{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:54:52Z","timestamp":1790794492649,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFD1600704"],"award-info":[{"award-number":["2021YFD1600704"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Biological Macromolecules"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.ijbiomac.2022.09.260","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T23:23:28Z","timestamp":1664493808000},"page":"1048-1062","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"PA","title":["Lactoferrin alleviates spermatogenesis dysfunction caused by bisphenol A and cadmium via ameliorating disordered autophagy, apoptosis and oxidative stress"],"prefix":"10.1016","volume":"222","author":[{"given":"Huanshan","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiping","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ijbiomac.2022.09.260_bb0005","first-page":"584","article-title":"Decline of semen quality among 10 932 males consulting for couple infertility over a 20-year period in Marseille,France","volume":"14","author":"Geoffroy-Siraudin","year":"2012"},{"key":"10.1016\/j.ijbiomac.2022.09.260_bb0010","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12958-015-0032-1","article-title":"A unique view on male infertility around the globe","volume":"13","author":"Agarwal","year":"2015","journal-title":"Reprod.Biol.Endocrinol."},{"issue":"Pt B","key":"10.1016\/j.ijbiomac.2022.09.260_bb0015","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1016\/j.ijbiomac.2018.09.030","article-title":"Extraction and incorporation of bioactives into protein formulations for food and biomedical applications","volume":"120","author":"Etxabide","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"12","key":"10.1016\/j.ijbiomac.2022.09.260_bb0020","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/s41422-018-0090-y","article-title":"Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis","volume":"28","author":"Zhou","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.ijbiomac.2022.09.260_bb0025","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ijbiomac.2021.08.089","article-title":"Nanoparticle impregnated self-supporting protein gel for enhanced reduction in oxidative stress: a molecular dynamics insight for lactoferrin-polyphenol interaction","volume":"189","author":"Raychaudhuri","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"10.1016\/j.ijbiomac.2022.09.260_bb0030","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s00345-013-1023-5","article-title":"Comparative proteomic study between human normal motility sperm and idiopathic asthenozoospermia","volume":"31","author":"Shen","year":"2013","journal-title":"World J. Urol."},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.09.260_bb0035","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12944-019-0969-8","article-title":"Antioxidant properties of milk and dairy products: a comprehensive review of the current knowledge","volume":"18","author":"Khan","year":"2019","journal-title":"Lipids Health Dis."},{"issue":"8","key":"10.1016\/j.ijbiomac.2022.09.260_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/nu13082492","article-title":"Lactoferrin and its detection methods: a review","volume":"13","author":"Zhang","year":"2021","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.09.260_bb0045","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/jat.4055","article-title":"Cadmium as a testicular toxicant: a review","volume":"41","author":"Bhardwaj","year":"2021","journal-title":"J.Appl.Toxicol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2022.09.260_bb0050","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.fertnstert.2016.07.1118","article-title":"Effects of bisphenol a on male and couple reproductive health: a review","volume":"106","author":"M\u00ednguez-Alarc\u00f3n","year":"2016","journal-title":"Fertil. Steril."},{"issue":"2","key":"10.1016\/j.ijbiomac.2022.09.260_bb0055","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000494085","article-title":"The nuclear translocation of mitogen-activated protein kinases: molecular mechanisms and use as novel therapeutic target","volume":"108","author":"Flores","year":"2019","journal-title":"Neuroendocrinology"},{"issue":"14","key":"10.1016\/j.ijbiomac.2022.09.260_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/ma12142285","article-title":"HEMA effects on autophagy mechanism in human dental pulp stem cells","volume":"12","author":"Diomede","year":"2019","journal-title":"Materials"},{"key":"10.1016\/j.ijbiomac.2022.09.260_bb0065","doi-asserted-by":"crossref","first-page":"4350965","DOI":"10.1155\/2016\/4350965","article-title":"ROS and ROS-mediated cellular signaling","volume":"2016","author":"Zhang","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.09.260_bb0070","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4161\/spmg.1.1.13971","article-title":"Environmental toxicants and male reproductive function","volume":"1","author":"Cheng","year":"2011","journal-title":"Spermatogenesis"},{"issue":"Pt A","key":"10.1016\/j.ijbiomac.2022.09.260_bb0075","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijbiomac.2017.08.151","article-title":"Lactoferrin promotes MC3T3-E1 osteoblast cells proliferation via MAPK signaling pathways","volume":"107","author":"Liu","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"9","key":"10.1016\/j.ijbiomac.2022.09.260_bb0080","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1080\/15548627.2019.1591672","article-title":"Mitophagy regulates mitochondrial network signaling, oxidative stress, and apoptosis during myoblast differentiation","volume":"15","author":"Baechler","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.ijbiomac.2022.09.260_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113996","article-title":"Bisphenol A exposure causes testicular toxicity by targeting DPY30-mediated post-translational modification of PI3K\/AKT signaling in mice","volume":"243","author":"He","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ijbiomac.2022.09.260_bb0090","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.toxlet.2018.04.005","article-title":"Cadmium inhibits lysine acetylation and succinylation inducing testicular injury of mouse during development","volume":"291","author":"Yang","year":"2018","journal-title":"Toxicol. Lett."},{"issue":"18","key":"10.1016\/j.ijbiomac.2022.09.260_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202100253","article-title":"Daily dose of bovine lactoferrin prevents ethanol-induced liver injury and death in male mice by regulating hepatic alcohol metabolism and modulating gut microbiota","volume":"65","author":"Li","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.09.260_bb0100","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/09712119.2021.1901716","article-title":"Effects of soy isoflavones on intake, body weight, sex hormones, antioxidant performance, and semen quality in Xinong Saanen goats","volume":"49","author":"He","year":"2021","journal-title":"J. Appl. Anim. Res."},{"issue":"6","key":"10.1016\/j.ijbiomac.2022.09.260_bb0105","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1039\/C3FO60702J","article-title":"A standardised static in vitro digestion method suitable for food - an international consensus","volume":"5","author":"Minekus","year":"2014","journal-title":"Food Funct."},{"issue":"2","key":"10.1016\/j.ijbiomac.2022.09.260_bb0110","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.nutres.2004.12.003","article-title":"Structurally related flavonoids with antioxidative properties differentially affect cell cycle progression and apoptosis of human acute leukemia cells","volume":"25","author":"Rusakc","year":"2005","journal-title":"Nutr. Res."},{"issue":"9","key":"10.1016\/j.ijbiomac.2022.09.260_bb0115","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrm2239","article-title":"Self-eating and self-killing: crosstalk between autophagy and apoptosis","volume":"8","author":"Maiuri","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2022.09.260_bb0120","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1159\/000493655","article-title":"Pterostilbene reduces acetaminophen-induced liver injury by activating the Nrf2 antioxidative defense system via the AMPK\/Akt\/GSK3\u03b2 pathway","volume":"49","author":"Fan","year":"2018","journal-title":"Cell.Physiol.Biochem."},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.09.260_bb0125","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1083\/jcb.200801099","article-title":"Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents","volume":"183","author":"Degtyarev","year":"2008","journal-title":"J. Cell Biol."},{"issue":"5","key":"10.1016\/j.ijbiomac.2022.09.260_bb0130","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1128\/MCB.20.5.1626-1638.2000","article-title":"Akt suppresses apoptosis by stimulating the transactivation potential of the RelA\/p65 subunit of NF-kappaB","volume":"20","author":"Madrid","year":"2000","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2022.09.260_bb0135","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1523-1755.2004.00779.x","article-title":"Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction","volume":"66","author":"Inazaki","year":"2004","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.ijbiomac.2022.09.260_bb0140","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.bbrc.2017.04.130","article-title":"Autophagy regulates endothelial-mesenchymal transition by decreasing the phosphorylation level of Smad3","volume":"487","author":"Wang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.ijbiomac.2022.09.260_bb0145","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1161\/STROKEAHA.111.626648","article-title":"Neuroprotection by interleukin-6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in ischemic stroke","volume":"42","author":"Jung","year":"2011","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.ijbiomac.2022.09.260_bb0150","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.molcel.2012.09.013","article-title":"Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity","volume":"48","author":"Shen","year":"2012","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.09.260_bb0155","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S1074-7613(00)80011-4","article-title":"Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells","volume":"10","author":"Catlett-Falcone","year":"1999","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.ijbiomac.2022.09.260_bb0160","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/jcb.23399","article-title":"AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1","volume":"113","author":"Sanchez","year":"2012","journal-title":"J. Cell. Biochem."},{"issue":"11","key":"10.1016\/j.ijbiomac.2022.09.260_bb0165","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.4161\/auto.7.11.16658","article-title":"Docosahexaenoic acid induces autophagy through p53\/AMPK\/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53","volume":"7","author":"Jing","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.ijbiomac.2022.09.260_bb0170","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1756-8722-3-8","article-title":"From basic research to clinical development of MEK1\/2 inhibitors for cancer therapy","volume":"3","author":"Fr\u00e9min","year":"2010","journal-title":"J. Hematol. Oncol."},{"issue":"6","key":"10.1016\/j.ijbiomac.2022.09.260_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0179772","article-title":"MicroRNA-144-3p inhibits autophagy activation and enhances Bacillus Calmette-Gu\u00e9rin infection by targeting ATG4a in RAW264.7 macrophage cells","volume":"12","author":"Guo","year":"2017","journal-title":"PloS one"},{"issue":"6","key":"10.1016\/j.ijbiomac.2022.09.260_bb0180","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.tiv.2009.06.020","article-title":"Intracellular oxidative stress and cadmium ions release induce cytotoxicity of unmodified cadmium sulfide quantum dots","volume":"23","author":"Li","year":"2009","journal-title":"Toxicol.In Vitro"},{"key":"10.1016\/j.ijbiomac.2022.09.260_bb0185","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.taap.2018.07.009","article-title":"Bisphenol A induced male germ cell apoptosis via IFN\u03b2-XAF1-XIAP pathway in adult mice","volume":"355","author":"Jiang","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.ijbiomac.2022.09.260_bb0190","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1093\/toxsci\/kfy061","article-title":"Prenatal exposure to bisphenol a analogues on male reproductive functions in mice","volume":"163","author":"Shi","year":"2018","journal-title":"Toxicol.Sci."},{"key":"10.1016\/j.ijbiomac.2022.09.260_bb0195","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bbrc.2021.03.138","article-title":"Melatonin regulates the cross-talk between autophagy and apoptosis by SIRT3 in testicular Leydig cells","volume":"555","author":"Wang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.09.260_bb0200","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1017\/S0954422417000191","article-title":"In vitro and in vivo antioxidant potential of milks, yoghurts, fermented milks and cheeses: a narrative review of evidence","volume":"31","author":"Fardet","year":"2018","journal-title":"Nutr. Res. Rev."},{"issue":"14","key":"10.1016\/j.ijbiomac.2022.09.260_bb0205","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1158\/0008-5472.CAN-05-0216","article-title":"Prostaglandin E2 activates mitogen-activated protein kinase\/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner","volume":"65","author":"Krysan","year":"2005","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.ijbiomac.2022.09.260_bb0210","first-page":"1997","article-title":"ERK\/MAPK signalling pathway and tumorigenesis","volume":"19","author":"Guo","year":"2020","journal-title":"Exp.Ther.Med."},{"key":"10.1016\/j.ijbiomac.2022.09.260_bb0215","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.tox.2015.05.003","article-title":"Cytotoxic mechanism related to dihydrolipoamide dehydrogenase in Leydig cells exposed to heavy metals","volume":"334","author":"Ji","year":"2015","journal-title":"Toxicology"},{"issue":"3","key":"10.1016\/j.ijbiomac.2022.09.260_bb0220","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3109\/15376516.2016.1139024","article-title":"Exposure to bisphenol A (BPA) in Wistar rats reduces sperm quality with disruption of ERK signal pathway","volume":"26","author":"Li","year":"2016","journal-title":"Toxicol. Mech. Methods"},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.09.260_bb0225","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.toxlet.2014.01.035","article-title":"Involvement of activating ERK1\/2 through G protein coupled receptor 30 and estrogen receptor \u03b1\/\u03b2 in low doses of bisphenol A promoting growth of Sertoli TM4 cells","volume":"226","author":"Ge","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ijbiomac.2022.09.260_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2019.114797","article-title":"Increasing ERK phosphorylation by inhibition of p38 activity protects against cadmium-induced apoptotic cell death through ERK\/Drp1\/p38 signaling axis in spermatocyte-derived GC-2spd cells","volume":"384","author":"Seong","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.ijbiomac.2022.09.260_bb0235","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/09553000701275432","article-title":"Time and dose-dependent activation of p53 serine 15 phosphorylation among cell lines with different radiation sensitivity","volume":"83","author":"Wittlinger","year":"2007","journal-title":"Int. J. Radiat. Biol."},{"issue":"7","key":"10.1016\/j.ijbiomac.2022.09.260_bb0240","article-title":"Phosphorylation time-course study of the response during adenovirus type 2 infection","volume":"20","author":"Vald\u00e9s","year":"2020","journal-title":"Proteomics"},{"key":"10.1016\/j.ijbiomac.2022.09.260_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175067","article-title":"Cell proliferation effects of S-allyl-L-cysteine are associated with phosphorylation of Janus kinase 2, insulin-like growth factor type-I receptor tyrosine kinase, and extracellular signal-regulated kinase 2 in primary cultures of adult rat hepatocytes","volume":"927","author":"Moteki","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.ijbiomac.2022.09.260_bb0250","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.pnpbp.2008.05.027","article-title":"Dose-dependent effect of intracerebroventricular injection of ouabain on the phosphorylation of the MEK1\/2-ERK1\/2-p90RSK pathway in the rat brain related to locomotor activity","volume":"32","author":"Kim","year":"2008","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.09.260_bb0255","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neuropharm.2007.06.005","article-title":"Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1\/2 MAP kinase signaling","volume":"54","author":"Daigle","year":"2008","journal-title":"Neuropharmacology"},{"issue":"18","key":"10.1016\/j.ijbiomac.2022.09.260_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24183217","article-title":"Moringin pretreatment inhibits the expression of genes involved in mitophagy in the stem cell of the human periodontal ligament","volume":"24","author":"Chiricosta","year":"2019","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.ijbiomac.2022.09.260_bb0265","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/14728222.2019.1601703","article-title":"Sequestosome 1\/p62-related pathways as therapeutic targets in hepatocellular carcinoma","volume":"23","author":"Denk","year":"2019","journal-title":"Expert Opin. Ther. Targets"},{"issue":"33","key":"10.1016\/j.ijbiomac.2022.09.260_bb0270","doi-asserted-by":"crossref","first-page":"24131","DOI":"10.1074\/jbc.M702824200","article-title":"p62\/SQSTM1 binds directly to Atg8\/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy","volume":"282","author":"Pankiv","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.ijbiomac.2022.09.260_bb0275","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2021.4957","article-title":"Neferine promotes the apoptosis of HNSCC through the accumulation of p62\/SQSTM1 caused by autophagic flux inhibition","volume":"48","author":"Zhu","year":"2021","journal-title":"Int. J. Mol. Med."}],"container-title":["International Journal of Biological Macromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813022022000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0141813022022000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T06:05:33Z","timestamp":1762236333000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0141813022022000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":55,"alternative-id":["S0141813022022000"],"URL":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.09.260","relation":{},"ISSN":["0141-8130"],"issn-type":[{"value":"0141-8130","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactoferrin alleviates spermatogenesis dysfunction caused by bisphenol A and cadmium via ameliorating disordered autophagy, apoptosis and oxidative stress","name":"articletitle","label":"Article Title"},{"value":"International Journal of Biological Macromolecules","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.09.260","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}