{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T16:43:14Z","timestamp":1772901794032,"version":"3.50.1"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.ijbiomac.2022.03.092","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T11:12:12Z","timestamp":1649329932000},"page":"426-440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"PA","title":["Insights into the inhibitory mechanism of skullcapflavone II against \u03b1-synuclein aggregation and its mediated cytotoxicity"],"prefix":"10.1016","volume":"209","author":[{"given":"Soha","family":"Parsafar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhang","family":"Aliakbari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sepideh Sadat","family":"Seyedfatemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Najarzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamdam","family":"Hourfar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Bardania","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Farhadpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Mohammadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Morshedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0005","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40035-019-0172-x","article-title":"Beyond the synucleinopathies: alpha synuclein as a driving force in neurodegenerative comorbidities","volume":"8","author":"Visanji","year":"2019","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0010","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13024-020-00368-6","article-title":"Initiation and propagation of \u03b1-synuclein aggregation in the nervous system","volume":"15","author":"Hijaz","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cger.2019.08.002","article-title":"Parkinson disease epidemiology, pathology, genetics, and pathophysiology","volume":"36","author":"Simon","year":"2020","journal-title":"Clin. Geriatr. Med."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0020","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41583-020-00416-6","article-title":"Reverse engineering Lewy bodies: how far have we come and how far can we go?","volume":"22","author":"Fares","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2019.101729","article-title":"A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson's disease: emerging concepts and challenges","volume":"185","author":"Vasquez","year":"2020","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00033","article-title":"Molecular signatures of neuroinflammation induced by \u03b1synuclein aggregates in microglial cells","volume":"11","author":"Sarkar","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0035","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s40478-019-0865-5","article-title":"Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates","volume":"7","author":"Elfarrash","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0040","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3390\/biom10030391","article-title":"Targeting \u03b1-synuclein for PD therapeutics: a pursuit on all fronts","volume":"10","author":"Teil","year":"2020","journal-title":"Biomolecules."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0045","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3233\/JPD-130186","article-title":"Levodopa in the treatment of Parkinson's disease: current status and new developments","volume":"3","author":"Salat","year":"2013","journal-title":"J. Parkinsons. Dis."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0050","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1080\/14756366.2020.1816999","article-title":"Rational design of small molecules able to inhibit \u03b1-synuclein amyloid aggregation for the treatment of Parkinson's disease","volume":"35","author":"Vittorio","year":"2020","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0055","series-title":"Synucleins - Biochem. Role Dis","article-title":"Therapeutic potential of baicalein in Parkinson's disease: focus on inhibition of \u03b1-synuclein oligomerization and aggregation","author":"Javed","year":"2020"},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0060","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12906-020-2849-1","article-title":"Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts","volume":"20","author":"Ardah","year":"2020","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0217801","article-title":"The interaction of several herbal extracts with \u03b1-synuclein: fibril formation and surface plasmon resonance analysis","volume":"14","author":"Honarmand","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0070","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7043213","article-title":"Flavonoids as therapeutic agents in Alzheimer's and Parkinson's diseases: a systematic review of preclinical evidences","volume":"2018","author":"de Andrade Teles","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0075","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1074\/jbc.RA118.005723","article-title":"Oleuropein derivatives from olive fruit extracts reduce \u03b1-synuclein fibrillation and oligomer toxicity","volume":"294","author":"Mohammad-Beigi","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0080","first-page":"2007765","article-title":"Multiple protective roles of nanoliposome-incorporated baicalein against alpha-synuclein aggregates","author":"Aliakbari","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0085","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/jnc.14707","article-title":"In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies","volume":"150","author":"Marvian","year":"2019","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0090","doi-asserted-by":"crossref","first-page":"85312","DOI":"10.1039\/C6RA08502D","article-title":"Gallic acid loaded onto polyethylenimine-coated human serum albumin nanoparticles (PEI-HSA-GA NPs) stabilizes \u03b1-synuclein in the unfolded conformation and inhibits aggregation","volume":"6","author":"Mohammad-Beigi","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0095","series-title":"Med. Plants","first-page":"141","article-title":"Skullcaps (Scutellaria spp.): ethnobotany and current research","author":"Irvin","year":"2019"},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0100","series-title":"A Dictionary of Iranian Plant Names","volume":"396","author":"Mozaffarian","year":"1996"},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184483","article-title":"A study on the modulation of alpha-synuclein fibrillation by Scutellaria pinnatifida extracts and its neuroprotective properties","volume":"12","author":"Sashourpour","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e04737","article-title":"Multiple neuroprotective features of Scutellaria pinnatifida\u2013derived small molecule","volume":"6","author":"Parsafar","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0115","doi-asserted-by":"crossref","first-page":"21299","DOI":"10.1074\/jbc.M114.554667","article-title":"How epigallocatechin gallate can inhibit \u03b1-synuclein oligomer toxicity in vitro","volume":"289","author":"Lorenzen","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0120","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.ijbiomac.2020.03.238","article-title":"The status of the terminal regions of \u03b1-synuclein in different forms of aggregates during fibrillization","volume":"155","author":"Marvian","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0125","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ab.2010.02.001","article-title":"Strategies to increase the reproducibility of protein fibrillization in plate reader assays","volume":"400","author":"Giehm","year":"2010","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0130","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1021\/bi701899y","article-title":"Fitting neurological protein aggregation kinetic data via a 2-step, Minimal\/\u201cOckham's razor\u201d model: the Finke\u2212Watzky mechanism of nucleation followed by autocatalytic surface growth \u2020","volume":"47","author":"Morris","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0135","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cyto.a.20022","article-title":"Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images","volume":"58","author":"Meijering","year":"2004","journal-title":"Cytom. Part A J. Int. Soc. Anal. Cytol."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0140","doi-asserted-by":"crossref","first-page":"W315","DOI":"10.1093\/nar\/gky497","article-title":"BeStSel: a web server for accurate protein secondary structure prediction and fold recognition from the circular dichroism spectra","volume":"46","author":"Micsonai","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0145","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.1021\/bi5007833","article-title":"High stability and cooperative unfolding of \u03b1-synuclein oligomers","volume":"53","author":"Paslawski","year":"2014","journal-title":"Biochemistry"},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.01.055","article-title":"The primary neuronal cells are more resistant than PC12 cells to \u03b1-synuclein toxic aggregates","volume":"701","author":"Heravi","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0155","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/cber.187901201117","article-title":"Bemerkungen zu der Abhandlung der HH. Weselsky und Benedikt \u201eUeber einige Azoverbindungen","volume":"12","author":"Griess","year":"1879","journal-title":"Berichte Der Dtsch. Chem. Gesellschaft"},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0160","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1039\/C9CP04610K","article-title":"Critical nucleus of Greek-key-like core of \u03b1-synuclein protofibril and its disruption by dopamine and norepinephrine","volume":"22","author":"Zou","year":"2020","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0165","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nsmb.3194","article-title":"Solid-state NMR structure of a pathogenic fibril of full-length human \u03b1-synuclein","volume":"23","author":"Tuttle","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0170","doi-asserted-by":"crossref","DOI":"10.2174\/1871524917666170427152849","article-title":"Investigation on the molecular interactions stabilizing the structure of \u03b1-synuclein fibril: an in silico study","volume":"17","author":"Sanjeev","year":"2017","journal-title":"Cent. Nerv. Syst. Agents Med. Chem."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0175","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.36402","article-title":"Cryo-EM structure of alpha-synuclein fibrils","volume":"7","author":"Guerrero-Ferreira","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0180","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0185","doi-asserted-by":"crossref","first-page":"W257","DOI":"10.1093\/nar\/gky318","article-title":"ProTox-II: a webserver for the prediction of toxicity of chemicals","volume":"46","author":"Banerjee","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0190","doi-asserted-by":"crossref","first-page":"H2336","DOI":"10.1111\/1750-3841.13016","article-title":"Cuminaldehyde as the major component of Cuminum cyminum, a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity","volume":"80","author":"Morshedi","year":"2015","journal-title":"J. Food Sci."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0195","doi-asserted-by":"crossref","first-page":"25297","DOI":"10.1074\/jbc.M201869200","article-title":"Activation of the phosphatidylinositol 3-Kinase\/Akt signaling pathway by retinoic acid is required for neural differentiation of SH-SY5Y human neuroblastoma cells","volume":"277","author":"L\u00f3pez-Carballo","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0200","doi-asserted-by":"crossref","DOI":"10.1017\/S0033583516000172","article-title":"Secondary nucleation of monomers on fibril surface dominates \u03b1 -synuclein aggregation and provides autocatalytic amyloid amplification","volume":"50","author":"Gaspar","year":"2017","journal-title":"Q. Rev. Biophys."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0205","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.semcdb.2019.07.010","article-title":"Axonal transport defects and neurodegeneration: molecular mechanisms and therapeutic implications","volume":"99","author":"Guo","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0210","doi-asserted-by":"crossref","first-page":"8421","DOI":"10.3390\/ijms21228421","article-title":"Neurodegeneration and inflammation\u2014an interesting interplay in Parkinson's disease","volume":"21","author":"Marogianni","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0215","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nature14547","article-title":"\u03b1-Synuclein strains cause distinct synucleinopathies after local and systemic administration","volume":"522","author":"Peelaerts","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0220","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/1742-2094-8-166","article-title":"The acute inflammatory response to intranigral \u03b1-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation","volume":"8","author":"Couch","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0225","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13052-018-0563-0","article-title":"Possible strategies to cross the blood\u2013brain barrier","volume":"44","author":"Bellettato","year":"2018","journal-title":"Ital. J. Pediatr."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0230","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1477-3155-11-26","article-title":"Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle","volume":"11","author":"Saptarshi","year":"2013","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0235","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.crfs.2020.03.001","article-title":"Physicochemical characterisation, molecular docking, and drug-likeness evaluation of hypotensive peptides encrypted in flaxseed proteome","volume":"3","author":"Ji","year":"2020","journal-title":"Curr. Res. Food Sci."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0240","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.3390\/molecules25051135","article-title":"A supramolecular approach to structure-based design with a focus on synthons hierarchy in ornithine-derived ligands: review,synthesis, experimental and in silico studies","volume":"25","author":"Bojarska","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0245","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10048-016-0478-0","article-title":"Up-regulation of SNCA gene expression: implications to synucleinopathies","volume":"17","author":"Tagliafierro","year":"2016","journal-title":"Neurogenetics"},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0250","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/s41419-019-2091-2","article-title":"Mitochondrial damage by \u03b1-synuclein causes cell death in human dopaminergic neurons","volume":"10","author":"Ganjam","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0255","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.318","article-title":"Elevated \u03b1-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells","volume":"6","author":"Oliveira","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0260","first-page":"38","article-title":"Mitochondrial dysfunction in Parkinson's disease cause or consequence","volume":"8","author":"Chen","year":"2019","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0265","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejmech.2019.01.045","article-title":"Toward the discovery and development of effective modulators of \u03b1-synuclein amyloid aggregation","volume":"167","author":"Oliveri","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0270","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1042\/BJ20111924","article-title":"Toxic prefibrillar \u03b1-synuclein amyloid oligomers adopt a distinctive antiparallel \u03b2-sheet structure","volume":"443","author":"Celej","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0275","first-page":"E1994","article-title":"Structural characterization of toxic oligomers that are kinetically trapped during \u03b1-synuclein fibril formation","volume":"112","author":"Chen","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0280","doi-asserted-by":"crossref","first-page":"955","DOI":"10.4103\/1673-5374.233432","article-title":"Natural polyphenols effects on protein aggregates in Alzheimer's and Parkinson's prion-like diseases","volume":"13","author":"Freyssin","year":"2018","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0285","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.3390\/molecules25204647","article-title":"Natural and synthetic derivatives of hydroxycinnamic acid modulating the pathological transformation of amyloidogenic proteins","volume":"25","author":"Muronetz","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0290","doi-asserted-by":"crossref","first-page":"9193","DOI":"10.1074\/jbc.M111.325548","article-title":"Curcumin prevents aggregation in \u03b1-synuclein by increasing reconfiguration rate","volume":"287","author":"Ahmad","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0295","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1159\/000491657","article-title":"The molecular mechanism of alpha-synuclein dependent regulation of protein phosphatase 2A activity","volume":"47","author":"Qu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0300","doi-asserted-by":"crossref","first-page":"8667","DOI":"10.1039\/C8CC02204F","article-title":"Secondary nucleation in amyloid formation","volume":"54","author":"T\u00f6rnquist","year":"2018","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0305","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/s41594-020-0505-6","article-title":"Kinetic fingerprints differentiate the mechanisms of action of anti-A\u03b2 antibodies","volume":"27","author":"Linse","year":"2020","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0310","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2020.582033","article-title":"Asparagine and glutamine side-chains and ladders in HET-s(218\u2013289) amyloid fibrils studied by fast magic-angle spinning NMR","volume":"7","author":"Wiegand","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0315","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.conb.2020.01.014","article-title":"New insights on the structure of alpha-synuclein fibrils using cryo-electron microscopy","volume":"61","author":"Guerrero-Ferreira","year":"2020","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0320","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13024-019-0329-1","article-title":"Alpha-synuclein structure and Parkinson's disease \u2013 lessons and emerging principles","volume":"14","author":"Meade","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0325","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41422-020-0299-4","article-title":"Cryo-EM structure of full-length \u03b1-synuclein amyloid fibril with Parkinson\u2019s disease familial A53T mutation","volume":"30","author":"Sun","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0330","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/s41422-018-0075-x","article-title":"Amyloid fibril structure of \u03b1-synuclein determined by cryo-electron microscopy","volume":"28","author":"Li","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0335","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020412","article-title":"The blood-brain barrier","volume":"7","author":"Daneman","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108738","article-title":"Nose-to-brain delivery of chrysin transfersomal and composite vesicles in doxorubicin-induced cognitive impairment in rats: insights on formulation, oxidative stress and TLR4\/NF-kB\/NLRP3 pathways","volume":"197","author":"Ibrahim","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ijbiomac.2022.03.092_bb0345","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ijpharm.2018.03.055","article-title":"Kaempferol-loaded mucoadhesive nanoemulsion for intranasal administration reduces glioma growth in vitro","volume":"543","author":"Colombo","year":"2018","journal-title":"Int. J. Pharm."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813022005621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813022005621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T09:30:06Z","timestamp":1758879006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813022005621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":69,"alternative-id":["S0141813022005621"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.03.092","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insights into the inhibitory mechanism of skullcapflavone II against \u03b1-synuclein aggregation and its mediated cytotoxicity","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.03.092","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}