{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:36:32Z","timestamp":1793910992262,"version":"4.8.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.ijbiomac.2022.09.182","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T11:56:33Z","timestamp":1664193393000},"page":"794-802","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"PA","title":["An adjustable amyloid-\u03b2 oligomers aptasensor based on the synergistic effect of self-enhanced metal-organic gel luminophore and triple-helix DNA system"],"prefix":"10.1016","volume":"222","author":[{"given":"Xiaoying","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0005","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s12276-019-0250-2","article-title":"Diagnosis of Alzheimer's disease utilizing amyloid and tau as fluid biomarkers","volume":"51","author":"Lee","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2022.102270","article-title":"Amyloid ?, Tau, and ?-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases","volume":"214","author":"Sengupta","year":"2022","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0015","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1471-4159.2011.07478.x","article-title":"Soluble A\u03b2 oligomer production and toxicity","volume":"120","author":"Larson","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0020","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/416535a","article-title":"Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo","volume":"416","author":"Walsh","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0025","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1039\/b807980n","article-title":"The chemistry of Alzheimer's disease","volume":"38","author":"Rauk","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0030","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nn1372","article-title":"Natural oligomers of the amyloid-protein specifically disrupt cognitive function","volume":"8","author":"Cleary","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114278","article-title":"Current trends in blood biomarker detection and imaging for Alzheimer's disease","volume":"210","author":"Hu","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0040","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1039\/D0CS00107D","article-title":"Chemical sensing platforms for detecting trace-level Alzheimer's core biomarkers","volume":"49","author":"Kim","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0045","article-title":"Alzheimer's dementia: the emerging role of positron emission tomography","author":"Tripathi","year":"2021","journal-title":"Neuroscientist"},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0050","doi-asserted-by":"crossref","first-page":"12768","DOI":"10.3390\/ijms222312768","article-title":"Magnetic resonance imaging in animal models of Alzheimer's disease amyloidosis","volume":"22","author":"Ni","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0055","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.3233\/JAD-215093","article-title":"Novel ultrasensitive detection technologies for the identification of early and minimally invasive Alzheimer's disease blood biomarkers","volume":"86","author":"Alvarez-Sanchez","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0060","article-title":"Optical sensor array for the early diagnosis of Alzheimer's disease","volume":"10","author":"Li","year":"2022","journal-title":"Front. Chem."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2020.116054","article-title":"Graphitic carbon nitride-based nanocomposites electrochemiluminescence systems and their applications in biosensors","volume":"132","author":"Zou","year":"2020","journal-title":"Trac-Trend Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0070","doi-asserted-by":"crossref","first-page":"36299","DOI":"10.1021\/acsami.9b09492","article-title":"Design and biosensing of a ratiometric electrochemiluminescence resonance energy transfer aptasensor between a g-C3N4 nanosheet and Ru@MOF for amyloid-beta protein","volume":"11","author":"Wang","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0075","doi-asserted-by":"crossref","first-page":"7541","DOI":"10.1021\/acssuschemeng.1c01237","article-title":"Design of a dual-wavelength ratiometric electrochemiluminescence immunosensor for sensitive detection of amyloid-beta protein in human serum","volume":"9","author":"Qin","year":"2021","journal-title":"ACS Sustain. Chem. Eng."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2019.111517","article-title":"Ultrasensitive electrochemiluminescence immunosensor for the detection of amyloid-beta proteins based on resonance energy transfer between g-C3N4 and pd NPs coated NH2-MIL-53","volume":"142","author":"Fang","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0085","article-title":"Electrochemiluminescence detection for beta-amyloid(1-)(42) oligomers using silver nanoparticle decorated CuS@CoS2 double shelled nanoboxes as dual-quencher","volume":"329","author":"Li","year":"2021","journal-title":"Sens. Actuators B Chem."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.electacta.2020.137096","article-title":"G-C3N4-heme bound to amyloid beta peptides: in-situ generation of the secondary co-reactant for dual-enhanced electrochemiluminescence assay of amyloid beta detection","volume":"361","author":"Zhang","year":"2020","journal-title":"Electrochim. Acta"},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0095","first-page":"665","article-title":"Advance in applications of organic polymer based electrochemiluminescence in biochemical analysis, chinese","volume":"49","author":"Cui","year":"2021","journal-title":"J. Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bios.2019.03.058","article-title":"Silver-based metal-organic gels as novel coreactant for enhancing electrochemiluminescence and its biosensing potential","volume":"134","author":"Li","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0105","doi-asserted-by":"crossref","first-page":"12191","DOI":"10.1021\/acs.analchem.8b03383","article-title":"Terbium(III) organic gels: novel antenna effect-induced enhanced electrochemiluminescence emitters","volume":"90","author":"Li","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.electacta.2020.136842","article-title":"Efficient peroxydisulfate electrochemiluminescence system based the novel silver metal-organic gel as an effective enhancer","volume":"357","author":"Xiao","year":"2020","journal-title":"Electrochim. Acta"},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0115","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00604-021-04704-5","article-title":"Switchable electrochemical aptasensor for amyloid-\u03b2 oligomers detection based on triple helix switch coupling with AuNPs@CuMOF labeled signaling displaced-probe","volume":"188","author":"Wang","year":"2021","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0120","doi-asserted-by":"crossref","first-page":"11612","DOI":"10.1074\/jbc.M210207200","article-title":"In vitro characterization of conditions for amyloid-beta peptide oligomeri-zation and fibrillogenesis","volume":"278","author":"Stine","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0125","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1002\/smll.201303827","article-title":"Proton-functionalized two-dimensional graphitic carbon nitride nanosheet: an excellent metal-\/label-free biosensing platform","volume":"10","author":"Ma","year":"2014","journal-title":"Small"},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0130","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.molstruc.2018.03.068","article-title":"Synthesis, X-ray structural, hirshfeld surface analysis, FTIR, MEP and NBO analysis using DFT study of a 4-chlorobenzylammonium nitrate (C7ClH9N)+(NO3)\u2013","volume":"1164","author":"Hakiri","year":"2018","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0135","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.rser.2017.09.026","article-title":"An overview on ag modified g-C3N4 based nanostructured materials for energy and environmental applications","volume":"82","author":"Patnaik","year":"2018","journal-title":"Renew. Sust. Energ. Rev."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0140","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1007\/s00216-021-03319-2","article-title":"An excellent electrochemical aptasensor for amyloid-\u03b2 oligomers based on triple-helix aptamer switch via target-triggered signal transduction DNA displacement events","volume":"413","author":"Wang","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0145","doi-asserted-by":"crossref","first-page":"6835","DOI":"10.1093\/nar\/gkr322","article-title":"Stabilization of unstable CGC(+) triplex DNA by single-walled carbon nanotubes under physiological conditions","volume":"39","author":"Song","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0150","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.electacta.2008.06.067","article-title":"Cathodic electrochemiluminescence behavior of norfloxacin\/peroxydisulfate system in purely aqueous solution","volume":"54","author":"Yao","year":"2008","journal-title":"Electeochim. Acta"},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0155","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00604-021-04710-7","article-title":"Determination of beta-amyloid oligomer using electrochemiluminescent aptasensor with signal enhancement by AuNP\/MOF nanocomposite","volume":"188","author":"Yin","year":"2021","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2019.120376","article-title":"Electrochemiluminescence immunosensor of \"signal-off\" for beta-amyloid detection based on dual metal-organic frameworks","volume":"208","author":"Dong","year":"2020","journal-title":"Talanta"},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0165","doi-asserted-by":"crossref","first-page":"7157","DOI":"10.1021\/acsami.8b21928","article-title":"MnCO3 as a new electrochemiluminescence emitter for ultrasensitive bioanalysis of beta-amyloid(1\u201342) oligomers based on site-directed immobilization of antibody","volume":"11","author":"Jia","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijbiomac.2022.09.182_bb0170","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.bios.2019.01.066","article-title":"Ultrasensitive amyloid-beta proteins detection based on curcumin conjugated ZnO nanoparticles quenching electrochemiluminescence behavior of luminol immobilized on Au@MoS2\/Bi2S3 nanorods","volume":"131","author":"Li","year":"2019","journal-title":"Biosens. Bioelectron."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813022021146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813022021146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T01:39:36Z","timestamp":1754703576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813022021146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":34,"alternative-id":["S0141813022021146"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.09.182","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An adjustable amyloid-\u03b2 oligomers aptasensor based on the synergistic effect of self-enhanced metal-organic gel luminophore and triple-helix DNA system","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.09.182","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}