhammad","family":"Sarfraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misbah","family":"Kanwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid Saeed","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Nazir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2018","key":"10.1016\/j.ijbiomac.2022.01.064_bb0005","first-page":"394","article-title":"GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA. Cancer J. Clin."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0010","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jddst.2017.06.001","article-title":"Fulvestrant-loaded polymer-based nanoparticles for local drug delivery: preparation and in vitro characterization","volume":"40","author":"Hascicek","year":"2017","journal-title":"J. Drug Deliv Sci. Technol."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0015","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/cac2.12178","article-title":"Advancing to the era of cancer immunotherapy","volume":"41","author":"Wang","year":"2021","journal-title":"Cancer Commun."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0020","doi-asserted-by":"crossref","DOI":"10.1111\/bjh.17736","article-title":"The incidence and type of cancer in patients with ataxia-telangiectasia via a retrospective single-centre study","author":"Bakhtiar","year":"2021","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics13010111","article-title":"Improved bioavailability and high photostability of methotrexate by spray-dried surface-attached solid dispersion with an aqueous medium","volume":"13","author":"Giri","year":"2021","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0030","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11010-013-1830-4","article-title":"Beneficial effects of chrysin against methotrexate-induced hepatotoxicity via attenuation of oxidative stress and apoptosis","volume":"385","author":"Ali","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep04430","article-title":"Inorganic nanovehicle targets tumor in an orthotopic breast cancer model","volume":"4","author":"Choi","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0040","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1517\/17425247.2012.642362","article-title":"Methotrexate: a detailed review on drug delivery and clinical aspects","volume":"9","author":"Khan","year":"2012","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0045","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jconrel.2015.09.057","article-title":"Self-assembled 20-nm 64Cu-micelles enhance accumulation in rat glioblastoma","volume":"220","author":"Seo","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0050","doi-asserted-by":"crossref","first-page":"16416","DOI":"10.1021\/am504849x","article-title":"Multifunctional lactobionic acid-modified dendrimers for targeted drug delivery to liver cancer cells: investigating the role played by PEG spacer","volume":"6","author":"Fu","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0055","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1016\/j.biomaterials.2013.11.039","article-title":"Star-branched amphiphilic PLA-b-PDMAEMA copolymers for co-delivery of miR-21 inhibitor and doxorubicin to treat glioma","volume":"35","author":"Qian","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0060","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1039\/C4TB01533A","article-title":"A redox-responsive drug delivery system based on RGD containing peptide-capped mesoporous silica nanoparticles","volume":"3","author":"Li","year":"2015","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0065","first-page":"313","article-title":"Mesoporous silica nanoparticles in drug delivery and biomedical applications, nanomedicine nanotechnology","volume":"11","author":"Wang","year":"2015","journal-title":"Biol. Med."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2021.116625","article-title":"Synthesis, characterization, toxicity and morphology assessments of newly prepared microemulsion systems for delivery of valproic acid","volume":"338","author":"Sargazi","year":"2021","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0075","article-title":"Pluronic F127\/Doxorubicin microemulsions: Preparation, characterization, and toxicity evaluations","author":"Rahdar","year":"2021","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0080","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.3390\/app11073006","article-title":"F127\/cisplatin microemulsions: in vitro, in vivo and computational studies","volume":"11","author":"Sargazi","year":"2021","journal-title":"Appl. Sci."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0085","article-title":"Nanotechnology for inflammatory bowel disease management: detection, imaging and treatment","volume":"32","author":"Barani","year":"2021","journal-title":"Sens. Bio-Sensing Res."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111843","article-title":"Recent advances in functionalized nanomaterials for the diagnosis and treatment of bacterial infections","volume":"121","author":"Colino","year":"2021","journal-title":"Mater. Sci. Eng. C."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0095","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ijpharm.2013.01.071","article-title":"A pH-responsive nano-carrier with mesoporous silica nanoparticles cores and poly(acrylic acid) shell-layers: fabrication, characterization and properties for controlled release of salidroside","volume":"446","author":"Peng","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0100","first-page":"569","article-title":"pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms","volume":"24","author":"Liu","year":"2017"},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0105","doi-asserted-by":"crossref","first-page":"5397","DOI":"10.2147\/IJN.S209662","article-title":"Development and in vitro evaluation of (\u03b2-cyclodextrin-g-methacrylic acid)\/Na+-montmorillonite nanocomposite hydrogels for controlled delivery of lovastatin","volume":"14","author":"Mahmood","year":"2019","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0110","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ijbiomac.2016.11.057","article-title":"A superporous and superabsorbent glucuronoxylan hydrogel from quince (Cydonia oblanga): stimuli responsive swelling, on-off switching and drug release","volume":"95","author":"Ashraf","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0115","doi-asserted-by":"crossref","first-page":"2004098","DOI":"10.1002\/adfm.202004098","article-title":"Potential applications of advanced Nano\/Hydrogels in biomedicine: static, dynamic, multi-stage, and bioinspired","volume":"30","author":"Ayoubi-Joshaghani","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0120","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.polymer.2008.01.027","article-title":"Hydrogels in drug delivery: progress and challenges","volume":"49","author":"Hoare","year":"2008","journal-title":"Polymer (Guildford)"},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0125","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jare.2013.07.006","article-title":"Hydrogel: preparation, characterization, and applications: a review","volume":"6","author":"Ahmed","year":"2015","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0130","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ijpharm.2019.03.011","article-title":"Natural biodegradable polymers based nano-formulations for drug delivery: a review","volume":"561","author":"George","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.btre.2017.02.001","article-title":"Biofabrication and characterization of silver nanoparticles using aqueous extract of seaweed Enteromorpha compressa and its biomedical properties","volume":"14","author":"Ramkumar","year":"2017","journal-title":"Biotechnol. Rep."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0140","series-title":"Undefined 2019, Droplet-Based Microgels: Attractive Materials for Drug Delivery Systems","author":"Hassan","year":"2019"},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0145","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.biomag.2013.06.002","article-title":"Effect of low molecular weight galactomannans from fenugreek seeds on animal models of diabetes mellitus","volume":"3","author":"Kamble","year":"2013","journal-title":"Biomed. Aging Pathol."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0150","doi-asserted-by":"crossref","first-page":"7686","DOI":"10.1039\/C9SM01380F","article-title":"High strength and antibacterial polyelectrolyte complex CS\/HS hydrogel films for wound healing","volume":"15","author":"Shu","year":"2019","journal-title":"Soft Matter"},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/ma12091569","article-title":"Physical hydrogels of oxidized polysaccharides and poly(vinyl alcohol) forwound dressing applications","volume":"12","author":"Baron","year":"2019","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0160","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.progpolymsci.2016.12.009","article-title":"Recent advances in vegetable oil-based polymers and their composites","volume":"71","author":"Zhang","year":"2017","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0165","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ijpharm.2015.10.013","article-title":"An in-vitro exploration of permeation enhancement by novel polysulfonate thiomers","volume":"496","author":"Mahmood","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0170","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ijbiomac.2012.12.008","article-title":"Fenugreek seed mucilage-alginate mucoadhesive beads of metformin HCl: design, optimization and evaluation","volume":"54","author":"Nayak","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0175","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ijbiomac.2020.06.110","article-title":"A review on biomacromolecular hydrogel classification and its applications","volume":"162","author":"Sharma","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0180","article-title":"Newly crocin-coated magnetite nanoparticles induce apoptosis and decrease VEGF expression in breast carcinoma cells","volume":"60","author":"Saravani","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0185","doi-asserted-by":"crossref","first-page":"293","DOI":"10.4314\/tjpr.v9i3.56292","article-title":"Formulation of nimesulide floating microparticles using low-viscosity hydroxypropyl methylcellulose","volume":"9","author":"Khan","year":"2010","journal-title":"Trop. J. Pharm. Res."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0190","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nprot.2006.179","article-title":"Sulforhodamine B colorimetric assay for cytotoxicity screening","volume":"2006 13. 1","author":"Vichai","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0195","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jchromb.2015.08.017","article-title":"A reversed-phase high performance liquid chromatography method for quantification of methotrexate in cancer patients serum","volume":"1002","author":"Li","year":"2015","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0200","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.carbpol.2017.10.025","article-title":"Extraction purification and characterization of galactomannan from fenugreek for industrial utilization","volume":"180","author":"Rashid","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0205","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ijbiomac.2010.01.002","article-title":"Extraction and characterization of \u03b2-d-glucan from oat for industrial utilization","volume":"46","author":"Ahmad","year":"2010","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0210","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.ijbiomac.2016.12.064","article-title":"Structural, physicochemical, antioxidant and antitumor property of an acidic polysaccharide from Polygonum multiflorum","volume":"96","author":"Zhu","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0215","first-page":"33","article-title":"Microwave assisted synthesis of polyacrylamide grafted polymeric blend of fenugreek seed mucilage-polyvinyl alcohol (FSM-PVA-g-PAM) and its characterizations as tissue engineered scaffold and as a drug delivery device, DARU","volume":"28","author":"Bal","year":"2020","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.110628","article-title":"Carboxymethyl fenugreek galactomannan-g-poly(N-isopropylacrylamide-co-N, N\u2032-methylene-bis-acrylamide)-clay based pH\/temperature-responsive nanocomposites as drug-carriers","volume":"110","author":"Bera","year":"2020","journal-title":"Mater. Sci. Eng. C."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116100","article-title":"Borax crosslinked fenugreek galactomannan hydrogel as potential water-retaining agent in agriculture","volume":"236","author":"Liu","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0230","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.polymdegradstab.2007.02.011","article-title":"Thermal and mechanical properties of cationic guar gum\/poly(acrylic acid) hydrogel membranes","volume":"92","author":"Huang","year":"2007","journal-title":"Polym. Degrad. Stab."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0235","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.ijbiomac.2020.05.232","article-title":"Doxorubicin-loaded carboxymethyl cellulose\/Starch\/ZnO nanocomposite hydrogel beads as an anticancer drug carrier agent","volume":"160","author":"Gholamali","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0240","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1208\/s12249-018-1066-4","article-title":"Development and gamma scintigraphy study of Trigonella foenum-graecum (Fenugreek) polysaccharide-based colon tablet","volume":"19","author":"Sharma","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0245","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ijpharm.2015.08.027","article-title":"Pectin\/anhydrous dibasic calcium phosphate matrix tablets for in vitro controlled release of water-soluble drug","volume":"494","author":"Mamani","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0250","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1021\/ma991398q","article-title":"Synthesis and characterization of pH- and temperature-sensitive poly(methacrylic acid)\/poly(N-isopropylacrylamide) interpenetrating polymeric networks","volume":"33","author":"Zhang","year":"2000","journal-title":"Macromolecules"},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0255","first-page":"696","article-title":"Development and characterization of n-propyl gallate encapsulated solid lipid nanoparticles-loaded hydrogel for intranasal delivery","volume":"14","author":"Sabir","year":"2021","journal-title":"Pharm."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0260","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.reactfunctpolym.2016.12.001","article-title":"Preparation and properties of quaternary ammonium chitosan-g-poly(acrylic acid-co-acrylamide) superabsorbent hydrogels","volume":"111","author":"He","year":"2017","journal-title":"React. Funct. Polym."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40543-018-0146-0","article-title":"Cytotoxicity evaluation of a Thai herb using tetrazolium (MTT) and sulforhodamine B (SRB) assays","volume":"9","author":"Vajrabhaya","year":"2018","journal-title":"J. Anal. Sci. Technol."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0270","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.1984","article-title":"Sulforhodamine B (SRB) assay in cell culture to investigate cell proliferation","volume":"6","author":"Orellana","year":"2016","journal-title":"Bio-Protocol."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0275","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.3390\/polym13183153","article-title":"Simulation, in vitro, and in vivo cytotoxicity assessments of methotrexate-loaded pH-responsive nanocarriers","volume":"13","author":"Barani","year":"2021","journal-title":"Polym."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0280","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/bmc.1628","article-title":"Simple and sensitive HPLC method for the fluorometric determination of methotrexate and its major metabolites in human plasma by post-column photochemical reaction","volume":"26","author":"Uchiyama","year":"2012","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.ijbiomac.2022.01.064_bb0285","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s00280-012-2062-0","article-title":"A review of therapeutic challenges and achievements of methotrexate delivery systems for treatment of cancer and rheumatoid arthritis","volume":"71","author":"Abolmaali","year":"2013","journal-title":"Cancer Chemother. Pharmacol."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813022000800?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813022000800?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T09:21:48Z","timestamp":1758878508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813022000800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":57,"alternative-id":["S0141813022000800"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.01.064","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fenugreek seed mucilage grafted poly methacrylate pH-responsive hydrogel: A promising tool to enhance the oral bioavailability of methotrexate","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.01.064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}