{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:52:12Z","timestamp":1789581132618,"version":"build-2803163510"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005317","name":"Kermanshah University of Medical Sciences","doi-asserted-by":"publisher","award":["4000211"],"award-info":[{"award-number":["4000211"]}],"id":[{"id":"10.13039\/501100005317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.ijbiomac.2022.02.096","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T21:09:38Z","timestamp":1645650578000},"page":"159-166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Controlled release of 5-fluorouracil to melanoma cells using a hydrogel\/micelle composites based on deoxycholic acid and carboxymethyl chitosan"],"prefix":"10.1016","volume":"206","author":[{"given":"Zahra","family":"Pourmanouchehri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayeh","family":"Ebrahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazdak","family":"Limoee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh","family":"Jalilian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajad","family":"Janfaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Vosoughi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Behbood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.126439","article-title":"Injectable multi-responsive micelle\/nanocomposite hybrid hydrogel for bioenzyme and photothermal augmented chemodynamic therapy of skin cancer and bacterial infection","volume":"404","author":"Zheng","year":"2021","journal-title":"Chem. Eng. J."},{"issue":"6","key":"10.1016\/j.ijbiomac.2022.02.096_bb0010","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1021\/acs.molpharmaceut.8b00047","article-title":"Fluorouracil-loaded gold nanoparticles for the treatment of skin cancer: development, in vitro characterization, and in vivo evaluation in a mouse skin cancer xenograft model","volume":"15","author":"Safwat","year":"2018","journal-title":"Mol. Pharm."},{"issue":"11","key":"10.1016\/j.ijbiomac.2022.02.096_bb0015","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1038\/s41591-018-0198-0","article-title":"Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma","volume":"24","author":"Blank","year":"2018","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.ijbiomac.2022.02.096_bb0020","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrc.2016.25","article-title":"Targeting metastasis","volume":"16","author":"Steeg","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0025","doi-asserted-by":"crossref","DOI":"10.1093\/annonc\/mdx683","article-title":"Intratumoral immunotherapy: using the tumor as the remedy","volume":"28","author":"Marabelle","year":"2017","journal-title":"Ann. Oncol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.02.096_bb0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2009.09.004","article-title":"Biodegradation, biodistribution and toxicity of chitosan","volume":"62","author":"Kean","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0035","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jconrel.2020.03.023","article-title":"Transdermal siRNA delivery by pH-switchable micelles with targeting effect suppress skin melanoma progression","volume":"322","author":"Wang","year":"2020","journal-title":"J. Control. Release"},{"issue":"6","key":"10.1016\/j.ijbiomac.2022.02.096_bb0040","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0190-9622(81)80196-X","article-title":"Topical chemotherapy with 5-fluorouracil: a review","volume":"4","author":"Goette","year":"1981","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.supflu.2020.104756","article-title":"Loading of 5-fluorouracil onto halloysite nanotubes for targeted drug delivery using a subcritical gas antisolvent process (GAS)","volume":"159","author":"Harikrishnan","year":"2020","journal-title":"J. Supercrit. Fluids"},{"issue":"2","key":"10.1016\/j.ijbiomac.2022.02.096_bb0050","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jphotobiol.2011.08.003","article-title":"FTIR and circular dichroism spectroscopic study of interaction of 5-fluorouracil with DNA","volume":"105","author":"Jangir","year":"2011","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0055","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.freeradbiomed.2013.07.002","article-title":"Selenocystine potentiates cancer cell apoptosis induced by 5-fluorouracil by triggering reactive oxygen species-mediated DNA damage and inactivation of the ERK pathway","volume":"65","author":"Fan","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0060","doi-asserted-by":"crossref","first-page":"5445","DOI":"10.2147\/IJN.S257700","article-title":"Recent advances in designing 5-fluorouracil delivery systems: a stepping stone in the safe treatment of colorectal cancer","volume":"15","author":"Entezar-Almahdi","year":"2020","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0065","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.ijbiomac.2019.01.140","article-title":"pH-sensitive ZnO\/carboxymethyl cellulose\/chitosan bio-nanocomposite beads for colon-specific release of 5-fluorouracil","volume":"128","author":"Sun","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2022.02.096_bb0070","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1039\/C8MD00565F","article-title":"Design of 5-fluorouracil (5-FU) loaded, folate conjugated peptide linked nanoparticles, a potential new drug carrier for selective targeting of tumor cells","volume":"10","author":"Kazi","year":"2019","journal-title":"MedChemComm."},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111591","article-title":"Topical formulations containing aptamer-functionalized nanocapsules loaded with 5-fluorouracil-an innovative concept for the skin cancer therapy","volume":"119","author":"Rata","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0080","unstructured":"J Rajkumar GV Radha. Topical Drug Delivery of 5-fluorouracil Proniosomal Gel for the Treatment of Skin Cancer: In Vitro and In Vivo Evaluation."},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0085","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ejpb.2021.04.007","article-title":"Combinatorial lipid-nanosystem for dermal delivery of 5-fluorouracil and resveratrol against skin cancer: delineation of improved dermatokinetics and epidermal drug deposition enhancement analysis","volume":"163","author":"Iqubal","year":"2021","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0090","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijbiomac.2017.12.027","article-title":"Microneedles: a versatile strategy for transdermal delivery of biological molecules","volume":"110","author":"Lim","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"8","key":"10.1016\/j.ijbiomac.2022.02.096_bb0095","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0001-7310(07)70133-3","article-title":"Topical chemotherapy for actinic keratosis and nonmelanoma skin cancer: current options and future perspectives","volume":"98","author":"Barrera","year":"2007","journal-title":"Actas Dermosifiliogr."},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.02.096_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.colsurfb.2008.07.020","article-title":"Chitosan-coated magnetic nanoparticles as carriers of 5-fluorouracil: preparation, characterization and cytotoxicity studies","volume":"68","author":"Zhu","year":"2009","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115207","article-title":"Cellulose-based injectable hydrogel composite for pH-responsive and controllable drug delivery","volume":"225","author":"Chen","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0110","doi-asserted-by":"crossref","first-page":"6337","DOI":"10.1126\/science.aaf3627","article-title":"Advances in engineering hydrogels","volume":"356","author":"Zhang","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0115","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ijbiomac.2017.12.137","article-title":"Mucoadhesive alginate pastes with embedded liposomes for local oral drug delivery","volume":"111","author":"Shtenberg","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"19","key":"10.1016\/j.ijbiomac.2022.02.096_bb0120","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1039\/C7TB00701A","article-title":"Switchable release nano-reservoirs for co-delivery of drugs via a facile micelle\u2013hydrogel composite","volume":"5","author":"Patel","year":"2017","journal-title":"J. Mater. Chem. B"},{"issue":"3","key":"10.1016\/j.ijbiomac.2022.02.096_bb0125","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1021\/acs.molpharmaceut.7b01091","article-title":"Bile acid-based drug delivery systems for enhanced doxorubicin encapsulation: comparing hydrophobic and ionic interactions in drug loading and release","volume":"15","author":"Cunningham","year":"2018","journal-title":"Mol. Pharm."},{"issue":"4","key":"10.1016\/j.ijbiomac.2022.02.096_bb0130","doi-asserted-by":"crossref","first-page":"1600262","DOI":"10.1002\/mabi.201600262","article-title":"Use of 5-fluorouracil loaded micelles and cisplatin in thermosensitive chitosan hydrogel as an efficient therapy against colorectal peritoneal carcinomatosis","volume":"17","author":"Yun","year":"2017","journal-title":"Macromol. Biosci."},{"issue":"12","key":"10.1016\/j.ijbiomac.2022.02.096_bb0135","doi-asserted-by":"crossref","first-page":"4554","DOI":"10.1021\/acs.biomac.8b01234","article-title":"Injectable maltodextrin-based micelle\/hydrogel composites for simvastatin-controlled release","volume":"19","author":"Yan","year":"2018","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0140","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.ijbiomac.2017.09.065","article-title":"A novel controlled drug delivery system based on alginate hydrogel\/chitosan micelle composites","volume":"107","author":"Cong","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.steroids.2020.108639","article-title":"Updates in bile acid-bioactive molecule conjugates and their applications","volume":"159","author":"Mishra","year":"2020","journal-title":"Steroids"},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0150","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.biomaterials.2017.09.022","article-title":"Bile acid transporter mediated endocytosis of oral bile acid conjugated nanocomplex","volume":"147","author":"Park","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107539","article-title":"Apical sodium-dependent bile acid transporter, drug target for bile acid related diseases and delivery target for prodrugs: current and future challenges","volume":"212","author":"Li","year":"2020","journal-title":"Pharmacol. Ther."},{"issue":"11","key":"10.1016\/j.ijbiomac.2022.02.096_bb0160","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1021\/np980178n","article-title":"Acanthosterol sulfates A\u2212 J: ten new antifungal steroidal sulfates from a marine sponge acanthodendrilla sp","volume":"61","author":"Tsukamoto","year":"1998","journal-title":"J. Nat. Prod."},{"issue":"3","key":"10.1016\/j.ijbiomac.2022.02.096_bb0165","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.steroids.2004.11.001","article-title":"Synthesis of biologically active steroid derivatives by the utility of Lawesson's reagent","volume":"70","author":"Mohamed","year":"2005","journal-title":"Steroids"},{"issue":"13","key":"10.1016\/j.ijbiomac.2022.02.096_bb0170","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.steroids.2005.06.007","article-title":"Synthesis and antifungal activity of oxygenated cholesterol derivatives","volume":"70","author":"Brunel","year":"2005","journal-title":"Steroids"},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0175","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.steroids.2007.04.001","article-title":"Synthesis and antimicrobial evaluation of water-soluble, dendritic derivatives of epimeric 5\u03b1-cholestan-3-aminesand 5\u03b1-cholestan-3-yl aminoethanoates","volume":"72","author":"Eko","year":"2007","journal-title":"Steroids"},{"issue":"6","key":"10.1016\/j.ijbiomac.2022.02.096_bb0180","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1021\/jm030376y","article-title":"New steroidal dimers with antifungal and antiproliferative activity","volume":"47","author":"Salunke","year":"2004","journal-title":"J. Med. Chem."},{"issue":"10\u201311","key":"10.1016\/j.ijbiomac.2022.02.096_bb0185","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.steroids.2011.04.012","article-title":"Synthesis, in vitro antifungal activity and mechanism of action of four sterol hydrazone analogues against the dimorphic fungus paracoccidioides brasiliensis","volume":"76","author":"Visbal","year":"2011","journal-title":"Steroids"},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0190","doi-asserted-by":"crossref","first-page":"939","DOI":"10.3389\/fphar.2018.00939","article-title":"Bile acid synthesis: from nature to the chemical modification and synthesis and their applications as drugs and nutrients","volume":"9","author":"\u0160arenac","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.ijbiomac.2022.02.096_bb0195","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/BF03190714","article-title":"Pharmacology of bile acids and their derivatives: absorption promoters and therapeutic agents","volume":"31","author":"Mikov","year":"2006","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"issue":"1\u20132","key":"10.1016\/j.ijbiomac.2022.02.096_bb0200","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ijpharm.2008.10.001","article-title":"Estimation of effective intestinal membrane permeability considering bile micelle solubilisation","volume":"368","author":"Sugano","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0205","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.ijbiomac.2019.07.225","article-title":"Synthesis of pectin-deoxycholic acid conjugate for targeted delivery of anticancer drugs in hepatocellular carcinoma","volume":"139","author":"Varshosaz","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"1\u20132","key":"10.1016\/j.ijbiomac.2022.02.096_bb0210","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF01243172","article-title":"Determination of critical micelle concentration of bile acid salts by micro-calorimetric titration","volume":"127","author":"Simonovi\u0107","year":"1997","journal-title":"Microchim. Acta"},{"issue":"17","key":"10.1016\/j.ijbiomac.2022.02.096_bb0215","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1016\/j.biomaterials.2003.09.100","article-title":"Synthesis and pH sensitivity of carboxymethyl chitosan-based polyampholyte hydrogels for protein carrier matrices","volume":"25","author":"Chen","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111527","article-title":"Dual pH-responsive-charge-reversal micelle platform for enhanced anticancer therapy","volume":"118","author":"Liao","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.02.096_bb0225","first-page":"77","article-title":"In-vitro drug release characterization models","volume":"2","author":"Singhvi","year":"2011","journal-title":"Int. J. Pharm. Stud. Res."},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0230","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.biopha.2015.12.025","article-title":"Preparation and in vitro evaluation of 5-flourouracil loaded magnetite\u2013zeolite nanocomposite (5-FU-MZNC) for cancer drug delivery applications","volume":"77","author":"Sa\u011fir","year":"2016","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.02.096_bb0235","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ejpb.2012.01.004","article-title":"Layered inorganic nanocomposites: a promising carrier for 5-fluorouracil (5-FU)","volume":"81","author":"Kevadiya","year":"2012","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.02.096_bb0240","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ijbiomac.2007.01.003","article-title":"Preparation and characterization of glutaraldehyde cross-linked O-carboxymethylchitosan microspheres for controlled delivery of pazufloxacin mesilate","volume":"41","author":"Liu","year":"2007","journal-title":"Int. J. Biol. Macromol."},{"issue":"8","key":"10.1016\/j.ijbiomac.2022.02.096_bb0245","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1063\/1.1539048","article-title":"Sphere-to-rod transitions of micelles in model nonionic surfactant solutions","volume":"118","author":"Al-Anber","year":"2003","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0250","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jcis.2021.06.140","article-title":"Revealing the complex self-assembly behaviour of sodium deoxycholate in aqueous solution","volume":"604","author":"Jover","year":"2021","journal-title":"J. Colloid Interface Sci."},{"issue":"56","key":"10.1016\/j.ijbiomac.2022.02.096_bb0255","doi-asserted-by":"crossref","first-page":"33782","DOI":"10.1039\/D0RA04287K","article-title":"Recent advances and future perspectives of sol\u2013gel derived porous bioactive glasses: a review","volume":"10","author":"Deshmukh","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0260","article-title":"Using zeta potential to study the ionisation behaviour of polymers employed in modified-release dosage forms and estimating their pKa","volume":"1","author":"Barbosa","year":"2019","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.ijbiomac.2022.02.096_bb0265","first-page":"255","article-title":"Effect of zeta potential on the properties of nano-drug delivery systems-a review (Part 1)","volume":"12","author":"Honary","year":"2013","journal-title":"Trop. J. Pharm. Res."},{"issue":"3","key":"10.1016\/j.ijbiomac.2022.02.096_bb0270","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3390\/polym10030235","article-title":"Chitosan based self-assembled nanoparticles in drug delivery","volume":"10","author":"Qui\u00f1ones","year":"2018","journal-title":"Polymers"},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.02.096_bb0275","doi-asserted-by":"crossref","first-page":"46911","DOI":"10.1002\/app.46911","article-title":"pH-sensitive hydrogel based on carboxymethyl chitosan\/sodium alginate and its application for drug delivery","volume":"136","author":"Xie","year":"2019","journal-title":"J. Appl. Polym. Sci."},{"issue":"17","key":"10.1016\/j.ijbiomac.2022.02.096_bb0280","first-page":"1914","article-title":"Release of urea from cellulosic hydrogel coated urea granule: modeling effect of crosslink density and pH triggering","volume":"58","author":"Sarkar","year":"2019","journal-title":"Polym. Plast. Technol. Mater."},{"issue":"4","key":"10.1016\/j.ijbiomac.2022.02.096_bb0285","doi-asserted-by":"crossref","first-page":"49723","DOI":"10.1002\/app.49723","article-title":"Macroporous open cell polyester amphigel using citric acid and PEO: solvent absorption, thermal behavior, and slow release of pesticide","volume":"138","author":"Sarkar","year":"2021","journal-title":"J. Appl. Polym. Sci."},{"issue":"10","key":"10.1016\/j.ijbiomac.2022.02.096_bb0290","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3816\/CBC.2007.n.035","article-title":"The role of efflux pumps in drug-resistant metastatic breast cancer: new insights and treatment strategies","volume":"7","author":"Fojo","year":"2007","journal-title":"Clin. Breast Cancer"},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0295","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.ijbiomac.2018.09.146","article-title":"Sericin\/RBA embedded gellan gum based smart nanosystem for pH responsive drug delivery","volume":"120","author":"Arjama","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119412","article-title":"Localized delivery of active targeting micelles from nanofibers patch for effective breast cancer therapy","volume":"584","author":"Mehnath","year":"2020","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.02.096_bb0305","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bmc.2013.11.029","article-title":"New highly toxic bile acids derived from deoxycholic acid, chenodeoxycholic acid and lithocholic acid","volume":"22","author":"M\u00e1jer","year":"2014","journal-title":"Bioorg. Med. Chem."},{"issue":"8","key":"10.1016\/j.ijbiomac.2022.02.096_bb0310","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1021\/acs.jmedchem.6b01536","article-title":"Reversing the cytotoxicity of bile acids by supramolecular encapsulation","volume":"60","author":"Zhang","year":"2017","journal-title":"J. Med. Chem."},{"issue":"10","key":"10.1016\/j.ijbiomac.2022.02.096_bb0315","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.3390\/ijms19103132","article-title":"Amphiphilic polymeric micelles based on deoxycholic acid and folic acid modified chitosan for the delivery of paclitaxel","volume":"19","author":"Li","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.111319","article-title":"pH-sensitive deoxycholic acid dimer for improving doxorubicin delivery and antitumor activity in vivso","volume":"196","author":"Xu","year":"2020","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2020.101730","article-title":"Tumor-targeted and self-assembled mixed micelles as carriers for enhanced anticancer efficacy of gemcitabine","volume":"57","author":"Zhang","year":"2020","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.ijbiomac.2022.02.096_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.reactfunctpolym.2020.104608","article-title":"Multifunctional micelles self-assembled from hyaluronic acid conjugate for enhancing anti-tumor effect of paclitaxel","volume":"152","author":"Li","year":"2020","journal-title":"React. Funct. Polym."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813022003427?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813022003427?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T09:25:43Z","timestamp":1758878743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813022003427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":66,"alternative-id":["S0141813022003427"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.02.096","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Controlled release of 5-fluorouracil to melanoma cells using a hydrogel\/micelle composites based on deoxycholic acid and carboxymethyl chitosan","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.02.096","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}