{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T22:55:06Z","timestamp":1781996106523,"version":"3.54.5"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005117","name":"Birjand University of Medical Sciences","doi-asserted-by":"publisher","award":["456339"],"award-info":[{"award-number":["456339"]}],"id":[{"id":"10.13039\/501100005117","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.ijbiomac.2022.02.113","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T21:46:30Z","timestamp":1645566390000},"page":"21-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Evaluation of anti-tumor effect of the exopolysaccharide from new cold-adapted yeast, Rhodotorula mucilaginosa sp. GUMS16 on chronic myeloid leukemia K562 cell line"],"prefix":"10.1016","volume":"206","author":[{"given":"Setare","family":"Kheyrandish","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Rastgar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Hamidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mehdi","family":"Sajjadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza Anani","family":"Sarab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ijbiomac.2022.02.113_bb0005","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/jobm.200610203","article-title":"Bacterial exopolysaccharides\u2013a perception","volume":"47","author":"Kumar","year":"2007","journal-title":"J. Basic Microbiol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2022.02.113_bb0010","doi-asserted-by":"crossref","first-page":"254","DOI":"10.34172\/apb.2020.030","article-title":"Characterization and prospective applications of the exopolysaccharides produced by rhodosporidium babjevae","volume":"10","author":"Seveiri","year":"2020","journal-title":"Adv. Pharm. Bull."},{"issue":"97","key":"10.1016\/j.ijbiomac.2022.02.113_bb0015","first-page":"381","article-title":"Characterization of the exopolysaccharides from Rhodotorula minuta IBRC-M 30135 and evaluation of their emulsifying, antioxidant and antiproliferative activities","volume":"23","author":"Seveiri","year":"2019","journal-title":"Med. Sci."},{"key":"10.1016\/j.ijbiomac.2022.02.113_bb0020","first-page":"1","article-title":"Polysaccharide-based hydrogels: properties, advantages, challenges, and optimization methods for applications in regenerative medicine","author":"Safarzadeh Kozani","year":"2021","journal-title":"Int. J. Polym. Mater."},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.02.113_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13205-018-1515-5","article-title":"Characterization of a new exopolysaccharide produced by Halorubrum sp. TBZ112 and evaluation of its anti-proliferative effect on gastric cancer cells","volume":"9","author":"Hamidi","year":"2019","journal-title":"3 Biotech"},{"key":"10.1016\/j.ijbiomac.2022.02.113_bb0030","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ijbiomac.2020.02.206","article-title":"Production, characterization and biological activities of exopolysaccharides from a new cold-adapted yeast: Rhodotorula mucilaginosa sp. GUMS16","volume":"151","author":"Hamidi","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2022.02.113_bb0035","first-page":"1","article-title":"Yeast exopolysaccharides and their physiological functions","author":"Saadat","year":"2021","journal-title":"Folia Microbiol. (Praha)"},{"key":"10.1016\/j.ijbiomac.2022.02.113_bb0040","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.carbpol.2013.08.010","article-title":"Optimization for production of exopolysaccharides with antitumor activity in vitro from paecilomyces hepiali","volume":"99","author":"Wu","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2022.02.113_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.117258","article-title":"Beta-d-glucan-based drug delivery system and its potential application in targeting tumor associated macrophages","volume":"253","author":"Su","year":"2021","journal-title":"Carbohydr. Polym."},{"issue":"12","key":"10.1016\/j.ijbiomac.2022.02.113_bb0050","doi-asserted-by":"crossref","first-page":"10397","DOI":"10.1039\/D0FO02272A","article-title":"Modulation of gut homeostasis by exopolysaccharides from Aspergillus cristatus (MK346334), a strain of fungus isolated from Fuzhuan brick tea, contributes to immunomodulatory activity in cyclophosphamide-treated mice","volume":"11","author":"Xie","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.ijbiomac.2022.02.113_bb0055","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.procbio.2018.06.009","article-title":"Microbial exopolysaccharides: resources and bioactive properties","volume":"72","author":"Yildiz","year":"2018","journal-title":"Process Biochem."},{"issue":"3","key":"10.1016\/j.ijbiomac.2022.02.113_bb0060","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3390\/chemengineering5030039","article-title":"Optimization of Exopolysaccharide (EPS) Production by Rhodotorula mucilaginosa sp. GUMS16","volume":"5","author":"Okoro","year":"2021","journal-title":"ChemEngineering"},{"issue":"7","key":"10.1016\/j.ijbiomac.2022.02.113_bb0065","first-page":"1957","article-title":"Exopolysaccharide from marine bacillus velezensis MHM3 induces apoptosis of human breast cancer MCF-7 cells through a mitochondrial pathway","volume":"19","author":"Mahgoub","year":"2018","journal-title":"APJCP"},{"key":"10.1016\/j.ijbiomac.2022.02.113_bb0070","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.carbpol.2014.12.045","article-title":"Exopolysaccharide of Antarctic bacterium pseudoaltermonas sp. S-5 induces apoptosis in K562 cells","volume":"121","author":"Chen","year":"2015","journal-title":"Carbohydr. Polym."},{"issue":"2","key":"10.1016\/j.ijbiomac.2022.02.113_bb0075","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00253-010-2886-7","article-title":"An exopolysaccharide produced by the novel halophilic bacterium Halomonas stenophila strain B100 selectively induces apoptosis in human T leukaemia cells","volume":"89","author":"Ruiz-Ruiz","year":"2011","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ijbiomac.2022.02.113_bb0080","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.carbpol.2017.11.080","article-title":"Characterization, antioxidativity, and anti-carcinoma activity of exopolysaccharide extract from Rhodotorula mucilaginosa CICC 33013","volume":"181","author":"Ma","year":"2018","journal-title":"Carbohydr. Polym."},{"issue":"1-2","key":"10.1016\/j.ijbiomac.2022.02.113_bb0085","first-page":"8","article-title":"Overview of mechanisms of cancer chemopreventive agents","volume":"591","author":"Flora","year":"2005"},{"key":"10.1016\/j.ijbiomac.2022.02.113_bb0090","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9540702","article-title":"Improvement of K562 cell line transduction by FBS mediated attachment to the cell culture plate","author":"Abbasalipour","year":"2019","journal-title":"Biomed. Res. Int."},{"issue":"2","key":"10.1016\/j.ijbiomac.2022.02.113_bb0095","first-page":"123","article-title":"The human erythroleukemia K562 cell culture system for identification of inducers of fetal hemoglobin","volume":"15","author":"Gambari","year":"2003","journal-title":"Minerva Biotecnol."},{"issue":"6","key":"10.1016\/j.ijbiomac.2022.02.113_bb0100","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.5958\/0974-360X.2020.00526.0","article-title":"Review on pathophysiological and pharmacotherapeutic approach on chronic myeloid leukemia","volume":"13","author":"Gudimetla","year":"2020","journal-title":"Res. J. Pharm. Technol."},{"issue":"3","key":"10.1016\/j.ijbiomac.2022.02.113_bb0105","article-title":"Re-evaluating the role of BCR\/ABL in chronic myelogenous leukemia","volume":"1","author":"Ross","year":"2014","journal-title":"Mol. Cell. Oncol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2022.02.113_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-021-03637-4","article-title":"Depleting long noncoding RNA HOTAIR attenuates chronic myelocytic leukemia progression by binding to DNA methyltransferase 1 and inhibiting PTEN gene promoter methylation","volume":"12","author":"Song","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ijbiomac.2022.02.113_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-020-06782-9","article-title":"The effects of combination treatments on drug resistance in chronic myeloid leukaemia: an evaluation of the tyrosine kinase inhibitors axitinib and asciminib","volume":"20","author":"Lindstr\u00f6m","year":"2020","journal-title":"BMC Cancer"},{"issue":"8","key":"10.1016\/j.ijbiomac.2022.02.113_bb0120","first-page":"469","article-title":"Presentating phases of chronic myeloid leukaemia","volume":"19","author":"Ahmed","year":"2009","journal-title":"J. Coll. Physicians Surg. Pak."},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.02.113_bb0125","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11864-000-0015-z","article-title":"Accelerated and blastic phase of chronic myeloid leukemia","volume":"1","author":"Dutcher","year":"2000","journal-title":"Curr. Treat. Options Oncol."},{"issue":"11","key":"10.1016\/j.ijbiomac.2022.02.113_bb0130","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/ajh.23282","article-title":"Chronic myeloid leukemia: 2012 update on diagnosis, monitoring, and management","volume":"87","author":"Jabbour","year":"2012","journal-title":"Am. J. Hematol."},{"issue":"7","key":"10.1016\/j.ijbiomac.2022.02.113_bb0135","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1002\/cam4.3660","article-title":"Perspectives and controversies regarding the use of natural products for the treatment of lung cancer","volume":"10","author":"Wen","year":"2021","journal-title":"Cancer Med."},{"key":"10.1016\/j.ijbiomac.2022.02.113_bb0140","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.3389\/fonc.2021.664380","article-title":"Nanomaterial complexes enriched with natural compounds used in cancer therapies: a perspective for clinical application","volume":"11","author":"Saavedra-Leos","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ijbiomac.2022.02.113_bb0145","article-title":"The soft agar colony formation assay","volume":"92","author":"Borowicz","year":"2014","journal-title":"J. Vis. Exp."},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.02.113_bb0150","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0023-6438(95)80008-5","article-title":"Use of a free radical method to evaluate antioxidant activity","volume":"28","author":"Brand-Williams","year":"1995","journal-title":"LWT - Food Sci. Technol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2022.02.113_bb0155","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.carbpol.2013.05.068","article-title":"Polysaccharides from Rhizopus nigricans mycelia induced apoptosis and G2\/M arrest in BGC-823 cells","volume":"97","author":"Chen","year":"2013","journal-title":"Carbohydr. Polym."},{"issue":"5","key":"10.1016\/j.ijbiomac.2022.02.113_bb0160","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3390\/md18050268","article-title":"Structure and in vitro bioactivity against cancer cells of the capsular polysaccharide from the marine bacterium psychrobacter marincola","volume":"18","author":"Kokoulin","year":"2020","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ijbiomac.2022.02.113_bb0165","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.carbpol.2015.09.108","article-title":"Exopolysaccharide from trichoderma pseudokoningii induces the apoptosis of MCF-7 cells through an intrinsic mitochondrial pathway","volume":"136","author":"Wang","year":"2016","journal-title":"Carbohydr. Polym."},{"issue":"3","key":"10.1016\/j.ijbiomac.2022.02.113_bb0170","first-page":"3577","article-title":"Exopolysaccharides produced by Lactobacillus strains suppress HT-29 cell growth via induction of G0\/G1 cell cycle arrest and apoptosis","volume":"16","author":"Di","year":"2018","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.02.113_bb0175","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1600-065X.2011.01044.x","article-title":"Caspase-1-induced pyroptotic cell death","volume":"243","author":"Miao","year":"2011","journal-title":"Immunol. Rev."},{"issue":"2","key":"10.1016\/j.ijbiomac.2022.02.113_bb0180","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.carbpol.2012.03.079","article-title":"An exopolysaccharide from Trichoderma pseudokoningii and its apoptotic activity on human leukemia K562 cells","volume":"89","author":"Huang","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijbiomac.2022.02.113_bb0185","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.ijbiomac.2020.06.277","article-title":"Characterization and antitumor activity of novel exopolysaccharide APS of lactobacillus plantarum WLPL09 from human breast milk","volume":"163","author":"Jiang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2022.02.113_bb0190","first-page":"123","article-title":"Cell-bound exopolysaccharide from probiotic bacteria induces autophagic cell death of tumour cells","volume":"51","author":"Kim","year":"2010","journal-title":"Lett. Appl. Microbiol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.02.113_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087223","article-title":"Molecular mechanisms of exopolysaccharide from aphanothece halaphytica (EPSAH) induced apoptosis in HeLa cells","volume":"9","author":"Ou","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.ijbiomac.2022.02.113_bb0200","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2174\/1566524023362456","article-title":"The role of STATs in apoptosis","volume":"2","author":"Battle","year":"2002","journal-title":"Curr. Mol. Med."},{"issue":"2","key":"10.1016\/j.ijbiomac.2022.02.113_bb0205","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/(SICI)1097-4652(200002)182:2<171::AID-JCP5>3.0.CO;2-3","article-title":"Role of p53 family members in apoptosis","volume":"182","author":"Sheikh","year":"2000","journal-title":"J. Cell. Physiol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2022.02.113_bb0210","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.canlet.2012.03.005","article-title":"Targeting survivin in cancer","volume":"332","author":"Altieri","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ijbiomac.2022.02.113_bb0215","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.carbpol.2018.09.069","article-title":"Isolation and characterization of an antioxidant exopolysaccharide produced by Bacillus sp. S-1 from Sichuan pickles","volume":"204","author":"Hu","year":"2019","journal-title":"Carbohydr. Polym."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813022003592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813022003592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T09:22:12Z","timestamp":1758878532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813022003592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":43,"alternative-id":["S0141813022003592"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.02.113","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of anti-tumor effect of the exopolysaccharide from new cold-adapted yeast, Rhodotorula mucilaginosa sp. GUMS16 on chronic myeloid leukemia K562 cell line","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.02.113","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}