{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:17:15Z","timestamp":1791685035140,"version":"4.3.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004702","name":"Universit\u00e0 degli Studi di Genova","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004702","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.ijbiomac.2022.08.063","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T21:27:30Z","timestamp":1660339650000},"page":"1618-1630","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Bevacizumab encapsulation into PLGA nanoparticles functionalized with immunouteroglobin-1 as an innovative delivery system for atherosclerosis"],"prefix":"10.1016","volume":"221","author":[{"given":"Giulia","family":"De Negri Atanasio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Francesco","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Bai\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Perego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Sarmento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Palombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Campardelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0005","article-title":"Biomimetic nano drug delivery carriers for treating cardiovascular diseases","volume":"33","author":"Zinger","year":"2021","journal-title":"Nanomedicine"},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0010","doi-asserted-by":"crossref","first-page":"8558","DOI":"10.1039\/D1TB01071A","article-title":"Innovative nanotools for vascular drug delivery: The atherosclerosis case study","volume":"9","author":"De Negri Atanasio","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0015","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/362801a0","article-title":"The pathogenesis of atherosclerosis: A perspective for the 1990s","volume":"362","author":"Ross","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jconrel.2019.12.021","article-title":"Cyclodextrin polymer improves atherosclerosis therapy and reduces ototoxicity","volume":"319","author":"Kim","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0025","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.vph.2018.06.014","article-title":"Pharmacological strategies to inhibit intra-plaque angiogenesis in atherosclerosis","volume":"112","author":"Perrotta","year":"2019","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0030","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.atherosclerosis.2006.12.034","article-title":"Inhibition of plaque neovascularization and intimal hyperplasia by specific targeting vascular endothelial growth factor with bevacizumab-eluting stent: An experimental study","volume":"195","author":"Stefanadis","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0035","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.3390\/polym14132593","article-title":"Bevacizumab-controlled delivery from polymeric microparticle systems as interesting tools for pathologic angiogenesis diseases","volume":"14","author":"De Negri Atanasio","year":"2022","journal-title":"Polymers"},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0040","doi-asserted-by":"crossref","first-page":"30417","DOI":"10.1038\/srep30417","article-title":"The therapeutic effect of bevacizumab on plaque neovascularization in a rabbit model of atherosclerosis during contrast-enhanced ultrasonography","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0045","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/S1734-1140(12)70901-5","article-title":"Nanoparticles as drug delivery systems","volume":"64","author":"Wilczewska","year":"2012","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0050","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3390\/polym3031377","article-title":"Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier","volume":"3","author":"Makadia","year":"2011","journal-title":"Polymers"},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0055","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ijbiomac.2021.02.058","article-title":"Dextran\/poly-L-arginine multi-layered CaCO3-based nanosystem for vascular drug delivery","volume":"177","author":"Ferrari","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0060","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/cjce.22871","article-title":"Engineered CaCO3 nanoparticles with targeting activity: A simple approach for a vascular intended drug delivery system","volume":"95","author":"Ferrari","year":"2017","journal-title":"Can. J. Chem. Eng."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0065","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/wnan.1157","article-title":"Recent advances in stealth coating of nanoparticle drug delivery systems","volume":"4","author":"Amoozgar","year":"2012","journal-title":"WIREs Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0070","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.nano.2018.06.010","article-title":"Aortic plaque-targeted andrographolide delivery with oxidation-sensitive micelle effectively treats atherosclerosis via simultaneous ROS capture and anti-inflammation","volume":"14","author":"Wu","year":"2018","journal-title":"Nanomedicine"},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0075","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.colsurfb.2013.07.045","article-title":"Coating barium titanate nanoparticles with polyethylenimine improves cellular uptake and allows for coupled imaging and gene delivery","volume":"112","author":"Dempsey","year":"2013","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0080","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.addr.2015.09.012","article-title":"PEGylation as a strategy for improving nanoparticle-based drug and gene delivery","volume":"99","author":"Suk","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0085","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jconrel.2020.01.035","article-title":"Functionalizing nanoparticles with cancer-targeting antibodies: A comparison of strategies","volume":"320","author":"Marques","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105520","article-title":"Considerations for efficient surface functionalization of nanoparticles with a high molecular weight protein as targeting ligand","volume":"155","author":"Thalhauser","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0095","doi-asserted-by":"crossref","first-page":"13750","DOI":"10.1021\/acs.analchem.0c01807","article-title":"Covalent inhibitor-based one-step method for endothelin receptor A immobilization: From ligand recognition to lead identification","volume":"92","author":"Zhao","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0100","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1007\/s10008-015-2912-x","article-title":"Oriented immobilization of antibody through carbodiimide reaction and controlling electric field","volume":"19","author":"Sun","year":"2015","journal-title":"J. Solid State Electrochem."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0105","doi-asserted-by":"crossref","first-page":"26646","DOI":"10.1074\/jbc.M109.025924","article-title":"Use of uteroglobin for the engineering of polyvalent, polyspecific fusion proteins","volume":"284","author":"Ventura","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0110","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.7150\/thno.24365","article-title":"Nanoparticles targeting extra domain B of fibronectin-specific to the atherosclerotic lesion types III, IV, and V-enhance plaque detection and cargo delivery","volume":"8","author":"Yu","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/7434376","article-title":"The role of monocytes and macrophages in human atherosclerosis, plaque neoangiogenesis, and atherothrombosis","volume":"2019","author":"Moroni","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fpls.2016.01156","article-title":"Efficient production of a bioactive bevacizumab monoclonal antibody using the 2A self-cleavage peptide in transgenic rice callus","volume":"7","author":"Chen","year":"2016","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0125","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1080\/02652048.2018.1453560","article-title":"Targeted delivery of monoclonal antibody conjugated docetaxel loaded PLGA nanoparticles into EGFR overexpressed lung tumour cells","volume":"35","author":"Patel","year":"2018","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0130","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.3390\/jcm9061750","article-title":"Theranostic designed near-infrared fluorescent poly (lactic-co-glycolic acid) nanoparticles and preliminary studies with functionalized VEGF-nanoparticles","volume":"9","author":"Varani","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0135","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.biopha.2017.08.108","article-title":"Development and characterization of hyaluronic acid modified PLGA based nanoparticles for improved efficacy of cisplatin in solid tumor","volume":"95","author":"Alam","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0140","doi-asserted-by":"crossref","first-page":"3736","DOI":"10.1038\/s41598-017-03959-4","article-title":"A new paradigm for antiangiogenic therapy through controlled release of bevacizumab from PLGA nanoparticles","volume":"7","author":"Sousa","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0145","doi-asserted-by":"crossref","first-page":"5176","DOI":"10.1016\/j.biomaterials.2007.08.011","article-title":"Tetanus toxin C fragment-conjugated nanoparticles for targeted drug delivery to neurons","volume":"28","author":"Townsend","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0150","doi-asserted-by":"crossref","first-page":"E486","DOI":"10.1002\/adv.21295","article-title":"Optimizing the process parameters for encapsulation of linamarin into PLGA nanoparticles using double emulsion solvent evaporation technique","volume":"32","author":"Hussein","year":"2013","journal-title":"Adv. Polym. Technol."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0155","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1021\/bm100971q","article-title":"Evaluation of nanoparticle aggregation in human blood serum","volume":"11","author":"Rausch","year":"2010","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0160","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/smll.200901158","article-title":"Effect of surface properties on nanoparticle\u2013cell interactions","volume":"6","author":"Verma","year":"2010","journal-title":"Small"},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.110191","article-title":"Development of PLGA nanoparticles for sustained release of a connexin43 mimetic peptide to target glioblastoma cells","volume":"108","author":"Roberts","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0170","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0168-3659(87)90035-6","article-title":"A simple equation for description of solute release II. Fickian and anomalous release from swellable devices","volume":"5","author":"Ritger","year":"1987","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0175","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/S0142-9612(01)00267-8","article-title":"Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake","volume":"23","author":"Zhang","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0180","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1039\/C3AN01684F","article-title":"ATR-FTIR spectroscopy as a tool to probe surface adsorption on nanoparticles at the liquid\u2013solid interface in environmentally and biologically relevant media","volume":"139","author":"Mudunkotuwa","year":"2014","journal-title":"Analyst"},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0185","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ejps.2013.07.014","article-title":"The protective effect of albumin on bevacizumab activity and stability in PLGA nanoparticles intended for retinal and choroidal neovascularization treatments","volume":"50","author":"Varshochian","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119895","article-title":"Formulation of nanoliposome-encapsulated bevacizumab (Avastin): Statistical optimization for enhanced drug encapsulation and properties evaluation","volume":"590","author":"Malakouti-Nejad","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0195","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1002\/jctb.6694","article-title":"Polyphenols from Nerone Gold 26\/6, a new pigmented rice, via non-conventional extractions: Antioxidant properties and biological validation","volume":"96","author":"Ferrari","year":"2021","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0200","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1080\/09205063.2013.878870","article-title":"Evaluation of the cytocompatibility hemocompatibility in vivo bone tissue regenerating capability of different PCL blends","volume":"25","author":"Padalhin","year":"2014","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0205","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3390\/cells8101209","article-title":"The hemocompatibility of nanoparticles: A review of cell\u2013nanoparticle interactions and hemostasis","volume":"8","author":"de la Harpe","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.ijbiomac.2022.08.063_bb0210","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.3390\/polym12112566","article-title":"Poly (lactic-co-glycolic acid) nanoparticles and nanoliposomes for protein delivery in targeted therapy: A comparative in vitro study","volume":"12","author":"De Negri Atanasio","year":"2020","journal-title":"Polymers"}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813022017639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813022017639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T04:51:58Z","timestamp":1786769518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813022017639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":42,"alternative-id":["S0141813022017639"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.08.063","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bevacizumab encapsulation into PLGA nanoparticles functionalized with immunouteroglobin-1 as an innovative delivery system for atherosclerosis","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.08.063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}