{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:55:07Z","timestamp":1789541707034,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.ijbiomac.2022.04.131","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T02:03:46Z","timestamp":1650506626000},"page":"1327-1338","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"PA","title":["In-depth investigation of the mechanisms of Echinacea purpurea polysaccharide mitigating alcoholic liver injury in mice via gut microbiota informatics and liver metabolomics"],"prefix":"10.1016","volume":"209","author":[{"given":"Wenhao","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2022.04.131_bb0005","doi-asserted-by":"crossref","DOI":"10.29219\/fnr.v63.1518","article-title":"Role of intestinal microecology in the regulation of energy metabolism by dietary polyphenols and their metabolites","volume":"63","author":"Lin","year":"2019","journal-title":"Food Nutr. Res."},{"issue":"10","key":"10.1016\/j.ijbiomac.2022.04.131_bb0010","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1111\/add.14234","article-title":"Global statistics on alcohol, tobacco and illicit drug use: 2017 status report","volume":"113","author":"Peacock","year":"2018","journal-title":"Addiction"},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.04.131_bb0015","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/alcalc\/agy083","article-title":"Executive functioning moderates responses to appetitive cues: a study in severe alcohol use disorder and alcoholic liver disease","volume":"54","author":"Logge","year":"2019","journal-title":"Alcohol Alcohol."},{"issue":"3","key":"10.1016\/j.ijbiomac.2022.04.131_bb0020","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.cld.2016.02.011","article-title":"Long-term management of alcoholic liver disease","volume":"20","author":"Allampati","year":"2016","journal-title":"Clin. Liver Dis."},{"issue":"4","key":"10.1016\/j.ijbiomac.2022.04.131_bb0025","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/alcalc\/agx025","article-title":"Gut-liver axis and sterile signals in the development of alcoholic liver disease","volume":"52","author":"Szabo","year":"2017","journal-title":"Alcohol Alcohol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2022.04.131_bb0030","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41575-018-0099-1","article-title":"Alcohol, liver disease and the gut microbiota","volume":"16","author":"Bajaj","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2022.04.131_bb0035","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1136\/gutjnl-2015-310585","article-title":"Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease","volume":"65","author":"Llopis","year":"2016","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.04.131_bb0040","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/hep.24018","article-title":"Enteric dysbiosis associated with a mouse model of alcoholic liver disease","volume":"53","author":"Yan","year":"2011","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.04.131_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0053028","article-title":"Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of lactobacillus rhamnosus GG treatment","volume":"8","author":"Bull-Otterson","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.04.131_bb0050","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1053\/j.gastro.2014.09.014","article-title":"Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice","volume":"148","author":"Chen","year":"2015","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.ijbiomac.2022.04.131_bb0055","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.jhep.2013.05.030","article-title":"The metabolomic window into hepatobiliary disease","volume":"59","author":"Beyoglu","year":"2013","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2022.04.131_bb0060","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1586\/14737159.4.2.189","article-title":"Metabonomics and its role in drug development and disease diagnosis","volume":"4","author":"Lindon","year":"2004","journal-title":"Expert. Rev. Mol. Diagn."},{"issue":"2","key":"10.1016\/j.ijbiomac.2022.04.131_bb0065","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1021\/pr100885w","article-title":"Metabonomic investigation of liver profiles of nonpolar metabolites obtained from alcohol-dosed rats and mice using high mass accuracy MSn analysis","volume":"10","author":"Loftus","year":"2011","journal-title":"J. Proteome Res."},{"issue":"9","key":"10.1016\/j.ijbiomac.2022.04.131_bb0070","first-page":"1367","article-title":"A serum metabonomic study on the difference between alcohol- and HBV-induced liver cirrhosis by ultraperformance liquid chromatography coupled to mass spectrometry plus quadrupole time-of-flight mass spectrometry","volume":"124","author":"Lian","year":"2011","journal-title":"Chin. Med. J."},{"issue":"3","key":"10.1016\/j.ijbiomac.2022.04.131_bb0075","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41564-019-0655-7","article-title":"Growth effects of N-acylethanolamines on gut bacteria reflect altered bacterial abundances in inflammatory bowel disease","volume":"5","author":"Fornelos","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.ijbiomac.2022.04.131_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153572","article-title":"Echinacea in hepatopathy: a review of its phytochemistry, pharmacology, and safety","volume":"87","author":"Xu","year":"2021","journal-title":"Phytomedicine"},{"issue":"9","key":"10.1016\/j.ijbiomac.2022.04.131_bb0085","doi-asserted-by":"crossref","first-page":"7576","DOI":"10.1039\/D0FO01367F","article-title":"Post-screening characterization of an acidic polysaccharide from Echinacea purpurea with potent anti-inflammatory properties in vivo","volume":"11","author":"Li","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.ijbiomac.2022.04.131_bb0090","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ijbiomac.2020.01.129","article-title":"Polysaccharide from Echinacea purpurea reduce the oxidant stress in vitro and in vivo","volume":"149","author":"Hou","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2022.04.131_bb0095","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ijbiomac.2021.07.095","article-title":"Echinacea purpurea polysaccharide prepared by fractional precipitation prevents alcoholic liver injury in mice by protecting the intestinal barrier and regulating liver-related pathways","volume":"187","author":"Jiang","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2022.04.131_bb0100","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.ijbiomac.2020.03.168","article-title":"Hepatoprotection mechanism against alcohol-induced liver injury in vivo and structural characterization of Pinus koraiensis pine nut polysaccharide","volume":"154","author":"Qu","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2022.04.131_bb0105","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.ijbiomac.2019.02.053","article-title":"Sulfated modification of the polysaccharides from Crassostrea gigas and their antioxidant and hepatoprotective activities through metabolomics analysis","volume":"129","author":"Zhao","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2022.04.131_bb0110","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cbi.2017.08.006","article-title":"Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARalpha-mediated lipogenic gene expression","volume":"275","author":"Wang","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ijbiomac.2022.04.131_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.117571","article-title":"Study on fecal fermentation characteristics of aloe polysaccharides in vitro and their predictive modeling","volume":"256","author":"Liu","year":"2021","journal-title":"Carbohydr. Polym."},{"issue":"4","key":"10.1016\/j.ijbiomac.2022.04.131_bb0120","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1021\/ac302881e","article-title":"Evaluation and optimization of metabolome sample preparation methods for Saccharomyces cerevisiae","volume":"85","author":"Kim","year":"2013","journal-title":"Anal. Chem."},{"issue":"7","key":"10.1016\/j.ijbiomac.2022.04.131_bb0125","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1021\/pr400362z","article-title":"Chronic ethanol consumption alters mammalian gastrointestinal content metabolites","volume":"12","author":"Xie","year":"2013","journal-title":"J. Proteome Res."},{"issue":"11","key":"10.1016\/j.ijbiomac.2022.04.131_bb0130","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.bbalip.2010.07.007","article-title":"Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms","volume":"1801","author":"Al-Lahham","year":"2010","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"9","key":"10.1016\/j.ijbiomac.2022.04.131_bb0135","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/jgh.13731","article-title":"Prophylactic tributyrin treatment mitigates chronic-binge ethanol-induced intestinal barrier and liver injury","volume":"32","author":"Cresci","year":"2017","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.04.131_bb0140","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/s41467-019-08711-2","article-title":"The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes","volume":"10","author":"Luu","year":"2019","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.ijbiomac.2022.04.131_bb0145","article-title":"Core altered microorganisms in colitis mouse model: a comprehensive time-point and fecal microbiota transplantation analysis","volume":"10","author":"Shang","year":"2021","journal-title":"Antibiotics-Basel"},{"key":"10.1016\/j.ijbiomac.2022.04.131_bb0150","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.3389\/fmicb.2019.02259","article-title":"Administration of Akkermansia muciniphila ameliorates dextran sulfate sodium-induced ulcerative colitis in mice","volume":"10","author":"Bian","year":"2019","journal-title":"Front. Microbiol."},{"issue":"6446","key":"10.1016\/j.ijbiomac.2022.04.131_bb0155","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1126\/science.aaw7479","article-title":"Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis","volume":"364","author":"Ansaldo","year":"2019","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.ijbiomac.2022.04.131_bb0160","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.celrep.2017.03.080","article-title":"NLRP6 protects Il10(-\/-) mice from colitis by limiting colonization of akkermansia muciniphila","volume":"19","author":"Seregin","year":"2017","journal-title":"Cell Rep."},{"issue":"17","key":"10.1016\/j.ijbiomac.2022.04.131_bb0165","doi-asserted-by":"crossref","first-page":"27820","DOI":"10.18632\/oncotarget.15482","article-title":"Multi-targeting therapeutic mechanisms of the Chinese herbal medicine QHD in the treatment of non-alcoholic fatty liver disease","volume":"8","author":"Feng","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ijbiomac.2022.04.131_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102360","article-title":"Metagenomic profiling of the pro-inflammatory gut microbiota in ankylosing spondylitis","volume":"107","author":"Zhou","year":"2020","journal-title":"J. Autoimmun."},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.04.131_bb0175","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1186\/s12870-021-03376-w","article-title":"Comparative transcriptome and metabolome analysis reveal glutathione metabolic network and functional genes underlying blue and red-light mediation in maize seedling leaf","volume":"21","author":"Liu","year":"2021","journal-title":"BMC Plant Biol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2022.04.131_bb0180","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1039\/C8FO00643A","article-title":"A comparative study of EPA-enriched ethanolamine plasmalogen and EPA-enriched phosphatidylethanolamine on Abeta42 induced cognitive deficiency in a rat model of Alzheimer's disease","volume":"9","author":"Che","year":"2018","journal-title":"Food Funct."},{"issue":"10","key":"10.1016\/j.ijbiomac.2022.04.131_bb0185","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/abbs\/gmq078","article-title":"Development and validation of a liquid chromatography-mass spectrometry metabonomic platform in human plasma of liver failure caused by hepatitis B virus","volume":"42","author":"Zhang","year":"2010","journal-title":"Acta Biochim. Biophys. Sin."},{"issue":"1\u20132","key":"10.1016\/j.ijbiomac.2022.04.131_bb0190","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11010-019-03580-1","article-title":"L-alpha-glycerylphosphorylcholine can be cytoprotective or cytotoxic in neonatal rat cardiac myocytes: a double-edged sword phenomenon","volume":"460","author":"Tuboly","year":"2019","journal-title":"Mol. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.ijbiomac.2022.04.131_bb0195","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/liv.13201","article-title":"Serum bile acids as marker for acute decompensation and acute-on-chronic liver failure in patients with non-cholestatic cirrhosis","volume":"37","author":"Horvatits","year":"2017","journal-title":"Liver Int."},{"issue":"6","key":"10.1016\/j.ijbiomac.2022.04.131_bb0200","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1177\/0148607114535265","article-title":"Glutamine improves innate immunity and prevents bacterial enteroinvasion during parenteral nutrition","volume":"39","author":"Wang","year":"2015","journal-title":"J. Parenter. Enter. Nutr."},{"key":"10.1016\/j.ijbiomac.2022.04.131_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173655","article-title":"The pharmacological activity of berberine, a review for liver protection","volume":"890","author":"Zhou","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"22","key":"10.1016\/j.ijbiomac.2022.04.131_bb0210","doi-asserted-by":"crossref","first-page":"6303","DOI":"10.1021\/acs.jafc.1c00273","article-title":"Host metabolic disorders induced by alterations in intestinal flora under dietary pesticide exposure","volume":"69","author":"Liu","year":"2021","journal-title":"J. Agric. Food Chem."},{"issue":"5","key":"10.1016\/j.ijbiomac.2022.04.131_bb0215","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/acer.12704","article-title":"Alcoholic liver disease: the gut microbiome and liver cross talk","volume":"39","author":"Hartmann","year":"2015","journal-title":"Alcoholism (NY)"},{"issue":"18","key":"10.1016\/j.ijbiomac.2022.04.131_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184568","article-title":"Alcohol or gut microbiota: who is the guilty?","volume":"20","author":"Meroni","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.ijbiomac.2022.04.131_bb0225","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.jhep.2018.05.021","article-title":"Intestinal HIF-1alpha deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction","volume":"69","author":"Shao","year":"2018","journal-title":"J. Hepatol."},{"issue":"6","key":"10.1016\/j.ijbiomac.2022.04.131_bb0230","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1002\/hep.29760","article-title":"Gut-liver axis alterations in alcoholic liver disease: are bile acids the answer?","volume":"67","author":"Bajaj","year":"2018","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.ijbiomac.2022.04.131_bb0235","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0955-2863(98)00022-9","article-title":"Antioxidant characteristics of L-histidine","volume":"9","author":"Wade","year":"1998","journal-title":"J. Nutr. Biochem."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813022008388?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813022008388?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T09:40:04Z","timestamp":1758879604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813022008388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":47,"alternative-id":["S0141813022008388"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.04.131","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In-depth investigation of the mechanisms of Echinacea purpurea polysaccharide mitigating alcoholic liver injury in mice via gut microbiota informatics and liver metabolomics","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.04.131","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}